Mango Leaf Extract

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Mango Leaf Extract Supplier

Product Name: Mango Leaf Extract

CAS No: 111-42-2

Purity: 99%

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Basic Info

Product Name:	Mango Leaf Extract
Other Names:	Mangifera Indica Leaf Extract
CAS:	111-42-2
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Yellow Viscous Liquid
EINECS No.:	NULL
Storage:	2-8°C
Provide:	Mango Leaf Extract MSDS； Mango Leaf Extract COA

What is Mango Leaf Extract?

Mango leaves are the leaves of Mango Mangiferaindica L. of Anacardiaceae. According to the “Dictionary of Chinese Medicine” records: mango folic acid, sweet, cool in nature. Promoting qi and dispersing stagnation, removing diarrhoea; treating abdominal pain and flatulence caused by heat stagnation; and washing rotten sores. The main component of mango leaf extract, mangiferin, is the main active ingredient in the treatment of respiratory diseases, and has been found in other plants. Modern pharmacological studies have shown that mango leaf extract has the effects of relieving asthma, relieving cough and expectorant, immune, anti-inflammatory and analgesic, anti-oxidation, anti-diabetic, antibacterial and antiviral. At present, there are mango cough tablets, mango cough capsules, Yinhua mango capsules, and Yinhua mango tablet preparations on the market in China, and the active ingredient of mango leaf extract is mangiferin.

Oral administration of mangiferin can reduce blood sugar levels in KK-Ay mice, but has no effect on blood sugar levels in normal mice, suggesting that mangiferin can be used to treat non-insulin-dependent diabetes. In addition, mangiferin improved hyperinsulinemia in KK-Ay mice. Based on the above results, mangiferin may exhibit antidiabetic activity through insulin sensitization.

In the prior art, the preparation method of mango leaf extract adopts the method of concentration and drying after extraction, and the content of mangiferin is low, which belongs to the crude method and the potency is low. Refining methods include the use of macroporous adsorption resin or silica gel chromatography. Silica gel chromatography uses a large amount of organic solvents and is not suitable for large-scale production. In the past, macroporous adsorption resin purification methods used high-concentration ethanol for elution, but it was difficult to obtain The mango leaf extract with a mangiferin content of more than 50%, and more importantly, the eluted mango leaf extract cannot achieve the effects of preventing and treating diabetes and lowering lipids.

Applications of Mango Leaf Extract

Modern medicinal research studies have actually revealed that the chemical components of mango fallen leave essence mainly consist of: mangiferin, homomangiferin, quercetin, gallic acid, catechol, shikimic acid, kaempferic acid, ellagic acid, thujene as well as unpredictable components. Mango fallen leave extract has the effect of easing bronchial asthma, soothing coughing and also expectorant. Nevertheless, there is no pertinent research report on the avoidance as well as therapy of mango fallen leave extract in metabolic syndrome. Mango fallen leave essence has good alleviative effect in treating persistent bronchitis. It is the primary active component of Tibetan blood vessel in the treatment of hepatitis and the antiviral energetic component in Anemarrhena rhizome. Mango leaf remove can also decrease great lines, indications of aging, as well as completely dry skin, “it also helps in collagen manufacturing, which decreases face creases and fine lines.”

Modern medical research has confirmed that mango leaf extract also has anti-oxidation, anti-inflammatory, antibacterial, anti-radiation, prevention and treatment of skin aging, lowering blood sugar, lowering uric acid, anti-tumor, immune regulation, choleretic, inhibiting the central nervous system, anti-inflammatory Anti-herpes simplex virus HSV-2, alleviating sacral radiculopathy caused by HSV-2 virus and other pharmacological effects. In the Chinese Pharmacopoeia and the quality standards of various Chinese medicinal materials and Chinese patent medicines, the content of mangiferin is often used as the quality standard. control indicators. At present, the new health care products or medicines developed with mango leaf extract as the main component are generally oral preparations. Due to the extremely low bioavailability of mangiferin to the human body, the clinical trial results of these oral preparations are not ideal.

Preparation Method of Mango Leaf Extract Toothpaste

1. Formula:
Mango leaf extract 20g, salicylic acid 4g, calcium hydrogen phosphate 500g, sodium pyrophosphate 17g, glycerin 350g, 70% sorbitol solution 160g, xanthan gum 3g, sodium carboxymethylcellulose 4g, xylitol 20g, sorbitol Potassium acid 2g, citric acid 10g, menthol 10g, sodium lauryl sulfate 30g, water 100g.

2. Production method: including the following steps:
A. Glue making: according to the amount in the formula, first put glycerin, 70% sorbitol solution, xanthan gum, and sodium carboxymethyl cellulose into the glue making pot, stir at high speed for 7 minutes, then add water, xylitol, coke Sodium phosphate, potassium sorbate, citric acid, continue to stir until it becomes a colloid, let it stand for 6 hours, then stir at a high speed for 20 minutes to obtain a transparent and uniform glue.

B. Kneading: Pour the glue into the kneader, add other components in the formula, and mix evenly to get a viscous paste.

C. Grinding: Put the paste into the colloid mill and grind until it becomes a uniform and soft paste.

D. Aging: transfer the ground paste into a temporary storage tank, and let it stand for 12 hours to let the air bubbles in the paste discharge and make the paste more viscous and uniform.

E. Vacuum degassing: Pour the aged paste into the vacuum degasser, start the machine to remove the air bubbles in the paste.

F. Filling: Put the paste after vacuum degassing into the automatic filling machine, divide it into toothpaste tubes, and then seal the end to obtain the product mango leaf extract toothpaste.

Preparation of Mango Leaf Extract

The specific steps of mango leaf extract sample preparation are as follows:

Accurately weigh 400g of mango leaf powder, add 8 times the amount of 70% ethanol solvent, soak for 1 hour, boil and reflux for extraction for 2 hours, filter while it is hot, continue to add 8 times the amount of 70% ethanol solvent to the filter residue, continue to reflux for 2 hours, and combine 2 filtrates, let stand at room temperature, accurately measure the total volume of 6.86L of the extract, concentrate to 800mL according to the ratio of crude drug (g): solution volume (mL) = 1:2, centrifuge at 3000 rpm for 15min and discard precipitation. Accurately measure 800mL of pretreated D101 macroporous adsorption resin, and put it on the column by wet method.

Take the processed concentrated solution and load the sample, the flow rate is 40min/BV, first pre-elute with 3BV of water, 5 times the amount of 15% ethanol for elution, the 15% ethanol eluate recovers ethanol and concentrates to the end, weighs mangiferin 10g of the crude product was heated and dissolved with 20mL of 50% ethanol solution to make the solution reach a supersaturated state, let stand, let cool, and suction filtered, then scraped off the filter cake and washed the precipitate with 20mL of 50% ethanol solution, fully stirred and mixed evenly, and suction filtered again. Put the filter cake into a vacuum drying oven at 60° C. to dry to obtain a mango leaf extract sample.

About That Product:
If you need Mango Leaf Extract, this cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Mango Leaf Extract manufacturer and supplier, ZSpharmac will provide Mango Leaf Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.