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L-Cysteine Hydrochloride Monohydrate CAS 7048-04-6

Molecular Formula: C3H10ClNO3S

Formula Weight: 175.63

ZSpharmac: L-Cysteine Hydrochloride Monohydrate Supplier

Product Name: L-Cysteine Hydrochloride Monohydrate
CAS No: 7048-04-6
Purity: 99%

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Basic Info

Product Name:L-Cysteine Hydrochloride Monohydrate
Other Names:L-Cysteine.HCL.H2O
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Solid
EINECS No.:615-117-8
Storage:Keep in Dark Place,Inert Atmosphere,Room Temperature
Provide:L-Cysteine Hydrochloride Monohydrate MSDS;
L-Cysteine Hydrochloride Monohydrate COA

What is L-Cysteine Hydrochloride Monohydrate?

L-cysteine hydrochloride monohydrate is a white crystal or crystalline powder with a sour taste, soluble in water and ethanol; L-cysteine hydrochloride monohydrate is mainly used in the field of medicine: the prepared medicine Clinically, it can treat leukopenia and leukopenia caused by the administration of anticancer drugs and radiopharmaceuticals. It is an antidote for heavy metal poisoning. It is also used to treat toxic hepatitis, thrombocytopenia, skin ulcers, and prevent liver necrosis. It can treat bronchitis and reduce phlegm; in food, it can be used as a quick bread accelerator, which can change the flavor of bread and food; in cosmetics, it can be used in cosmetic hair perm essence, sunscreen, hair growth perfume and hair conditioner, etc.

L-Cysteine Hydrochloride Monohydrate Property

Melting point 175°C
alpha +6.0~+7.5゜ (20℃/D)(c=8,6mol/l HCl)(calculated on the dried basis)
density 1.54 g/cm3
vapor pressure <0.1 hPa (20 °C)
refractive index 6 ° (C=8, 1mol/L HCl)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: 1 M at 20 °C, clear, colorless
form Solid
color White
PH0.8-1.2 (100g/l, H2O, 20℃)
PH Range1 – 2
optical activity[α]20/D +5.6±0.3°, c = 5% in 5 M HCl
Water Solubility Soluble in cold water.


Applications of L-Cysteine Hydrochloride Monohydrate

The main application of L-cysteine hydrochloride monohydrate is:

1. Because it is soluble in water, it can be quickly absorbed by the human body after being made into injections or tablets, so it can be directly pharmaceutical, and it can treat leukopenia clinically, and white blood cells caused by the administration of anticancer drugs and radiopharmaceuticals It can also be used to treat toxic hepatitis, thrombocytopenia, skin ulcers, prevent liver necrosis, treat bronchitis and reduce phlegm, and detoxify acrylic acid and aromatic poisoning. The role of preventing radiation damage;

2. It is the main raw material for the production of carboxymethylcysteine and acetylcysteine;

3. It has the function of promoting fermentation and preventing oxidation. It can be used as a quick bread accelerator in food and can change the flavor of bread and food;

4. In terms of cosmetics, it can be used in cosmetics such as perm essence, sunscreen, hair growth perfume and hair conditioner;

5. It can be utilized as a dietary supplement, anti-oxidant, and also color-protecting representative. It can be made use of in all-natural fruit juices to stop vitamin C from oxidizing and blemishing.

Preparation of L-Cysteine Hydrochloride Monohydrate

Method 1: a method for producing L-cysteine hydrochloride monohydrate, the device is equipped with a ceramic reactor, a filter, an electrolytic cell, a concentration kettle, a vacuum dryer, a pulverizer, and a packing machine, and the L- Cystine, hydrochloric acid, activated carbon, and water are used as raw materials, and L-cysteine hydrochloride monohydrate is prepared through processes such as decolorization after acid addition, filtration, electrolysis, concentration, filtration, drying, crushing, and packaging. The technical solution is:

(1) Put L-cystine into the ceramic reaction kettle, add water five times the weight of L-cystine, start the agitator at a speed of 20 rpm, and dilute the L-cystine and water into a viscous Liquid, slowly add hydrochloric acid to the ceramic reactor, stop adding hydrochloric acid when the pH value in the ceramic reactor is adjusted to 1-1.2, stir and react for 2-2.2 hours, at this time, add catalyst activated carbon to the ceramic reactor, the quantity is L – 2-2.2% of the weight of cystine, while raising the temperature to 60° C. and stirring for 0.5-0.6 hours to carry out the decolorization reaction.

(2) Cool down to normal temperature, send the material in the ceramic reactor to the filter for filtration, and discharge and recover the solid impurities obtained after filtration, and send the liquid part to the electrolytic cell for electrolysis for 10-10.5 hours. After the electrolysis, the material is sent to the concentrated The kettle is concentrated to one-half of the original liquid volume, and the concentrated material is sent to a filter to filter out the liquid and discharged for recovery. The solid part is sent to a vacuum dryer for drying at a drying temperature of 70-75°C. The time is 3-3.5 hours, and the L-cysteine hydrochloride monohydrate solid is obtained after drying.

(3) Send the obtained L-cysteine hydrochloride monohydrate solid into a pulverizer to be pulverized into a uniform powder, and then send it into a packaging machine, and after the product powder is packaged, a finished product is obtained.

Method 2: a production method of L-cysteine hydrochloride monohydrate, which is characterized in that it consists of the following steps:

(1) Put the L-cystine into the ceramic reaction kettle, add an appropriate amount of water, start the agitator at a speed of 25 rpm, and dilute the L-cystine and water into a viscous liquid. At this time, add 9‑11 equivalent hydrochloric acid After being filtered through a precision filter, slowly add to the ceramic reactor, measure the pH value between 0.8-1.2, add catalyst activated carbon, the amount is 2% of the weight of L-cystine, and then send steam to start heating, when the temperature rises to Insulate and stir for 0.5 hours at 58°C-62°C.

(2) After the reaction, the materials in the ceramic reaction kettle are sent to the decolorization reaction kettle for decolorization. After decolorization, they are sent to the filter for filtration. The filtered filtrate is sent to the electrolytic cell for electrolysis for 9-11 hours. After the electrolysis, the materials are filtered with After filtering by machine, L-cysteine hydrochloride solution was obtained.

(3) Send the L-cysteine hydrochloride solution into a ceramic reactor for heating and concentration under reduced pressure, and send the concentrated and crystallized material into a centrifuge for solid-liquid separation to obtain a solid L-cysteine hydrochloride monohydrate.

(4) Send the obtained L-cysteine hydrochloride monohydrate solid into a vacuum dryer for drying at a drying temperature of 75°C-85°C and a drying time of 4-6 hours to obtain L-cysteine hydrochloride monohydrate The obtained L-cysteine hydrochloride monohydrate crystals are sieved, and then packaged to obtain the L-cysteine hydrochloride monohydrate finished product.

Preparation route of L-Cysteine Hydrochloride Monohydrate

Hydrolyze the hair with hydrochloric acid for 6-8 hours, distill the hydrochloric acid under reduced pressure, decolorize with activated carbon, filter, and neutralize the filtrate with ammonia water to obtain crude crystals of L-cystine, and then recrystallize with ammonia water to obtain L-cystine. Then L-cystine is used as raw material, and L-cysteine can be obtained by reduction. There are two methods.

1. Tin particle reduction method:
Dissolve L-cystine in dilute hydrochloric acid, add tin particles and heat up to reflux for reduction reaction for 2 hours, filter out the remaining tin particles in the reducing solution, dilute with water, then pass hydrogen sulfide to make it saturated; filter, and wash the filter residue with a small amount of water ; Combine the washing liquid and the filtrate, concentrate under reduced pressure, cool and crystallize, separate and dry to obtain L-cysteine hydrochloride.


2. Electrolytic reduction method
Add L-cystine and dilute hydrochloric acid to the electrolytic cell, stir to dissolve, and electrolyze at 50°C; let the electrolyte flow through hydrogen sulfide for several hours to make it saturated; filter, add activated carbon to the filtrate for decolorization, and decolorize the decolorized solution by concentrating under reduced pressure and cooling to crystallize , separation, and drying to obtain L-cysteine hydrochloride, 0.7t of cystine and 1t of hydrochloric acid are consumed per ton of product.

About Products:
If you need L-Cysteine Hydrochloride Monohydrate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L-Cysteine Hydrochloride Monohydrate manufacturer and supplier, ZSpharmac will provide L-Cysteine Hydrochloride Monohydrate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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