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L(+)-Rhamnose Monohydrate CAS 10030-85-0

Molecular Formula: C6H14O6

Formula Weight: 182.17

ZSpharmac: L(+)-Rhamnose Monohydrate Supplier

Product Name: L(+)-Rhamnose Monohydrate
CAS No: 10030-85-0
Purity: 99%

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Basic Info

Product Name:L(+)-Rhamnose Monohydrate
Other Names:L-Rhamnose Monohydrate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystals or Crystalline Powder
EINECS No.:600-058-2
Storage:Inert Atmosphere,Room Temperature
Provide:L(+)-Rhamnose Monohydrate MSDS;
L(+)-Rhamnose Monohydrate COA

What is L(+)-Rhamnose Monohydrate?

It is the most widely distributed in bacteria and plants. In bacteria, polysaccharides or lipopolysaccharides with rhamnose as the constituent sugar exist on the cell surface. This sugar chain structure mostly becomes an antigen-specific factor. In the leaves and flowers of Rhus toxicodendron in plants, in addition to the free sugar form, it is also distributed in the form of various glycosides such as rutin and the constituent sugars of polysaccharides such as gum arabic.

Plant source: Widely distributed in plants as a trace sugar. It can exist in many kinds of plant glycosides (such as quercetin, isohesperidin, etc.), polysaccharides, especially pectin and pectin in the form of sugar, and can also exist in anacardin.

The pathway of rhamnose biosynthesis from glucose in bacterial cells is: α-glucose-1-phosphate→dTOP-D-glucose→dTDP-4-keto-6-deoxy-D-glucose→dTDP-4-drinking-L- Rhamnose → dTDP-L-rhamnose, the final product sugar nucleotides are acted by specific rhamnosyltransferases, and the rhamnose residues are incorporated into glycosides and polysaccharides.

L(+)-Rhamnose Monohydrate is a typical 6-deoxyhexose, comparable to fucose, comparable in sweet taste to D-mannose, somewhat bitter, and has physiological Task, consequently, in an effort to develop and also use these sugar chains as products for drugs and also farming chemicals, L(+)-Rhamnose Monohydrate or its derivatives have actually been made use of as elements for the growth as well as application of these sugar chains. On top of that, rhamnose is likewise considered as a material for reacting tastes, because it creates a distinct scent in the Maillard response with amino acids.

L(+)-Rhamnose Monohydrate Property

Melting point 90-95 °C(lit.)
alpha 8.2 º (c=4.5,H2O)
density 1.47
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 0.1 g/mL, clear, colorless
form Crystals or Crystalline Powder
color White
PH Range7.8 – 8.6
optical activity[α]20/D +8±0.5°, 2 hr, c = 5% in H2O
Water Solubility 300 g/L (20 ºC)


L(+)-Rhamnose Monohydrate Uses

L(+)-Rhamnose Monohydrate can be made use of to determine intestinal leaks in the structure, can be used as a sweetener, and can likewise be utilized to generate tastes and scents. It can not just be utilized as a clinical discovery reagent, yet also can be used as a preservative in the processing of state-of-the-art coffee, beverages, bread, meat products, and so on. At present, rhamnose has actually been extensively used in commercial production as well as scientific research.

L(+)-Rhamnose Monohydrate Prevents Aging of Dermal-Epidermal Junction

The dermal-epidermal junction (DEJ) is a complex structure that plays a critical role in maintaining the structural and mechanical properties of the skin. Intrinsic and extrinsic aging are associated with flattening of the DEJ and decreased expression of some of its constituent proteins. These changes are involved in aging skin that becomes brittle and in wound healing. L(+)-Rhamnose Monohydrate, a natural monosaccharide with cell-promoting and anti-inflammatory properties, targets lectin-expressing cells recognized by L(+)-Rhamnose Monohydrate, such as keratinocytes and papillary Fibroblasts. Since keratinocytes and fibroblasts are involved in the formation of DEJ, we investigated the effect of L(+)-Rhamnose Monohydrate on the expression of DEJ components. L-rhamnose has very poor skin absorption, and we attached it to methylsilanetriol (MTS), a carrier molecule that confers cell-promoting and connective tissue-restructuring properties.

L(+)-Rhamnose Monohydrate targets DEJ
Localization and expression of four important DEJ components were determined using immunofluorescence:

— Laminin 5 (Laminin5) is a protein produced by keratinocytes that binds basal keratinocyte plasma membrane and Lamina Densa type VII collagen. L-rhamnose alone had no significant effect on this protein, but rhamnose-silanol (R-S) enhanced the protein expression (data: 1% R-S increased by 18%, 5% R-S increased by 18%).

– Perlecan is a ubiquitous heparan sulfate proteoglycan present in all basement membranes, linking nidogen and type IV collagen. 5% R-S significantly increased the expression of perlecan (+25%).

—Type IV collagen (IV Collagen), one of the most abundant collagen glycoproteins in the basement membrane, is an important component of the dense layer. L-rhamnose alone induces moderate collagen type IV expression (+17%), while the same concentration of R-S greatly enhances collagen IV expression (+64%), and expression increases at low concentrations of R-S (1%) Already very noticeable (+41%).

– Type VII Collagen, a large protein located beneath the compact layer, is considered a major component of the anchoring fibril, whose flexibility is necessary to maintain the epidermis-dermis bond. L-rhamnose can boost collagen VII expression (25%), and this boost is synergistic when combined with silanols (58%).

Afterwards, it was further proved by immunofluorescence analysis carried out in human extracorporeal skin that L-rhamnose was combined with MTS to enhance bioavailability and efficacy. In this experiment, L(+)-Rhamnose Monohydrate had no apparent effect. Notably, MTS alone was able to promote type VII collagen expression. The R-S combination clearly promotes type VII collagen expression and migration to the DEJ, suggesting that MTS facilitates the delivery of L-rhamnose to dermal fibroblasts responsible for the synthesis of type VII collagen (and many other DEJ components).

The role of rhamnose silanol in the multiple layers of the skin
Aging affects all skin layers: the epidermis becomes thinner and less regenerative, and the extracellular matrix (ECM) of the dermis decreases and deteriorates. We therefore measured other parameters to demonstrate the efficacy of R-S on the epidermis and dermis:

– Ki67 nucleoprotein, a marker protein of epidermal cell cycle.

— Collagen type I, the main collagen in the dermis, the decline of which is a sign of aging. As previously shown, R-S was able to promote the expression of DEJ components (collagen type IV, laminin 5). Furthermore, we found that R-S promoted keratinocyte proliferation (Ki67) and expression of type I collagen in the dermis.

Biological Activity of L(+)-Rhamnose Monohydrate

L(+)-Rhamnose Monohydrate is a plant cell wall polysaccharide, one of the components of rhamnuronic acid I and rhamnuronic acid, present on the surface of Gram-negative and Gram-positive bacteria. It is also present in the bacterial cell wall and is the major antigenic determinant responsible for pathogenicity. L(+)-Rhamnose Monohydrate cannot be absorbed by the human body, but can be fermented by intestinal flora, which can slow down gastric emptying, bind to immunogens, and be used for cancer immunotherapy. Intake can increase serum propionate levels . In addition, L-rhamnose monohydrate can also be used for enhanced detection of Streptococcus pneumoniae biofilm and human intestinal barrier permeability test (as a sugar drink).

About Products:
If you need L(+)-Rhamnose Monohydrate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L(+)-Rhamnose Monohydrate manufacturer and supplier, ZSpharmac will provide L(+)-Rhamnose Monohydrate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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