Zhishang Chemical

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Zhishang Chemical

L-Menthol CAS 2216-51-5

Molecular Formula: C10H20O

Formula Weight: 156.27

ZSpharmac: L-Menthol Raw Material Supplier

Product Name: L-Menthol
CAS No: 2216-51-5
Purity: 99%

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Basic Info

Product Name:L-Menthol
Other Names:Menthol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless to White Crystals or Crystalline Needles
EINECS No.:218-690-9
Storage:Store Below +30°C.
Provide:L-Menthol MSDS;
L-Menthol COA

What is L-Menthol?

Menthol, additionally referred to as hexahydrothymol, is generally referred to as menthol, and its taxonomic name is 5-methyl-2-isopropyl-cyclohexanol. It is a really essential cycloterpene alcohol. L-menthol has a particular mint aroma and has a cooling effect. Racemic – menthol also has a cooling impact, while various other isomers have no cooling impact. L-menthol make up a large proportion of applications in medication and wellness. It can be made use of as poultice, ointment, analgesic, anesthetic, cooling agent, antipruritic representative, mouthwash, bactericide, and for the therapy of tooth pain, Tablets for stomach discomfort, neuralgia, etc; the 2nd largest usage is seasonings. L-menthol is one of the most required flavor amongst cyclic monoterpene alcohols. It can be utilized as cigarette flavoring, used with peppermint oil to prepare tooth paste tastes, and various other spices. Prepare toilet water; menthol can also be utilized as a flavor agent for a variety of foods, such as candies, chewing periodontal, cakes, fruit red wine, rejuvenating beverages, etc.

L-Menthol Property

Melting point 

41-45 °C (lit.)

Boiling point 

212 °C (lit.)


-51 º (589nm, c=10, EtOH)


0.89 g/mL at 25 °C (lit.)

vapor pressure 

0.8 mm Hg ( 20 °C)

refractive index 



200 °F

storage temp. 

Store below +30°C.




Crystals or Crystalline Needles



Specific Gravity



Colorless to white


at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty

Odor Type


optical activity

[α]22/D 49°, c = 10 in 95% ethanol

Water Solubility 



L-Menthol Uses

  1. Menthol is an edible flavor that is allowed to be made use of in my country and is primarily utilized for flavoring tooth paste, candies, and drinks. The dosage is based upon typical manufacturing requirements, generally 1100mg/kg in eating gum tissue; 400mg/kg in sweets; 130mg/kg in baked goods; 68mg/kg in ice cream; and 35mg/kg in sodas.
  2. Both L-Menthol and racemic menthol can be used as flavoring agents in toothpastes, fragrances, drinks, candies, and so on. It is utilized as a stimulant in medication, acting upon the skin or mucous membrane layers, and has a cooling and antipruritic effect; when taken orally, it can be made use of as a carminative for migraines and inflammation of the nose, throat, and larynx. Its esters are made use of in seasonings and medicines. Worldwide, my nation and Brazil are the main all-natural mint producers, with the yearly result of peppermint oil getting to 2000-3000t.

Types of L-Menthol

Artificial menthol is normally separated right into 3 types:
( 1) Prepare racemic menthol and after that divided it. The German Dezhixin Company utilizes this technique to generate it, and it is currently the menthol synthesis technique with the largest result worldwide;

( 2) Make use of uneven synthesis technology to obtain chiral sources. Japan’s Takasago Company uses this approach to generate, and its outcome is likewise substantial;

( 3) Make use of natural chiral precursors to obtain L-menthol with simple change, such as straight hydrogenation of all-natural L-menthol to acquire L-menthol. Nevertheless, because of constraints in basic material supply, the scale and result of manufacturers are little.

The global production status of levo-menthol in 2007 is shown in Table 1. The raw materials for synthetic menthol in various other regions come from all-natural items, such as natural levo-menthol. The natural peppermint oils in Brazil, Taiwan, and Japan mainly originate from India and landmass China.

L-Menthol Synthesis

The route of Germany’s Dezhixin Firm is received Plan 4, which is currently the world’s biggest menthol synthesis method. The advantage of this path is that the synthesis steps are reasonably simple, however the disadvantage is that the splitting up and recuperation process is difficult. First, m-cresol and propylene are utilized in Lewis Thymol 9 was acquired in 63% return under acid catalysis [16], and afterwards the benzene ring was hydrogenated under the catalysis of a nickel/iron/chromium/ aluminum alloy to acquire various stereoisomer mixes of menthol 6. This action The return is 99.5%, which has 60.3% of the mixture of L-Menthol (1R, 3R, 4S)-6 and d-menthol (1ST, SIX, 4R)-6, and 39.2% of other stereoisomers. (1R, Mixtures of 3R,4 S)-6 and (1ST,3 S,4 R)-6 and various other stereoisomers can be divided by distillation. (1R,3 R,4 S)-6 and (1S,3 S,4 R)-6 After esterification with benzoic acid, (1R,3 R,4 S)-10 and (1S,3 S,4 R)-10 were acquired specifically, and afterwards optically pure menthyl benzoate was utilized for seeding and crystallization, and after that the high-purity (1R, 3R,4 S)-10 and (1ST,3 S,4 R)-10. Finally, the separated esters are just hydrolyzed to obtain high-purity L-menthol and D-menthol. Except for the product L-menthol, all other After recouping the configured menthol, it can be catalytically dehydrogenated once more to acquire thymol 9, and after that hydrogenated and separated. The total return of this route can surpass 90%. For the splitting up action, Dezhixin Business in 2002 Lipase splitting up modern technology was created. As an example, using lipase drawn out from Yeast for splitting up, the acquired L-Menthol ee value can be virtually 100%, however the cost is too high and has not been industrialized.

About Products:
If you need L-Menthol, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced L-Menthol manufacturer and supplier, ZSpharmac will provide L-Menthol raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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