[Pharmacological action] It has a killing result on microfilariae, and also its exact mechanism is unidentified. This item may work as an agonist of the neurotransmitter γ-tyrosine (GABA), ruining the GABA-mediated synaptic transmission procedure in the main nerves, leading to paralysis of the bloodsucker’s nerve system and also death. Although this product has no result on grown-up worms, it can influence the regular development of Onchocerciasis microfilariae in the womb of women worms and also prevent its launch from the womb of expecting worms. Ivermectin is a lot more efficient on microfilariae than ethylamine. Zine is slow-moving and also long-lasting. It can rapidly minimize the variety of microfilariae in the skin of the patient, but it has a slow impact on the microlarvae in the cornea and also the former chamber of the client, and also the variety of microfilaria in this field reduces fairly gradually.
[Pharmacokinetics] After oral administration, the plasma concentration reaches its top at 4 hrs, as well as T1/2 is 10 hours. Pet experiments reveal that just 1-2% of the dental dosage appears in the urine as the prototype medication, et cetera is excreted in the feces. The medicine focus in the liver and fat is very high as well as can not go through the blood-brain barrier. The medication concentration in animal nerve cells consisting of GABA is really reduced, so the main nerve system reaction is rare after taking the drug.
[Indications] It is the primary medication for the therapy of onchocerciasis.
[Usage and dose] Oral. Take 1 hr before meals. The common dose for the therapy of onchocerciasis: 0.15-0.2 mg/kg of body weight each time, as soon as every 6-12 months, depending on the signs as well as the reappearance time of microfilaria. It can avoid the further development of eye sores (primarily triggered by microfilariae), yet due to the fact that this product can not kill adult worms, it can not be healed.
[Prep work as well as Specifications] Ivermectin Tablets 6mg [Damaging Response] This item is well tolerated by clean individuals and various other mammals.Animals may experience drowsiness, ataxia, mydriasis, tremor and other reactions after being given a large dose. The side effects of onchocerciasis patients after medication are short-lived and mild, mostly limited to rash or itching (due to the death of intradermal microfilariae), lymphadenopathy (swelling and pain, found in the neck, armpit, groin, etc.). Rare dizziness, orthostatic hypotension (fainting), fever, headache, joint pain, fatigue, etc. Ocular lesions did not worsen. Occasionally ECG changes, the significance of which is unclear. No carcinogenic and teratogenic effects. The side effects of onchocerciasis patients after medication are short-lived and mild, mostly limited to rash or itching (due to the death of intradermal microfilariae), lymphadenopathy (swelling and pain, found in the neck, armpit, groin, etc.). Rare dizziness, orthostatic hypotension (fainting), headache, joint pain, fatigue, etc. Ocular lesions did not worsen. Occasionally ECG changes, the significance of which is unclear. No carcinogenic and teratogenic effects.