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Zhishang Chemical

L-Ornithine L-Aspartate Salt CAS 3230-94-2

Molecular Formula: C9H19N3O6

Formula Weight: 265.26

ZSpharmac: L-Ornithine L-Aspartate Salt Supplement

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Product Name: L-Ornithine L-Aspartate Salt
CAS No: 3230-94-2 
Purity: 99%

Basic Info

Product Name:L-Ornithine L-Aspartate Salt
Other Names:L-Ornithine-L-Aspartate
CAS:3230-94-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Powder
EINECS No.:221-772-7
Storage:2-8°C
Provide:L-Ornithine L-Aspartate Salt MSDS;
SigmaAldrich COA

What is L-Ornithine L-Aspartate Salt?

Ornithine aspartate was developed in Germany in the 1960s, and was first used clinically for the treatment of hangover and hepatic encephalopathy. With the accumulation of clinical application experience, ornithine aspartate has been more widely used in the treatment of liver diseases, and has achieved exact curative effects on hepatic encephalopathy, drug-induced liver damage, fatty liver, chronic hepatitis and other diseases , has been widely recognized by clinicians

L-Ornithine L-Aspartate Salt Properties:

Melting point 202.0 to 206.0 °C
storage temp. 2-8°C
form powder
color white
Merck 14,6874
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Effects of L-Ornithine L-Aspartate Salt

  1. Ornithine Aspartate can significantly improve the clinical symptoms of patients with overt hepatic encephalopathy and mild hepatic encephalopathy, and can significantly reduce the blood ammonia content of patients. It can also effectively reduce blood ammonia and improve intelligence test indicators.
  2. Ornithine aspartate granules have a certain therapeutic effect on hepatic steatosis and hepatic inflammation, and show a better effect on improving hepatic steatosis in patients with moderate to severe fatty liver.
  3. Drug-induced liver injury Ornithine aspartate can significantly reduce the levels of ALT, AST, TBI1, GGT and ALT in patients with drug-induced liver injury.
  4. Ornithine aspartate is suitable for patients to take a long course of treatment, it is not easy to rebound after drug withdrawal, and has high safety.
  5. Ornithine aspartate gradually becoming the main therapeutic drug for the treatment of various liver diseaOrnithine aspartate can significantly improve liver damage caused by chemotherapy drugs and improve the therapeutic effect of tumor patients.
  6. Ornithine aspartate can prevent and treat postoperative liver damage and promote postoperative recovery of patients.

Effects of L-Ornithine L-Aspartate Pharmacological Effects

In vivo, ornithine aspartate acts on two major ammonia detoxification pathways—urea synthesis and glutamine synthesis—by producing two amino acids, aspartic acid and ornithine. Urea synthesis occurs in hepatocytes around the portal vein, and ornithine acts as a catalyst and substrate for two enzymes, ornithine carbamoyltransferase and carbamoyl-phosphate synthase, and participates in the process of urea synthesis from ammonia. . Glutamine synthesis occurs in hepatocytes around the hepatic veins, and especially in pathological conditions, aspartate and other dicarboxylates, such as metabolites of ornithine, are taken up by hepatocytes around the hepatic veins , synthesizes glutamine and combines ammonia in the form of glutamine. In both physiological and pathological states, glutamine acts as an amino acid that binds ammonia, which not only allows ammonia to be excreted in a non-toxic form, but also activates important Urea cycle and glutamine exchange between cells. Under physiological conditions, the role of ornithine aspartate is not limited to urea synthesis. Animal experiments have found that increased glutamine synthesis has the effect of reducing blood ammonia levels. Some clinical trials have also found that they can improve the ratio of branched-chain amino acids to aromatic amino acids. effect. In addition, due to the promoting effect of aspartic acid on the metabolic process of the tricarboxylic acid cycle in the hepatocytes, the energy production in the hepatocytes is promoted, so that the function of the damaged hepatocytes can be restored.

Clinical Application of L-Ornithine L-Aspartate Salt

Ornithine can activate the key enzymes in the process of urea synthesis – ornithine carbamoyltransferase and carbamoyl phosphate synthase, and promote ammonia Metabolism to achieve detoxification of blood ammonia, aspartic acid as a substrate can generate glutamic acid and oxaloacetic acid, glutamine is the detoxification product of ammonia, and it is also the storage and transportation of ammonia. Oxaloacetic acid participates in the tricarboxylic acid cycle, promotes the production of energy in liver cells, repairs and regenerates damaged liver cells, and restores liver function. Ornithine aspartate can effectively improve liver function, reduce blood ammonia, and synergistically reduce ammonia with lactulose and ofloxacin, thereby significantly improving the cure rate of hepatic encephalopathy, which is worthy of clinical application.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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