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L-Cystine CAS 56-89-3

Molecular Formula: C6H12N2O4S2

Formula Weight: 240.3

ZSpharmac: L-Cystine Supplier

Product Name: L-Cystine
CAS No: 56-89-3
Purity: 99%

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Basic Info

Product Name:L-Cystine
Other Names:L-Cystine, 99%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder/Solid
EINECS No.:200-296-3
Provide:L-Cystine MSDS;
L-Cystine COA

What is L-Cystine?

L-cystine, English name is L-Cystine, it is a white strong powder at normal temperature and also pressure, soluble in water, however insoluble in ethanol as well as various other natural solvents, conveniently soluble in thin down acid and also alkaline service, in warm alkali Easy to decay in fluid. L-cystine was uncovered in 1810 by Wollaston from bladder stones.

L-Cystine Property

Melting point >240 °C (dec.) (lit.)
alpha -224 º(c=2 in 1M HCl)
Boiling point 468.2±45.0 °C(Predicted)
density 1.68
refractive index -222.5 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 1 M HCl: 100 mg/mL
form Powder/Solid
pka1.0, 2.1, 8.02, 8.71(at 25℃)
color White
optical activity[α]20/D 219±5°, c = 1% in 1 M HCl
Water Solubility 0.112 g/L (25 ºC)


L-Cystine Uses

1. L-Cystine is utilized in biochemical study. Prepare biological media. It is used in biochemical and dietary research, and also in medication, it can promote the oxidation and also decrease feature of body cells, boost white blood cells and also protect against the growth of pathogenic germs. Mainly utilized for numerous alopecia. It is also utilized for dysentery, typhoid high temperature, influenza and other severe infectious diseases, asthma, neuralgia, eczema and numerous poisoning diseases, and so on, and also has the result of preserving protein arrangement. Likewise used as a food flavor representative.
2. Biochemical reagent, L-Cystine is used in the prep work of biological medium. It is also a vital part of amino acid infusion and also substance amino acid preparations
3. L-Cystine is made use of as feed nourishment booster, which is beneficial to animal growth, raising body weight, liver and kidney function, and boosting hair top quality.
4. L-Cystine can be used as an aesthetic additive, which can promote injury recovery, avoid skin allergies and also deal with dermatitis.

Uses of L-Cystine in Medicine

L-cystine is one of the essential amino acids for the human body. It is of great value in medicine, as a nutritional enhancer, and in the food industry. Except that it can be prepared by chemical synthesis, it is mainly extracted from hair at present. There is no adverse effect on the human body. Uses: Used in biochemical and nutritional research, in medicine, it can promote the oxidation and reduction function of body cells, increase white blood cells and prevent the development of pathogenic bacteria. Mainly used for various alopecia. It is also used for dysentery, typhoid fever, influenza and other acute infectious diseases, asthma, neuralgia, eczema and various poisoning diseases, etc., and has the effect of maintaining protein configuration. Also used as a food flavoring agent. L-cystine is an amino acid drug, which can promote the redox function of cells, make the liver function vigorous, neutralize toxins, promote white blood cell proliferation, and prevent the development of pathogenic bacteria; vitamin B1 combines with adenosine triphosphate to form vitamin B1 pyrophosphate (sulfur diphosphate) amine, cocarboxylase), is a coenzyme necessary for carbohydrate metabolism; vitamin B1 can inhibit the activity of cholinesterase, when lacking, the activity of cholinesterase is enhanced, the hydrolysis of acetylcholine is accelerated, and the nerve impulse conduction disorder is caused, which affects the gastrointestinal tract , myocardial function; calcium pantothenate is the precursor of coenzyme A, and it is an essential substance for various metabolic links (including carbohydrates, proteins and lipids). It can participate in the synthesis of steroids, porphyrins, acetylcholine and other substances, and can maintain normal blood circulation. Epithelial function.

Production Method of L-Cystine

Today, although the fermentation approach as well as chemical technique of amino acid production have actually created rapidly, as well as the production cost has dropped, the healthy protein hydrolysis technique for the manufacturing of amino acids has actually been substantially affected, however the manufacturing technique of some amino acids using healthy protein acid hydrolysis still can not be overlooked, such as cystine, cells Numerous amino acids such as amino acid, arginine, leucine, tyrosine, as well as serine are still mainly hydrolyzed. Since our nation is rich in natural protein resources, such as human hair, pig hair, waste silk, and so on are all good resources. Cystine is normally prepared from pig hair or human hair basic materials, acid hydrolysis, separation as well as purification (making use of isoelectric factor rainfall approach). Pig hair or human hair [HCl (hydrolysis)] → [110-117 ℃, 6.5-7h] hydrolyzate [30% -40% NaOH (neutralization)] → [get used to pH4.8, stand for 36h, filter] Crude L-cystine I.

Crude item I [HCl, 1% activated carbon (refined)] → [85 ° C, warm decolorization 0.5 h] filtrate [12% NH4OH (neutralization)] → [gotten used to pH3.5-4] L-cystine.

Hydrolysis In the hydrolysis tank (tank), put 10mol/L HCl1000kg, heat 70-80 ℃, then put in cleaned as well as dried out pig hair or human hair, which has to do with half the amount of hydrochloric acid (500kg), and also continue warming to 100 ℃ Currently, start to change the temperature level, make it rise to 110-117 ° C within 1-1.5 h, heat-preserve and also hydrolyze for 7h (calculated from 100 ° C), discharge and also filter, and also take the filtrate (hydrolyzate). The neutralization hydrolyzate is presented right into the neutralization container, gradually include 30% -40% NaOH remedy as well as maintain stirring, change the hydrolyzate to pH 4.8 and stop adding alkali. Continue to stir for 15 minutes, retest the pH to 4.8 to acquire a counteracting service, allow it represent 36 hrs, filter to gather the precipitate, and also centrifuge to completely dry to obtain crude L-cystine I.

Crude, counteracted, take about 200kg of L-cystine crude item I, include 120kg of 10mol/L HCl service, 480kg of water (800kg in overall), warmth to dissolve, and maintain stirring, when the temperature rises to 80 ° C, include the weight of the unrefined item remedy 2% triggered carbon (concerning 16kg) and also keep warm at 80-90 ° C for 0.5 h, filter to get rid of activated carbon, readjust the pH value of the gotten filtrate with 30% NaOH remedy, keep mixing to make it pH 4.8, as well as let it stand for formation, and afterwards precipitated the supernatant, the bottom precipitated crystals were dried out to obtain unrefined L-cystine II.

Refining and also neutralization Take 50kg of the unrefined product of L-cystine II above, add 250L of 1mol/L HCl service, mix and also warmth to liquify, when the temperature rises to 70 ° C, include activated carbon (3kg) with 1% weight of crude product II hydrochloric acid remedy to heat up Decolorize at 85 ° C for 0.5 h, filter to get rid of turned on carbon, and acquire a colorless and also transparent filtrate. After that include 1.5 times the weight of pure water, warm at 75-80 ° C, stir as well as counteract with 12% ammonia water to pH 3.5-4.0, suck out the mom alcohol above the formation while it is warm, filter the condensation at the bottom, as well as remove the chlorine-free ion with pure water, pump Dry as well as vacuum-dry to obtain L-cystine.

About Products:
If you need L-Cystine, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L-Cystine manufacturer and supplier, ZSpharmac will provide L-Cystine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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