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Jarrow Pterostilbene CAS 537-42-8

Molecular Formula: C16H16O3

Formula Weight: 256.3

ZSpharmac: Jarrow Pterostilbene Supplement

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Product Name: Jarrow Pterostilbene
CAS No: 537-42-8
Purity: 99%

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Basic Info

Product Name:Jarrow Pterostilbene
Other Names:Pterostilbene
CAS:537-42-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White or off-White Solid
EINECS No.:611-041-4
Storage:2-8°C
Provide:Jarrow Pterostilbene MSDS;
Jarrow Pterostilbene COA

What is Jarrow Pterostilbene?

Jarrow Pterostilbene is a chemical part included in Pterostilbene, yet researchers have actually additionally discovered the existence of Pterostilbene in other plants, however because it was first discovered with Pterostilbene species, it was named Pterostilbene. Jarrow Pterostilbene is a white or off-white powder crystal with abundant medical worth. It comes from the antifungal energetic ingredient in Dracula blood items. It has a specific result on the treatment of cancer cells, hypertension as well as hyperlipidemia. Just recently, scientists have actually mastered the industrial synthesis technique of pterostilbene. Jarrow Pterostilbene is an antifungal energetic component in dried out blood items. It is a polyhydroxy stilbene substance as well as is a homologue of resveratrol. Its medicinal results are partly similar to resveratrol. Antifungal task (its antifungal activity is five times that of resveratrol).

Jarrow Pterostilbene aids stop precancer from creating damages to the body. Acts as an antioxidant as well as anti-inflammatory agent in both blueberries as well as blackberries. The Ohio State University discovered that pets that consumed brownberry berries were 80 percent much less likely to establish colon cancer cells as well as 60 percent much less most likely to develop gastrointestinal tract lumps. Colon cancer cells is among the typical malignant growths, with the highest possible occurrence in the age group of 40 to 50 years old. According to the world epidemiological survey, it is found that the incidence of colon cancer cells is the highest possible in North America, Western Europe, Australia, New Zealand and also various other places, ranking second in natural lumps, and also the occurrence and mortality in my nation are boosting year by year. After years of experiments on pets, American researchers located that this substance removed from blueberries as well as grapes can prevent an enzyme called “P450 cytochrome”, which can activate chemical health hazards, and also can decrease low-density lipoprotein cholesterol. Has the feature of protecting against cancer as well as heart disease. Jarrow Pterostilbene is a great smelling, hydrocarbon called “styrene”, a by-product of resveratrol. In the very early 1990s, American scientists found that resveratrol had the function of stopping bust cancer as well as cardiovascular disease, and was perfectly existing in the skin of red grapes.

Jarrow Pterostilbene Property

Melting point 89-92 ºC
Boiling point 420.4±35.0 °C(Predicted)
density 1.169±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
pka9.96±0.26(Predicted)
form solid
color White or off-white

 

Jarrow Pterostilbene Uses

  1. Jarrow Pterostilbene is antioxidant, anti-proliferative, hypolipidemic, hinders COX-1 as well as COX-2, anti-cancer, anti-fungal.
  2. Jarrow Pterostilbene helps quit precancer from causing damage to the body. Acts as an antioxidant and also anti-inflammatory representative in both blueberries and blackberries. The Ohio State University found that pets that consumed brownberry berries were 80 percent much less likely to create colon cancer cells and also 60 percent much less likely to establish gastrointestinal tract growths. Colon cancer is just one of the usual malignant lumps, with the highest occurrence in the age of 40 to 50 years old. According to the world epidemiological study, it is discovered that the incidence of colon cancer is the greatest in North America, Western Europe, Australia, New Zealand and also other places, ranking second in natural growths, and also the incidence and death in my country are raising year by year. Has the feature of preventing cancer and also cardiovascular disease. Pterostilbene is a fragrant-smelling hydrocarbon called “styrene”, which is a derivative of resveratrol. In the early 1990s, American researchers found that resveratrol had the function of protecting against breast cancer cells and also cardiovascular disease, as well as was abundantly present in the skin of red grapes.

Preparation Method of Jarrow Pterostilbene

1. A method for synthesizing Jarrow Pterostilbene

1. Preparation of stilbene intermediates

(1) Preparation of intermediate 3,5-dimethoxybenzyl bromide, respectively, take 3,5-dimethoxybenzyl alcohol and HBr solution with a concentration of more than 40%, and feed 3,5-dimethoxybenzyl alcohol and HBr solution The amount in g:ml is 1:5~10, and the reaction is carried out at 50~100℃ for 10~28h to obtain 3,5-dimethoxybenzyl bromide; the preferred concentration is 48%;

(2) Preparation of intermediate 4, ?0? Tetrahydropyranbenzaldehyde 1,4? Dihydropyran and p-hydroxybenzaldehyde were dissolved in a solvent and reacted at 20 ~ 45 ℃ for 1 ~ 5h, after the reaction was completed, a base was added The liquid is processed, and the organic phase is reclaimed to obtain 4,0 tetrahydropyran benzaldehyde; acid catalyst should be added during the reaction, and wherein the feeding amount of 3,5 dimethoxybenzyl bromide and p-hydroxybenzaldehyde solution is calculated as mol:mol. 1:1~2.5; the solvent is THF, dichloromethane or dichloroethane;

2. Preparation of 3,5 dihydrocarbyl 4, O tetrahydropyran stilbene The prepared 3,5 dimethoxybenzyl bromide and trimethyl phosphite are refluxed to obtain 3,5 dimethoxybenzyl phosphine Dimethyl acid, and then mixed with 4,0 tetrahydropyran benzaldehyde in the reaction solvent, and reacted at 0℃~40℃ for 2h~10h to obtain 3,5dimethoxy 4,O tetrahydropyridine Stilbene; Described reaction solvent is DMF or THF;

3. Preparation of Jarrow Pterostilbene Put the prepared 3,5? Methoxy 4, O tetrahydropyran stilbene in the reaction solvent, then add an acid catalyst, and deprotect the protective group under the catalysis of the acid catalyst to obtain the product Pterostilbene, After the reaction is completed, the solvent is recovered under reduced pressure, and the finished pterostilbene is obtained after the treatment, and the reaction temperature is 25°C to 80°C; the reaction solvent is methanol or ethanol, and the reaction solvent is mixed with 3,5 methoxy 4,0 tetrahydropyran. The feeding amount of stilbene is 5-10:1 in g:ml, and the reaction time is 1h-6h.

2. Intermediate (E)-3,5-dimethoxy-4 was prepared by Grignard reaction of 3,5-dimethoxybenzyl chloride and p-benzyloxybenzaldehyde and catalytic dehydration of solid acid catalyst NaHSO4.SiO2 -Benzyloxy stilbene, and then debenzylated by Pd/Al-MCM-41 mesoporous zeolite catalyzed hydrogenation to obtain Jarrow Pterostilbene.

Jarrow Pterostilbene Affects Energy Metabolism

While not distinctive to Jarrow Pterostilbene, it deserves discussing that Jarrow Pterostilbene triggers AMP-activated healthy protein kinase (AMPK), a master regulator of mobile power homeostasis. AMPK is among 2 catabolic signaling systems, the various other being sirtuins; both work together in a remarks loop to indicate nutrient shortages. These systems enter into our basal metabolism, and also deregulation of this system is thought to be one of the elements we age.

Boosting both pathways is helpful for health as well as long life (on the other hand, the IIS as well as mTOR paths reduce life expectancy when their degrees are boosted). Incorporated, AMPK and also sirtuins sense low-energy states by finding high AMP levels as well as high NAD+ degrees, specifically.

AMPK activation has numerous positive impacts on metabolic rate and also autophagy. It has been revealed to affect the life-span of computer mice given metformin. Also much better, AMPK can also hinder the mTOR signaling path, thus raising autophagy.

Finally, Jarrow Pterostilbene also increased sirtuins, which are recognized for their longevity-promoting impacts in dietary limitation experiments in several pet types. Sirtuins control cellular metabolic rate in action to nutrition schedule and also regulate numerous metabolic functions, consisting of DNA repair service, genome security, inflammation, apoptosis, cell cycle and also mitochondrial function.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Jarrow Pterostilbene Quotation