L-serine National Drug Standard: H19994011, is just one of the aliphatic polar amino acids, belongs to sugar-producing amino acids, and also commonly exists in natural proteins. L-serine, as a fundamental amino acid for healthy protein, is widely used in medication, food, cosmetics as well as other sectors, as well as the marketplace need continues to enhance. The primary techniques for generating L-serine are: healthy protein hydrolysis removal, chemical conversion, chemical synthesis and microbial fermentation.
L-Serine Supplement Property
222 °C (dec.) (lit.)
15.2 º (c=10, 2N HCl)
197.09°C (rough estimate)
H2O: 50 mg/mL
5-6 (100g/l, H2O, 20℃)
wh. cryst. or cryst. powd., odorless, sweet taste
[α]20/D +13.5±0.5°, c = 5% in 5 M HCl
250 g/L (20 ºC)
Application of L-Serine Supplement
Application of L-serine in medicine L-Serine Supplement can be used as a precursor to synthesize purine, thymine, phospholipid, and choline; L-tryptophan, L-cystine, L-cycloserine, and L-dopa can be synthesized with L-serine as an intermediate; L-serine has the function of stabilizing the pH of eye drops, so that there is no irritation after being instilled into the eyes; L-serine can also be used to prepare compound amino acid infusions and nutritional supplements; serine can also promote the metabolism of fat and fatty acids, which helps Maintain the balance of the immune system; and the derivatives of L-serine also have important physiological functions, such as: phosphoserine is one of the components of phospholipids; the antibiotic that can be used to treat tuberculosis is a kind of cycloserine; it can be used to treat tumors One of the most popular anticancer agents is azaserine, which can also be used to treat acute leukemia and Kedgkin’s disease.
Application of L-serine in food and cosmetics In terms of food, the 2-hydroxyacetaldehyde produced by heating L-Serine Supplement and glucose has the aroma of maple syrup and can be used as a food additive. As a nutrient, it can be added to animal feed to enable the body to absorb and utilize plant protein It can also promote the growth and development of animals; in terms of cosmetics, L-Serine Supplement can be added to advanced cosmetics as a skin nutrient. As a key component of natural moisturizing factors, it has the functions of moisturizing, Anti-aging function.
Production Method of L-Serine Supplement
Chemical synthesis The chemical synthesis process route of L-Serine Supplement mainly includes copper glycine method, α-isoacetaldehyde amine method, acrylonitrile method and dichloropropionitrile method, etc. The raw materials used in chemical synthesis are relatively cheap, the process route is relatively simple, and it is easy to produce on a large scale, but the product synthesized by this method is DL-serine, so further resolution is required to obtain L-serine, which will greatly improve The cost of producing L-serine by chemical synthesis affects large-scale industrial production. The following is a brief introduction to the chemical synthesis process of L-serine by the copper glycine method:
Proteolysis Some proteins in nature (such as the content of L-serine in silk reaches 13.64%) are rich in a large amount of L-Serine Supplement, so through proteolysis, separation and purification can obtain relatively pure L-serine. This method was widely used in the early production of L-serine, but the method is complicated to operate, produces a large amount of polluted water, and there are many types of amino acids in the product, and the cost of separation and purification is relatively high, so it is gradually favored by other L-serine production methods replace.
Enzyme method Compared with the chemical method, the enzymatic method has a simpler reaction process, the product is easy to extract, and there are fewer by-products. The specific reaction is:
At present, the key to the enzymatic production is whether the serine hydroxymethyltransferase (SHMT) with excellent characteristics can be obtained. Serine hydroxymethyltransferase (SHMT) with high enzymatic activity was screened from nature, and its enzymatic activity, substrate tolerance and enzyme stability were improved through exogenous expression, site-directed mutation and other techniques. This is also the main trend of bio-enzymatic production of L-serine. However, subject to the catalytic ability of the enzyme, the production of L-serine by this method is still in the stage of laboratory research.
Microbial Fermentation The use of cheap carbon sources for microbial fermentation to produce L-Serine Supplement has the advantages of low cost and low environmental pollution, which has attracted the attention of researchers at home and abroad. However, this method has not yet been industrialized due to problems such as low yield and high production cost. This is partly because L-serine is an intermediate metabolite, which cannot be effectively accumulated in the cell, and the synthesized L-serine can be effectively degraded into other products; in addition, the flow of sugar metabolism into L-serine synthesis is relatively small . With the development of genetic engineering technology, the use of metabolic engineering to modify microorganisms to efficiently produce target products has become the mainstream. With the help of newly developed microbial technology, there are more and more reports on the production of L-serine by microbial fermentation, and the advantages of L-serine produced by fermentation are becoming more and more prominent.
The breeding of L-Serine Supplement high-yielding strains by system metabolic engineering has gradually become the focus of breeding L-Serine high-yielding strains in the past two years. In recent years, there have been many successful cases of using systematic metabolic engineering to construct L-serine production strains:
About Products: If you need L-Serine Supplement, the cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price. As an experienced L-Serine Supplement manufacturer and supplier, ZSpharmac will provide L-Serine Supplement raw materials to customers all over the world for a long time. Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.
Company Profile and Corporate Culture
ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .
The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .
The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.
OUR MISSION Help China Chemicals to benefit the happiness of human life OUR VISSION Become the most trusted chemical supplier in the world OUR BUSINESS PHILOSOPHY Striver – oriented, enrich employees, customer first, deep service, seek development OUR VALUES Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
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You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
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Yes. We’ll give you product analysis report before shipping.
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Different quantity has different discount.
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
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