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Zhishang Chemical

Mannitol Pulver CAS 87-78-5

Molecular Formula: C6H14O6

Formula Weight: 182.17

ZSpharmac: Mannitol Pulver Supplier

Product Name: Mannitol Pulver
CAS No: 87-78-5
Purity: 99%

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Basic Info

Product Name:Mannitol Pulver
Other Names:Mannitol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:201-770-2
Storage:Inert Atmosphere,Room Temperature
Provide:Mannitol Pulver MSDS;
Mannitol Pulver COA

What is Mannitol Pulver?

Mannitol, in addition called mannitol, is a six-carbon polyol extracted from brown algae cells, Particularly, the material of aquatic brown algae in the kelp member of the family is really high. Mannitol Pulver is a storage room product in brown algae cells. Big brown algae such as kelp are the major raw materials for extracting mannitol. Mannitol Pulver removed from kelp and also niacin mannitol lipid produced with niacin have obvious impacts on alleviating angina pectoris as well as have excellent alleviative effect on hyperlipidemia. It can handle troubles such as high cholesterol, hypertension along with arteriosclerosis. Mannitol is additionally a drying agent in addition to can be used medically. When its 20% solution is infused right into the capillary, due to the fact that it is rarely broken down in the body, it causes a short-term increase in blood osmotic pressure, to guarantee that the water in the cells can get in the blood, hence lowering cells edema. When Mannitol Pulver is filteringed system from the glomerulus, it is hard to be reabsorbed in the kidney tubules, which improves the osmotic pressure of the original pee in the kidney tubules and extracts a big amount of water to play a diuretic impact.

Mannitol Pulver Property

Melting point 167°C
Boiling point 494.9°C
density 1.596
refractive index 1.5970 (estimate)
storage temp. Inert atmosphere,Room Temperature
pkapKa 13.50(H2O,t =18)(Approximate)
Water Solubility 177.3g/L(25 ºC)


Application of Mannitol Pulver

1. Food
Mannitol Pulver is just one of the commonly used sugar alcohol sugar changes, frequently made use of in sugar-free consuming periodontal ingredients. Mannitol is the sugar alcohol with the least water absorption, which can be used in food anti-sticking powder. my country’s artificial additive usage hygiene basic GB2760-2007 defines that it can be used in sugar-free eating gum, as well as the optimum dosage is 200g/kg. Confirmed by JECFA, the ADI worth is 0-50 mg/( kg body weight · d). The USA FDA states that the optimum use Mannitol Pulver in numerous foods is as adhere to: 98% mints, 40% soft desserts, 5% hard candies, 8% sweet fruit and also ice cream, 5% throat lozenge, 15% jam jelly, gummies 31%, other food 2.5%. Mannitol is outlined in the USA Pharmacopoeia, Natural Medicines, in addition to pharmacopoeias worldwide, consisting of the Guidebook of Food Chemistry (FEC).

2. Drug
It can be utilized as a large mixture of shot to lower brain stress, intraocular tension, and additionally remove cerebral edema; it can be made use of as a diuretic; it can be utilized for kidney feature as well as digestive system examination; Mannitol Pulver mixture has a specific result on oliguria and renal failing caused by edema in addition to burns; it can be made use of with amino acids Substance mixture service. Because of its good compression homes, it has really end up being a superior excipient in the pharmaceutical market Furthermore, mannitol nitrogen mustard and also mannitol dimethanesulfonic acid synthesized from Mannitol Pulver are antitumor medicines, which are suitable for persistent leukemia and more.

3. Chemical market.
Mannitol is esterified in addition to etherified to generate various materials as well as surfactants. Mannitol Pulver ester can be utilized as polyvinyl chloride plasticizer; as well as likewise polyurethane stringent foam based upon polyether generated by polymerization of propylene oxide, which can be used for warm insulation, sound insulation and also moisture-proof materials.

4. Cosmetics
Mannitol is utilized mostly in cosmetics as a humectant to avoid dehydration of products and as a humectant to avoid completely dry skin.

Pharmacological Actions of Mannitol Pulver

Mannitol Pulver is a monosaccharide that is not metabolized in the body and also has low transmembrane transportation capacity. It creates dehydration as well as diuresis by raising plasma osmotic pressure and also urine osmotic pressure.
( 1) Tissue dehydration: Injecting this product into the blood can enhance the plasma osmotic pressure, creating water in the tissue (including eyes, mind, cerebrospinal fluid, and so on) to go into the blood vessel, therefore minimizing tissue edema, decreasing intraocular stress, intracranial pressure as well as Cerebrospinal liquid volume and also its stress. Mannitol Pulver1g can create an osmotic focus of 5.5 mmol/L, injection of Mannitol Pulver100g can move 2L of intracellular water to the beyond the cell, and excrete 50g of urinary sodium.
( 2) Diuretic impact: ① Mannitol Pulver enhances blood quantity and advertises the secretion of prostaglandin I2, therefore expanding kidney blood vessels and also enhancing kidney blood circulation including renal medullary blood flow. Glomerular afferent arterioles expanded, glomerular capillary stress increased, cortical glomerular filtering price increased. ② This product is hardly ever (<10%) reabsorbed by kidney tubules after glomerular purification, so it can boost the osmotic concentration of kidney tubular liquid, minimize renal tubules’ action to water, Na+, Cl-, K+, Ca2+, Mg2+ as well as other Solute reabsorption. After the application of huge doses of mannitol, the water and Na+ travelling through the proximal tubule only increased by 10% to 20% and also 4% to 5% respectively; while the water and Na+ getting to the distal tubule increased by 40% and also 25%, specifically, recommending that Heinz Loophole reabsorption of water and reduction of Na+ play a vital duty in the diuretic effect of Mannitol Pulver. This might be because of the boosted blood flow of the kidney medulla, the raised loss of urea as well as Na+ in the medulla, thereby destroying the medullary osmotic pressure slope.
( 3) Detoxification: Due to the boost in the fluid flow in the glomeruli and kidney tubules after mixture of Mannitol Pulver, when some drugs and also poisonous substances are infected, the focus of these compounds in the renal tubules decreases, reducing the toxicity to the kidneys, and also passing through the kidneys. Excretion is sped up.

Mannitol Pulver Production Method

Method 1. Extraction method
Soaking, alkali refining, acidification Put about 2-3 tons of tap water in the algae washing tank, put in 120kg of seaweed, and after the algae body expands, carefully wash the Mannitol Pulver on the seaweed into the water, and the washed seaweed is used for extracting sodium alginate . Wash the second batch of seaweed with the washing liquid, and wash about four batches like this. Add 300g/L (30%) sodium hydroxide solution to the above washing solution, Ph10-11, and let it stand for 8 hours until the fucoidan solution, starch and other organic viscous substances are fully coagulated and precipitated. Siphon the supernatant, acidify it with sulfuric acid (1:1), adjust it to pH 6-7, further remove the jelly, and obtain a neutral supernatant.
Seaweed or kelp [tap water] → lotion [NaOH] → [pH10-11, 8h] supernatant
[H2SO4]→[pH6-7] Concentrate the neutral clear liquid and wash with alcohol. Heat the above neutral clear liquid with direct fire or steam until boiling and evaporation. The temperature is 110-115°C. A large amount of sodium chloride is precipitated. Take out the glue dirt until it becomes a concentrated solution, take a small sample and pour it on the ground, let it solidify after a little cooling, and then discharge the material, containing more than 30% of Mannitol Pulver and about 10% of water. Cool the concentrated solution to 60-70°C, add 95% ethanol (2:1) while it is hot, keep stirring, and gradually cool to room temperature, then centrifuge to dry to remove gum, and obtain off-white loose matter.
Neutral clear liquid [110-115°C] → concentrate [ethanol] → [60-70°C] loose matter extraction Weigh the loose matter, put it into an extraction pot equipped with a reflux condenser, add 94% of 8 times the amount Ethanol, stirred, heated slowly, boiled and refluxed for 30 minutes to discharge, cooled in running water for 8 hours, left for a day and night, centrifuged and dried to obtain white loose Mannitol Pulver crude product, containing 70%-80% mannitol. The same operation as above, ethanol recrystallization once, to obtain industrial mannitol, the content is more than 90%, and the Cl- content is <0.5%.
Loose matter [94% ethanol]→[reflux for 30min, cooling for 8h] refine the crude Mannitol Pulver, take industrial mannitol and add distilled water to dissolve it, then add 1/10-1/8 of medicinal activated carbon, keep stirring, keep warm at 80℃ for half hours, filter while hot, wash the activated carbon twice with a little water, combine the washed filtrate, and concentrate until the mannitol reaches 70%, if there is turbidity, re-filter. Cool to room temperature under stirring, crystallize, filter with suction, wash the crystals, and filter with suction to obtain crystalline Mannitol Pulver.
Crude mannitol [distilled water, activated carbon] → [80°C, 30min] concentrate the filtrate → crystallize mannitol and dry the above crystallized mannitol, after the Cl- is qualified (Cl-<0.007%), dry it with steam at 105-110°C , turn it frequently, take it out in 4 hours, and it is the finished product of medicinal Mannitol Pulver. Content 98%-102%, melting point 166-168°C, [α]20D+23°-+24°
Crystalline mannitol [105-110°C, 4h] → finished medicinal mannitol
Preparation of Injection The finished product of mannitol is dissolved in water for injection according to the dose to form a solution, and the mannitol injection is obtained after sterilization.
Mannitol Pulver Finished Product [Water for Injection] → Mannitol Injection
Method two, direct fermentation method
Breeding strains Aspergillus Oryzae3.409 was transplanted into a test tube filled with 10ml slant medium (2.1% agar was added to the wort) and cultured at 31°C for 4 days. Get slant bacteria.
The strain preservation system adopts the low-temperature preservation method, put the strain on a slant in a refrigerator at 4°C, and store it for 2-3 months for passage once. Before use, it needs to be re-transplanted and activated to ensure fermentation.
Amitramycin [strain slant medium] → [31°C, 4d] slant strain
Seed culture Take 2 wort slant planes of strains that have been cultured for 4 days, and transplant them into 17.5L seed medium. Preparation of seed medium: sodium nitrate 0.3%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, potassium chloride 0.05%, ferrous sulfate 0.001%, corn steep liquor 0.5%, starch hydrolyzed sugar 2%, corn flour 2% , initial pH6-7. Ventilation 1: 0.5V/(V·min), temperature 31°C±1°C, stirring at 350r/min, tank pressure 98.1kPa (1kgf/cm2) and culture for 20-24h to obtain seed culture solution.
Incline strains [seed medium] → [pH6-7, 31°C, 20-24h] seed culture solution
Preparation of fermentation medium: sodium nitrate 0.3%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, ferrous sulfate 0.001%, corn steep liquor 3%, corn flour 3.5%, starch hydrolyzed sugar 12.5%, initial pH 6-7 .
Take 350L of fermentation medium and put it into a 600L fermentation tank, steam sterilize it at 146.15kPa (1.5kgf/cm2) for 30min, transfer it into the seed culture solution, the inoculum size is 5%, the tank pressure is 98.1kPa (1kgf/cm2), the ventilation volume 1: 0.3V/(V min), after 20 hours of fermentation, change to 1: 0.4V/(V min), temperature 30-32°C, stirring 230r/min, fermentation cycle 4-5d. In order to prevent foaming, add 200ml soybean oil when making ingredients. The obtained fermented liquid contains more than 5% of mannitol, and the conversion rate is 40%.
Seed culture liquid [steam] → [pH6-7, 30-32℃, 4-5d] fermentation liquid
Coagulation, concentration, crystallization, decolorization, desalination Heat the fermentation broth at 100°C for 5 minutes, add 1% activated carbon at 80-85°C for 30 minutes, filter or shake dry to obtain a clear liquid. Then the clarified filtrate was concentrated in vacuum at 50-60°C to 31°Be, left at room temperature for 24h, and dried to obtain mannitol crystals. Dissolve the crystals in 0.7 times water, add 2% activated carbon, heat at 70°C for 30 minutes to decolorize, and filter. The filtrate is desalted by 717 strong basic anion exchange resin (OH-type) and strong acidic cation exchange resin (H+ type) 2:1 mixed bed resin, and the effluent is checked for no chloride ion reaction.
Fermentation broth [1% activated carbon] → [100°C, 5min; 80-85°C, 30min] clarified filtrate [55-60°C] → [decompression] crude product [water, 2% activated carbon] → [70°C, 30min] Filtrate [yin and yang mixed bed resin] → effluent
Concentrate, crystallize, and dry the effluent with steam at 55-60°C, 80kPa (600mmHg) under reduced pressure to 25°Be, let the concentrated solution cool to room temperature for 24h to crystallize, shake dry, dry at 105-110°C, and pulverize to obtain Medicinal finished product, yield 60%, content 98.83%-100.9%.
Effluent [55-60°C] → [Decompression] Concentrate [Room Temperature] → [24h] Crystallization [105-110°C] → API
For the preparation, take an appropriate amount of water for injection, heat it to about 90°C, weigh Mannitol Pulver at a content of 20%, dissolve it, add activated carbon in a water bath and heat for 5 minutes to decolorize, filter through a Buchner funnel, and then add water for injection to the full amount. After the determination of content and pH is qualified, filter it with G3 vertically fused glass filter ball until it is clear, dispense it into 50ml, 100ml or 250ml ampoules or infusion bottles, and sterilize it with 98.1kPa (1kgf/cm2) hot-pressed steam for 40min to obtain Mannitol Pulver injection.

About Products:
If you need Mannitol as a cosmetic raw material, please contact our service personnel directly, and we will provide you with high-quality products at the best price.
As an experienced Mannitol manufacturer and supplier, ZSpharmac will provide Mannitol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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