L-Alanyl-L-Glutamine CAS 39537-23-0

Molecular Formula: C8H15N3O4

Formula Weight: 217.22

ZSpharmac: L-Alanyl-L-Glutamine Supplier

Product Name: L-Alanyl-L-Glutamine

CAS No: 39537-23-0

Purity: 99%

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Basic Info

Product Name:	L-Alanyl-L-Glutamine
Other Names:	Glutamine
CAS:	39537-23-0
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Solution
EINECS No.:	475-290-9
Storage:	2-8°C
Provide:	L-Alanyl-L-Glutamine MSDS； L-Alanyl-L-Glutamine COA

What is L-Alanyl-L-Glutamine?

L-Glutamine is a vital matrix secreted by the kidneys of providers whose outer cells are moved to interior body organs, and plays an important function in the body’s immune function and injury fixing. Nonetheless, as a result of the reduced solubility of L-glutamine, it is unsteady in aqueous remedy and can not withstand warmth sterilization, and Heating is very easy to generate harmful compounds, which limits its application in parenteral nutrition. L-alanyl-L-glutamine (Ala-Gln) dipeptide is generally made use of as the provider of Gln clinically.
L-alanyl-L-glutamine is stable as well as soluble, can stand up to high-temperature disinfection as well as can be quickly hydrolyzed right into L-glutamine to play its role when it goes into the body. It has high bioavailability and also vast application variety, offseting L-glutamine. Lack of aminoamides plays a crucial role specifically in patients with unexpected injury. In amazing times, L-alanyl-L-glutamine plays a crucial duty in making sure the health and wellness of soldiers and also boosting the battle efficiency of the army, and also its application in parenteral nutrition has been paid a growing number of focus. Currently, the large bulk of L-alanyl-L-glutamic acid amide in China counts on imports, and will face the circumstance of no medication to get in phenomenal times, and also its market prospect is unlimited.
L-alanyl-L-glutamine, described as alanyl-glutide (Ala-Gln), its 20% intravenous shot was created as well as created by FreseniusAG in Germany, and it was registered as well as provided in Germany in April 1995. The brand name is Dipeptamin was registered and detailed in China in 1999, and also its brand name is 20% Dipeptamin (Lipeptide). C-Gludipeptide is medically made use of as a glutamine donor for parenteral nourishment. Like normal saline as well as glucose, it is a need for saving individuals, and its market possibility is infinite.
L-alanyl-L-glutamyl is a chemically synthesized dipeptide, which is weakened right into L-glutamine and alanine in the body for nutritional medicines to supply the body for product synthesis or energy usage. The drug works for extreme catabolic illness, such as major shed injury surgical procedure, intense and chronic infection, bone marrow hair transplant as well as several organ dysfunction disorder, intestinal disorder such as enteritis brief bowel disorder and mucosal injury triggered by radiotherapy and chemotherapy, immune shortage syndrome such as AIDS, essential ailment or bone marrow transplant It has a good restorative effect on illness such as low immune function and also is widely utilized scientifically.

L-Alanyl-L-Glutamine Property

Melting point	215 °C
Boiling point	615℃
density	1.305±0.06 g/cm3(Predicted)
vapor pressure	0-1000Pa at 20-313.7℃
RTECS	MA2275262
refractive index	10 ° (C=5, H2O)
Fp	>110°(230°F)
storage temp.	2-8°C
solubility	Water (Sparingly)
form	solution
pka	3.12±0.10(Predicted)
color	White
PH	pH(50g/l, 25℃) : 5.0～6.0
Water Solubility	Soluble in water.

L-Alanyl-L-Glutamine Uses

L-Glutamine is a dipeptide made use of as a glutamine replacement in animal cell culture media; glutamine is unsteady in solution and the ammonia developed has unhealthy results in cell society; Ala-Glu is heat sterilizable It is steady and much less effective in creating ammonia than glutamine. As one of the medium elements, it is beneficial to play its advantages.
L-Glutamine is a component of parenteral nourishment for individuals calling for glutamine supplementation, including those in catabolic and also hypermetabolic conditions. Such as: Injury, burn, large as well as average operation, bone marrow as well as various other organ hair transplant, gastrointestinal syndrome, tumor, extreme infection and also various other ICU patients under anxiety. This item is a supplement to the amino acid service, as well as ought to be included in various other amino acid options or mixtures having amino acids when made use of.
L-Glutamine can be utilized as a glutamate substitute in mammalian cell culture medium and also is stable throughout warm sanitation.

L-Glutamine and Disease

1. L-Alanyl-L-Glutamine and craniocerebral injury

Gln can promote protein synthesis, improve nutritional status, protect the barrier function of intestinal mucosa, stimulate the immune system, and enhance the immune function of patients with traumatic brain injury. And it can effectively improve the nutritional status of patients with craniocerebral injury, and promote prognosis and rehabilitation.

Formulas containing glutamine are recommended for patients with traumatic brain injury.

2. L-Alanyl-L-Glutamine and critical illness

Early administration of Gln-enhanced enteral nutrition can prevent intestinal infection and reduce the risk of pneumonia and sepsis in trauma patients. Reduce the hospitalization time of patients and reduce hospitalization costs. For patients with severe trauma, glutamine (0.2-0.3 g/kg/d) was supplemented through the intestines 5 days before enteral nutrition support treatment. During the healing of complex wounds, the use of glutamine can be appropriately extended for 10-15 days.

L-Alanyl-L-Glutamine can reduce the activity of plasma DAO after severe burns, reduce the degree of intestinal mucosal damage, and promote intestinal mucosal repair. For patients with burns whose body surface area is greater than 20%, glutamine (0.3-0.5 g/kg/d) should be supplemented through the intestines during enteral nutrition support for 10-15 days.

Except for burn and trauma patients, additional glutamine supplementation is not recommended for other critically ill patients.

3. L-Alanyl-L-Glutamine and surgery

For postoperative patients with insufficient enteral nutrition supply and parenteral nutrition supplementation, 0.5 g/kg/d of glutamine can be supplemented parenterally. However, routine oral glutamine-rich formulas are not recommended for postoperative patients.

Oral administration of formula containing glutamine in adult patients with parenteral fistula can promote fistula closure and reduce mortality. Oral administration of glutamine/glutamine-containing formulations alone in patients with pressure ulcers promotes wound healing.

4. L-Alanyl-L-Glutamine and acute pancreatitis

Nutritional support rich in Gln has a better curative effect on the traditional treatment of acute severe pancreatitis, and parenteral Gln supplementation can increase plasma albumin levels and reduce plasma C-reactive protein levels and the incidence of infection compared with enteral Gln supplementation.

For acute pancreatitis (supplementation with alanyl-glutamine dipeptide injection in the form of parenteral nutrition, >0.30 g/kg/d), adding glutamine to enteral nutrition is not recommended.

5. L-Alanyl-L-Glutamine and Tumor

Gln can reduce the severity of chemotherapy-induced mucositis in patients with esophageal cancer, and can reduce the mucositis caused by radiotherapy and chemotherapy in patients with head and neck cancer. Oral administration of Gln can effectively prevent lymphopenia and reduce intestinal permeability in patients with esophageal cancer during radiotherapy. For malnourished patients undergoing major tumor surgery, it is recommended to use oral nutritional preparations containing four main immunonutrients (glutamine, arginine, nucleic acids, and essential fatty acids) in addition to conventional nutritional therapy.

Preparation of L-Alanyl-L-Glutamine

A preparation method of L-Alanyl-L-Glutamine, the steps of the preparation method are as follows:

1) Preparation of chloro-Boc-alanine: 18.9g of Boc-alanine was added to the reaction flask, then 17.9g of thionyl chloride was added, and then 0.7g of N,N-dimethylformamide was added , stirred at 75°C to 85°C for 5h, then cooled to 40°C to 50°C, controlled the temperature at 45°C to 55°C and concentrated under reduced pressure until no distillate was obtained, and the obtained oil was directly used in the next reaction;

2) Preparation of Boc-alanyl succinimide: Dissolve 13.8 g of N-hydroxysuccinimide in 90 ml of acetone, then add 50.5 g of triethylamine, and dissolve chloro-Boc-propane under the condition of ice-water bath Dissolve 0.1 mol of amino acid in 40ml of acetone and add it dropwise to the above system. After the addition, react at room temperature for 4 hours, then add 400g of purified water to the reaction system, a large amount of solid will precipitate, filter with suction, and rinse the filter cake with purified water for 50 ℃ blast drying to obtain Boc-alanyl succinimide;

3) Preparation of Boc-glutamine dipeptide: Add 10.2g of glutamine and 7mL of water to the reaction bottle, then add 10g of ammonia water, stir until clear, then add 10ml of ethanol, and add dropwise Boc-propanol dissolved in 40ml of ethanol under stirring conditions. For the aminoacylsuccinimide system, continue to react at room temperature for 2 hours after the dropwise addition; then slowly add 2M hydrochloric acid dropwise to the system, adjust the pH to 2-3, stir for 1 hour, precipitate a large number of crystals, filter them with suction, and dry them to obtain a white solid;

4) Preparation of CG dipeptide: removal of tert-butoxycarbonyl group. The procedure for removing the tert-butoxycarbonyl group is as follows: add 60ml of dichloromethane and 20ml of trifluoroacetic acid to a reaction flask containing 19.0g of Boc-glutin dipeptide, react at room temperature for 5h, then add 50ml of methyl tert-butyl ether, The solid precipitated, was suction filtered and dried to obtain solid L-Alanyl-L-Glutamine.

About Products:
If you need L-Alanyl-L-Glutamine as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced L-Alanyl-L-Glutamine manufacturer and supplier, ZSpharmac will provide L-Alanyl-L-Glutamine raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.