Zhishang Chemical

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Zhishang Chemical


Molecular Formula: C15H12O4

Formula Weight: 256.25

ZSpharmac: LIQUIRITIGENIN Supplement

CAS No: 578-86-9
Purity: 99%

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Basic Info

Other Names:(S)-7-Hydroxy-2-(4-Hydroxyphenyl)Chroman-4-One
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Long Needle Crystal
Storage:Under Inert Gas (Nitrogen or Argon) at 2-8°C


LIQUIRITIGENIN is a leguminous perennial medicinal plant that is distributed throughout Europe and Asia. Since ancient times, my country has widely used it in medicine and food processing. LIQUIRITIGENIN prairie is a wild plant that grows in deep sandy soil near water, and is now mostly cultivated artificially. The best planting season is March, and in October of the third or fourth year after planting, when the leaves fall off, you can dig out and cut off the rhizomes, rinse them, and place them in the air to dry naturally for 4 to 6 months.


Melting point 206-208°C
Boiling point 529.5±50.0 °C(Predicted)
density 1.386±0.06 g/cm3(Predicted)
Fp 207℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C



Folks often use licorice powder as a flavoring agent to impart sweetness and unique flavor to food, such as licorice olives, licorice ginger and other spices and dried fruits. Licorice extract can be canned and doubled as a spice. In my country’s Hygienic Standard for the Use of Food Additives (GB 2760), the scope of use of licorice is stipulated as canned food, seasonings, candies, biscuits, and secret money (Cantonese-style cold fruit), and the amount of use is not limited.

LIQUIRITIGENIN is a low-calorie sweetener whose sweet taste is different from that of sucrose, i.e., glycyrrhizin responds later to the sweet stimuli, while sucrose responds earlier. The time for LIQUIRITIGENIN to produce sweetness and stimulation is roughly the same as that of table salt. Therefore, when LIQUIRITIGENIN is used together with table salt, it can buffer the saltiness of foods with high salt content, so that the taste is not too salty, and produces a round and soft ambiguity. Therefore, LIQUIRITIGENIN is suitable for For the seasoning of pickled food, if LIQUIRITIGENIN is used in combination with salt and monosodium glutamate, in addition to enhancing the seasoning effect, it can also save the amount of monosodium glutamate. Mix LIQUIRITIGENIN and saccharin in a ratio of 3~4:1, and then combine with sucrose and sodium citrate to be used in food, and the sweetness effect is better.

LIQUIRITIGENIN has strong masking properties, which can mask the bitter taste in food. For example, its masking effect on caffeine is 40 times that of sucrose, which can reduce the bitter taste in coffee.

LIQUIRITIGENIN also has a certain emulsification effect in water. For example, when mixed with sucrose, protein, etc., it can form fine and stable foam, which is suitable for soda, candy, cakes and beer. LIQUIRITIGENIN is insoluble in fat, so when it is used in fat (such as cream, chocolate), some measures must be taken to make it evenly dispersed. LIQUIRITIGENIN also has a strong aromatizing effect and works well when applied to dairy, chocolate, egg products and beverages.

Pharmacological Principles of LIQUIRITIGENIN

Previous research studies in our lab have actually found that liquiritigenin can hinder the growth of human liver cancer SMMC-7721 cells and also human cervical cancer cells Hela cells, induce apoptosis by managing apoptosis-related healthy proteins as well as mitochondrial signaling pathways moderated by responsive oxygen varieties (ROS), as well as can additionally generate apoptosis. Prevents the intrusion as well as metastasis of human lung adenocarcinoma A549 cells by managing the PI3K/AKT pathway as well as its downstream matrix metalloproteinase 2 (MMP2). Liquiritigenin can down-regulate the expression of hsa-miR-4487 as well as hsa-miR-4534, raise the expression of PTEN and TIMP2, and all at once prevent the expression of p-AKT as well as MMP2,and also finally hinder the intrusion and also transition of human cancer malignancy A375 cells Transfection experiments better showed that the expression of PTEN and TIMP2 were controlled by hsa-miR-4534 and hsamiR-4487, PTEN was a feasible target gene of hsa-miR-4534, as well as TIMP2 was a possible target gene of hsa-miR-4487. The increased degrees of PTEN as well as TIMP2 and also the lowered levels of p-AKT as well as MMP2 caused by liquiritigenin are triggered by the down-regulation of the expression degrees of hsa-miR-4487 and also hsa-miR-4534. For that reason, liquiritigenin hinders the invasion as well as metastasis of human melanoma A375 cells as well as miRNA Policy is inseparable.

Researches have actually revealed that liquiritigenin can prevent the proliferation of human cervical cancer HeLa cells and induce apoptosis. Autophagy is a collection of biochemical procedures in which eukaryotic cells do “self-digestion” by deteriorating their own cytoplasm and organelles. The reduced autophagy activity in some tumor cells has a specific relationship with tumorigenesis. Anti-tumor medicines can induce autophagy in cells, which have positive and also unfavorable results on growth cells, as well as the autophagy pathway as a target of anti-tumor medications has wide leads. Moreover, liquiritigenin can hinder the growth of human bust cancer MCF-7 cells, and its growth restraint is associated with the promo of apoptosis and the induction of autophagy.

Extraction Method of LIQUIRITIGENIN

The method for extracting liquiritigenin from licorice is characterized by comprising the following steps:
(1) Pulverize the licorice into 60 mesh powder, extract it with a hydrochloric acid solution with a concentration of 1 mol/L for 120 minutes at 80 ° C and the mass ratio of material to liquid is 1:5 to 8, filter with four layers of gauze, and wait for the filtrate to cool. To room temperature, add 1 mol/L sodium hydroxide solution and adjust to neutrality to obtain a crude extract of liquiritigenin;
(2) Put the crude extract of liquiritigenin on a mixed resin column, and use 5-8 times the column volume of deionized water, 5 times the column volume of the volume percentage concentration to be 20% to 40% ethanol aqueous solution, 4 times the column volume of The volume percent concentration is 70% ethanol aqueous solution for elution, the volume percent concentration is 70% ethanol aqueous solution eluate, concentrated under reduced pressure to 30% sugar content, add an equal volume of deionized water, stir evenly, at 20 ℃ condition Crystallize for 8 hours, suck off the supernatant, add 4 times the volume of anhydrous ethanol to dissolve the crystal, concentrate under reduced pressure to 30% sugar content, add an equal volume of deionized water, stir well, and crystallize at 20 ° C for 8 hours, filtered, and the crystals were washed with deionized water until there was no alcohol smell, and dried under reduced pressure at 60 °C to obtain the purified liquiritigenin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.