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Magnesium Ascorbyl Phosphate CAS :113170-55-1

Molecular Formula: C6H11MgO9P

Formula Weight: 282.42

ZSpharmac: Magnesium Ascorbyl Phosphate Supplement

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Product Name: Magnesium Ascorbyl Phosphate
CAS No: :113170-55-1
Purity: 99%

Basic Info

Product Name:Magnesium Ascorbyl Phosphate
Other Names:Sodium L-Ascorbic Acid -2-Phosphate
CAS:113170-55-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:601-239-9
Storage:Inert atmosphere,Room Temperature
Provide:Magnesium Ascorbyl Phosphate MSDS;
Magnesium Ascorbyl Phosphate COA

What is Magnesium Ascorbyl Phosphate?

The phosphorylation of vitamin C mainly has two methods: one is the phosphorylation of phosphorus oxychloride (as described in European Patents 388869 and 582924, U.S. Patent 4179445, Japanese Patent Publication Sho 60-69079, etc.), with vitamin C C is the raw material, the hydroxyl groups on the 5th and 6th carbons are protected before esterification, that is, vitamin C is first reacted with acetone to generate 5,6-oxo-isopropylidene-L-ascorbic acid (5,6 -0 — isopropylidene-L-ascorbic acid), then dissolved in pyridine solution, adjusted the pH value with KOH, added phosphorous oxychloride dropwise to react, evaporated the pyridine and removed the salt for many times, concentrated, and then exchanged with cation resin, collected and eluted liquid, add MgO for reaction, and finally complete the crystallization, filtration and drying of low-carbon alcohol. Its product is mainly L-ascorbic acid-2-monophosphate, and by-products are mainly L-ascorbic acid-3-phosphate and 2-pyrophosphate and two (ascorbic acid)-2,2′-diphosphate.

The reaction product requires a complicated process for purification, and it is not possible to dry all the reaction mixture by a simple method. The second method is to use phosphate to phosphorylate, such as the methods of U.S. Patent Nos. 4,647,672 and 5,110,950, and the main product obtained is L-ascorbic acid-2-polyphosphate. 2-triphosphate, but also contains a proportion of L-ascorbic acid-2-monophosphate.

The former can be degraded to monophosphate by excess base, the ratio of which depends on the stoichiometric ratio of the starting materials and the specific reaction conditions. The purification of L-ascorbic acid-2-monophosphate from the mixture is not easy either, and the residual inorganic salts in the product are often high. Although the method synthetic route is short, there are many by-products, product separation and purification are difficult, and the total product yield is low. The traditional synthesis process of Magnesium ascorbyl phosphate is complicated, with many impurities, and the use of organic solutions such as acetone causes damage to the environment.

Magnesium Ascorbyl Phosphate Properties:

storage temp. Inert atmosphere,Room Temperature
solubility 8g/100ml water (25℃)
InChIKeyACFGRWJEQJVZTM-LEJBHHMKSA-L

 

Magnesium Ascorbyl Phosphate Uses

  1. Magnesium ascorbyl phosphate has come to be the primary element of feed additives, food fortifiers as well as progressed cosmetic whitening, and also is a beneficial great chemical.
  2. Magnesium ascorbyl phosphate On top of that, it can also be used as a food nourishment fortifier.
    Magnesium ascorbyl phosphate as feed additive.
  3. Magnesium ascorbyl phosphate1. Hinders tyrosinase activity, decreases melanin, and has freckle as well as bleaching effects. 2. After getting in the body, it can get rid of oxygen cost-free radicals, so it has anti-wrinkle as well as anti-aging features. 3. It has a synergistic result with vitamin E.

Summary of the Invention of Magnesium Ascorbyl Phosphate

The item of the present innovation is to get rid of the shortages existing in the prior art, give a kind of prep work method of Magnesium Ascorbyl Phosphate with basic technique, practical operation, low cost and also high yield, this technique does not make use of organic solvent in the preparation procedure, aftertreatment It is straightforward, does not trigger environmental pollution, as well as the ready item has high purity.

According to technical plan given by the innovation, a kind of preparation approach of Magnesium Ascorbyl Phosphate, is characterized because, consists of the complying with processing steps:

( 1) including vitamin C, anhydrous calcium chloride, deionized water according to the mass ratio of 1: (0.08 ~ 0.4): (1 ~ 5) temperature is in the activator of -10 ~ 20 DEG C, mixes 2 ~ For 3 hrs, include the sodium hydroxide liquid remedy with a focus of 30 ~ 70% dropwise, readjust the pH to 5 ~ 10.5, then add sodium trimetaphosphate with 1 ~ 2.5 times the quantity of vitamin C, keep the temperature level at 25 ~ 45 ° C, and respond 2 ~ 6 hrs, the obtained reactant is vitamin C ester calcium;

( 2) adding vitamin C ester calcium into the container cleaner to wash with water, and afterwards readjusting the pH with sulfuric acid to be 1.5 to 3.5, as well as the gotten reactant is vitamin C phosphate;

( 3) execute nanofiltration membrane purification with vitamin C phosphate via the roll kind nanofiltration membrane layer filter, the temperature level of the roll kind nanofiltration membrane filter inlet is 120 ~ 140 ℃, and the temperature level of the roll type nanofiltration membrane layer filter electrical outlet is 30 ~ 50 ℃; Nanofiltration membrane has nanometer pore dimension, the molecular weight cut-off of nanofiltration membrane layer is 500 ~ 1500, and also the roll type nanofiltration membrane filter has greater removal price to not natural salt, as well as removal rate is 90 ~ 98 %;

( 4) adding the filtrate acquired by the action (3) purification into the activator, through weakly standard anion exchange resin, eluting with 0.05 M hydrochloric acid and also 0.5 M ~ 1.5 M hydrochloric acid together, gathering the elution component, as well as the elution component is continuously Adjusting pH with magnesium oxide under mixing is 7 ~ 11, as well as the reactant that gets is vitamin C magnesium phosphate;

( 5) Magnesium Ascorbyl Phosphate is filtered to eliminate rainfall through gac filter, filtrate is concentrated to one-fifth of original volume at 30 DEG C under minimized pressure, adding quantity is that 3 ~ 6 times of focused filtrate content is 95% ethanol, then by Spray clothes dryer drying out, drying out temperature level is 140 ~ 160 ℃, and also drying out time is 30 ~ 40min, promptly obtains explained Magnesium Ascorbyl Phosphate completed product.

Compared with the previous art, the present development has the complying with benefits:
The phosphoric acid esterification response of today development is performed in an aqueous solvent, does not make use of an organic solvent, and also the whole process is straightforward, not only accelerates the phosphoric acid esterification response rate, reduces the response time, simplifies the operation treatment, yet also is eco secure; a new sort of nanofiltration membrane is used. process, the elimination efficiency of contaminations is high, and the pureness of the ended up Magnesium Ascorbyl Phosphate is greater than 95%, and the security is excellent.

Magnesium Ascorbyl Phosphate Specific Implementation:

The present invention will be further described below in conjunction with specific embodiments.

A preparation method of Magnesium Ascorbyl Phosphate, comprising the following processing steps:

(1) 110Kg vitamin C, 8.8Kg anhydrous calcium chloride, 110Kg deionized water are added in the 500L reactor that temperature is-10 ℃, stir 2 hours, then drip the sodium hydroxide aqueous solution of concentration 30%, adjust PH is 5, adds sodium trimetaphosphate 110Kg again, keeps temperature at 25 ℃, reacts 2 hours, and the reactant that obtains is vitamin C ester calcium;

(2) adding vitamin C ester calcium to the 500L bucket cleaner for washing with water, then adjusting the pH with sulfuric acid to be 1.5, and the obtained reactant is vitamin C phosphate;

(3) nanofiltration membrane filtration is carried out by vitamin C phosphate through the roll-type nanofiltration membrane filter, the temperature of the roll-type nanofiltration membrane filter inlet is 120 ° C, and the temperature of the roll-type nanofiltration membrane filter outlet is 30 ° C; the nanofiltration membrane has nano-scale pore size, the molecular weight cut-off of the nanofiltration membrane is 500, and the roll-type nanofiltration membrane filter has a higher removal rate of inorganic salts, and the removal rate is 90%

(4) adding the filtrate obtained by step (3) filtration into the 500L reaction kettle, through weak basic anion exchange resin, eluting with 0.05M hydrochloric acid and 0.5M hydrochloric acid successively, collecting the elution part, and the elution part is under constant stirring Adjusting PH with magnesium oxide is 7, and the obtained reactant is Magnesium Ascorbyl Phosphate;

(5) Magnesium Ascorbyl Phosphate is filtered through gac filter to remove precipitation, filtrate is concentrated to one-fifth of original volume at 30 DEG C under reduced pressure, adding volume is that 3 times of concentrated filtrate content is 95% ethanol, then by spray drying Machine drying, drying temperature is 140 ℃, drying time is 30min, promptly obtains white Magnesium Ascorbyl Phosphate79.85KG, Magnesium Ascorbyl Phosphate content 97.75%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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