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Laureth-4 CAS 5274-68-0

Molecular Formula: C20H42O5

Formula Weight: 362.54

ZSpharmac: Laureth-4 Supplier

Product Name: Laureth-4
CAS No: 5274-68-0
Purity: 99%

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Basic Info

Product Name:Laureth-4
Other Names:Tetraethylene Glycol Monododecyl Ether
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials

Colorless Liquid

EINECS No.:226-097-1
Provide:Laureth-4 MSDS;
Laureth-4 COA

What is Laureth-4?

Laureth-4 comes from polyether defoamer, polyether defoamer is a substantial choice of defoamer today, it is safe, unappetizing, non-irritating, immune to difficult water in addition to acid along with antacids, as well as compatible with the system Compared to one more big class of silicon-containing defoamers, although its defoaming performance is not high, its antifoaming performance is rather excellent.

Laureth-4 is used as an antistatic agent as well as emulsifier in cosmetics. It must be noted that it is most likely to develop skin allergic reactions and also acne.

Laureth-4 Property

Melting point 14°C
Boiling point 185°C/0.2mmHg(lit.)
density 0.946 g/mL at 20 °C(lit.)
refractive index n20/D 1.453
Fp >230 °F
storage temp. 2-8°C


Application of Laureth-4

CN201811249391.5 discloses a makeup remover composition and its preparation method and application, wherein, by weight percentage, the makeup remover composition is mainly made of the following raw materials: 20% to 60% vegetable oil, 10% to 30% lauryl alcohol Ether sulfate ester salt, 15%-30% laureth-4, 5%-25% emollient, 1%-10% foam stabilizer and 0-1% plant acne removing agent. The makeup remover composition has a good makeup remover effect, does not require secondary cleaning, is mild and non-irritating to the skin, and has a good moisturizing effect.

CN201911332927.4 discloses a bubble bath oil and its preparation method, which includes the following components by weight percentage: sweet almond oil: 30-55%, cocamide DEA: 1-4%, lauryl polyether Sulfate TIPA: 15-25%, Propylene Glycol: 3-8%, Laureth-4: 20-35%, PEG-7 Glyceryl Cocoate: 1-4%, Auxiliary Ingredients: 0.5%-1 %, the bubble bath oil of the present invention can not only remove dirt and excess sebum on the skin, but also maintain the oil balance of the skin, improve the condition of itchy and dry skin, increase the lubricating feeling of the skin, and have the effect of nourishing while cleaning. Efficacy, to achieve the real two-in-one washing and care.

Preparation of Laureth-4

Synthetic General Approach: Under the protection of argon, add iodoalkane (1eq.) to a DMF (40mL) remedy having triethylene glycol or tetraethylene glycol (1eq.), cool down the blend to 0 ° C, add Salt hydride (1.5 eq.60% in mineral oil), stirred for 2h, satiated with water, extracted with ethyl acetate (20mL × 2), combined ethyl acetate stage, cleaned with saturated salt water, and after that dried out over anhydrous sodium sulfate, focused to obtain an unrefined item, which was detoxified by silica gel column chromatography (ethyl acetate-n-hexane), and also the acquired example was right away utilized in the next response.

Laureth-4 was synthesized making use of the above basic synthetic approach, tetraethylene glycol (2mL, 11.59 mmol) and 1-iodododecane (4.42 g, 11.59 mmol), salt hydride (0.70 g, 17.38 mmol) After the response, laureth-4 (2.18 g, 6.02 mmol, yield 52%) was gotten as an anemic oil; Rf=0.41 (ethyl acetate-n-hexane 3:2).

Action and Function of Laureth-4

The material is a popular surfactant used as an active ingredient in body care as well as health items. As a surfactant, Laureth-4 reduces the surface area stress in between 2 immiscible phases (two liquids or a fluid and a strong) as well as enables them to integrate, i.e. to develop emulsions (cosmetics are mostly in emulsion form). The Laureth-4 particle has a hydrophilic component that is brought in to the water stage as well as a hydrophobic part that is drawn in to the oil stage. As a result of these buildings, surfactants like Laureth-4 can get rid of built-up oily pollutants, dirt as well as other contaminants from the skin. As an emulsifier, Laureth-4 boosts the uniformity of cosmetics, helping to make sure also application and attain topical benefits. This is especially vital because cosmetic formulations, such as lotions, tend to break down with time due to inappropriate storage space or settling of the item. Therefore, for example emulsifiers are utilized to preserve a continuous dispersion of the stages. Laureth-4 can likewise improve the result of other cleaning agents, enhance the thickness of solutions, and as an ingredient in shampoos can stop hair from absorbing static electrical energy.

The non-cosmetic applications of Laureth-4 are primarily based on its emulsifying properties. As an emulsifier, it is utilized in family products (cleaners, dishwashing fluids) and also lubricating products (generally silicone-based formulations).

The textile industry utilizes Laureth-4 as an additive in formulas for the elimination of oil stains on woven/knitted fabrics that happen during commercial knitting/knitting. Laureth-4 has great wetting residential properties. When touching cotton fabrics, fluid droplets having this surfactant spread openly throughout the surface area and pass through into the pores of the fabric (decreasing the surface stress so that the fabric can be moistened rapidly). Due to its moistening ability, Laureth-4 is an active ingredient in bleaching compositions made use of in the lightening of raw cotton woven/knitted materials. It is likewise an essential ingredient in removing excess color from the dyebath at the final stage of the fabric dyeing phase.

About Products:
If you need Laureth-4 as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Laureth-4 manufacturer and supplier, ZSpharmac will provide Laureth-4 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Laureth-4 Quotation