L-FUCOSE CAS 2438-80-4

Molecular Formula: C6H12O5

Formula Weight: 164.16

ZSpharmac: L-FUCOSE Supplement

Product Name: L-FUCOSE

CAS No: 2438-80-4

Purity: 99%

Basic Info

Product Name:	L-FUCOSE
Other Names:	L-(-)-Fucose
CAS:	2438-80-4
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Pharmaceutical Intermediates
Appearance:	Beige to Light Brown to Purple-Grayish Powder
EINECS No.:	219-452-7
Storage:	Inert Atmosphere,Store in Freezer, Under -20°C
Provide:	L-FUCOSE MSDS； L-FUCOSE COA

What is L-FUCOSE?

L-FUCOSE is an example of a so-called rare monosaccharide. Fucose is found in a wide variety of natural products from many different sources, in both D and L forms. L-fucose is present in several human milk oligosaccharides, in sea urchin eggs and frog eggs, and in sources such as seaweed (as fucoidan, a sulfated fucose polymer), In the polysaccharides of tragacanth, potato, kiwi, soybean, wing bean varieties, canola and other plants.
In plant matter, fucose is often associated with plant polysaccharides, which tend to be highly branched structures with L-fucopyranosyl units at the ends of or within the polysaccharide chain. Both the N-glycosyl chain and the O-glycosyl chain of a human or animal glycoprotein can contain L-fucose attached to the end of the carbohydrate chain. In addition, exopolysaccharides from various bacteria, fungi and microalgae also contain L-fucose.
L-fucose has recently received increasing attention due to its potential in the medical field for the treatment of various disease conditions, such as tumors, inflammatory conditions and disorders related to the human immune system. L-fucose also has various uses in the cosmetic field, for example as a skin moisturizer, skin rejuvenator and anti-aging agent, or for the prevention of epidermal (skin) inflammation.

L-FUCOSE Properties:

Melting point	150-153 °C(lit.)
alpha	-73～-77°(D/20℃)(c=4,H2O,24hr)
Boiling point	211.61°C (rough estimate)
density	1.1738 (rough estimate)
refractive index	-75.5 ° (C=10, H2O)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	H₂O: 0.1 g/mL, clear, colorless
pka	12.50±0.20(Predicted)
form	Powder
color	Beige to light brown to purple-grayish
Water Solubility	Soluble in water.

L-FUCOSE Uses

L-fucose also has various uses in the cosmetic field, for example as a skin moisturizer, skin rejuvenator and anti-aging agent, or for the prevention of epidermal (skin) inflammation.
A type of six-carbon sugar. And can be seen as a methyl pentose. The vast majority of fucose existing in nature is L-fucose, and fucose with D configuration is only a rare sugar and is found in some glycosides. L-fucose is present in large quantities in algae and also gums, and is additionally located in the polysaccharides of specific germs. As an element of sugar chains in glycoproteins, Fucose in certain blood group molecules is a pen of a particular blood group.
L-fucose controls the activation of intestinal Treg cells by managing the immune feedback of DC cells, and also regulates the production of bile acids in the digestive tract plants. At the same time, L-fucose can prevent digestive muscle contraction and convulsion by controling nNOS. L-fucose can integrate with viruses, bacteria and contaminants to stop them from infecting cells, thus improving the body’s resistance. In the research and development of new anti-cancer targeted drugs, the CarboConnect technology is currently used in antibody-drug conjugates (ADCs) and extracellular drug conjugates (EDCs), which are currently active in international research and have made major breakthroughs. Antibodies and drugs are linked together with L-fucose amino group for different drug activity screening. L-fucose is just one of the 8 essential sugars in the human body and among the oligosaccharides in human bust milk (human bust milk also includes sialic acid, N-acetylglucosamine, D-glucose and also D-galactose, etc), which is an excellent nutritional supplements and dietary supplements and immune-enhancing variables for child food.

L-fucose Application

CN201710025866.1 provides the application of L-fucose in medicines and health products for treating digestive tract lesions.

L-Fucose (L-Fucose, chemical formula C6H12O5) is a deoxyhexose sugar. It is commonly found in N-linked glycans on the surface of mammalian, insect and plant cells and O-linked glycans in mammalian intestinal mucus and epithelium, and is the basic subunit of fucoglycan polysaccharides. L-fucose can be released from fucose-containing polymers by enzymes called alpha-fucosidases.

As an important component of intestinal epithelium and mucus glycosylation, L-fucose has been reported by many high-quality studies on its regulation of intestinal flora and immunity. For example, L-fucose has now been found Sylation can reduce the binding of antibodies to natural killer cell Fc receptors, thereby reducing antigen-dependent cytotoxicity, thereby affecting the body’s cell killing ability by regulating the core fucosylase (FUT8). Regrettably, although there is a lot of evidence that fucose affects gastrointestinal lesions in the laboratory, its clinical role in the treatment of gastrointestinal lesions has not been reported except as a disease observation index.

L-fucose is used in the treatment of digestive tract lesions. First, the experimental group confirmed that L-fucose can obtain significant long-term prognostic benefits through animal models of intestinal lesions. Secondly, in terms of immune regulation, L-fucose can regulate the activation of Treg cells in mesenteric lymph nodes through DC cells, and inhibit the potential of colon Th1 and Th17 differentiation. Finally, it is clear that L-fucose inhibits intestinal muscle contraction and spasm through the nNOS pathway, which can ultimately alleviate the symptoms of abdominal pain and diarrhea.

Fucosyllactose Gets EU New Food Status

Recently, 2′-FL (fucosyllactose) produced by the German company BASF has obtained EU Novel Food status, and the company is currently working to enter other important market areas with the help of regulations. .
Breast milk is the gold standard for infant nutrition. Compared to infant formula, breastfeeding is associated with better growth patterns, immune function, cognitive development, and long-term health benefits. For mothers who cannot breastfeed, the addition of 2′-FL to infant formula is an important step in bridging the functional gap between formula and breast milk.

The composition of HMOs (human milk oligosaccharides) featured prominently in the news in the first half of 2018. FrieslandCampina’s HMO ingredients are certified for use in infant formula in both the European and US markets. DuPont’s CARE4U HMO has also received GRAS certification from the US FDA for use in infant formula. The companies also received regulatory approvals for the European market.

Research has shown that 2′-fucosyllactose supports healthy gut microbial composition and immune system development, protects against allergic disease, and plays an important role in normal brain function and cognitive development in humans. Based on its ability to deal with mucosal inflammation, 2′-FL is also a promising ingredient in the field of digestive health.

François Scheffler, Senior Vice President at BASF, said that HMOs are a breakthrough in the nutritional improvement of infant formula, and 2′-fucosyllactose will provide children with new options – improving health from infancy and beyond.

Scheffler revealed that the 2′-FL is the first product in BASF’s line of HMOs. Development work and collaboration have begun to show potential for new scientific applications in HMO functionality. It is understood that the new research aims to promote the company’s nutritional field to be at the forefront of science. The development of this new product is only the first step in the HMO infant nutrition portfolio, and it will also enter the field of dietary supplements in the near future.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.