Zhishang Chemical

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L-Proline CAS 147-85-3

Molecular Formula: C5H9NO2

Formula Weight: 115.13

ZSpharmac: L-Proline Supplier

Product Name: L-Proline
CAS No: 147-85-3
Purity: 99%

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Basic Info

Product Name:L-Proline
Other Names:Proline
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-702-2
Provide:L-Proline MSDS;
L-Proline COA

What is L-Proline?

L-Proline (described as proline) is one of the 18 sort of amino acids synthesized by the human body. It is anemic to white crystal or crystalline powder at area temperature level. Ethanol, insoluble in ether and n-butanol. Amino acid is a basic term for a class of natural substances consisting of amino and also carboxyl groups. The existence of amino acids in the body not just provides essential raw materials for healthy protein synthesis, yet furthermore provides a product basis for promoting development, regular metabolic price, and also keeping life.

L-Proline Property

Melting point 

228 °C (dec.) (lit.)


-85.5 º (c=4, H2O)

Boiling point 

215.41°C (rough estimate)



vapor pressure 

0Pa at 25℃

refractive index 

-85 ° (C=4, H2O)

storage temp. 



H2O: 50 mg/mL




1.95, 10.64(at 25℃)




6.0-7.0 (25℃, 1M in H2O)

optical activity

[α]20/D 85.0±1.0°, c = 5% in H2O

Water Solubility 




L-Proline Uses

  1. L-Proline acts as a moisturizing, conditioning, buffering and neutralizing agent.
  2. L-Proline is used in amino acid drugs. It is one of the raw materials of compound amino acid infusion, used for malnutrition, protein deficiency, severe gastrointestinal disorders, protein supplement after scald and surgery.
  3. L-Proline is used in nutritional supplements. Flavoring agent, co-heated with sugar to undergo amino-carbonyl reaction, can generate special flavor substances. According to my country’s GB 2760-86 regulations, it can be used as a spice.
  4. L-Proline is used in amino acid injections, compound amino acid infusions, food additives, nutritional supplements and other pharmaceutical raw materials and food additives.

L-Proline Production Method

Ecological Information for L-Proline

The production and also use (L)-proline in parenteral nutrition, nutritional supplements, and pharmaceutical raw materials might cause its release into the atmosphere via numerous waste streams. (L)-Proline is located in numerous plants as well as is a non-essential amino acid for human development. If launched to air, the estimated vapor stress at 25 ° C is 3.0X10-8 mmHg, showing that (L)-proline will only exist in the particulate stage in the ambience. The particulate stage (L)-proline will be gotten rid of from the environment by wet and dry deposition. (L)-Proline does not consist of a chromophore that soaks up at > 290 nm as well as is for that reason expected to be less prone to photolysis by straight sunshine. If launched right into dirt, (L)-proline is expected to be extremely mobile based on an estimated Koc of 3.4. carbon and clay than their neutral equivalents. Volatilization from damp soil is not anticipated because the substance exists as ions, which do not volatilize. (L)-Proline is not anticipated to volatilize from dry dirt surface areas based upon its vapor stress. Using water testing assays, 100% biodegradation of (L)-proline was reported, suggesting that biodegradation is a vital environmental fate procedure in soil as well as water. If launched into water, (L)-proline is not anticipated to adsorb to put on hold solids as well as sediments based on the estimated Koc. The pKa values show that (L)-proline will exist as a zwitterion at pH 5 to 9, so volatilization from the water surface area is not expected to be a vital fate process. An estimated BCF of 3 indicates a reduced bioconcentration possibility in aquatic organisms. Hydrolysis is not anticipated to be an important ecological fate process because the compound lacks functional teams that hydrolyze under ambient problems (pH 5 to 9). Occupational direct exposure to (L)-proline may arise from breathing and also facial direct exposure to this compound in offices where (L)-proline is produced or utilized. Monitoring data suggest that the general populace may be exposed to (L)-proline via food intake, food preparation fume inhalation, and cigarette smoking.

About Products:
If you need L-Proline, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced L-Proline manufacturer and supplier, ZSpharmac will provide L-Proline raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get L-Proline Quotation