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L-Leucine Powder CAS 61-90-5

Molecular Formula: 61-90-5

Formula Weight: 131.17

ZSpharmac: L-Leucine Powder Supplier

Product Name: L-Leucine Powder
CAS No: 61-90-5
Purity: 99%

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Basic Info

Product Name:L-Leucine Powder
Other Names:L-Leucine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:200-522-0
Provide:L-Leucine Powder MSDS;
L-Leucine Powder COA

What is L-Leucine Powder?

L-leucine (L-leucine), additionally called leucine, is α-amino-γ-methylpentanoic acid, α-aminoisocaproic acid, as well as likewise its molecular formula is C6H13O2N. Proust was first separated from cheese in 1819, as well as additionally later Braconnot was taken shape from the acid hydrolyzate of muscular tissue in addition to woollen, and also called leucine.

L-Leucine Powder Property

Melting point 

>300 °C (lit.)


15.4 º (c=4, 6N HCl)

Boiling point 

122-134 °C(Press: 2-3 Torr)


1,293 g/cm3

vapor pressure 

<1 hPa (20 °C)

refractive index 

1.4630 (estimate)



storage temp. 



1 M HCl: 50 mg/mL




2.328(at 25℃)


White to Off-white


at 100.00?%. odorless


5.5-6.5 (20g/l, H2O, 20℃)

optical activity

[α]20/D +15.5°, c = 2 in 6 M HCl

Water Solubility 

22.4 g/L (20 C)


L-Leucine Powder Uses

L-Leucine Powder is used in nutritional supplements; flavoring and also seasoning agents. Prep work of amino acid mixture and also extensive amino acid preparations, hypoglycemic agents and also plant development marketers. According to my nation’s GB2760-96 guidelines, it can be utilized as a flavor. It is used in biochemical study as well as in medicine for the therapy and diagnosis of idiopathic hyperglycemia in young children, as well as for the treatment of anemia, poisoning, muscular degeneration, sequelae of poliomyelitis, neuritis and mental disorder. amino acid medications. It is made use of as amino acid infusion as well as comprehensive amino acid prep work. It is utilized for the diagnosis and treatment of idiopathic hyperglycemia in youngsters, in addition to problems of glucose metabolic rate, liver condition with reduced bile secretion, anemia, poisoning, muscular degeneration, sequelae of poliomyelitis, neuritis = and mental disorder, and so on. Diabetes, cerebrovascular sclerosis as well as kidney disease people with proteinuria as well as hematuria need to not be utilized. Patients with stomach and duodenal abscess ought to not take it. It is an essential amino acid, and also the adult guy requires 2.2 g/d, which is necessary for the normal growth of babies and also the upkeep of typical nitrogen equilibrium for adults. This product is made use of as a dietary supplement to prepare amino acid infusion as well as thorough amino acid prep work, hypoglycemic agents, and plant development marketers. According to the stipulations of my nation’s GB2760-86, this item can be made use of as a seasoning. It is made use of as a medical resources as well as a food additive biochemical reagent. It is a crucial amino acid for the human body. It is mostly made use of as a dietary supplement and has the effects of decreasing blood sugar as well as advertising development.

Function of L-Leucine Powder

L-Leucine Powder can generate pancreatic insulin secretion with its metabolite KIC, and also this insulin release is hindered by various other two BCAAs as well as two comparable branched amino acids (norvaline as well as norleucine). 10 mM is roughly 73% as potent as glucose. In general, leucine acts additively or synergistically with sugar in inducing insulin secretion (eg, leucine as well as glucose rise by 170% and 240%, specifically, as well as much as 450% with the combination). Although leucine and yohimbine are equally powerful, they are not additive as a result of their overlapping mechanisms.

This anabolic result of L-Leucine Powder appears to favor skeletal muscular tissue over hepatic (liver) cells, as well as seems enhanced by workout (contraction), with some research studies showing that preloading leucine to exercise is more effective (greatly increased protein synthesis) than at other times.

L-Leucine Powder seems the most effective of all amino acids at promoting muscle healthy protein synthesis.

Preparation of L-Leucine Powder

A method for producing L-Leucine Powder by fermentation

(1) Activation culture: Inoculate the L-Leucine Powder producing bacteria (i.e., Corynebacterium glutamicum ACCC16522, purchased from Shanghai Fuxiang Biotechnology Co., Ltd.) on the activation medium, and activate the culture in an incubator at 32°C for 12 hours to obtain the activated bacteria.

Activation medium: anhydrous glucose 1g/L, peptone 10g/L, beef extract 10g/L, yeast extract 5g/L, NaCl 2.5g/L, agar powder 20g/L, pH=7.0-7.2.

(2) Seed cultivation: Take a ring of well-growing activated bacteria and inoculate them into a shaker flask containing a seed medium for seed cultivation. The liquid volume is 200mL/500mL. The conditions for seed cultivation are 32°C and 150r/min shaker culture for 20h. The concentration of bacteria in the fermentation broth is measured with a spectrophotometer. If the OD620 value of the bacteria reaches 1.2, it can be used as a qualified seed solution to obtain a seed solution.

Seed medium: anhydrous glucose 20g/L, corn steep liquor powder 25g/L, ammonium sulfate 2g/L, KH2PO4·3H2O 1.5g/L, vitamin B1 300μg/L, biotin 200μg/L, pH=7.0-7.2.

(3) Fermentation culture: according to the inoculum amount of 10%, take the seed liquid obtained in step (2), inoculate it into a 10L fermenter containing fermentation medium, the liquid volume is 6L/10L, the culture temperature is 30°C-35°C, the stirring speed is 600rpm/min, and the feeding medium is added during the cultivation process. The ventilation rate in the first 12h is 80-100L/h, and the ventilation volume after 12h is 100-120L/h. Add ammonia through automatic flow Water controls pH=6.6±0.05 during the fermentation process, cultures for 30-32 hours, and obtains a fermentation liquid. The end time of fermentation was judged by the fact that acid production no longer increased. Before and after fermentation culture, the content of L-leucine is measured by high performance liquid chromatography; the content of residual sugar in the fermentation liquid is detected by a biosensing analyzer.

Fermentation medium: sodium malate 2.0-4.0g/L, anhydrous glucose 140-160g/L, corn steep liquor dry powder 35g/L, ammonium sulfate 20g/L, KH2PO4 3H2O 1.0g/L, MgSO4 7H2O 0.4g/L, MnSO4 H2O 0.1g/L, vitamin B1 300μg/L, biotin 50μg/L, CaCO3 30g/L, defoamer 0.5%, pH=7.0-7.2.

Feed medium: sodium malate 1.0g/L, inositol 1.0-2.0g/L, corn steep liquor dry powder 12g/L, ammonium sulfate 25g/L, KH2PO4·3H2O 2.0g/L, MgSO4·7H2O 0.6g/L, MnSO4·H2O 0.3g/L, vitamin B1 400μg/L, biotin 60μg/L, CaCO3 20g/L, defoamer 1.0%, pH=7.0-7.2.

(4) Extraction of L-Leucine Powder: take the fermentation broth after fermentation, centrifuge at 8000r/min for 10min, collect the supernatant, extract and purify the supernatant through an ion exchange column, load the sample at a flow rate of 0.5BV/h, and the loading volume is 260mL of fermentation broth. Calculate the yield of L-leucine in the effluent.

About Products:
If you need L-Leucine Powder as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced L-Leucine Powder manufacturer and supplier, ZSpharmac will provide L-Leucine Powder raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get L-Leucine Powder Quotation