Zhishang Chemical

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Zhishang Chemical

Mangiferin CAS 4773-96-0

Molecular Formula: C19H18O11

Formula Weight: 422.34

ZSpharmac: Mangiferin Supplement

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Product Name: Mangiferin
CAS No: 4773-96-0
Purity: 99%

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Basic Info

Product Name:Mangiferin
Other Names:Mangiferin, 98%, From Mangifera Persiciformis
CAS:4773-96-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Pale Yellow Solid
EINECS No.:624-757-7
Storage:2-8°C
Provide:Mangiferin MSDS;
Mangiferin COA

What is Mangiferin?

Mangiferin, also known as Guanzhimuning or mangiferin, is a carbon ketone glycoside of tetrahydroxypyridone, which belongs to the flavonoids of bisphenone, mainly derived from the dried rhizomes of the perennial herb Anemarrhena of Liliaceae. , the leaves, fruits, bark of plants almonds, mangoes, the roots of the genus Pentaphyllum genus of the genus Pentaphyllum, etc.; it has the functions of relieving cough, relieving asthma and expectorating phlegm, immune, anti-inflammatory and analgesic, protecting liver and gallbladder, anti-inflammatory and anti-inflammatory properties. Lipid peroxidation, anticancer, antidiabetic, antibacterial, antiviral and other pharmacological activities, the current clinical applications mainly include mango cough tablets, mango cough capsules, mangiferin tablets, mangiferin dripping pills, and these drugs are only used in in respiratory diseases.

Mangiferin Properties:

Melting point 269-270°C
storage temp. 2-8°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly), Pyridine (Slightly, Heated)
pKa6.09±0.20(Predicted)
Boiling point 842.7±65.0 °C(Predicted)
density 1.843±0.06 g/cm3(Predicted)
form Solid
color Pale Yellow

 

Mangiferin Uses

  1. Mangiferin is used for content determination/identification/pharmacological experiments, etc. Pharmacological and pharmacological effects: This product has the functions of inhibiting the central nervous system, anti-inflammatory, bacteriostatic, anti-herpes simplex virus, choleretic and immune, and has a protective effect on the simulated high altitude acute hypoxic liver injury. Pharmacological experiments show that this product has good curative effect in the treatment of chronic bronchitis. It is the main active ingredient of Zangyinchen in the treatment of hepatitis, and the active ingredient of antiviral in the rhizome of Anemarrhena.
  2. Mangiferin is a natural phenolic flavonoid that has been investigated as an antimicrobial or antidiabetic drug with anti-inflammatory and antioxidant activity.MGF may act as a promoter of gastrointestinal transit (GIT).

Mangiferin Extraction Method

1. The organic solvent extraction process uses more than 90% ethanol as the extraction solvent, and high-purity mangiferin can be extracted from mango leaves.
2. Water-based solvent extraction process Mangiferin was extracted from mango leaves with weak alkaline water as the extraction solvent, and the extract was successively eluted with D101 column macroporous resin and D301 column to remove impurities and decolorize. This high-purity mangiferin extraction process is suitable for large-scale industrial production.
3. Enzymatic extraction process Mangiferin was extracted from mango leaves by enzymatic hydrolysis with cellulase. The experimental conditions were as follows: the pH of the enzymatic hydrolysis was 5.0, the temperature was 55 °C, and the time was 2 h.
4. Ultrasonic-assisted extraction process The ultrasonic-assisted extraction process has the advantages of simplicity, short time consumption, energy saving, etc., and has a good development and application prospect. An overview of mangiferin, pharmacological effects, clinical applications, etc.

Pharmacological Effects of Mangiferin

1. Antioxidant effect Due to the special structure of mangiferin, there are several phenolic hydroxyl groups in the molecule, and the phenolic hydroxyl teams are simply vital teams for scavenging free radicals and also reactive oxygen species. The system of its activity on complimentary radicals can be credited to 2 elements: on the one hand, it acts directly on scavenging totally free radicals, on the other hand, it acts upon iron and also copper ions to lower their further reaction with cost-free radicals. 2. Anti-tumor impact The event of leukemia is connected to the condition of cell cycle policy, and also there is a close relationship between cell cycle policy and also the expression of telomerase activity. Consequently, the study of abnormal guideline of telomerase and also cell cycle has actually become a new direction to explore the occurrence as well as therapy of leukemia. The occurrence of leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. 3. Neuroprotective effect Mangiferin with polyphenolic structure can protect neurons by reducing the influx of Ca2+ and the degree of oxidative stress, thereby reducing cell death caused by glutamate in neurons. 4. Antiviral effect It has in vitro anti-herpes simplex virus type I (HSV-I) effect with a plaque reduction rate of 56.8%, and its antiviral effect is attributed to its ability to inhibit intracellular viral replication. 5. Antipyretic effect It has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, which is positively correlated with the dose, and has a good protective effect on thermal injury. 6. Analgesic effect It has a significant analgesic effect on pain induced by acetic acid and hot plate test. Compared with naloxone hydrochloride, it is found that mangiferin-induced analgesia is not dependent on opioid receptors, and its analgesic effect is significant and has little effect on peripheral nerves. 7. Anti-parasitic effect Mangiferin has obvious inhibitory effect on Cryptosporidium parvum in young mice. Effects of mangiferin on mice infected with the nematode, Trichinella spiralis. 8. Anti-diabetic effect After oral administration of mangiferin and its glucoside, the blood sugar level of normal mice did not change, but it could reduce the blood sugar concentration of KK-Ay mice, an animal model of spontaneous diabetes, and the serum insulin level also decreased. Fructin and its glucosides may exhibit antidiabetic activity through insulin sensitization. 9. Hepatoprotective and choleretic effects For the protection of the liver, mangiferin can stabilize the lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effect. 10. Effects on the central nervous system Mangiferin has obvious central nervous system excitatory effect. Mangiferin has the effect of removing lipid peroxides in brain tissue, reducing the damage of lipid peroxides to neurons, thereby protecting the normal function of neurons. 11. Effects on the respiratory system It has adrenal glucocorticoid-like anti-inflammatory effect, can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, which is manifested as (1) the induction time of asthma is significantly longer than that in the asthma group; (2) the degree of asthma is relieved, and the incidence of convulsions is significantly lower than that in the asthma group; (3) the emphysema is caused Significantly reduced, the infiltration of inflammatory cells in the lung was significantly less than that in the asthma group, and the lung/body weight ratio was significantly lower than that in the asthma group, and was close to the dexamethasone group. At the same time, mangiferin can reduce serum NO and endothelin-1 (ET-1) levels in bronchoalveolar lavage fluid, and play a certain preventive effect on asthma attacks. The combined use of mangiferin and dexamethasone can improve the efficacy.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Mangiferin Quotation