Magnolol CAS 528-43-8

Molecular Formula: C18H18O2

Formula Weight: 266.33

ZSpharmac: Magnolol Supplier

Product Name: Magnolol

CAS No: 528-43-8

Purity: 99%

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Basic Info

Product Name:	Magnolol
Other Names:	5,5′-Diallyl-2,2′-dihydroxybiphenyl
CAS:	528-43-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Almost White Neat
EINECS No.:	610-903-7
Storage:	Sealed in Dry,2-8°C
Provide:	Magnolol MSDS； Magnolol COA

What is Magnolol?

Magnolol is an active compound removed from the completely dry bark, branch bark and origin bark of Magnolia officinalis Rehd. et Wils. as well as Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils. Swelling, anti-tumor, anti-endomycin, muscle relaxation, alleviation of intense inflammatory pain, etc. In regards to anti-bacterial impact, Magnolol has significant anti-bacterial activity against Gram-positive germs, acid-resistant bacteria, and also filamentous fungis, and has a much more substantial anti-bacterial impact on Streptococcus mutans, and has the toughest repressive result on Staphylococcus. Medically, it is generally utilized to eliminate fullness in the chest as well as abdomen, soothe the central nerves, loosen up the muscles of athletes, anti-fungal, anti-ulcer as well as other drugs.
Habitat as well as distribution It typically expands mixedly in the assorted woodlands at the foot of hills and also roadside streams at an elevation of 800-1700 meters. It is a light-loving mesophytic tree species; it suches as an awesome as well as moist climate.It is suggested to utilize a little acidic or neutral dirt with deep, abundant, loosened up, humus-rich, as well as well-drained dirt. It is normally produced in Enshi, Jianshi, Badong, Yichang, Lichuan, as well as Chengkou, Kaixian, Wuxi, Wushan, Shizhu, Wulong, as well as Fengjie of Chongqing City in Hubei Area. It is furthermore spread in Yunyang, Wanzhou, Zhongxian, Fengdu, Fuling, Jiangjin, Qianjiang, Pengshui, Xiushan, Nanchuan and various other locations in Chongqing.
Plant kind Deciduous tree, 7-15m high. The bark is purple-brown, the winter buds are covered by stipules, and also the stipules reduce after opening. Alternating solitary fallen leaves, gathered in addition to branchlets, elliptic obovate leaves, 20-45cm long, 10-25cm substantial, pinnacle obtuse or short sharp, base cuneate or round, entire or curly, the back is beige when young Quick hairs, white powder when old. Flowers as well as additionally leaves open at the same time, single branch top, white, aromatic, concerning 15cm in size, pedicel thick, covered with brownish hairs; perianth sections 9-12; endurances several; pistils lots of carpels, organized on the extensive receptacle. Aggregate fruit ovate-elliptic, woody, with 1 seed per cell. The blooming period is from April to May, as well as the fruiting period is from September to October.

Magnolol Property

Melting point	101.5-102°
Boiling point	180°C/1mmHg(lit.)
density	1.107±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	ethanol: soluble1mg/mL
form	neat
pka	9.49±0.43(Predicted)
color	White to Almost white

Magnolol Uses

Magnolol is made use of for content determination/identification/pharmacological experiments, and so on. Pharmacological effects: magnolol has evident and also long lasting central muscle mass leisure, central nervous system restraint, anti-inflammation, anti-bacterial, anti-pathogenic microorganisms, anti-ulcer, anti-oxidation, anti-tumor, prevents morphine withdrawal reaction, can prevent Medicinal effects such as platelet aggregation, Magnolol is used to treat intense enteritis, microbial or amoebic dysentery, persistent gastritis, etc. Amongst them, in terms of antibacterial result, Magnolol has significant anti-bacterial activity versus Gram-positive germs, acid-resistant germs, and filamentous fungi, has a more substantial anti-bacterial result on Streptococcus mutans, and has the toughest repressive impact on Staphylococcus. Scientifically, it is mainly made use of to get rid of volume in the upper body and also abdomen, calm the main nerves, loosen up the muscle mass of athletes, anti-fungal, anti-ulcer as well as other medicines.
Magnolol has antifungal, antibacterial as well as antioxidant bioactive materials, and has anti-inflammatory activity by hindering NF-κB signaling.

Application of Magnolol

Magnolol is a mixture of phenols extracted from the traditional Chinese medicine Magnolia officinalis, which has various biological functions such as antiviral, antibacterial, anti-inflammatory and anti-diarrhea, and the antioxidant effect of magnolol is the reason for its biological functions. important basis.

1) Magnolol’s antibacterial and anti-hemolytic effects on Staphylococcus aureus. In order to study the antibacterial activity and anti-infection mechanism of magnolol against mastitis pathogenic bacteria (mainly Staphylococcus aureus), the minimum inhibitory concentration of Magnolol against Staphylococcus aureus was detected by the broth dilution method firstly, and the hemolysis test , Western blot test, fluorescent quantitative PCR test and LDH release test verified the effect of magnolol on the pathogenicity of Staphylococcus aureus from different levels and angles. The results showed that Magnolol had certain antibacterial activity against Staphylococcus aureus, and its minimum inhibitory concentration range for Staphylococcus aureus was 8-16 μg·mL-1. In addition, the results of this study show that magnolol at subinhibitory concentration can inhibit the expression of α-hemolysin to reduce the pathogenicity of Staphylococcus aureus, and can significantly alleviate the cell proliferation mediated by Staphylococcus aureus α-hemolysin. damage effect.

2) The effect of Magnolol on the contraction function of guinea pig isolated tracheal smooth muscle. Using the isolated guinea pig tracheal strip method, the direct effect of magnolol on the isolated guinea pig bronchial strip and the antagonism to the contraction caused by high potassium, histamine and acetylcholine were observed. Results: Total magnolol had no significant effect on the basal tension of guinea pig bronchial strips. It can inhibit the contraction of tracheal smooth muscle induced by potassium chloride, acetylcholine, and phosphate histamine, and its effect is dose-dependent. 3×10-5g/mL Magnolol can inhibit the contraction induced by KCl, Ach, and His at the highest (95.96±3.02)%, ( 93.98±4.62)%, (92.15±5.66)%. Conclusion: Magnolol has a significant relaxation effect on tracheal smooth muscle, and its mechanism is related to the voltage-dependent calcium channel on the cell membrane and the release of intracellular calcium.

Preparation of Magnolol

A method for preparing high-purity Magnolol from bark bark, the method comprises the following processing steps:

1) Dry the magnolia bark, crush the magnolia bark and set aside;

2) Extract the magnolia bark that has been crushed above to obtain an oily extract, namely Magnolol crude extract A, for later use;

3) Weigh the silica gel with 20%~50% weight of the Magnolol crude extract A, stir it with the magnolol total phenol crude extract A, and then add the magnolol total phenol silica gel with a weight ratio of 3~6 times the amount of n-hexane, Heat to a temperature of 60-80°C for extraction, filter the n-hexane extract, and repeat the extraction for 1-3 times on the filter residue, combine the n-hexane extract to obtain n-hexane extract B, and set aside;

4) Concentrate the n-hexane extract B in vacuum, place it in cold storage to crystallize, control the crystallization temperature at 2°C-5°C, and then suction-filter the n-hexane crystals of total magnolol phenols to obtain white total magnolol phenol crystals C;

5) Add Magnolol crystal C to petroleum ether with a boiling point of 60~90°C, the weight ratio of petroleum ether to magnolol total phenol crystal C is 10~30 times, heat it in a water bath to a temperature of 60~90°C, and keep the oil in the round bottom flask Slightly boil the ether, completely dissolve the magnolia total phenol crystal C, pour out the petroleum ether solution supernatant, refrigerate and crystallize the poured petroleum ether solution, control the crystallization temperature at 2°C-5°C, and remove the crystallized Magnolia officinalis The total phenols were suction-filtered to obtain the crystal D of total phenols of magnolol, and the refined Magnolol was obtained.

About That Product:
If you need Magnolol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Magnolol, ZSpharmac will provide Magnolol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.