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Liquiritigenin CAS 578-86-9

Molecular Formula: C15H12O4

Formula Weight: 256.25

ZSpharmac: Liquiritigenin Supplier

Product Name: Liquiritigenin
CAS No: 578-86-9
Purity: 99%

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Basic Info

Product Name:Liquiritigenin
Other Names:7,4”-DIHYDROXYFLAVANONE hplc
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:Liquiritigenin MSDS;
Liquiritigenin COA

What is Liquiritigenin?

Licorice is a seasonal leguminous medical plant that is dispersed throughout Eurasia. Given that old times, it has been commonly utilized in medicine and also food handling in my country. Licorice grassland is a wild plant that expands in deep sandy soil near water, and is now mainly planted synthetically. The most effective planting season is March, as well as in October of the 3rd or 4th year after growing, when the fallen leaves fall off, you can dig out and cut off the roots, wash them and let them completely dry normally airborne for 4-6 months. It can be unpeeled, and after that bundled as well as shipped to the processing factory.

Liquiritigenin, likewise called glycyrrhizin, is a dihydroflavonoid monomer compound existing in the leguminous plant licorice (Glycyrrhizauralensis Fisch). It is extracted from licorice and belongs to non-sugar all-natural sugar. Liquiritigenin has antispasmodic, antiulcer, antibacterial, hepatocyte monoamine oxidase repressive impacts.

Liquiritigenin Property

Melting point 206-208°C
Boiling point 529.5±50.0 °C(Predicted)
density 1.386±0.06 g/cm3(Predicted)
Fp 207℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO : 125 mg/mL (487.80 mM; Need ultrasonic)
form powder
color White


Application of Licorrhizin

Individuals often use licorice powder as a flavor agent to enhance foods with sweet taste and special tastes, such as making licorice olives, licorice ginger and also various other seasonings and also dried fruits. Licorice remove can be used for canning and also as a flavor. In my nation’s sanitary requirements for the use of preservative (GB 2760), the range of use of licorice is defined as junk food, spices, sweets, biscuits, and also thick coins (Cantonese-style preserved fruits), and the usage is not restricted.

Liquiritigenin is a low-calorie sweetener, and its sweetness is different from that of sucrose, that is, the sweetness of liquiritigenin is boosted later, while that of sucrose is previously. The sweetness excitement time of glycyrrhizin is about the like that of common salt, so when using it together with table salt, it can buffer the saltiness of food with high salt content, to make sure that the preference will certainly not be also salted, as well as generate a round and soft taste, so licorice It is suitable for the flavoring of pickled foods. As an example, incorporating Licorrhizin with salt and monosodium glutamate can not just enhance the flavoring result, but additionally save the quantity of monosodium glutamate. Mix liquiritigenin and saccharin at a proportion of 3 ~ 4:1, and then integrate it with sucrose and also salt citrate in food for far better sweetness.

Glycyrrhizin has a strong masking effect as well as can mask the bitter preference in food. For example, its masking impact on caffeine is 40 times that of sucrose, and also it can reduce the bitter preference when used in coffee.

Liquiritigen additionally has a particular milk emulsification effect in water. For instance, when combined with sucrose, healthy protein, etc, it can develop fine and secure foam, which is suitable for making sodas, candies, cakes, and beer. Glycyrrhizin is insoluble in fat, so when it is utilized in fat (such as lotion, chocolate), some procedures need to be required to make it equally spread. Licorrhizin likewise has a strong flavor-enhancing impact, and also it works well when related to dairy items, chocolate, egg items and also drinks.

Licorrhizin has anti-oxidation, anti-ulcer, anti-allergic, anti-fungal, anti-aging, efficient elimination of superoxide ions as well as other functions.

Liquiritigenin is an excellent resources for bleaching cosmetics, and it can well inhibit the task of tyrosinase.

The Medicinal Principle of Liquiritigenin

Liquiritigenin hinders the invasion as well as metastasis of human cancer malignancy A375 cells by managing miRNA
Researches have shown that flavonoids have antitumor task. Liquiritigenin is a dihydroflavone monomer substance drawn out from the natural plant licorice. Previous researches in our research laboratory have actually discovered that liquiritigenin can prevent the growth of human liver cancer cells SMMC-7721 cells and human cervical cancer Hela cells, cause apoptosis by controling apoptosis-related healthy proteins as well as reactive oxygen species (ROS)- mediated mitochondrial signaling pathways, and also can additionally By managing the PI3K/AKT pathway and also its downstream matrix metalloproteinase 2 (MMP2), it inhibits the intrusion and transition of human lung adenocarcinoma A549 cells [6] Liquiritigenin can down-regulate the expression of hsa-miR-4487 as well as hsa-miR-4534, boost the expression of PTEN as well as TIMP2, hinder the expression of p-AKT as well as MMP2, as well as ultimately prevent the invasion as well as transition of human melanoma A375 cells Transfection experiments further showed that the expressions of PTEN and also TIMP2 were controlled by hsa-miR-4534 and also hsamiR-4487, PTEN was a possible target genetics of hsa-miR-4534, and TIMP2 was a feasible target genetics of hsa-miR-4487. The rise of PTEN and also TIMP2 degrees and also the reduction of p-AKT as well as MMP2 levels triggered by liquiritigenin were brought on by the down-regulation of hsa-miR-4487 and also hsa-miR-4534 expression levels, so liquiritigenin hindered the invasion and metastasis of human melanoma A375 cells as well as miRNA Law is inseparable.

Results of liquiritigenin on proliferation, apoptosis and also autophagy of human breast cancer MCF-7 cells.
Researches have actually revealed that liquiritigenin can inhibit the expansion of human cervical cancer HeLa cells and also induce apoptosis. Autophagy is a collection of biochemical procedures in which eukaryotic cells “self-digest” by degrading their very own cytoplasm as well as organelles. It is a physiological device that is ubiquitous in normal and infected cells. The low activity of autophagy in some growth cells has a particular relationship with the event of growths. Antitumor medicines can cause cells to generate autophagy, which can have both positive and unfavorable effects on lump cells. It has broad potential customers to use the autophagy pathway as the target of antitumor medicines. In addition, liquiritigenin can hinder the development of human breast cancer MCF-7 cells, and its growth inhibition is associated with the promotion of apoptosis and also induction of autophagy.

Liquiritigenin Preparation

The method for extracting glycyrrhizin from licorice is characterized in that it comprises the following steps:
(1) Crush licorice into 60-mesh powder, extract with hydrochloric acid solution with a concentration of 1mol/L for 120 minutes at 80°C, and the mass ratio of solid to liquid is 1:5-8, filter with four layers of gauze, and wait for the filtrate to cool to room temperature, adding 1mol/L sodium hydroxide solution to adjust to neutrality, to obtain a crude extract of glycyrrhizin;
(2) Put the crude glycyrrhizin extract on the mixed resin column, use 5-8 times the column volume of deionized water, 5 times the column volume with a volume percentage concentration of 20% to 40% ethanol aqueous solution, and 4 times the column volume The volume percent concentration is 70% ethanol aqueous solution for elution, the volume percent concentration is 70% ethanol aqueous solution eluate, concentrate under reduced pressure to 30% sugar content, add an equal volume of deionized water, stir well, and store at 20°C The crystallization was carried out for 8 hours, the supernatant was sucked off, the crystals were dissolved by adding 4 times the volume of absolute ethanol, concentrated under reduced pressure to a sugar content of 30%, an equal volume of deionized water was added, stirred evenly, and crystallized at 20°C for 8 hours. hours, filtered, and the crystals were washed with deionized water until there was no alcohol smell, and dried under reduced pressure at 60°C to obtain purified Liquiritigenin.

About Products:
If you need Liquiritigenin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Liquiritigenin, ZSpharmac will provide Liquiritigenin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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