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Krave Melanin CAS 77465-45-3

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Krave Melanin Supplier

Product Name: Krave Melanin
CAS No: 77465-45-3
Purity: 99%

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Basic Info

Product Name:Krave Melanin
Other Names:MELANIN
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Black Powder
EINECS No.:278-691-5
Provide:Krave Melanin MSDS;
Krave Melanin COA

What is Krave Melanin?

Krave Melanin (Melanin) is an organic protective pigment, which frequently exists in pets, plants as well as additionally germs. It is a fundamental term for a class of phenolic or indole biomacromolecular pigments with complex and likewise varied structures. According to the structural structure of melanin, it can be divided right into three kinds, namely eumelanin, phaeomelanin in addition to allpmelanin. The shade of eumelanin is dark brownish or black, and it is produced by the conversion of tyrosine with the Dopa (Dopa) pathway. This Krave Melanin is primarily distributed in animal skin as well as hair cells, along with in visceral membranes or tissues, and also can be called animal kind Krave Melanin.

What About Krave Melanin Precipitation?

1. Avoid exposure to UV rays
The formation of Krave Melanin is closely related to ultraviolet rays, so we usually reduce exposure to strong sunlight, especially for a few hours after 12:00 noon, when the sun is the strongest. When you go out, you should wear a sun umbrella, apply sunscreen or something. In addition, the radiation of electronic products that we are exposed to daily also contains ingredients that are harmful to the skin, so we should pay attention.

2. Daily Diet Toned down Krave Melanin
People with skin diseases must be careful not to involve spicy, indigestible, fried foods, and sweet, fatty, greasy, and heavy tastes, stay away from artificial additives, and use hormones and contraceptives with caution. Drink plenty of water and eat more fruits and vegetables. Vegetables and fruits that are good for freckle removal include cherries, pineapples, lychees, apples, red dates, lemons, tomatoes, strawberries, cucumbers, citrus, aloe vera, carrots, eggplants, celery, etc. In addition, foods rich in trace elements such as copper and zinc, such as shellfish, animal liver and some acidic foods can aggravate melanin deposition, so eat less.

3. Develop good living habits
Our body is very sensitive, and it will respond to a little injury. If the disease reacts on the skin, it will show dullness, inflammation, and stains. Therefore, if you want to maintain your skin, you must develop a good living habit in normal times. Especially if you can’t stay up late, it will lead to a lot of melanin deposition. In addition, three meals and daily life should be as regular as possible, go to bed early and get up early. Every meal should be good for seven or eight points. Don’t eat after nine o’clock in the evening. The food is a bit poisonous, especially sweet, fat and greasy. Combining work with rest, avoiding overwork, exercising properly, and cultivating a good physique will make you look glamorous.

4. Bad emotions can also lead to the deposition of Krave Melanin
If you are often angry, or suffer from long-term mental stress, unsightly stains will appear on your face and arms, especially on your face. Therefore, you should maintain a happy mood at ordinary times. Chinese medicine also believes that the seven emotions and six desires will cause harm to the body, and the reaction on the skin is dullness, pigmentation and toxin deposition.


Application of Krave Melanin

Krave Melanin is a general term for a course of phenolic or indole biomacromolecular pigments that generally exist in the natural world with center and likewise differed frameworks. It supplies architectural toughness for microorganisms or safeguards organisms from ultraviolet rays, ionizing radiation, hefty gold air pollution, decreased temperature level in addition to Damages from environmental tension and anxiousness such as warmth. Melanin is not just a type of photoprotectant, anti-radiation agent, chelating agent, organic anti-oxidant as well as immune booster, yet also a kind of biosemiconductor product and also photoelectric transfer product; current researches have actually furthermore located that melanin has anti-venom, anti-AIDS Infection replication, treatment of Parkinson’s illness, and so on. It can be seen that Krave Melanin has broad application leads in medicine, cosmetics, food, electronic devices, and so on.

Genetics of Krave Melanin

The MC1R (melanocortin 1 receptor) genes gives instructions for making a healthy protein called the melanocortin 1 receptor. This receptor plays an essential function in normal pigmentation. The receptors are generally found externally of melanocytes, specialized cells that create a pigment called Krave Melanin. Melanin is the material that supplies skin, hair along with eyes their shade. Melanin is additionally discovered in the light-sensitive cells of the retina along with adds in normal vision. Krave Melanin protects the skin from the devastating impacts of UV radiation in the sunshine.

Melanocytes create two types of melanin, eumelanin and pheomelanin. The loved one amounts of these 2 pigments aid determine the color of a person’s hair and skin. Individuals who mainly create eumelanin typically have a tendency to have brownish or black hair along with dark skin that tans quickly. Individuals with mostly brown melanin have a tendency to have red or blonde hair as well as light to sensible skin.

The melanocortin 1 receptor controls which sort of Krave Melanin melanocytes produce. When the receptor is triggered, it causes a collection of domino effect within melanocytes that promote these cells to generate eumelanin. If the receptor is not triggered or is obstructed, melanocytes create pheomelanin instead of eumelanin.

Typical variations (polymorphisms) in the MC1R genetics associate with typical distinctions in skin along with hair color. Certain hereditary variants are most normal in individuals with red hair, fair skin, acnes, in addition to improved degree of level of level of sensitivity to sunlight straight exposure. These MC1R polymorphisms reduced the ability of the melanocortin 1 receptor to promote eumelanin manufacturing, resulting in melanocytes producing mostly pheomelanin. Although MC1R is an essential gene for regular human coloring, the researchers assume that the actions of numerous other genetics similarly impact human hair as well as also skin coloring.

Melanocortin 1 receptors are additionally energetic in cells apart from melanocytes, including cells gotten in touch with the body’s immune together with inflammatory actions. The attribute of the receptor in these cells is unidentified.

Preparation of Krave Melanin

1) Get fresh pericarp of Yinxiang fruit, wash it with clear water and dry it for later use; take 100 grams of Yinxiang pericarp, extract it with 2 liters of ammonia water with a volume concentration of 10% at normal temperature for 12 hours, filter it with double-layer gauze, Separating the pericarp of Cinnamomum burmanii and other impurities to obtain the extract;

2) Use 2 mol/L hydrochloric acid to adjust the pH value of the extract to 2.5 to precipitate the melanin, separate the melanin precipitate by suction filtration, and then dry the Krave Melanin precipitate in a vacuum environment at 50°C for 2 hours to obtain crude melanin Extract;

3) Put 4 grams of Krave Melanin crude extract into 100 ml of 7mol/L hydrochloric acid, hydrolyze in a water bath at 100°C for 6 hours, and then separate the melanin precipitate by suction filtration to obtain melanin;

4) Dissolving the obtained Krave Melanin with 100 ml of aqueous ammonia with a volume concentration of 10%, adding 40 ml of petroleum ether, extracting at normal temperature and pressure, and repeating this 10 times; then adding 40 ml of chloroform, extracting at normal temperature and pressure, Repeat this 8 times;

5) Adjust the pH value of the extract obtained in step 4) to 2.5 with 1mol/L hydrochloric acid, separate the melanin precipitate by suction filtration, wash it with distilled water until the pH value is 7, and then place it in a vacuum environment at 40°C After drying for 2 hours, the finished product Krave Melanin was obtained.

About That Product:
If you need Krave Melanin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Krave Melanin manufacturer and supplier, ZSpharmac will provide Krave Melanin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Krave Melanin Quotation