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Kojic Acid CAS 501-30-4

Molecular Formula: C6H6O4

Formula Weight: 142.11

ZSpharmac: Kojic Acid Raw Material Supplier

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Product Name: Kojic Acid
CAS No: 501-30-4
Purity: 99%

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Basic Info

Product Name:Kojic Acid
Other Names: 5-Hydroxy-2-(Hydroxymethyl)-
CAS:501-30-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:207-922-4
Storage:Store Below +30°C.
Provide:Kojic Acid MSDS;
Kojic Acid COA

What is Kojic Acid?

Kojic acid, also referred to as koji acid and kojic acid, is an organic acid with antibacterial properties that is produced through the aerobic fermentation of glucose by Aspergillus and Candida at temperatures between 30-32°C. Its chemical structure is a γ-pyrone with a substituent. Kojic acid and maltol are the only well-known naturally occurring gamma-pyrone compounds.

Kojic acid can be found in koji, a food that is consumed by people and is considered safe for use. In recent years, numerous patent documents have reported the use of kojic acid in cosmetics. The key enzyme responsible for melanin production is tyrosinase. Kojic acid can chelate the copper in tyrosinase, deactivating it and serving as the basis for its skin whitening effect. Clinical and application tests have demonstrated that kojic acid effectively inhibits melanin production in human skin, and it is considered safe, non-toxic, and does not cause vitiligo sequelae. Kojic acid is most effective when combined with other preparations such as SOD, placenta extract, amino acids, sunscreen agents, and various plant extracts. It is primarily used in skin whitening products, anti-aging products, sunscreen products, whitening facial cleansers, and beauty cosmetics.

Kojic acid also possesses some antibacterial activity. Gram-negative bacteria are more sensitive to sodium kojate than Gram-positive bacteria, which is opposite to the response observed with most other antimicrobial substances. However, the antibacterial effect of kojic acid is relatively weaker compared to other antibacterial substances, and it exhibits bacteriostatic rather than bactericidal activity. Kojic acid is not effective against yeast, viruses, and bacteriophages.

Kojic Acid Property

Melting point 152-155 °C (lit.)
Boiling point 179.65°C (rough estimate)
density 1.1712 (rough estimate)
refractive index 1.4434 (estimate)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form Crystalline Powder
pka7.9(at 25℃)
color White to beige-brown
Water Solubility SOLUBLE

 

Kojic Acid Uses

(1) Kojic acid is commonly utilized in the food industry for various purposes. Traditionally, it has been employed as an antioxidant to prevent oils from becoming rancid. However, recent literature has highlighted its bactericidal and anti-insect properties. This versatile compound acts as a preservative, color-protecting agent, and can even replace certain chemicals. It finds wide application in meat processing for preservation and color protection, fruit and vegetable preservation, and sterilization and preservation of raw foods. Additionally, it can extend the shelf life of cut flowers. Importantly, the addition of kojic acid to food does not affect its taste, aroma, or texture while also inhibiting the formation of carcinogenic nitrosamines. This hindrance has a negative impact on cured meat products, making the replacement and upgrade of traditional preservatives crucial. In agricultural production, kojic acid serves as a biopesticide, insecticide, and biofertilizer, effectively increasing grain and vegetable yields and income.

(2) Maltol and ethyl maltol, both used as food flavoring agents, can be derived from kojic acid.

(3) Kojic acid can serve as a raw material for the production of cephalosporin antibiotics.

(4) Apart from its widespread use in food processing, kojic acid also possesses remarkable cosmetic benefits, particularly in the removal of freckles and skin whitening. Its derivatives, such as kojic acid acetate, exhibit antibacterial properties without causing skin irritation. Therefore, they find application as preservatives in cosmetics and food products. Moreover, kojic acid effectively absorbs ultraviolet rays and can be used alone or in combination with other sunscreen products, such as soaps, to prevent the formation of skin blemishes like liver spots. With a dosage of 1 to 2.5%, it visibly improves moisture retention and reduces wrinkles. Additionally, it is used in hair products to combat dandruff.

(5) Kojic acid can be employed as a seasoning and as a raw material for the production of larch bark and ethyl larch bark.

Kojic Acid Safety

Japanese scholars use the presence of kojic acid in traditional fermented products to illustrate the safety of kojic acid as a food additive, and believe that it can be added without limit.
Because kojic acid has certain antibacterial and antioxidant effects, Japan has widely used kojic acid in food processing and color protection, transportation and preservation of fruits and vegetables, preservation of aquatic products, and medical anti-inflammatory agents. As early as April 1988, the Japanese government approved the addition of kojic acid to cosmetics as a new non-medical product for sun protection, spot removal, and whitening.
In 1991, the Ministry of Health of my country approved the 142-kojic acid anti-freckle cream produced by Nanjing Shishantou Pharmaceutical Factory for the first time as a special-purpose cosmetic. In August 1992, the kojic acid produced by Shanghai Normal University Science and Technology Development Company passed the Shanghai chemical toxicity review as a cosmetic additive.

Extraction and Refining of Kojic Acid

Kojic acid and divalent metal ions can form insoluble metal chelates, and this property can be utilized during extraction. Secondly, although kojic acid is soluble in water, its solubility is not large. Temperature has a great influence on its solubility, which is conducive to concentration, cooling and crystallization.
Kojic acid can be used as an iron reagent. Even if a stainless steel fermentation tank is used, the fermentation liquid is reddish brown, which affects the extraction and refining process.
The copper salt precipitation method, ethyl acetate extraction method, diethyl ether continuous extraction method, concentrated crystallization or freeze crystallization method have been used to extract kojic acid from the fermentation broth. In the 1970s, Beijing Daily Chemical Factory No. 1 used the zinc salt method.

About Products:
If you need the cosmetic raw material Kojic Acid, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Kojic Acid manufacturer and supplier, our company, ZSpharmac will provide Kojic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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