1. Analgesic effect
The natural active ingredients that exert analgesic effect mainly include: polysaccharides, alkaloids, flavonoids, volatile oils, saponins, etc. Among them, linalool is the most studied monoterpenoid in volatile oils.
2. Anti-anxiety effect
After inhaling linalool Oil, mice showed anxiolytic activity in light-dark tests, improved social behavior, decreased aggressive behavior, and only at high doses did side effects that impair memory function. .
3. Sedative and hypnotic effect
Aromatherapy has been used in world health care for a long time. It mainly uses the aromatic molecules in natural aromatic plants to act on human skin, respiratory tract, lungs, lymph and blood, nervous system, etc. through inhalation, massage, oral intake and other methods. Parts, resulting in health care, treatment and other effects. Lavender essential oil is a natural medicine commonly used in aromatherapy. Linalool, the main component of lavender essential oil, has also been shown to have sedative and hypnotic pharmacological effects. After inhaling different concentrations of linalool (1%, 3%) in mice, pentobarbital-induced sleep time was prolonged, body temperature was lowered, motor behavior was slowed down, and the motor coordination of mice was not affected.
4. Anti-inflammatory effect
Inflammation is a defense response of the body to stimuli, mainly manifested as redness, swelling, heat, pain and dysfunction. Inflammation as the body’s defense mechanism is usually beneficial to the human body, but when it develops into chronic inflammation, it may lead to the production of other diseases, such as cancer, asthma, rheumatism, allergic dermatitis, and gastrointestinal disorders.
5. Anti-tumor effect
Although there is no anti-tumor preparation of linalool Oil in the clinic, its anti-tumor effect and preliminary mechanism have been confirmed by many research reports. When screening anti-tumor small molecule compounds, it was found that linalool could significantly inhibit the proliferation of various human lymphocytic leukemia cells, but had no significant effect on the proliferation of normal bone marrow hematopoietic cells and peripheral blood cells. Further studies have shown that its mechanism of action is that linalool increases the expression of DNA damage-related genes such as p53, p21, p27, and p57, and accordingly increases the expression of GADD45α, thereby activating the c-JUN/JNK apoptosis signaling pathway and initiating apoptosis. death procedure.
6. Antibacterial effect
The research on the antibacterial mechanism of linalool oil phase shows that, compared with other plant essential oils, linalool oil has the most significant inhibitory effect on Escherichia coli, Streptococcus pneumoniae, hemolytic streptococcus, and Staphylococcus aureus, and linalool is the main Antibacterial active substances, the hydroxyl group in the structure is the center of antibacterial activity, and the minimum inhibitory concentration (MIC) is 200 μL·L-1. In vitro antibacterial experiments revealed that linalool has a significant inhibitory effect on periodontal pathogenic bacteria and cariogenic bacteria, but high concentrations of linalool Oil have greater cytotoxicity, so when used in combination with oral hygiene products, its concentration should be lower than 0.4g·L-1.
7. Antioxidant effect
The antioxidant activity of linalool Oil depends on a variety of factors, and different cell types, oxidative reaction initiators, or experimental conditions can produce dramatically different effects. It was found that in human hepatoma cells HepG2 and human lymphoid B cells NC-NC, linalool has a protective effect on tert-butyl hydroperoxide (t-BOOH)-induced cytotoxicity due to its free radical scavenging ability. In contrast, 2,2′-azobisisobutylamidine dihydrochloride (ABAP) induced lipid peroxidation, using the thiobarbituric acid reactant method (Method A) and the conjugated diene method (Method A), respectively. B), the antioxidant activity of more than 100 volatile oil components was explored, and the results showed that linalool Oil had no antioxidant effect at all in the determination of method B, but showed a pro-oxidative effect in the determination of method A.
