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L-Alanyl-L-Glutamine CAS 39537-23-0

Molecular Formula: C8H15N3O4

Formula Weight: 217.22

ZSpharmac: L-Alanyl-L-Glutamine Cosmetic Raw Material Supplier

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Product Name: L-Alanyl-L-Glutamine
CAS No: 39537-23-0
Purity: 99%

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Basic Info

Product Name:L-Alanyl-L-Glutamine
Other Names:ALA-GLN
CAS:39537-23-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White  Liquid
EINECS No.:475-290-9
Storage:2-8°C
Provide:L-Alanyl-L-Glutamine MSDS;
L-Alanyl-L-Glutamine COA

What is L-Alanyl-L-Glutamine?

L-Alanyl-L-Glutamine, referred to as Ala-Gln, is a 20% intravenous service created and produced by Fresenius AG in Germany. It was signed up and provided in Germany in April 1995 under the brand name Dipeptamin was registered and launched in China in 1999 with the brand name of 20% Dipeptamin. G-glutamine is medically made use of as a glutamine contributor for parenteral nutrition. Like typical saline and glucose, it is a requirement for rescuing clients, and its market possibility is unlimited.

L-Alanyl-L-Glutamine Property

Melting point 

215 °C

Boiling point 

615℃

density 

1.305±0.06 g/cm3(Predicted)

vapor pressure 

0-1000Pa at 20-313.7℃

RTECS 

MA2275262

refractive index 

10 ° (C=5, H2O)

Fp 

>110°(230°F)

storage temp. 

2-8°C

solubility 

Water (Sparingly)

form 

solution

pka

3.12±0.10(Predicted)

color 

White

PH

pH(50g/l, 25℃) : 5.0~6.0

Odor

mild savory

Water Solubility 

Soluble in water.

L-Alanyl-L-Glutamine Uses

Cell power source: L-Alanyl-L-Glutamine is the primary metabolic substratum of monocytes and macrophages, supplying energy for cell metabolic process via the glutamine glycolysis pathway. Offers purine for cell synthesis of DNA and mRNA, and is the precursor of pyrimidine and nucleotide biosynthesis. Provides glucosamine, a nitrogen forerunner for GTP and NAD synthesis.

Important nitrogen resource for cells: It is the precursor substance for the synthesis of amino acids, proteins, and nucleic acids.

Enhance intestinal nutrition: L-Alanyl-L-Glutamine can efficiently prevent digestive mucosal degeneration, preserve typical digestive tract mucosal weight, framework and protein web content, boost intestinal tract cell activity, boost intestinal tract immune feature, minimize digestive germs and Translocation of endotoxin.

Enhance immunity: L-Alanyl-L-Glutamine provides energy for immune cells such as lymphocytes and macrophages in the intestinal-associated lymphoid tissue to make certain the proliferation of immune cells; by enhancing the standing of Paneth cells and cup cells, it remedies the condition of the whole intestinal tract. Abnormal degrees of Th2 cytokines caused by outside nourishment improve the ability to withstand microbial invasion, consequently improving intestinal tract non-specific immunity.

Antioxidant result: It is a precursor material for glutathione synthesis. By raising glutathione synthesis, inhibiting the activity of the nuclear transcription factor kappa B (NF-κB) pathway, reducing the degrees of interleukin-8 (IL-8) and lump necrosis factor-α (TNF-α), and minimizing the inflammatory response.

Preparation of L-Alanyl-L-Glutamine

A prep work technique of L-Alanyl-L-Glutamine. The steps of the preparation technique are as adhere to:

1) Prep work of chloro-Boc-alanine: Include 18.9 g of Boc-alanine into the reaction container, then add 17.9 g of sulfoxide chloride, and afterwards consist of 0.7 g of N,N-dimethylformamide, mix at 75-85 ° C for 5 hours, after that awesome to 40-50 ° C, regulate the temperature level at 45-55 ° C and concentrate under reduced tension till there is no extract, and the oil obtained is used directly for the following action of the response;

2) Prep Work of Boc-alanylsuccinimide: Dissolve 13.8 g of N-hydroxysuccinimide in 90ml of acetone, after that include 50.5 g of triethylamine, and liquify chloro-Boc-alanylsuccinimide in an ice-water bathroom. Dissolve 0.1 mol of amino acid in 40 ml of acetone and include it dropwise to the above system. After the addition is overall, respond at location temperature level for 4 hours. After that add 400g of detoxified water to the reaction system. A huge quantity of strong will certainly speed up. Filter with suction. Wash the filter cake with detoxified water for 50 ℃ blast drying to get Boc-alanyl succinimide;

3) Prep Job of Boc-Proglutide: Add 10.2 g glutamine and 7mL water to the response container, after that include 10g ammonia water, mix till clear, then consist of 10ml ethanol, and dropwise add Boc-Protein liquified in 40ml ethanol under stirring conditions. For the system of aminoacyl succinimide, continue the reaction at area temperature degree for 2 hours after the dropwise addition; after that gradually include 2M hydrochloric acid dropwise right into the system, readjust the pH to 2 ~ 3, stir for 1 hour, and precipitate a wide variety of crystals, after that filter and completely dry to get white shade strong;

4) Prep Work of L-Alanyl-L-Glutamine: eliminate tert-butoxycarbonyl group. The treatment of removing the tert-butoxycarbonyl team is as complies with: consist of 60ml of methylene chloride and 20ml of trifluoroacetic acid to the reaction container containing 19.0 g of Boc-propylene glycol dipeptide, react at area temperature level for 5 hours, and afterwards consist of 50ml of methyl tert-butyl ether. The solid is precipitated, filteringed system with suction, and dried out to get solid proglutamine dipeptide.

Contact Us

About Products:
If you need the cosmetic raw material L-Alanyl-L-Glutamine, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced L-Alanyl-L-Glutamine manufacturer and supplier, our company, ZSpharmac will provide L-Alanyl-L-Glutamine raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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