1. Antioxidant effect Due to the special structure of mangiferin, there are several phenolic hydroxyl groups in the molecule, and the phenolic hydroxyl teams are simply vital teams for scavenging free radicals and also reactive oxygen species. The system of its activity on complimentary radicals can be credited to 2 elements: on the one hand, it acts directly on scavenging totally free radicals, on the other hand, it acts upon iron and also copper ions to lower their further reaction with cost-free radicals. 2. Anti-tumor impact The event of leukemia is connected to the condition of cell cycle policy, and also there is a close relationship between cell cycle policy and also the expression of telomerase activity. Consequently, the study of abnormal guideline of telomerase and also cell cycle has actually become a new direction to explore the occurrence as well as therapy of leukemia. The occurrence of leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. 3. Neuroprotective effect Mangiferin with polyphenolic structure can protect neurons by reducing the influx of Ca2+ and the degree of oxidative stress, thereby reducing cell death caused by glutamate in neurons. 4. Antiviral effect It has in vitro anti-herpes simplex virus type I (HSV-I) effect with a plaque reduction rate of 56.8%, and its antiviral effect is attributed to its ability to inhibit intracellular viral replication. 5. Antipyretic effect It has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, which is positively correlated with the dose, and has a good protective effect on thermal injury. 6. Analgesic effect It has a significant analgesic effect on pain induced by acetic acid and hot plate test. Compared with naloxone hydrochloride, it is found that mangiferin-induced analgesia is not dependent on opioid receptors, and its analgesic effect is significant and has little effect on peripheral nerves. 7. Anti-parasitic effect Mangiferin has obvious inhibitory effect on Cryptosporidium parvum in young mice. Effects of mangiferin on mice infected with the nematode, Trichinella spiralis. 8. Anti-diabetic effect After oral administration of mangiferin and its glucoside, the blood sugar level of normal mice did not change, but it could reduce the blood sugar concentration of KK-Ay mice, an animal model of spontaneous diabetes, and the serum insulin level also decreased. Fructin and its glucosides may exhibit antidiabetic activity through insulin sensitization. 9. Hepatoprotective and choleretic effects For the protection of the liver, mangiferin can stabilize the lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effect. 10. Effects on the central nervous system Mangiferin has obvious central nervous system excitatory effect. Mangiferin has the effect of removing lipid peroxides in brain tissue, reducing the damage of lipid peroxides to neurons, thereby protecting the normal function of neurons. 11. Effects on the respiratory system It has adrenal glucocorticoid-like anti-inflammatory effect, can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, which is manifested as (1) the induction time of asthma is significantly longer than that in the asthma group; (2) the degree of asthma is relieved, and the incidence of convulsions is significantly lower than that in the asthma group; (3) the emphysema is caused Significantly reduced, the infiltration of inflammatory cells in the lung was significantly less than that in the asthma group, and the lung/body weight ratio was significantly lower than that in the asthma group, and was close to the dexamethasone group. At the same time, mangiferin can reduce serum NO and endothelin-1 (ET-1) levels in bronchoalveolar lavage fluid, and play a certain preventive effect on asthma attacks. The combined use of mangiferin and dexamethasone can improve the efficacy.
