Zhishang Chemical

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Zhishang Chemical

Ketoconazole Usp CAS 65277-42-1

Molecular Formula: C26H28Cl2N4O4

Formula Weight: 531.43

ZSpharmac: Ketoconazole Usp Supplement

Product Name: Ketoconazole Usp
CAS No: 65277-42-1
Purity: 99%

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Basic Info

Product Name:Ketoconazole Usp
Other Names:Ketoconazole
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Yellow Off-White Solid
EINECS No.:265-667-4
Provide:Ketoconazole Usp MSDS;
Ketoconazole Usp COA

What is Ketoconazole Usp?

Ketoconazole Usp is an imidazole broad-spectrum antifungal medication, which is marketed under the brand name of Jindakning, Miconazole and also Kening. It prevents the task of fungal cytochrome P-450 by highly uniquely interfering with Biosynthesis of ergosterol. It works for both superficial as well as deep fungal infections, not just inhibiting the growth of fungi, yet likewise preventing the transformation of spores into mycelium, avoiding more infection. Low focus bacteriostatic, high concentration bactericidal. It has antibacterial impact on Candida albicans, Chromophytes, Coccidioides, Histoplasma, Sporothrix and also Trichophyton. It is scientifically appropriate for the treatment of tinea pedis, tinea pedis, tinea pedis, tinea corporis, tinea cruris, dental yeast infection, tinea versicolor and skin candidiasis.

Ketoconazole Usp cream is used as a topical medication for the skin. It is mainly utilized medically to treat as well as protect against various infections triggered by Malassezia, such as tinea versicolor, seborrheic dermatitis as well as pityriasis scalp (dandruff), and also can promptly soothe the symptoms caused by lipid Scaling as well as itching due to epidermal dermatitis and also pityriasis scalp.

Ketoconazole Usp Properties:

Melting point 148-152 °C
Boiling point 753.4±60.0 °C(Predicted)
density 1.4046 (rough estimate)
refractive index -10.5 ° (C=0.4, CHCl3)
Fp 9℃
storage temp. 2-8°C
solubility methanol: soluble50mg/mL
pkapKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form Off-white solid
color white to light yellow
optical activity[α]20/D -1 to 1°, c = 4 in methanol
Water Solubility Soluble in DMSO, ethanol, chloroform, water, and methanol.


Ketoconazole Usp Uses

  1. Ketoconazole Usp is an imidazole antifungal.
  2. Ketoconazole Usp is an antifungal medicine made use of to deal with conditions such as athlete’s foot and also excessive dandruff.
  3. Ketoconazole Usp is a broad-spectrum antifungal agent indicated for the treatment of candidiasis, chronic mucocutaneous candidiasis, thrush, candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromatin chemistry Books and Paracoccidioidomycosis. It is used to identify p-glycoprotein/CYP3A-restricted bioavailability in monkey models, to study drug interleukin-1-mediated antitumor effects in vivo,

Ketoconazole Usp Adverse Reactions and Precautions

Adverse Reactions


external use
1. Common erythema, burning, itching, tingling or other irritation signs, folliculitis, skin degeneration and also thinning, telangiectasia and so forth.
2. Dry skin, hirsutism, stretch marks, enhanced susceptibility to infection, etc can be seen.
3. Long-lasting drug may cause cortical hyperfunction, materialized as hirsutism, acne, full moon face, osteoporosis and also various other signs and symptoms.
4. Occasionally can cause allergic get in touch with dermatitis.
Dental adverse effects
1. Hepatotoxicity: Ketoconazole Usp can cause product aminotransferase (ACkST, ALT) elevation, which is reversible. Severe hepatotoxicity occasionally happens, generally hepatocellular type, with an occurrence rate of concerning 0.01%. The clinical manifestations are jaundice, dark pee, white stool, unusual tiredness, and so on, normally recover after medication withdrawal, but there are also deaths; youngsters; There are also instances of liver disease.
2. Gastrointestinal reactions: such as nausea, throwing up and also anorexia are much more typical.
3. Gynecomastia and also lack of seminal fluid, which relate to the restraint of testosterone and adrenal cortical hormone synthesis by this product.


1. The adhering to circumstances must be used with care:
( 1) Gastric acid shortage (may cause reduced absorption of this item).
( 2) Alcohol addiction or liver damage (this product can create liver poisoning).
2. Liver function should be inspected frequently prior to as well as during therapy. Elevations of lotion aminotransferases might not be connected with signs of liver disease, nonetheless, therapy with Ketoconazole Usp should be stopped if lotion aminotransferase degrees persist or worsen, or if symptoms of hepatotoxicity exist.
3. If cimetidine or fursultiamine is utilized at the same time, it should be taken a minimum of 2 hours after taking this item.
4. This product can cause photosensitivity responses, so you must avoid prolonged exposure to brilliant light during taking the medication, and also you can put on colored glasses.
5. Do not drink liquors while taking the medicine. Attention must be paid to the occurrence of wooziness as well as drowsiness.
6. Individuals with damaged kidney function do not require to reduce the dosage of this product.
7. Ketoconazole Usp has inadequate penetration to the blood-cerebrospinal liquid obstacle, so it is not suitable for the treatment of fungal meningitis; this product has inadequate efficiency on Aspergillus, Mucor or Mycobacterium foot infections, and also is not suitable for use.
8. Disturbance with medical diagnosis: it can trigger the increase of serum aminotransferase as well as the rise of blood bilirubin.

Pharmacological Effects and Pharmacokinetics of Ketoconazole Usp

1. Pharmacology Ketoconazole Usp comes from pyrrole antifungal drug, which has anti-bacterial result on deep infection fungis such as Yeast infection, Chromophytes, Coccidioides, Histoplasma, Sporothrix, and so on. Bacteria additionally have antibacterial activity. This item has a weak impact on Aspergillus, Sporothrix schenckii, some dark spores, and Mucor. By disrupting the activity of cytochrome P-450, this item hinders the biosynthesis of ergosterol, the major steroid in the fungal cell membrane layer, damages the fungal cell membrane as well as alters its leaks in the structure, leading to the leak of crucial intracellular compounds. Ketoconazole Usp can prevent the biosynthesis of fungal triacylglycerols and also phospholipids, inhibit the activities of oxidase and also peroxidase, as well as trigger the build-up of intracellular hydrogen peroxide leading to cellular submicrostructure degeneration and also cell death. For Candida albicans, the change from spores to invasive hyphae can be hindered.
2. Toxicology Pet long-term toxicity experiments reveal that Ketoconazole Usp can dramatically raise alkaline phosphatase and also deterioration of liver cells.

This item is liquified as well as soaked up in gastric acid. When the level of acidity of gastric acid is reduced, the absorption can be lowered, and the absorption can be raised by taking it after meals. The bioavailability of Ketoconazole Usp taken after meals is 75%. After a solitary dental dose of 200 mg and also 400 mg of this item, the top plasma focus were 3.6 ± 1.65 mg/L and 6.5 ± 1.44 mg/L, respectively. The peak time is 1 to 4 hours. This product is commonly dispersed in the body after being taken in, as well as can reach inflammatory joint fluid, saliva, bile, urine, ligament, skin and soft cells, feces, and so on. It has bad infiltration of the blood-cerebrospinal fluid obstacle, as well as most of the times, the cerebrospinal liquid medication focus is less than 1 mg/L. This product can likewise travel through the blood-placental obstacle. Lotion healthy protein binding rate is about 90% or more. The elimination half-life is 6.5 to 9 hrs. Some drugs are metabolized in the liver and also degraded into non-active imidazole as well as piperazine rings. Metabolites as well as prototype medications are mostly secreted by bile, as well as just 13% of the dose is excreted through the kidneys, of which regarding 2% to 4% are model medications, and also this product can also be produced into milk.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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