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Itaconic Acid CAS 97-65-4

Molecular Formula: C5H6O4

Formula Weight: 130.1

ZSpharmac: Itaconic Acid Raw Material Supplier

Product Name: Itaconic Acid
CAS No: 97-65-4
Purity: 99%

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Basic Info

Product Name:Itaconic Acid
Other Names:Methylene-Butanedioicaci
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Beige Crystalline Powder or Crystals
EINECS No.:202-599-6
Storage:Store Below +30°C.
Provide:Itaconic Acid MSDS;
Itaconic Acid COA

What is Itaconic Acid?

Itaconic acid is an organic unsaturated dicarboxylic acid and a vital metabolite created by the mitochondrial tricarboxylic acid (TCA) cycle. In 1836, Swiss drug store Samuel Baup initially discovered itaconic acid in the purification product of citric acid. Currently, the manufacturing of itaconic acid is mostly attained via microbial synthesis. Microorganisms that can create itaconic acid generally consist of filamentous fungi, yeast, basidiomycete fungis, bacteria, and so on. Itaconic acid biosynthesis was not uncovered for the first time in animal immune cells until 2011. In 2013, the biosynthetic pathway of mammalian itaconic acid was disclosed for the first time.

Itaconic Acid Property

Melting point 165-168 °C (lit.)
Boiling point 268°C
density 1.573 g/mL at 25 °C (lit.)
vapor pressure 0.0000115 Pa (20 °C)
refractive index 1.4980 (estimate)
Fp 268°C
storage temp. Store below +30°C.
solubility 77.49g/l
form Crystalline Powder or Crystals
pka3.85(at 25℃)
color White to light beige
Specific Gravity1.573
OdorCharacteristic Odor
PH3.5(1 mM solution);2.95(10 mM solution);2.43(100 mM solution);
Water Solubility Soluble in water, acetone, methanol, hexane and ethanol. Slightly soluble in benzene, chloroform, carbon disulfide and petroleum ether.


Itaconic Acid Uses

1. Itaconic acid and its polymers can be made right into trustworthy antiperspirants by adding a percentage of natural compounds, which can respond with ammonia, amines, alkaline odors, hydrogen sulfide and various other acidic odors, and can in addition be squared away into paper with ventilating attribute, plastic film and numerous other collection of things.
2. Itaconic acid can be copolymerized with styrene and butadiene to make S.B.R latex, which can be utilized for paper covering to make the paper solid and the printing pattern bright; utilized for steel and concrete treatments, it is easy to color and is not influenced by natural troubles; Made use of as a paint additive to enhance paint premium; used in carpeting sizing to make artificial fiber rugs long lasting.
3. Itaconic acid is polymerized with acrylic acid or methacrylic acid or its esters to produce a product, which can be utilized for surface treatments and emulsified paints. As an all-natural natural leather ending up, it can enhance the plasticity of all-natural leather; as an ending up for cars, electrical devices, and cold store, it has the advantages of strong bond, attractive color, and resistance to rough climate; as an electrophoretic completing, it has impressive bond; it can be made by including polyvalent steel oxides It can establish an oral adhesive with fantastic extrusion efficiency, strong tool and remarkable physical flexibility; including chloroalkyl dimethyl benzyl ammonium chloride can make a water-soluble covering, which can be taken advantage of in food packaging items to decrease product packaging things Surface area microbial contamination.
4. Esters made from itaconic acid can be utilized in paints, weakly acidic ion exchange materials, lubing oil ingredients, binders and plasticizers, powdered plastics and sealants.
5. Itaconic acid types various other spin-offs that can be made use of as medicines, aesthetic reagents, lubricating substances, thickeners, herbicides and to increase the residential properties of silk and woollen fabrics.
6. Itaconate is a resources for the manufacturing of citraconic acid, mesaconic acid, itaconic anhydride, and a lot more.

Itaconic Acid Production Method

1. The fermentation technique is produced by adding an appropriate quantity of nitrogen resource and not natural salt to carbohydrates (sugar, starch, and so on) and by means of the biochemical activity of Aspergillus terreus.
2. Chemical synthesis methods can be divided right into the following 2 kinds according to various resources of basic materials: (1) Using farming products as resources. Such resources include citric acid, isocitric acid, aconitic acid or its anhydride, etc. Utilizing citric acid as resources and supported phosphate as driver, the reaction is executed at 290-340 ° C to get citraconic acid, which is after that heated up to 220 ° C for isomerization to get itaconic acid. (2) Utilize petrochemical things as resources, succinic anhydride or succinic acid diester as basic materials, and thorium salt as catalyst to react with formaldehyde to create citraconic acid, which is after that warmed and isomerized to obtain itaconic acid.
3. The new chemical synthesis strategy utilizes maleic anhydride as the major resources to produce itaconic acid through four-step responses of esterification, enhancement, methyleneization and hydrolysis.

Contact Us

About Products:
If you need Itaconic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Itaconic Acid manufacturer and supplier, our company, ZSpharmac, will provide Itaconic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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