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Mangiferin CAS 4773-96-0

Molecular Formula: C19H18O11

Formula Weight: 422.34

ZSpharmac: Mangiferin Supplier

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Product Name: Mangiferin
CAS No: 4773-96-0
Purity: 99%

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Basic Info

Product Name:Mangiferin
Other Names:MANGIFERIN 98% HPLC
CAS:4773-96-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Pale Yellow Solid
EINECS No.:624-757-7
Storage:2-8°C
Provide:Mangiferin MSDS;
Mangiferin COA

What is Mangiferin?

Mangiferin (mangiferin), also referred to as Guan Zhi Mu Ning or Mangiferin, is a carboxyketone glycoside of tetrahydroxypyrrole, which comes from the flavonoid compound of bispheniron, and additionally is generally derived from the completely dry root of Anemarrhena anemarrhena, a seasonal herb of the Liliaceae family., leaves, fruits, bark of almonds along with mangoes, origins of the category Salacia in the group Salacia, and more; it has the features of alleviating coughing,alleviating bronchial asthma and also getting rid of phlegm, immune, anti-inflammatory as well as analgesic, safeguarding liver as well as gallbladder, anti-inflammatory Lipid peroxidation, anti-cancer, anti-diabetic, anti-bacterial, anti-viral and also other pharmacological activities, the current scientific applications mostly consist of mango cough tablets, mango cough pills, mangiferin tablet computers, mangiferin leaking tablets, and these representatives are restricted to make use of in respiratory system illness.

Mangiferin Property

Melting point 269-270°C
storage temp. 2-8°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly), Pyridine (Slightly, Heated)
Boiling point 842.7±65.0 °C(Predicted)
density 1.843±0.06 g/cm3(Predicted)
pKa6.09±0.20(Predicted)
form Solid
color Pale Yellow

 

Pharmacological Effects of Mangiferin

1. Antioxidant influence As a result of the particularity of the structure of mangiferin, there are multiple phenolic hydroxyl groups in the particle, and the phenolic hydroxyl groups strike be important teams for scavenging cost-free radicals along with active oxygen. Its device of action on complimentary radicals can be attributed to 2 elements: on the one hand, it straight acts on scavenging cost-free radicals; on the other hand, it acts upon iron and also copper ions to lower their additional response with cost-free radicals.
2. Anti-tumor outcome The event of leukemia is connected with the trouble of cell cycle policy, and there is a close relationship in between cell cycle standard and likewise the expression of telomerase job. As a result, the research of telomerase and additionally cell cycle policy problem has really ended up being a brand-new instructions to discover the occurrence in addition to treatment of leukemia. The occasion of leukemia is related to the condition of cell cycle legislation, as well as additionally there is a close relationship between cell cycle regulation and the expression of telomerase job. As a result, the research study of telomerase as well as cell cycle law problem has really become a new instructions to take a look at the occurrence and also treatment of leukemia.
3. Neuroprotective result Mangiferin with polyphenol framework can secure nerve cells by decreasing the cell death brought on by glutamate in nerve cells by weakening Ca2+ rise and oxidative stress and anxiety.
4. Antiviral effect It has anti-herpes simplex infection kind I (HSV-I) result in vitro, as well as the plaque decrease rate is 56.8%. The antiviral result is attributed to its capability to hinder infection replication in cells.
5. The antipyretic result has a fantastic antipyretic impact on the experimental animal version of high temperature triggered by endotoxin, as well as is favorably associated with the dose, in addition to has an excellent safety result on thermal injury.
6. The analgesic effect has a substantial analgesic impact on the pain generated by acetic acid as well as warmer assessment. Compared to naloxone hydrochloride, it is found that the analgesia induced by mangiferin is not based on opioid receptors, and also its analgesic result is significant. External nerves were a little impacted.
7. Anti-parasitic result Mangiferin has visible repressive result on Cryptosporidium parvum in young computer mice. Impacts of mangiferin on computer system mice polluted with the nematode, Trichinella spiralis.
8. Anti-diabetic effect After oral administration of mangiferin as well as its glucoside, the blood sugar degree of routine computer mice does not alter, yet it can decrease the blood sugar focus of spontaneous diabetic person animal design KK-Ay computer mice, as well as the lotion insulin degree furthermore tends to lower. Fruit glycosides and also their glucosides might reveal antidiabetic activity with insulin sensitization.
9. Hepatoprotective and likewise choleretic effect Protecting the liver, mangiferin has the impact of supporting the lysosome membrane layer, as well as additionally has a direct repressive influence on the job of lysosome acid phosphatase. Mangiferin similarly has recognizable choleretic influence.
10. The influence on the major nerve system Mangiferin has evident excitatory effect on the major nerves. Mangiferin has the function of doing away with lipid peroxide in brain cells, decreasing the damage of lipid peroxide to neurons, consequently safeguarding the routine feature of nerve cells.
11. The impact on the breathing system has adrenal glucocorticoid-like anti-inflammatory outcome, which can minimize capillary permeability, and its anti-inflammatory action rate gets to 38%. Because of the anti-inflammatory impact of mangiferin, it has a particular effect on bronchial asthma, as received ① it can significantly extend the induction time compared to the bronchial asthma group; ② it can reduce the degree of bronchial asthma, as well as the occurrence of convulsions is significantly less than that of the asthma team; The inflammatory cell infiltration in the lungs was considerably less than that of the bronchial asthma group, in addition to the lung/body weight proportion was dramatically less than that of the asthma group as well as also near that of the dexamethasone team. At the same time, mangiferin can decrease the degree of product NO as well as also endothelin-1 (ET-1) in alveolar lavage fluid, and also has a certain precautionary effect on asthma strikes. The mix of mangiferin in addition to dexamethasone can improve the effectiveness.

Extraction Method of Mangiferin

1. Organic solvent removal procedure
Making use of greater than 90% ethanol as the elimination solvent, high-purity mangiferin can be drawn out from mango leaves.
2. Water-based solvent extraction procedure
Mangiferin was eliminated from mango leaves weak alkaline water as the removal solvent, as well as additionally the essence was eluted with D101 column macroporous product as well as D301 column to remove contaminations and also decolorize. This high-purity mangiferin removal procedure is suitable for large business manufacturing.
3. Chemical extraction process
Utilizing cellulase to remove mangiferin from mango leaves by chemical hydrolysis, the speculative conditions: chemical hydrolysis pH 5.0, temperature 55 ° C, time 2h.
4. Ultrasonic-assisted extraction process
The ultrasonic-assisted removal process has the advantages of simpleness, short time consumption, power conserving, and so on, along with has a great development as well as application prospect.

The Content of the Invention of Mangiferin

In view of this, the object of the present invention is to provide a process for extracting and purifying mangiferin using a biologically active enzyme method, which not only improves the yield of the product, but also improves the purity of the product, while greatly reducing the production cost. The process is simple and feasible, and meets the conditions of large-scale production.

In order to solve the above technical problems, the technical solution provided by the invention is: a preparation method of mangiferin, the preparation method comprising the following steps:

(1), get raw material mango leaf, through drying, pulverizing, soak 0. Ihr~1. Ohr with the enzyme solution of 6~10 times raw material weight, at pH4.0~7.0 and 40 ℃~55 ° C lower water bath enzymolysis 1hr~4hr, and fully stir;

(2), filter, get medicinal dregs and carry out degreasing process 2~3 times with the sherwood oil of 6~10 times of weight respectively;

(3), step (2) the dregs after the degreasing treatment are extracted 2 to 3 times with 60% to 80% ethanol aqueous solution equivalent to 6 to 10 times of raw material weight, and the combined extracts reclaim ethanol;

(4), the extract of step C3) is spray-dried to obtain a dry powder, and then the dry powder is dissolved with 10%~30% ethanol aqueous solution, and centrifugally filtered;

(5), get the filtrate after the centrifugal filtration of step (4), concentrate and dry under reduced pressure in a water bath to obtain mangiferin.

Preferably, the mangiferin that step (5) obtains is recrystallized twice with 20%~50% ethanol solution to obtain the pure product of mangiferin.

Preferably, the enzyme solution in step (1) is selected from one or more of cellulase solution, pectinase solution and papain solution.

Preferably, the enzymolysis temperature in step (1) is 50 DEG C.

Preferably, the enzyme solution pH value in step (1) is 4.0~5.0.

Preferably, the pH value of the enzyme solution is 4.5.

Preferably, the concentration of the aqueous ethanol solution in step (3) is 75%.

Preferably, the concentration of the aqueous ethanol solution in the step is 20%.

Preferably, the concentration of the ethanol solution is 40%.

Preferably, the amount of enzyme added per gram of raw material is respectively 40 μ g to 140 μ g of cellulase, 20 μ g to 120 μ g of pectinase, and 1.5% to 7.5% of papain.

Compared with the prior art, the present invention adopts enzymatic method to extract mangiferin from mango leaves for waste utilization, greatly reduces production cost, not only improves the yield of the product, but also improves the purity of the product, and the whole production process has mild conditions, Simple and easy.

In the present invention, the mango leaf is first adjusted to the pH value, and then the active enzyme is added thereto, and the pH value is not adjusted by adding the enzyme first, which can effectively prevent the solution of adding the enzyme preparation from dripping a strengthened acidic solution, causing the solution to be localized. The acidity is too strong, so that the actual enzyme content in the solution is reduced.

About Products:
If you need Mangiferin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Mangiferin manufacturer and supplier, ZSpharmac will provide Mangiferin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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