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L-Pyroglutamic Acid CAS 98-79-3

Molecular Formula: C5H7NO3

Formula Weight: 129.11

ZSpharmac: L-Pyroglutamic Acid Supplier

Product Name: L-Pyroglutamic Acid
CAS No: 98-79-3
Purity: 99%

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Basic Info

Product Name:L-Pyroglutamic Acid
Other Names:H-Pyr-OH
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Powder
EINECS No.:202-700-3
Provide:L-Pyroglutamic Acid MSDS;
L-Pyroglutamic Acid COA

What is L-Pyroglutamic Acid?

L-Pyroglutamic acid is a non-protein amino acid, its chemical name is 5-oxoproline or L-2-pyrrolidone-5-carboxylic acid, and its molecular formula is C5H7NO3. It is a cyclic amino acid formed from glutamic acid through a lactonization reaction between the amino and carboxyl groups of its side chain. It is naturally present in a variety of foods and organisms, such as plants, animal tissues and microbial fermentation products.

L-pyroglutamic acid has multiple functions in the body, including participating in metabolic pathways, regulating as a neurotransmitter, and playing a role in protein modification. It also acts as an antioxidant and has the ability to scavenge free radicals, so it also has applications in the health food and cosmetics industries. In addition, the sodium salt form of L-pyroglutamate (Sodium L-pyroglutamate) is often used as a food flavor enhancer, which can enhance the taste of food. It is similar to the effect of MSG (sodium L-glutamate), but has Different flavor enhancing properties.

In chemical and biochemical research, L-pyroglutamic acid can be used as a standard, biochemical reagent, and as an intermediate in organic synthesis. Due to its special ring structure, L-pyroglutamic acid and its derivatives also show potential application value in drug development, agricultural chemicals and fine chemical production.

L-Pyroglutamic Acid Property

Melting point 160-163 °C(lit.)
alpha -27.5 º (c=10, 1 N NaOH)
Boiling point 239.15°C (rough estimate)
density 1.3816 (rough estimate)
vapor pressure 0.002Pa at 25℃
refractive index -10 ° (C=5, H2O)
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Crystalline Powder
pka3.32(at 25℃)
color White to off-white
PH1.7 (50g/l, H2O, 20℃)
Odorwh. crystal, odorless, sl. acidic taste
optical activity[α]20/D 10.5±1°, c = 5% in H2O
Water Solubility 10-15 g/100 mL (20 ºC)


L-Pyroglutamic Acid Uses

Medical and health fields
Drug synthesis: L-pyroglutamic acid, as a chiral source, participates in asymmetric synthesis and can prepare a variety of alkaloids and amino acids. These compounds show strong physiological activity in the nervous system and are of great significance for drug development.
Disease prevention: Some studies have shown that L-pyroglutamic acid may have a potential role in preventing neurodegenerative diseases such as Alzheimer’s disease, and its research in the medical field is gradually deepening.
Skin care: The hydrochloride form of L-pyroglutamic acid has the effect of inhibiting the activity of tyrosine oxidase, reducing the deposition of “melanoidin” in the skin, showing the functions of whitening and softening cuticles, and is suitable for skin care product formulations middle.

Cosmetics industry
Thickening and stabilization: In cosmetics, L-pyroglutamic acid can be used as a thickener to stabilize the emulsification system, improve the texture of the product, and make it easier to apply and last longer.
Skin protection: Due to its mildness to the skin, L-pyroglutamic acid is used in anti-allergic and soothing cosmetics to help protect the skin from external irritations.
Whitening and anti-aging: Its ability to inhibit melanin production gives it a place in whitening cosmetics, and its antioxidant properties also contribute to anti-aging products.

Food industry
Food additive: As a food-grade raw material, L-pyroglutamic acid can be used as a flavor enhancer to enhance the flavor of food, similar to the effect of MSG, but with different flavor characteristics.
Nutritional supplements: In some specific nutritional supplements and health foods, L-pyroglutamic acid is used as an amino acid supplement source and participates in the body’s metabolic process.

Agriculture and Feed
Fermentation raw materials: In fermentation technology, L-pyroglutamic acid can be used as a component of microbial culture media to promote the growth of specific strains and be used to produce specific chemicals or enzymes.
Feed additive: In animal feed, it can be used as a supplement of minerals and trace elements to promote healthy growth of animals.

Research and Education
Biochemical Research: As a biochemical reagent, L-pyroglutamic acid is used in laboratories to study protein structure, enzyme activity testing, and biochemical pathway exploration.
Teaching example: In chemistry and biochemistry teaching, L-pyroglutamic acid can be used as a typical example to help students understand the properties of amino acids and the synthesis principles of biomolecules.

Prominent Applications of L-Pyroglutamic Acid in Cosmetics

Moisturizing properties: The sodium salt of L-pyroglutamic acid is an efficient moisturizer. Compared with traditional moisturizing ingredients such as glycerin and sustenol, it can lock in moisture more effectively and provide long-lasting moisturizing effect. This property keeps skin soft and elastic, reducing fine lines and roughness caused by dryness, and is suitable for all types of skin care products, including creams, serums and masks.

Whitening function: L-pyroglutamic acid can inhibit the activity of tyrosine oxidase, which is involved in the synthesis of melanin. By reducing the production and deposition of melanin, it helps brighten skin tone, reduce spots and dullness, and becomes an important ingredient in whitening cosmetics. Its gentle and effective whitening mechanism is particularly suitable for product formulas that pursue natural whitening effects.

Cutin softening: It has the ability to soften the cuticle of the skin, helping to improve skin texture and make the skin more delicate and smooth. This feature is particularly important for exfoliating products and deep cleansing masks, which can promote the shedding of aging cuticles and accelerate skin metabolism.

Surface activity and cleansing: L-pyroglutamic acid can be used as a surfactant, which can effectively remove oil and dirt on the skin surface. At the same time, due to its mildness, it will not cause skin tightness or irritation. It is a cleanser suitable for sensitive skin. , shower gel and other cleaning products.

Chemical stability and compatibility: Due to its good water solubility and compatibility with other cosmetic ingredients, L-pyroglutamic acid is easy to mix and can exist stably in various formulations, enhancing the overall efficacy and safety of cosmetics.

Nail care: It can also be added to nail care products to make nails look healthier and glossier by improving their moisture retention and strength.


National Center for Biotechnology Information. PubChem Compound Summary for CID 7405, L-Pyroglutamic acid. https://pubchem.ncbi.nlm.nih.gov/compound/L-Pyroglutamic-acid. Accessed May 22, 2024.

As a company specializing in the production and supply of L-Pyroglutamic Acid raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the L-Pyroglutamic Acid raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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