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Lithium Diisopropylamide Solution CAS 4111-54-0

Molecular Formula: C6H16LiN

Formula Weight: 109.14

ZSpharmac: Lithium Diisopropylamide Solution  Supplement

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Product Name: Lithium Diisopropylamide Solution
CAS No: 4111-54-0
Purity: 99%

Basic Info

Product Name:Lithium Diisopropylamide Solution
Other Names:Lithium Diisopropylamide
CAS:4111-54-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Brown Liquid
EINECS No.:223-893-0
Storage:2-8°C
Provide:Lithium Diisopropylamide MSDS;
Lithium Diisopropylamide COA

What is Lithium Diisopropylamide?

Lithium diisopropylamide (LDA) is a sterically hindered non-nucleophilic strong base reagent widely used in organic synthesis, with pka=35.7 in tetrahydrofuran, and is often used to generate carbanions and enolate ions.

Lithium Diisopropylamide Properties:

Melting point decomposes [MER06]
Boiling point 65 °C
density 0.864 g/mL at 25 °C (lit.)
vapor density >1 (vs air)
Fp 91 °F
storage temp. 2-8°C
form liquid
color brown
Water Solubility decomposes

 

Lithium Diisopropylamide Uses

  1. Lithium diisopropylamide is widely used in metallized alkaline reagents, and also in large sterically hindered non-nucleophilic strong alkaline reagents, etc.
  2. Lithium diisopropylamide is a well-known bulky strong base for carbanion formation. Lithium diisopropylamide is widely used in metallized alkaline reagents, and also in large sterically hindered non-nucleophilic strong alkaline reagents, etc.
  3. Lithium diisopropylamide is widely used in the enolation reaction of aldehydes, ketones and esters, and the generated enolate ions are captured by silicon derivatives or sulfonyl groups to generate corresponding silyl ethers or sulfonates.

Application of Lithium Diisopropylamide

LDA is widely used in the enolization of aldehydes, ketones and esters, and the generated enolate ions are captured by silicon derivatives or sulfonyl groups to generate corresponding silyl ethers or sulfonates. Since the sulfonate group is attached to the sp2-hybridized carbon atom, the subsequent metal-catalyzed reaction is very easy to occur, making this reaction more interesting. The reaction is generally completed within a few minutes at low temperature, and the reaction conditions are very mild, and other functional groups are not significantly affected. The yield of the product is mainly affected by the activity of the capture reagent, with triflate very easily giving satisfactory results (Equation 1 and Equation 2).

The most immediate use of LDA is to catalyze the α-alkylation of aldehydes, ketones, esters and amides. Due to the activation of the α-methylene and methine groups by the carbonyl groups in these compounds, LDA can take up their protons to generate carbanions at low temperatures. A wide variety of groups can be conveniently introduced in the presence of various alkylating agents. Because the reagent decomposes above 0°C, it is sometimes necessary to add equimolar HMPA as an auxiliary solvent to increase the reactivity and stability of the reagent. The reaction can be completed within 1~2h at low temperature, and the olefinic bond is not affected in any way (formula 3), and the alkylating reagent has an ester group and is not affected in any way (formula 4). However, the reaction of the amide requires warming to room temperature (Equation 5).

An interesting phenomenon is that when 1,3-dicarbonyl compounds undergo α-position alkylation under the action of LDA, the alkylation occurs not at the 2-position, which is thought to be more acidic, but at the α-position next to it. -bit. This case has very good regioselectivity in the reaction of 1,3-ketoesters

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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