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Ketoconazole Solution CAS 65277-42-1

Molecular Formula: C26H28Cl2N4O4

Formula Weight: 531.43

ZSpharmac: Ketoconazole Solution Raw Material Supplier

Product Name: Ketoconazole Solution
CAS No: 65277-42-1
Purity: 99%

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Basic Info

Product Name:Ketoconazole Solution
Other Names:Ketoconazole
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Yellow Solid
EINECS No.:265-667-4
Provide:Ketoconazole Solution MSDS;
Ketoconazole Solution COA

What is Ketoconazole Solution?

Ketoconazole is an imidazole broad-spectrum antifungal drug. It is marketed under the trade names of jindaconine, mecoconazole, and coconine. It hinders the fungal cell membrane by very selectively disrupting the activity of fungal cytochrome P-450. Biosynthesis of ergosterol. It is effective against both superficial and deep fungal infections. It can inhibit the growth of fungis and prevent the improvement of spores right into mycelium to prevent further infection. Reduced focus is bacteriostatic, high concentration is antiseptic. It has anti-bacterial effects on Yeast infection, chromogenic fungi, Coccidioides, Histoplasma, Sporothrix and Trichophyton. Clinically ideal for the treatment of tinea manuum, tinea pedis, tinea skin, tinea corporis, tinea cruris, yeast infection, tinea versicolor and cutaneous candidiasis.
Ketoconazole cream is made use of as a topical skin medication. It is mainly made use of medically to treat and prevent numerous infections caused by Malassezia, such as tinea versicolor, seborrheic dermatitis and pityriasis of the scalp (dandruff), and can promptly soothe the symptoms triggered by Malassezia.

Ketoconazole Solution Property

Melting point 148-152 °C
Boiling point 753.4±60.0 °C(Predicted)
density 1.4046 (rough estimate)
refractive index -10.5 ° (C=0.4, CHCl3)
Fp 9℃
storage temp. 2-8°C
solubility methanol: soluble50mg/mL
pkapKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form Off-white solid
color white to light yellow
optical activity[α]20/D -1 to 1°, c = 4 in methanol
Water Solubility Soluble in DMSO, ethanol, chloroform, water, and methanol.


Ketoconazole Solution Uses

Treat acne vulgaris
Use: ① Ketoconazole 200 mg, taken orally with supper daily, 4 weeks as a training course of therapy; ② Proper amount of 2% ketoconazole lotion, use very finely to the damaged area with your hands, and delicately massage therapy the impacted skin with your hands, 3 times a day, continual use for one month until the acne disappears.

Effectiveness: 185 people with acne vulgaris were treated, with a total effective rate of 96.54%, which was considerably better than the effectiveness of cimetidine or acne cream in dealing with acne.

Treat seborrheic dermatitis
Usage: Wash the location with cozy water before usage (if the scalp is damaged, the hair should be cut). After that use 2% ketoconazole lotion externally, twice a day, and a program of treatment is 14 days. Normally, the impact can be achieved after 1 to 2 courses of treatment.

Efficacy: 97 clients with seborrheic dermatitis were treated, with a treatment rate of 57.8% and a total effective price of 100%. The efficiency was dramatically far better than the control group treated with outside cold cream.

Dealing with Hypercortisolism
Usage: Take Ketoconazole Option by mouth, 200 to 400 mg each time, two times a day, after meals.

Efficacy: After taking the medicine, blood and pee cortisol and testosterone can be substantially minimized, and the scientific signs of individuals with adrenal cortex hyperplasia are much better enhanced.

Treat psoriasis
Use: Take 200 mg by mouth daily for 4 weeks.

Efficacy: It can make patients’ erythema subside, lower ranges and relieve itchiness. The complete effective rate gets to 68.5%, and the effect is significantly greater than that of the control group. The quantity of Pityrosporum pityrosporum bacteria on the person’s skin was considerably decreased.

Ketoconazole Solution Precautions

1. The list below conditions need to be made use of with caution: (1) Achlorhydria (may cause decreased absorption of this item). (2) Alcohol addiction or liver feature damage (this item can trigger liver poisoning).
2. Liver feature should be examined consistently before and during treatment. The boost in product aminotransferase may not be accompanied by signs of liver disease. Nevertheless, if the lotion aminotransferase worth continues to boost or worsens, or is accompanied by signs and symptoms of hepatotoxicity, treatment with Ketoconazole Solution must be stopped.
3. If cimetidine or furthiamine are used at the same time, they need to be taken at least 2 hours after taking this product.
4. This product can cause photosensitivity reactions, so you need to avoid extended direct exposure to brilliant light while taking the medicine, and you can wear colored glasses.
5. Do not take alcohols while taking the medication. Attention needs to be paid if wooziness or drowsiness occurs.
6. People with renal disability do not need to decrease the dose of this item.
7. Ketoconazole Option has bad infiltration right into the blood-cerebrospinal liquid barrier and is not suitable for the treatment of fungal meningitis. This item is also not effective in treating Aspergillus, Mucor or Mycetoma infections and need to not be used.
8. Interference with diagnosis: It can cause an increase in lotion aminotransferase and likewise cause a boost in blood bilirubin.

Indications of Ketoconazole Solution

Ketoconazole Remedy is shown for the therapy of the complying with systemic fungal infections:
1. Candidiasis, persistent mucocutaneous candidiasis, dental candidiasis, urinary system candidiasis, chronic and frequent genital candidiasis that are inefficient with neighborhood treatment.
2. Dermatitis blastomycosis.
3. Coccidioidomycosis.
4. Histoplasmosis.
5. Coloring fungal disease.
6. Paracoccidioidomycosis.
For dermatomycosis, tinea versicolor and tinea versicolor triggered by dermatophytes and yeasts, this item can be made use of when topical therapy or dental griseofulvin is inadequate, or when extreme and refractory skin fungal infections are hard to approve griseofulvin treatment. reward.

About Products:
If you need the cosmetic raw material Ketoconazole Solution, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced Ketoconazole Solution manufacturer and supplier, our company, ZSpharmac will provide Ketoconazole Solution raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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