Zhishang Chemical

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Zhishang Chemical

L-Cysteine Hydrochloride CAS 52-89-1

Molecular Formula: C3H8ClNO2S

Formula Weight: 157.62

ZSpharmac: L-Cysteine Hydrochloride Supplier

Product Name: L-Cysteine Hydrochloride
CAS No: 52-89-1
Purity: 99%

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Basic Info

Product Name:L-Cysteine Hydrochloride
Other Names:L-Cysteinehydrochloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Brown Solid
EINECS No.:200-157-7
Storage:Inert Atmosphere,Room Temperature
Provide:L-Cysteine Hydrochloride MSDS;
L-Cysteine Hydrochloride COA

What is L-Cysteine Hydrochloride?

L-cysteine hydrochloride (L-CysteineHyolrochloride) is an important organic chemical intermediate, which has a wide range of uses in biochemistry, medicine, food, feed and cosmetics, and the demand at home and abroad is increasing year by year. It is produced when it is transformed into L-cysteine under the action of hydrochloric acid. It is a colorless crystal with a melting point of 175-179°C and decomposes when it reaches the melting point. It has certain hygroscopicity, slowly oxidizes in air, and is soluble in water. , ethanol, acetone, glacial acetic acid and ammonia water, etc., insoluble in organic solvents such as ether, benzene, carbon disulfide and chloroform. Methods for L-cysteine synthesis include electrolytic reduction, chemical synthesis, and enzymatic methods. Among them, the chemical synthesis method has been adopted because of its high conversion rate.

L-Cysteine Hydrochloride Property

Melting point 180°C
alpha 5.5 º (c=8, 6 N HCL)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 1 M at 20 °C, clear, colorless
form Solid
color White to light brown
optical activity[α]20/D +6.4±0.3°, c = 5% in 5 M HCl
Water Solubility SOLUBLE


Application of L-Cysteine Hydrochloride

Preparation of L-Cysteine Hydrochloride

Add 3.1g of L-cystine and 80mL of hydrochloric acid solution into a 250mL three-necked flask equipped with a thermometer and a reflux condenser, heat and dissolve in a water bath with magnetic stirring, and when the temperature rises to the reaction temperature, add 2.0g of reduced iron powder , continue the reflux reaction, the reaction is over, remove the unreacted iron powder by suction filtration, measure the volume of the filtrate, and measure the absorbance of L-cysteine hydrochloride in the solution by the o-phenanthroline-Fe3+ method, calculate the solution according to the standard curve equation Calculate the amount of L-cysteine hydrochloride, and calculate the yield of the reaction. The reaction time is 4h, the HCl concentration is 4mol/L, and the reaction temperature is 80°C, the product yield is as high as 99.51%.

The Production Method of L-Cysteine Hydrochloride

Method 1. Hydrolysis-electrolysis
Pig hair and hair are used as raw materials to separate cystine through hydrolysis and adjust the isoelectric point of cystine, and then electrolytically reduce cystine to obtain cysteine.
Cystine is hydrolyzed
Pig hair, hair [HCl, 117°C, 7h] → [acid hydrolysis] hydrolyzate [NaOH, pH4.8] → [neutralization] L-cystine (crude product) electrolytic reduction in two separate pools, one Pour 1mol/L HCl into the pool, insert the ink stick, connect the positive pole of the power supply, this pool is the anode, and fill the other pool with hydrochloric acid solution of cystine (cystine:concentrated HCl:water=1:1:4), Insert the lead plate and connect to the negative pole of the power supply, this pool is the cathode. Add a salt bridge connection between the two pools. Turn on the power supply and adjust the current to 5A to carry out electrolysis, and the electrolysis is completed in about 6-7 hours.
Take a little electrolyte solution and add pyridine dropwise, no turbidity indicates that the electrolysis is complete. L-cystine [HCl] → [electrolytic reduction] L-cysteine ​​hydrochloride [decolorization, concentration, crystallization] → L-cysteine ​​hydrochloride crystal decolorization, concentration, crystallization After completion of electrolysis, cut off Power supply, add 10g/L (1%) activated carbon according to the feeding amount, heat to 70°C, and keep warm for half an hour. Filter to get the filtrate. Concentrate under reduced pressure until there are crystals, stir to completely precipitate the crystals, collect the crystals by filtration, wash with 95% ethanol, and dry in vacuum below 60°C to obtain L-cysteine ​​hydrochloride without crystal water.
Method two, enzymatic method
DL-2-aminodihydrothiazoline-4-carboxylic acid (DL-ATC) enzymatic hydrolysis method

About Products:
If you need L-Cysteine Hydrochloride as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L-Cysteine Hydrochloride manufacturer and supplier, ZSpharmac will provide L-Cysteine Hydrochloride raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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