Ivomec Ivermectin CAS 70288-86-7

Molecular Formula: C48H74O14

Formula Weight: 875.09

ZSpharmac: Ivomec Ivermectin Supplement

Product Name: Ivomec Ivermectin

CAS No: 70288-86-7

Purity: 99%

Basic Info

Product Name:	Ivomec Ivermectin
Other Names:	Ivermectin
CAS:	70288-86-7
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Pharmaceutical Raw Materials
Appearance:	White Powder
EINECS No.:	274-536-0
Storage:	2-8°C
Provide:	Ivomec Ivermectin MSDS； Ivomec Ivermectin COA

What is Ivomec Ivermectin?

Ivomec Ivermectin is a brand-new kind of high-efficiency semi-synthetic antibiotic pesticide, acaricide, and also nematicide. It is an insect nerve agent as well as an organic penetrant. The system of activity is to disrupt the neurophysiological tasks of insects, promote the release of γ-aminobutyric acid, act upon the nerve-muscle junction, raise the release of chloride ions, hinder the information transmission of the nerve junction, and also create paralysis as well as poisoning fatality of pests and termites. Its product is anemic or light brown yellow liquid. Ivermectin is a new broad-spectrum, high-efficiency, low-toxicity antibiotic antiparasitic medication, which has an excellent murder effect on internal and also external bloodsuckers, especially nematodes as well as arthropods. However it is inadequate versus tapeworms, flukes as well as protozoa. The repelling effect of macrolide antiparasitic medicines on nematodes as well as arthropods is to raise the release of the repressive transmitter γ-aminobutyric acid (GABA) of the worms, as well as to open up the Cl ion network controlled by glutamate, Boost the permeability of the nerve membrane to Cl, thus blocking the transmission of nerve signals, at some point nerve paralysis, to make sure that muscular tissue cells shed the ability to contract, resulting in the death of the worm.

Ivomec Ivermectin Properties:

alpha	D +71.5 ± 3° (c = 0.755 in chloroform)
RTECS	IH7891500
storage temp.	2-8°C
solubility	H₂O: ≤1.0% KF
form	powder
color	White
Water Solubility	4mg/L(temperature not stated)

Ivomec Ivermectin Uses

Ivomec Ivermectin is highly curative for sheep mange. At the same time, it can also fight against scab tsutsugamushi, sheep lice, larvae of sheep flies, and most of the nematodes and lung parasites in the gastrointestinal tract, and can control the myiasis caused by the excrement of blowfly. When used on sheep mange, the most commonly used dosage form is the long-acting ivermectin controlled-release capsule.
Ivomec Ivermectin is a dihydro derivative of the macrolide avermectin Bla produced by Actinomyces, and is a broad-spectrum antiparasitic drug. By binding to glutamate-gated chloride channels in nerve cells and muscle cells in the parasite (the channel is only expressed in non-vertebral animals), it leads to paralysis and death of the parasite.

Research on Ivomec Ivermectin

Ivomec Ivermectin has antiviral effects against several positive single-stranded RNA viruses including SARS-CoV-2 in vitro. Subsequent studies found that the half-inhibitory concentration of this drug against SARS-CoV-2 in monkey kidney cells was 2.2–2.8 μM. The dose required for ivermectin to achieve antiviral effects in humans is much higher than the highest approved human dose, and also exceeds the dose that can be safely achieved. The drug achieves antiviral effect by inhibiting the nuclear transport of importin α/β1, and is toxic to the host at the above dose. Therefore, there is currently no reason to conduct clinical testing of this drug for COVID-19.

Multiple hospitalizations for equine Ivomec Ivermectin concentrate; overdose has also resulted in death; death likely due to ivermectin interaction with other drugs as of June 2021. In order to resolve the uncertainty of the original small-scale, low-quality studies, large-scale clinical studies have been launched in the United States and the United Kingdom.

Many scholars have significant methodological flaws in the research on the use of this drug in COVID-19, and the level of evidence is therefore very low. Numerous companies have for that reason openly stated that the proof for the medicine’s efficiency in the therapy of COVID-19 is weak. In February 2021, Merck, the manufacturer of the medication, released a declaration stating that there is presently no ideal proof that the drug works versus COVID-19, and also its use for this objective is also rather dangerous. The National Institutes of Health’s COVID-19 therapy guidelines state that the proof for this medicine is too minimal to make any kind of referrals. The UK National Advisory Board on the Treatment of COVID-19 established that the proof and expediency of this medication for the therapy of COVID-19 was insufficient for more examination.

The medicine is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any viral illness in the USA, neither for the therapy of COVID-19 in Europe. After evaluating the proof related to the medication, the European Medicines Company (EMA) specified that the existing data do not support the use of the medication beyond well-designed medical tests. In March 2021, both the FDA and EMA released standards mentioning that this medicine must not be used to treat COVID-19. The World Health and wellness Company has actually additionally specified that the drug should not be made use of to treat COVID-19 other than in professional trials. The Brazilian National Wellness Security Agency, the Brazilian Society of Transmittable Illness, as well as the Brazilian Thoracic Culture released a statement against using this medicine to avoid or deal with very early COVID-19.

Ivomec Ivermectin Discovery Journey

Ivomec Ivermectin is a derivative of avermectin. The discoverers of avermectin, William C. Campbell and Satoshi Omura, won the 2015 Nobel Prize in Physiology and Medicine for their outstanding achievements in the fight against river blindness and elephantiasis. In 1973, Japanese microbiologist Satoshi Ōmura discovered a new type of Streptomyces in soil, which was successfully isolated and cultured in the laboratory. SatoshiŌmura found that these Streptomyces can produce anti-parasitic substances. With the assistance of the Merck Drug Screening Laboratory, the researchers completed the purification and identification of the active ingredient in 1975 and named it Avermectins.
When avermectin was discovered, it was considered to be a new class of antiparasitic drugs, which had the effect of killing various pathogens in vivo or in vitro. In 1979, Abamectin was first reported in a paper, in which it was identified that Abamectin is an 18-membered macrolide, and the method of obtaining the product by fermentation with Streptomyces avermectinius (S.avermectinius) was introduced. The avermectin family has shown extraordinary anthelmintic potential, and a chemically engineered structural analog, ivermectin, is a safer and more effective product, which is a blend of two chemically engineered avermectin analogs , containing 80% 22,23-dihydroavermectin-B1a and 20% 22,23-dihydroavermectin-B1b,
In 1981, Ivomec Ivermectin obtained marketing approval (trade name, Mectizan) in animal husbandry, agriculture, aquaculture and other fields. A few years later, ivermectin was proven to have potential for human health applications. Registration was completed in 1987, and patients soon enjoyed free use. At that time, human society was trying to control the endemic epidemic in poor tropical regions. Filariasis (Onchocerciasis, also known as river blindness).

Instructions for Ivomec Ivermectin

[Pharmacological action] It has a killing result on microfilariae, and also its exact mechanism is unidentified. This item may work as an agonist of the neurotransmitter γ-tyrosine (GABA), ruining the GABA-mediated synaptic transmission procedure in the main nerves, leading to paralysis of the bloodsucker’s nerve system and also death. Although this product has no result on grown-up worms, it can influence the regular development of Onchocerciasis microfilariae in the womb of women worms and also prevent its launch from the womb of expecting worms. Ivermectin is a lot more efficient on microfilariae than ethylamine. Zine is slow-moving and also long-lasting. It can rapidly minimize the variety of microfilariae in the skin of the patient, but it has a slow impact on the microlarvae in the cornea and also the former chamber of the client, and also the variety of microfilaria in this field reduces fairly gradually.
[Pharmacokinetics] After oral administration, the plasma concentration reaches its top at 4 hrs, as well as T1/2 is 10 hours. Pet experiments reveal that just 1-2% of the dental dosage appears in the urine as the prototype medication, et cetera is excreted in the feces. The medicine focus in the liver and fat is very high as well as can not go through the blood-brain barrier. The medication concentration in animal nerve cells consisting of GABA is really reduced, so the main nerve system reaction is rare after taking the drug.
[Indications] It is the primary medication for the therapy of onchocerciasis.
[Usage and dose] Oral. Take 1 hr before meals. The common dose for the therapy of onchocerciasis: 0.15-0.2 mg/kg of body weight each time, as soon as every 6-12 months, depending on the signs as well as the reappearance time of microfilaria. It can avoid the further development of eye sores (primarily triggered by microfilariae), yet due to the fact that this product can not kill adult worms, it can not be healed.
[Prep work as well as Specifications] Ivermectin Tablets 6mg [Damaging Response] This item is well tolerated by clean individuals and various other mammals.Animals may experience drowsiness, ataxia, mydriasis, tremor and other reactions after being given a large dose. The side effects of onchocerciasis patients after medication are short-lived and mild, mostly limited to rash or itching (due to the death of intradermal microfilariae), lymphadenopathy (swelling and pain, found in the neck, armpit, groin, etc.). Rare dizziness, orthostatic hypotension (fainting), fever, headache, joint pain, fatigue, etc. Ocular lesions did not worsen. Occasionally ECG changes, the significance of which is unclear. No carcinogenic and teratogenic effects. The side effects of onchocerciasis patients after medication are short-lived and mild, mostly limited to rash or itching (due to the death of intradermal microfilariae), lymphadenopathy (swelling and pain, found in the neck, armpit, groin, etc.). Rare dizziness, orthostatic hypotension (fainting), headache, joint pain, fatigue, etc. Ocular lesions did not worsen. Occasionally ECG changes, the significance of which is unclear. No carcinogenic and teratogenic effects.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.