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Lumbrokinase CAS 556743-18-1

Molecular Formula: C12H15N3O2S

Formula Weight: 0

ZSpharmac: Lumbrokinase Raw Material Supplier

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Product Name: Lumbrokinase
CAS No: 556743-18-1
Purity: 99%

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Basic Info

Product Name:Lumbrokinase
Other Names:Lumbrokinase Capsules
CAS:556743-18-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Slightly Yellow Powder
EINECS No.:211-390-9
Storage:2-8°C
Provide:Lumbrokinase MSDS;
Lumbrokinase COA

What is Lumbrokinase?

Lumbrokinase is an enzyme facility drawn out and separated from the artificially cultured worm Eisenia lumbricoides. It is a light yellow powder. Consists of plasmin and plasminogen activator, consisting of active ingredients comparable to tissue plasminogen activator (t-PA).

Pharmacological Effects of Lumbrokinase

Lumbrokinase is a proteolytic enzyme. Pet experiments show that this product has the effect of liquifying arterial thrombus in bunnies and also inferior vena cava thrombus in rats, and can dramatically shorten the dissolution time of euglobulin in bunnies. Professional experiments show that this product can decrease fibrinogen web content, shorten the dissolution time of protein, lower whole blood thickness and also plasma thickness, as well as boost t-PA task. Reduce the activity of plasminogen activator inhibitors and enhance fibrin deterioration items.
After intravenous shot of 125II-labeled lumbrokinase, the degrees often tend to absolutely no after 18 hours, as well as even large doses will not remain in the body for more than 24 hours. It reveals that the medication will certainly not collect in the body after lasting use.

 

Four Major Functions of Lumbrokinase

① Thrombolysis
Lumbrokinase, as a biological genetics active enzyme product, its most representative effect is that it has a strong thrombolytic effect. Its mechanism of activity is: after lumbrokinase enters the body, it rapidly integrates with fibrin, the major part of thromboembolism, as well as hydrolyzes it to accomplish the objective of liquifying the thrombus. Lumbrokinase not just hydrolyzes plasminogen-rich fibrin, yet likewise hydrolyzes plasminogen-free fibrin bits. Therefore, lumbrokinase also has the effective result of dissolving apoplexy as well as uncloging arteries for new thrombi as well as old thrombi. It is really efficient and effective for individuals with apoplexy in various phases.

Via the blood concentration dimension of lumbrokinase and the blood monitoring test of fibrinolytic capacity, the thrombolytic capacity of lumbrokinase is much more than that of urokinase and streptokinase. This alters the conventional unsafe and also inconvenient technique of intravenous administration of blood clots.

② Anticoagulation.
Via blood tracking of lumbrokinase, it was located that lumbrokinase can adsorb coagulation factors and also hydrolyze them, while inhibiting more attachment of platelets on its surface area. Therefore, lumbrokinase can regulate existing thrombi while preventing the incident of new thrombi, resolving the clinical problem of wall thrombi often diminishing and also creating other tissue embolism when regulating thrombus in scientific medication, and boosting the safety and security of thrombolysis. sex. At the same time, lumbrokinase has solid targeting in the process of thrombolysis and also anticoagulation. It just absorbs as well as hydrolyzes coagulation factors and also platelets that have a tendency to gathering, without damaging the blood coagulation system, so thrombolysis and bleeding will not occur.

③ Turn on enzyme.
Medical monitoring located that lumbrokinase turns on the fibrinolytic system in the body. It creates a long-term stable interior atmosphere in the body that stops thrombosis and has long-lasting anti-thrombotic effects. In addition, lumbrokinase can substantially prolong the occlusion time of blood vessels, so that the capillary do not need the activity of outside drugs, but can enhance blood circulation with their own flexible modification, total cells perfusion, and boost tissue vigor.

④ Online cells.
Lumbrokinase is one of the most active proteolytic enzyme. It can activate different cells in the human body, specifically cells in shock and semi-shock states in cells with insufficient blood supply, and can quickly bring back typical physiological functions as well as organic task. Therefore, lumbrokinase has an excellent promoting effect on the healing of analytical thrombosis, cerebral infarction sequelae and heart attack.

Suitable Groups for Lumbrokinase

1. “3 High” individuals:
Hypertension, hyperlipidemia, hyperglycemia, frequent migraines, dizziness, chest rigidity, chest pain, palpitation, lack of breath, tiredness and also tiredness, feeling numb in hands as well as feet, sleeplessness and also lapse of memory, etc

2. Individuals with cardio and cerebrovascular illness:
Hyperlipidemia creates cardiovascular disease, coronary heart problem, angina pectoris, heart attack, arrhythmia, analytical thrombosis, stroke and sequelae.

3. Obese and fatty individuals:
Individuals who are genetically obese and also consume excessive; people that are busy at the workplace, have numerous social tasks, are under excellent stress, have uneven lives and lack of workout.

4. Those that smoke and also consume exceedingly and also live irregularly:
Bad living habits can conveniently trigger vasospasm and also poor blood circulation, resulting in premature cardio and also cerebrovascular illness.

Clinical Evaluation of Lumbrokinase

1560 patients with cerebral infarction took lumbrokinase pills orally for 21 days. Throughout the treatment, nothing else cerebral vasodilators, drugs impacting hemorrheology, as well as medications for advertising blood circulation and also removing blood tension were utilized. The total effective rate was 88.21%, and also the effective price was 68.91%. Fibrin The dissolution time of protoglobulin as well as euglobulin was substantially lowered; there were adjustments in blood rheology, which were statistically considerable by X2 test. With the exception of private cases of rash, skin irritation, nausea or vomiting, etc after taking the medicine, there are nothing else damaging reactions.
One more report used random sampling, double-blind method, and observed the scientific effectiveness of lumbrokinase in the therapy of ischemic cerebrovascular illness according to a combined approach. There were 303 situations in the therapy team that took this product by mouth, 2 pills each time, 3 times a day, half a hr before meals, for 21 consecutive days, and also 150 situations in the control group. The outcomes revealed that the efficient rate was 93.7%, as well as the reliable rate was 73.6%. After therapy in the therapy team There were substantial changes in fibrinogen material, euglobulin dissolution time, whole blood viscosity, plasma thickness, and platelet gathering function.

About Products:
If you need Lumbrokinase, a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Lumbrokinase, our company, ZSpharmac will provide Lumbrokinase raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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