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L-Fucose CAS 2438-80-4

Molecular Formula: C6H12O5

Formula Weight: 164.16

ZSpharmac: L-Fucose Supplier

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Product Name: L-Fucose
CAS No: 2438-80-4
Purity: 99%

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Basic Info

Product Name:L-Fucose
Other Names:L-(-)-Fucose
CAS:2438-80-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Beige to Light Brown to Purple-Grayish Powder
EINECS No.:219-452-7
Storage:Inert Atmosphere,Store in Freezer, Under -20°C
Provide:L-Fucose MSDS;
L-Fucose COA

What is L-Fucose?

L-Fucose is a natural sugar, usually derived from brown algae and human breast milk, and also exists in some human organs, such as skin and nervous system. Fucose in nature is often in the L configuration, and exists in seaweed in the form of polysaccharides such as fucoidan and fucoidan. D-configuration fucose is only found as a rare sugar in some glycosides.

As an important basic sugar, L-fucose is essential to human development and health, and its physiological effects include: nerve conduction and immune regulation.

An article published in Nature (Nature , 01 October 2014; doi: 10.1038 / nature 13823) confirmed that L-Fucose metabolically affects gut bacteria. To protect gut bacteria during illness, L-fucose was produced in the gut of sick mice as food for the microbiota and to maintain a healthy microbial balance. This protective mechanism also appears to help fight off other harmful pathogens, and its disruption may play a role in human diseases such as Crohn’s disease.

L-Fucose Property

Melting point 150-153 °C(lit.)
Boiling point 211.61°C (rough estimate)
alpha -73~-77°(D/20℃)(c=4,H2O,24hr)
density 1.1738 (rough estimate)
refractive index -75.5 ° (C=10, H2O)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility H2O: 0.1 g/mL, clear, colorless
form Powder
pka12.50±0.20(Predicted)
color Beige to light brown to purple-grayish
Water Solubility Soluble in water.

 

L-Fucose Uses

Biochemical research study
For the research study of glycan polysaccharides having glycans;
Research of L-fucose as a glycan-modified carbohydrate that creates antigenic sites acknowledged by IgE antibodies;
Use as a substrate to identify, set apart and also identify enzymes such as fucosidase, 1-fucose isomerase and also L-fucose dehydrogenase;
Can be made use of to study organelles, bacterial microchambers, and also join the degradation of plant and algal cell wall surface sugars;
Can be made use of as a recommendation compound in the identification as well as evaluation of unusual sugars.

Drug R&D
L-fucose can integrate with infections, germs, and also toxins to avoid them from contaminating cells, consequently improving the body’s resistance. Avoid and also fight against the growth and also metastasis of cancer cells, stop and treat breathing infections;
Antibody-drug conjugates (ADCs) and also extracellular medicine conjugates (EDCs), which are presently active in the study of new anti-cancer targeted drugs on the planet and also have actually made significant advancements, use L-fucose and also amino teams to combine antibodies as well as Drugs are combined for different medicine activity screening;
It works in the treatment of kind II leukocyte adhesion deficiency disorder (BOY II). Signs of boy II include immunodeficiency as well as neutropenia, mental retardation, dyskinesia, and also substantially hampered development because of the absence of selectin bonds.

Cosmetic
Using a lotion consisting of 1% L-fucose on the skin of mice for four consecutive weeks can enhance the density of collagen fibers in the skin of mice, enhance the thickness of the skin, dermis as well as overall skin density, increase the manufacturing of skin cells, and also reduce wrinkles, boost flexibility, hold-up aging;
It can stimulate the expansion of fibroblasts and stop the damages caused by salt ascorbate to fibroblasts;
Reduce the task of proteolytic enzymes MMP-2 as well as MMP-9 in the skin, thus reducing skin damage.

Food wellness
It is among the eight important sugars in the human body and one of the oligosaccharides in human bust milk. It is a suitable dietary supplement and immune improvement element for dietary supplements and also baby food. It can eliminate the symptoms of anorexia, looseness of the bowels, and also lowered nutrient absorption effectiveness after weaning, as well as aid discouraging babies go through the discouraging adaptation period in a healthy way;
As a low-calorie and also low-sweetness sugar to change sucrose, it is applied to drinks as well as dairy products that need to minimize sugar as well as sweetness while enhancing nourishment;
Including it to foods with high fat content such as ice cream and also cheese can reduce the threat of cholesterol increase brought on by metabolizing fat;
Including an appropriate amount of L-fucose to fermented milk as well as lactic acid beverages can completely put in the biological features of beneficial germs;
Adding L-fucose to soy items can grant soy products with functions such as readjusting the equilibrium of intestinal plants as well as boosting the content of immune elements, which will certainly drive item upgrades;
Included organic food, it can minimize the material of triglyceride and also cholesterol in product, boost the immunity of unique populations, and also enhance rest, lack of nutrition, loss of appetite as well as other signs.

Application of L-Fucose

CN201710025866.1 provides an application of L-fucose in medications and also health and wellness items for the treatment of stomach lesions.

L-fucose (L-Fucose, chemical formula C6H12O5) is a deoxyhexose. It is frequently found in N-linked glycans on the surface of animal, insect and also plant cells and O-linked glycans in mammalian digestive tract mucus and epithelium, as well as is the fundamental subunit of fucoidan polysaccharides. L-fucose can be released from fucose-containing polymers by an enzyme called α-fucosidase.

As an integral part of intestinal epithelial and mucus glycosylation, L-fucose has been reported by numerous top quality research studies on its regulation of digestive tract vegetation as well as immunity. For instance, it has been found that L-fucose Kylation can lower the binding of antibodies to all-natural awesome cell Fc receptors, consequently decreasing antigen-dependent cytotoxicity, and therefore can influence the body’s cell murder capacity by regulating the core fucosylation enzyme (FUT8). Sadly, although a big quantity of evidence related to fucose affecting intestinal sores has arised busy, its medical role in the treatment of stomach sores has not been reported except as a condition observation index.

L-fucose is made use of in the treatment of intestinal sores. First of all, the speculative group clarified that L-fucose can get considerable lasting prognostic advantages through animal models of intestinal tract sores. Secondly, in regards to immune law, L-fucose can manage the activation of Treg cells in mesenteric lymph nodes via DC cells, as well as inhibit the distinction capacity of colon Th1 and also Th17. On the other hand, L-fucose might prevent the manufacturing of bile acids as well as lower swelling through the law of digestive plants. Finally, it was clarified that L-fucose can prevent intestinal muscle contraction as well as spasm with the nNOS pathway, which can lastly ease the symptoms of abdominal pain and also diarrhea.

In summary, L-fucose controls the activation of digestive tract Treg cells by controling the body’s DC cell immune reaction, and also controls the bile acid manufacturing of intestinal tract vegetation. At the same time, L-fucose can hinder digestive muscle contraction and also convulsion by regulating nNOS.

Preparation of L-fucose

Di-O-isopropylidene-L-fucose (780 mg, 3.20 mmol) was put on hold in water (6.0 mL), then Amberlite IR120(H+) (ca. 1 mL) was included. The response mix was mixed at 60 ° C for 2 hrs. The material was filtered off and also the water was allowed to evaporate. The deposit was liquified in hot EtOH (2.0 mL), the remedy was enabled to cool down to room temperature, and some seeds were added. The option was stirred at 4 ° C for thirty minutes. The created crystals were filtered off and cleaned with cool EtOH to offer 410 mg (2.50 mmol, 78%) of colorless crystals.

About Products:
If you need L-fucose as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company as an experienced L-fucose manufacturer and supplier, ZSpharmac Will provide L-fucose raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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