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Lithium tri-Tert-butoxyaluminum Hydride CAS 17476-04-9

Molecular Formula: C12H28AlLiO3

Formula Weight: 254.27

ZSpharmac: Lithium tri-Tert-butoxyaluminum Hydride  Supplement

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Product Name: Lithium tri-Tert-butoxyaluminum Hydride
CAS No: 17476-04-9
Purity: 99%

Basic Info

Product Name:Lithium tri-Tert-butoxyaluminum Hydride
Other Names:Lithium Tri tertiary Butoxyaluminum Hydride
CAS:17476-04-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear to Slightly Turbid Colorless Solution
EINECS No.:241-490-8
Storage:2-8°C
Provide:Lithium tri-Tert-butoxyaluminum Hydride MSDS;
Lithium tri-Tert-butoxyaluminum Hydride COA

What is Lithium tri-Tert-butoxyaluminum Hydride?

Lithium tris(tert-butoxy)aluminum hydride (LTBA) is one of the reducing agents commonly used in laboratories. This reagent can provide one equivalent of hydride ions in the reaction, so it needs to be added in an equivalent amount according to the theoretical amount of hydrogen atoms required for the reduction of the substrate.

Lithium tri-Tert-butoxyaluminum Hydride Properties:

Melting point 300-319 °C (dec.) (lit.)
Boiling point 66°C (THF)
density 0.942 g/mL at 25 °C
Fp 95 °F
storage temp. 2-8°C
solubility It is soluble in organic solvents at low temperatures.
form Solution
color Clear to slightly turbid colorless
Water Solubility Reacts with water.

 

Lithium tri-Tert-butoxyaluminum Hydride Uses

  1. Lithium 3-tert-butyl hydride solution as a nucleoside prodrug for selective synthesis of steroids for the treatment of hepatitis C virus (HCV)-hydroxy-d-2′-deoxy-2′-sulfo-fluoro-2′-chloro- C-methyl-3′, 5′-cyclophosphate
  2. Lithium tert-butoxyaluminum hydride is a mild and also very discerning lowering agent that decreases ketones, aldehydes and also acid chlorides in diethyl ether or diglyme at 0 ° C, does not decrease fat esters as well as nitriles, however can reduce Phenyl esters of fats and alicyclic acids, lowered tetrahydrofuran (ring opening). It is used as a decreasing representative in medicine, flavors, pesticides, dyes and various other great natural synthesis.

Lithium tri-tert-butoxyaluminum hydride Properties

Lithium tri-tert-butoxyaluminum hydride is a white powder with a melting point of 319°C, which is sublimated under vacuum at 280°C. This product is soluble in ethylene glycol dimethyl ether, diglyme and tetrahydrofuran, and slightly soluble in ether. Stable in dry air, hydrolyzed slowly in moist air. It is a mild and highly selective reducing agent. Ketones, aldehydes and acid chlorides can be reduced in diethyl ether or diglyme at 0°C, fatty acid esters and nitriles are not reduced, but phenyl esters of fatty acids and alicyclic acids can be reduced.

Preparation of Lithium Tri-tert-butoxy Aluminum Hydride

Lithium tri-tert-butoxyaluminum hydride has attracted extensive interest from scientists and technicians all over the world due to its wide use. Research on the improvement of the synthesis method of lithium tri-tert-butoxyaluminum hydride is in the ascendant. In the prior art, lithium hydride is prepared by using metal lithium as a raw material, and lithium hydride is reacted with aluminum trichloride to prepare lithium aluminum hydride. Lithium aluminum hydride reacts with tert-butanol in ether to prepare tri-tert-butoxy lithium aluminum hydride. Method 1. Bake a 2-liter three-necked flask equipped with a stirrer, a constant pressure dropping funnel and a condenser containing dry ice and blow it with dry nitrogen; A solution of 600 ml of aluminum hydride (0.32 mol) in ether was placed, and 74 g (1.00 mol) of tert-butanol was added dropwise with stirring. Most of the ether was decanted and the remainder and excess t-butanol were removed under reduced pressure. The product was 81.0 g, essentially quantitative yield. Method 2. We have carried out a lot of synthesis research. The main improvement points are: replacing the expensive metal lithium with cheap metal sodium and lithium chloride, reducing the reaction temperature by nearly 200 °C, at the same time, using cheap and relatively safe methyl tertiary Butyl ether is used as the reaction medium instead of high-priced and flammable ether, which not only reduces the production cost, but also improves the safety of the technological process.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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