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Zhishang Chemical

L-Pyroglutamic Acid CAS 98-79-3

Molecular Formula: C5H7NO3

Formula Weight: 129.11

ZSpharmac: L-Pyroglutamic Acid Supplier

Product Name: L-Pyroglutamic Acid
CAS No: 98-79-3
Purity: 99%

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Basic Info

Product Name:L-Pyroglutamic Acid
Other Names:H-Pyr-OH
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to off-White Crystalline Powder
EINECS No.:202-700-3
Provide:L-Pyroglutamic Acid MSDS;
L-Pyroglutamic Acid COA

What is L-Pyroglutamic Acid?

L-Pyroglutamic Acid is 5-oxyproline. It is formed by the dehydration between the α-NH2 group and the γ-hydroxyl group of glutamic acid to form an intramolecular amide bond; it can also be formed by losing the amido group in the glutamine molecule. If glutathione synthetase deficiency, can cause pyroglutamic acidemia, a series of clinical symptoms. L-Pyroglutamic Acidemia is an organic acid metabolic disorder caused by glutathione synthetase deficiency. Clinical manifestations include onset within 12 to 24 hours of birth, progressive hemolysis, jaundice, chronic metabolic acidosis, mental retardation, etc.; urine contains L-Pyroglutamic Acid, lactic acid, and α-deoxy-4-glycotolactone. Treatment, symptomatic, pay attention to diet adjustment after one year old.

L-Pyroglutamic Acid Property

Melting point 160-163 °C(lit.)
Boiling point 239.15°C (rough estimate)
alpha -27.5 º (c=10, 1 N NaOH)
density 1.3816 (rough estimate)
vapor pressure 0.002Pa at 25℃
refractive index -10 ° (C=5, H2O)
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Crystalline Powder
pka3.32(at 25℃)
color White to off-white
PH1.7 (50g/l, H2O, 20℃)
optical activity[α]20/D 10.5±1°, c = 5% in H2O
Water Solubility 10-15 g/100 mL (20 ºC)


L-Pyroglutamic Acid Uses

  1. L-Pyroglutamic Acid includes a water-soluble compound with moisturizing function in human skin – all-natural moisturizing element. Its make-up is roughly amino acid (including 40%), pyroglutamic acid (containing 12%), inorganic salts (Na, K, Ca, Mg, etc including 18.5%), other organic matter (containing 29.5%). Therefore, pyroglutamic acid is just one of the main elements of the skin’s natural moisturizing factor, and also its moisturizing capacity much surpasses that of glycerin and also propylene glycol. And also non-toxic, non-irritating, it is an excellent raw material for contemporary skin care and also hair treatment cosmetics. Pyroglutamic acid can also prevent the task of tyrosine oxidase, therefore preventing the deposition of “melanoid” materials in the skin, and also has a bleaching impact on the skin. It has a conditioning impact on cutin as well as can be made use of in nail cosmetics. Along with the application in cosmetics, L-pyroglutamic acid can additionally form by-products with a few other natural compounds, which have unique effects in surface area activity, openness and brightening. It can likewise be made use of as a surfactant for cleaning agents; chemical reagents for the resolution of racemic amines; organic intermediates.
  2. L-Pyroglutamic Acid is used as organic synthesis intermediate, food additive, etc.

Pharmacodynamics of L-Pyroglutamic Acid

L-Pyroglutamic acid is a normally occurring but inadequately examined amino acid by-product that can be created enzymatically or non-enzymatically and also joins numerous chemical paths as organic intermediates. Raised acid levels in the blood might be associated with problems with glutamine or glutathione metabolism. Normally, big amounts of pipecolic acid are located in brain tissue and also other tissues such as the skin. Additionally, adequately high degrees of picolinic acid can function as an acid generator with the ability of generating acidosis as well as metabolic toxins with negative wellness impacts. Chronically raised degrees of picolinic acid have been linked to at the very least 5 innate mistakes of metabolic rate, including 5-oxoprolinuria (where 5-oxoproline is additionally referred to as picolinic acid), 5-oxoprolinuria Enzyme shortage, glutathione synthetase deficiency, hawkinginuria, and propionic acidemia. Particularly, abnormally high degrees of organic acids such as picolinic acid in the blood, pee, brain, and/or other tissues can lead to systemic metabolic acidosis. This acidosis generally takes place when the arterial pH is below 7.35. In babies, the first symptoms of acidosis include inadequate feeding, throwing up, loss of appetite, weak muscular tissue tone (hypotonia), and lack of energy. Ultimately, acidosis and the signs of acidosis can cause heart, liver, and kidney abnormalities, seizures, coma, and also possibly fatality. Several youngsters with organic acidemia create intellectual impairment or developing hold-up. In grownups, acidosis, or acidemia, is characterized by migraine, complication, really feeling weary, drinking, sleepiness, as well as seizures. Acetaminophen overdose, causing enhanced acidity, referred to as high anion gap metabolic acidosis.

L-Pyroglutamic Acid and Autococrystallization: Charge Density Analysis

The heat-induced conversion of glutamate to L-Pyroglutamic Acid is well known. Nevertheless, there is still confusion regarding the precise temperature at which this occurs. Moreover, no diffraction data are readily available to support this transition. In this article, we executed an organized research including thermal analysis, hot stage microscopy and single crystal X-ray diffraction to research the one-pot thermal conversion of glutamic acid to L-Pyroglutamic Acid and also the succeeding products (moisturized pyroglutamic acid acid) in between self-cocrystallized acid) and unreacted precursor (glutamic acid). Hirshfeld area evaluation was accomplished for quantitative evaluation of intermolecular communications.To gain insight into the stamina and security of the co-crystal, the transferability concept was utilized to do topological evaluation and also examine electron density-derived residential properties. The movement model has been located to outshine the classic Independent Atom Design (IAM). Speculative outcomes have been compared with those of multipole refinement using theoretical structure elements produced from thickness practical concept (DFT) computations. Very strong timeless hydrogen bonds drive the co-crystallization as well as offer security to the resulting co-crystal. Vital conclusions have actually been drawn regarding this shift.

Preparation Method of L-Pyroglutamic Acid

L-pyroglutamic acid is formed by removing a molecule of water from the L-glutamic acid molecule. Its preparation process is simple, and the key steps are the control of temperature and dehydration time.
(1) Add 100 g of L-glutamic acid into a 500 ml beaker, heat the beaker with an oil bath, and when the temperature rises to 145-150°C, keep it warm for 45 minutes to carry out dehydration reaction. The dehydrated solution was brown in color.
(2) After the dehydration reaction is finished, the solution is poured into boiling water with a volume of about 350 milliliters, and the solution is completely dissolved in water. After cooling to 40-50°C, add an appropriate amount of activated carbon for decolorization (repeated twice). A colorless and transparent solution was obtained.
(3) When the colorless transparent solution prepared in step (2) is directly heated, evaporated and concentrated until the volume is reduced to about half, then transferred to a water bath and continued to concentrate until the volume is about 1/3, then the heating can be stopped, and the Allow to cool in a water bath to slowly crystallize. Colorless prismatic crystals can be obtained after 10 to 20 hours. The amount of L-pyroglutamic acid used in cosmetics depends on the formula. This product can also be used in cosmetics in the form of 50% concentrated solution.

About Products:
If you need L-Pyroglutamic Acid as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L-Pyroglutamic Acid manufacturer and supplier, ZSpharmac will provide L-Pyroglutamic Acid raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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