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Lidocain Hydrochlorid CAS 6108-05-0

Molecular Formula: C14H25ClN2O2

Formula Weight: 288.81

ZSpharmac: Amrinone Supplement

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Product Name: Lidocain Hydrochlorid
CAS No: 6108-05-0
Purity: 99%

Basic Info

Product Name:Lidocain Hydrochlorid 
Other Names:Linocaine Hydrochloride
CAS:6108-05-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Solid
EINECS No.:612-079-4
Storage:2-8°C
Provide:Lidocain Hydrochlorid  MSDS;
Lidocain Hydrochlorid  COA

What is Lidocain Hydrochlorid ?

The chemical name of Lidocain Hydrochlorid is N-(2,6-xylyl)-2-(diethylamino)acetamide hydrochloride-hydrate, which is a common amide local anesthetic. The patch can be used as a topical anesthetic, has analgesic effect, can be absorbed through the skin or mucous membranes, and is clinically used for local infiltration anesthesia before superficial surgery on the skin or mucous membranes; it can also relieve post-herpetic neuralgia, like other local anesthetics , Topical application has a certain antipruritic effect, and also has an antiarrhythmic effect.

Lidocain Hydrochlorid  Properties:

Melting point 75-79℃
storage temp. 2-8°C
solubility H2O: soluble
form solid
color white
Water Solubility Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.

 

Lidocain Hydrochlorid Uses

  1. Lidocain Hydrochlorid has the characteristics of solid penetrability, strong dispersibility, and fast start of activity. The anesthetic efficacy is two times that of procaine, as well as the toxicity is 1.After absorption, it can hinder the main nerve system, hinder ventricular automaticity, shorten the refractory duration, and can be made use of to manage ventricular tachycardia and also treat arrhythmia symptoms such as ventricular premature beats, ventricular tachycardia and also ventricular fibrillation. It works for cardiovascular disease or cardiac arrhythmia brought on by cardiac glycosides, however not for supraventricular tachycardia. This product has a quick action, a short duration, and also is ineffective when taken orally. It is typically provided as an intravenous injection.
  2. Lidocain Hydrochlorid is an anesthetic. Big, improved impact or poisoning, anticonvulsant result at sub-toxic plasma focus.

Preparation of Lidocain Hydrochlorid

report one,
(1) Preparation of intermediate 2,6-dimethylaniline
24.43 g (0.2 mol) of 2,6-xylenol, 63.1 g (0.6 mol) of ammonia water, 1.06 g of 5% Pd/C, and 2.52 g (0.02 g of 2,6-dimethylcyclohexanone) were successively added to the reaction vessel. mol), reacted at 185 °C for 6 h, cooled to room temperature, filtered, recovered Pd/C and applied; the filtrate was distilled under reduced pressure, recovered 2,6-dimethylcyclohexanone and applied next time, the residue was washed with water once, and left to stand for stratification. , the oil layer is the intermediate 2,6-dimethylaniline 23.35g, the HPLC purity is 98.32%, and the yield is 94.73%.

(2) Preparation of Lidocain Hydrochlorid
To the there-necked flask with the distillation device, add 15.12g (0.28mol) of sodium methoxide, 24.24g (0.2mol) of the intermediate 2,6-dimethylaniline and 31.9g (0.22g) of N,N-diethylaminoacetate methyl ester successively. mol), heated to 95°C, and the methanol generated by the reaction was distilled off while reacting, until no methanol was evaporated, continued the reaction for 30 min, cooled to room temperature, added dichloroethane to dissolve, washed twice with water, and allowed to stand for stratification. The organic layer is the dichloroethane solution of lidocaine base.

In the dichloroethane solution of above-mentioned lidocaine base, add hydrochloric acid 2.56g, then adjust the pH to 3.5 with hydrogen chloride, add activated carbon to reflux for 20min, filter, concentrate the filtrate, crystallize by cooling, and dry to obtain Lidocain Hydrochlorid 48.28g, HPLC purity was 99.52%, the yield was 88.72%, and the total yield was 84.04%.

report two,
(1) Add acetone 200L, 2,6-dimethylaniline 50.0kg (412.6mol), potassium carbonate 142.6kg (1031.5mol) to the 500L enamel reaction kettle, stir and adjust the temperature of the material to 20±5°C, keep at Within this temperature range, 48.9 kg (433.2 mol) of chloroacetyl chloride was added dropwise at a high position, and the reaction was stirred at this temperature for 0.5 h after the dropping. Add 33.2kg (453.9mol) of diethylamine, heat to 60±5°C for 8h, filter, add hydrochloric acid to the filtrate with stirring, and adjust the pH of the filtrate to below 4.

(2) Concentrate the above reaction solution under reduced pressure at 50±5°C until no liquid is evaporated, add 200L acetone, heat and dissolve completely, add 2kg activated carbon, stir and decolorize at 55~65°C for 0.5h, press filter to clean area Crystallization kettle, stirring and cooling for crystallization, cooling to below -5°C for 3h, shaking off for filtration, and vacuum drying at 40-50°C in double cones for 4h to obtain 93.4kg of white crystalline powder, yield: 78.38%, HPLC normalized purity: 99.84 %.

Precautions for Lidocain Hydrochlorid

(1) Those who are allergic to other local anesthetics may also be allergic to lidocaine hydrochloride.
(2) Use with caution in the following situations: pregnancy, neonates, especially premature infants, patients with reduced hepatic blood flow, liver and kidney insufficiency, congestive heart failure, severe myocardial damage, hypovolemia and shock.
(3) Strictly control the concentration and the total amount of medication, overdose can cause convulsions and cardiac arrest; its metabolism in the body is slower than that of procaine, and it has an accumulation effect, which can cause poisoning and convulsions.
(4) The dose for the elderly should be adjusted according to the needs and tolerance, and the dose should be halved for those over 70 years old.
(5) Prevent accidental entry into blood vessels during anesthesia and prevent local anesthetic poisoning.
(6) When treating arrhythmia, attention should be paid to monitoring blood pressure, electrocardiogram, and rescue equipment; if the P-R interval of electrocardiogram is prolonged or the QRS wave is widened, and other arrhythmias occur or the original arrhythmia is aggravated, the drug should be discontinued immediately.
(7) During anesthesia, the P-R interval of the electrocardiogram is prolonged or the QRS wave is widened, and the drug should be discontinued immediately if other arrhythmias occur or the original arrhythmia is aggravated.

Lidocain Hydrochlorid Drug Interactions And Adverse Reactions

Drug Interactions:

(1) Cimetidine as well as β-blockers can hinder the metabolic rate of lidocaine in the liver and increase the blood concentration, which can trigger negative reactions of the heart as well as nerves. The dosage of lidocaine hydrochloride must be readjusted. (2) Barbiturates can advertise the metabolic process of Lidocain Hydrochlorid, and the mix of the two medicines can create bradycardia and sinus arrest.
( 3) Mix with procainamide can generate transient delirium as well as hallucinations, however does not impact the plasma concentration of this item.
( 4) Isoproterenol can enhance the complete clearance price of this item by raising the hepatic blood flow; norepinephrine can decrease the overall clearance price of Lidocain Hydrochlorid by minimizing the hepatic blood flow.
( 5) Conflict with the following drugs: phenobarbital, thiopental sodium, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine.

Adverse Reactions:

The incidence of damaging responses of Lidocain Hydrochlorid has to do with 6.3%. Most negative reactions are dose-related. Damaging responses include drowsiness, wooziness, vertigo, queasiness, vomiting, lethargy, euphoria, complication, muscle twitches, convulsions, blurred vision, complication and also dyspnea. Big dosages can create severe sinus bradycardia and also heart arrest., Serious atrioventricular block as well as deteriorated myocardial contractility, blood pressure and so forth.

Extreme focus of Lidocain Hydrochlorid in the blood can create slowing of atrial conduction velocity, atrioventricular block (A-V-B), as well as inhibition of myocardial contractility as well as decreased heart result. A few have allergies such as erythematous breakout as well as angioedema.

Lidocain Hydrochlorid Indications and Dosage

Indications:

Lidocain Hydrochlorid is an intermediate-acting amide local anesthetic. For anesthetics and antiarrhythmic medicines. Primarily utilized: ( 1) Infiltration anesthetic, epidural anesthesia, topical anesthesia (consisting of mucosal anesthesia during thoracoscopy or abdominal surgery) and also nerve conduction block. ( 2) Deal with ventricular premature beats as well as ventricular tachycardia after acute myocardial infarction (AMI), and also ventricular arrhythmia brought on by digitalis poisoning, cardiac surgical treatment, as well as heart catheterization, however it is usually inadequate for supraventricular arrhythmias.

Dosage:

Topical anesthetic with 2% to 5% remedy. Infiltration anesthetic with 0.25% ~ 0.5% option. Conduct anesthesia with 2% Lidocain Hydrochlorid service, each injection point, 8-12 ml for horses and cattle, and also 3-4 ml for sheep. Epidural anesthetic 2% solution, 8-12 ml for horses as well as cattle, 0.22 ml per kilogram of body weight for canines and also pet cats. 2% solution for subcutaneous shot, maximum quantity, 80ml for pigs and lamb, 400ml for steeds and also livestock, 25ml for pets and 8.5 ml for cats. 
About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Lidocain Hydrochlorid  Quotation