Currently, the main synthesis methods of 6-furfuryl aminopurine contain: condensation of adenine and furfuryl chloride under the activity of antacids; condensation of methylthiopurine and furfurylamine; condensation of adenine and furfurylamine; condensation of acylpurine and furoyl chloride to create furoylpurine. After that it is gotten by decline of lithium light weight aluminum hydride; condensation of adenine and furfuryl alcohol, and so forth. However, these approaches have troubles such as limited resources of basic materials or reduced returns. The reaction method of 6-chloropurine and furfurylamine is added straight, due to the fact that the chlorine at the 6-position is exceptionally active., it has actually been reported in the literary works that feedback in ethanol or butanol solvents can easily generate spin-offs in which chlorine is altered by alcohol, resulting in single-hybrid failure.
WO2020048343A1 discloses a method for making high-purity 6-furfurylaminopurine, which is identified by including the following actions: reacting furfurylamine and 6-chloropurine in hexamethyldisilazane in the presence of DBU to acquire 6- Raw furfuryl aminopurine is recrystallized to acquire high purity 6-furfuryl aminopurine, with HPLC purity of above 99.5% and single contaminations less than 0.1%.
Additionally, in the above technological service, the response is preferably executed by blending furfurylamine and DBU, raising the temperature of 6-chloropurine and hexamethyldisilazane to 110-115 ° C, and starting to drop the mix of furfurylamine and DBU.
Much more, in the above technological treatment, the molar percentage of 6-chloropurine to furfurylamine is 1:1 -1.15.
Much more, in the above technological option, the molar proportion of 6-chloropurine to DBU is 1:1 -1.2.
Furthermore, in the above technical service, the feedback temperature degree is 110-130 ° C.
Furthermore, in the above technical remedy, the recrystallization solvent is ethanol.
This technique has easy procedure, high yield and no drainage discharge.