Laurocapram CAS 59227-89-3

Molecular Formula: C18H35NO

Formula Weight: 281.48

ZSpharmac: Laurocapram Supplier

Product Name: Laurocapram

CAS No: 59227-89-3

Purity: 99%

Navigation Bar

Basic Info

Product Name:	Laurocapram
Other Names:	Azone
CAS:	59227-89-3
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Colourless Oil
EINECS No.:	261-668-9
Storage:	Sealed in Dry,Room Temperature
Provide:	Laurocapram MSDS； Laurocapram COA

What is Laurocapram?

Laurocapram is a new type of skin penetrating agent first reported by American Stoughton in the early 1980s, and its chemical name is 1-n-dodecylazepan-2-one. Referred to as azone. At normal temperature, azone is a colorless, odorless, non-toxic and non-irritating oily transparent liquid with lubricity, easy coating and strong permeability. It is also an organic chemical with a wide range of uses, and its high-efficiency permeation-promoting properties, non-toxic safety and other characteristics have attracted people’s attention. It has a permeation-promoting effect on both hydrophilic and hydrophobic compounds.

Laurocapram Property

Melting point	-7°
Boiling point	bp50m 160°
density	0.906-0.926
refractive index	1.470-1.473
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	-0.43±0.20(Predicted)
form	Oil
color	Colourless

Application of Laurocapram

Laurocapram, as a high-efficiency skin penetration enhancer and a new type of non-ionic surfactant, has been widely used in medicine, daily chemical, pesticide, printing and dyeing, chemical fiber, leather and other industries. Keep expanding.

1. Pharmaceutical and cosmetic industry
Laurocapram has obvious drug penetration-promoting and synergistic effects, which can promote the body’s absorption and utilization of drug active ingredients, and it has a good curative effect on the treatment of dermatitis, psoriasis, and eczema. Its mechanism of action is to enhance the fluidity of the stratum corneum and make the lipids in the stratum corneum irregularly arranged, thereby increasing the osmotic absorption of drugs. It can be used for carrying and controlled release of almost all kinds of antibiotics, hormones, steroids, antiviral and antitumor drugs, especially for various plant extracts and alkaloids, and the dosage is 0.5% to 2%. It is widely used in cardiovascular, anti-inflammatory and analgesic, anthelmintic, anti-viral and anti-tumor drugs and other drugs with poor transdermal properties. Pharmacological effects, and reduce the dosage of the main drug, reduce the cost. Such as containing 1.8% laurocapram can increase the penetration of anticancer drug fluoropyrimidine by 80 times.

Laurocapram, as a drug adjuvant, does not react chemically with the drug to be penetrated, and has no pharmacological effect itself, thus adding some traditional drug delivery methods, which can be used to prepare paracetamol, aminophylline, erythromycin, phenobarbital, butyl External preparations of amikacin and other drugs, such as cream, liniment, ointment, film, etc., thereby avoiding the toxic and side effects of oral administration on the human body and improving the therapeutic effect of local external application. Laurozone can also be used as an additive for various nutritional, curative and functional health-care cosmetics, making the product more comfortable and smooth, non-irritating and non-damaging to the skin, and excreting quickly with less skin residue.

In addition, Laurocapram has a strong antibacterial effect. It can destroy the cell wall structure, causing a large number of enzymes in the bacteria to leak out and lose, leading to the apoptosis of bacteria and spores.

2. Pesticide industry
Laurocapram has remarkable strong permeability and emulsification compatibility. It has been successfully mixed with insecticides, fungicides and herbicides at home and abroad to make high-permeability pesticide preparations, such as organophosphorus, carbamates, and pyrethroids. New formulations of pesticides such as nicotine, nicotine, etc. After the liquid is sprayed, it can quickly spread and wet the surface of animals and plants, and be strongly infiltrated and absorbed by pests and eggs, so that the pesticide ingredients can effectively enter the body. Under the same drug efficacy, the active ingredients of hypertonic pesticides are about 50% lower than ordinary pesticides, which not only improves the insecticidal effect, eliminates the resistance of pests and diseases, but also reduces the consumption of pesticides and production costs, making highly toxic pesticides less expensive. Poisoning is beneficial to the protection of the ecological environment and has obvious economic and social benefits.

3. Printing and dyeing, leather and chemical fiber industries
As a dyeing enhancer, Laurocapram can enhance the coloring permeability, strong affinity with dyes, strong leveling, low coloring temperature, good color fixing effect, can increase the softness and gloss of fabrics and leather, and greatly improve the quality of dyeing .

4. Other industries
Laurocapram can also be applied to photosensitive film to increase the depth of sensitivity, improve the color level, and greatly save the amount of silver halide used in photosensitive. In addition, applications in petroleum, aviation and other fields continue to expand.

Mechanism of Action of Laurocapram

The high-efficiency penetration of Laurocapram is to affect the cuticle of the active organism, and promote the effective ingredients to enter the body through the epidermis. Because the gap between the cells on the surface of the active tissue increases and the defense ability decreases, the effective drug can quickly enter the body through the epidermis. Reach the target to make the drug effective.

1. The mechanism of action on pests: most of the pests are insects, and the surface of the pests has a lipid protective layer or a hard shell protective layer. Fully possessed, each has its own focus. When the contact or stomach poisonous insecticide is added to Laurocapram, it first has affinity and infiltration with the surface of the pest to form a uniform drug film, destroying the surface structure of the pest, reducing its skin defense ability, and promoting the insecticide In a relatively short period of time, it enters the pest body and reaches the action site relatively smoothly. If it is a stomach toxic insecticide, it will destroy the gastric lining of the pest, quickly absorb and metabolize it to reach the action point, and quickly kill the pest.

2. The mechanism of action of plant diseases: All kinds of crop diseases are composed of cells. Whether it is a contact fungicide or a systemic fungicide, it must be sprayed on the surface of the crop at an effective concentration to affect the disease. A process of contact and penetration is required. Due to the nature of the fungicide, the effective drug that enters the plant or enters the disease within a unit of time is certain. To improve the killing performance and speed, the dosage must be increased. The fungicide added with Laurocapram can quickly pass through the cell wall to kill diseases and protect plants.

3. Mechanism of action on weeds: All kinds of plants have a self-protecting waxy layer on the surface of their leaves. Harmful weeds, especially vicious weeds, have a dense and thick waxy layer, and all kinds of herbicides are It must be in contact with weeds and pass through the waxy layer before it can work. The herbicide added with Laurocapram is sprayed on the surface of the weeds, which can destroy the waxy layer and prompt the herbicide to work quickly to kill weeds.

Method of use: Azone is directly added in the production of pesticide preparations, and its addition amount is 0.5%-2% of the pesticide preparation, and the conventional dosage is 1%. Azone is widely used in organophosphorus, pyrethroids, carbamates and compound insecticides, fungicides, herbicides and other pesticides.

In short, from the perspective of the mechanism of action of Laurocapram, it is a high-efficiency transdermal accelerator that promotes the entry of active ingredients into the active body. This is also the theoretical basis for the reduction in the amount of pesticides and the improvement of drug efficacy after the use of azone.

Generally, the pesticides added with azone can save 30-70% of pesticides compared with the original preparations, increase the insecticidal speed by 1 to 5 times, and have rapid drug effects, and the drug effects can be extended for 3 to 7 days, making pesticides more efficient, less toxic, faster and longer lasting. trail of.

Preparation of Laurocapram

Azone is generally created by the reaction of caprolactam as well as bromopentodecane under various problems with a proton agent as well as a driver. The primary manufacturing methods are as follows:

1. Salt hydride method
This technique is the initial procedure of creating azone. In toluene or petroleum ether solvent, caprolactam first responds with salt hydride to generate caprolactam sodium salt. Then, under home heating as well as stirring, it undertakes condensation reaction with the dropwise included dodecane bromide to acquire azone. All the really active chemical reagents such as salt hydride utilized in this technique are expensive and also harmful to operate. Record [2] uses salt alkoxide as opposed to salt hydride to enhance the procedure, yet still requires inert gas security, solvent drying out therapy, and so on, the reaction time is as long as 25 hours, as well as the return is less than 50%.

2. Liquid-liquid phase transfer catalytic approach
This method is based on the caprolactam N-alkylation synthesis approach using NaOH aqueous service as the proton-removing agent, as well as is gotten by reacting caprolactam and bromopentyl dodecane under the stage transfer catalyst of tetrabutylammonium bromide. The attribute of this approach is that the synthesis process is simple, no anhydrous procedure is needed, as well as the reaction conditions are very easy to regulate. But the item return is low, and also the reaction time is more than 10 hours. The result of dissolving in water has side responses, a large quantity of solvent, a huge amount of antacids, challenging post-processing, high requirements for equipment, as well as lack of certain competition.

3. Solid-liquid stage transfer catalytic technique
This method uses KOH-K2CO3 dual alkali instead of potassium hydroxide or salt hydroxide as a proton-removing agent, and tetrabutyl salt bromide or polyethylene glycol as a phase transfer catalyst. Caprolactam and also dodecane bromide react in toluene or ethane solvent to produce azone in one action with a return of over 93%.

The response conditions are light, no N 2 security is called for, and also it is very easy to operate, however it must be performed in a non-aqueous solvent, which is currently the manufacturing process extensively made use of in the production of azone in China.

About Products:
If you need Laurocapram as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Laurocapram, ZSpharmac will provide Laurocapram raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.