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Matrine CAS 519-02-8

Molecular Formula: C15H24N2O

Formula Weight: 248.36

ZSpharmac: Matrine Supplement

Product Name: Matrine
CAS No: 519-02-8
Purity: 99%

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Basic Info

Product Name:Matrine
Other Names:Matrine Upl
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Solid
EINECS No.:610-750-6
Storage:Sealed in Dry,2-8°C
Provide:Matrine MSDS;
Matrine COA

What is Matrine?

Matrine is an alkaloid removed from the roots, stems, as well as fruits of the leguminous plant Sophora flavescens by natural solvents such as ethanol. The primary components of Sophora flavescens include matrine, oxymatrine, sophocarpine, oxysophocarpine, sophoridine as well as other alkaloids, amongst which matrine and oxymatrine have the highest material. With different formation conditions, matrine has 4 crystal types: α-form: needle-like, melting point 76 ° C; β-form: short prismatic, melting point 87 ° C; type; δ-type: fallen leave or prismatic, melting point 84 ℃. These crystal forms can change into each other and also develop the exact same salts. The relative thickness is 1.0888 (85/4 ° C), the refractive index is 1.52865 (85 ° C )[ α] D20-39.11 ° C water. Soluble in cold water, ethanol, ether, chloroform and also benzene, insoluble in oil ether, as well as less soluble in hot water than in cold water. Oxymatrine is generated with hydrogen peroxide. Both matrine and oxymatrine are fairly soluble in water. Nevertheless, the oxygen atom in the oxymatrine particle shares a pair of electrons with the N atom with a semi-polar coordination bond, which is similar to alkaloid salts and has a greater polarity, so the solubility in water is more than Matrine is less soluble than matrine in organic solvents.

Matrine has a reasonably strong basicity. It has 2 nitrogen atoms in its particle. N16 remains in an amide state as well as has practically no basicity. N1 is a tertiary amine., which compromises the influence of the stereo effect, so the alkalinity is fairly solid. Another example is in the particle of scopolamine, as a result of the presence of the three-membered oxygen ring, the only electron set on the nitrogen atom generates a considerable stereo result (boosting steric hindrance), making it challenging for the nitrogen atom to give electrons, so the basicity is deteriorated.

The alkalinity of alkaloids is not only related to the binding state of the N atom in the heterocyclic structure, yet likewise to the chemical setting in which the N atom is located, such as whether there are electric impacts, steric impacts, as well as other substituent groups as well as intramolecular hydrogen. vital and various other elements. But the more vital thing is to take into consideration the integrity of the particle.

Matrine has a selection of medicinal effects such as antibacterial, antiasthmatic, and also leukocyte boost. Animal experiments have actually shown that it has an inhibitory impact on some malignant lumps. Oxymatrine is specifically famous, and also its chemotherapeutic index is 7.8 times that of self-immobilization. The killing result on LA-795 cells was substantially boosted under hypoxia.

Matrine Property

Melting point 77 C
Boiling point 86-88C/2,5Torr
alpha D20 +38° (alc)
density 1,191g/cm
refractive index 1,536
storage temp. Sealed in dry,2-8°C
solubility Soluble in Water (up to 25 mg/ml)
form solid
color White


Matrine Uses

Anti-bacterial and also antiviral impacts:
0.3% ~ 1% matrine option has solid inhibitory impact on beta streptococcus, Shigella, Proteus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, 7.5% ~ 10% of oxymatrine Antacid likewise has inhibitory impacts on dysentery, Escherichia coli, Staphylococcus aureus, and also beta streptococcus.On top of that, Shandougen preparation contains active substances versus CoxB5 infection. Has a certain antiviral result.

Agricultural pesticides:
Matrine is a reduced toxicity plant pesticide.The insecticide has get in touch with murder as well as belly poisoning effects on bugs, and has better control impacts on cabbage worms, aphids and red crawlers on vegetables, apple trees, cotton and also various other crops.

Characteristics of Matrine as a Biological Pesticide

First off, matrine is an herb pesticide with specific and also natural attributes. It just acts on particular organisms and also can be swiftly disintegrated in nature, and also the end products are carbon dioxide and water. Second of all, matrine is a plant endogenous chemical material that is active versus damaging organisms. The composition is not solitary, yet the mix of multiple groups with comparable chemical outcomes and also several groups with various chemical frameworks, which match each other and collaborate. Third, matrine is challenging to create hazardous materials to establish medication resistance as a result of the joint action of a selection of chemical compounds, and also can be used for a long period of time. Fourth, the corresponding pests will not be straight and entirely infected, however the number of biological populations of the parasites will not be seriously affected to the production and recreation of the plant populations. This mechanism is extremely comparable to the concept of insect control in the incorporated control system that has actually been examined for years after the side effects of chemical pesticide defense have become popular. To sum up the above 4 points, it can be shown that matrine is obviously different from the basic high toxicity as well as high deposit chemical pesticides, and it is very green and also eco-friendly.

How to Use Matrine:

1. Prevention as well as control of veggie pests: Caterpillars, diamondback moths, millet armyworms, etc need to be sprayed from the top of egg hatching to the young larval stage (2-3 instars), utilizing 100 ~ 150 grams of 0.3% water option per 667 square meters, or 0.36% 80 ~ 120g of water, or 30 ~ 45ml of 1% soluble liquid, or 15 ~ 20ml of 2% water, mixed with 40-50kg of water and sprayed uniformly. The representative has a good result on young larvae, yet has inadequate sensitivity to 4-5 instar larvae.

2. Avoidance and also control of fruit tree bugs: begin spraying in the onset of the rapid incident of mites, when every 10-15 days, as well as spray twice straight. – Typically, make use of 0.3% liquid solution 250-300 times, or 0.36% liquid option 300-350 times, or 1% soluble remedy 800– 1000 times, or 2% aqueous remedy 1500-2000 times to spray equally.

Avoidance as well as control of underground insect pests: use 700-1300 litres of o. 3% water agent per 667 square meters, or 600-1200 ml of 0.36% water agent, or 200-400 ml of 1% soluble wave agent, or 100-200 ml of 2% water agent After sprinkling, irrigate the roots. In addition to its insecticidal as well as antiseptic effects, matrine likewise has particular plant growth regulating tasks: the fresh weight and dry weight of fallen leaves are dramatically increased; matrine can advertise fallen leave photosynthesis; boost fruit shade; matrine also significantly promotes rooting as well as root development. It has great emulsifying and decontamination impacts on plant surface areas, maintaining fruit trees tidy; boosting granulocytes, triggering endogenous hormonal agents, as well as improving plant resistance. Matrine has evident growth-promoting task. Although matrine is a low-toxicity pesticide, every person requires to listen in the process of utilizing it. It is strictly forbidden to mix matrine with alkaline drugs. Matrine has poor quick result. Avoidance as well as control of pesticides at a young age.

3. Matrine commonly made use of preparations include 0.3% matrine service, 1% matrine alcohol remedy, 0.2% matrine service, 1.1% matrine powder, and 1% matrine liquid service.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Matrine Quotation