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Itaconic Acid CAS 97-65-4

Molecular Formula: C5H6O4

Formula Weight: 130.1

ZSpharmac: Itaconic Acid Raw Material Supplier

Product Name: Itaconic Acid
CAS No: 97-65-4
Purity: 99%

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Basic Info

Product Name:Itaconic Acid
Other Names:Methylene-Butanedioicaci
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Beige Crystalline Powder or Crystals
EINECS No.:202-599-6
Storage:Store Below +30°C.
Provide:Itaconic Acid MSDS;
Itaconic Acid COA

What is Itaconic Acid?

Itaconic Acid (adipic acid) is an organic compound with a chemical name of 2-methylidenebutanedioic acid and a molecular formula of C5H6O4. It is a white crystalline solid that is acidic and soluble in water and some organic solvents. Itaconic Acid usually exists in the form of dimethacrylic acid.

Itaconic Acid Property

Melting point 165-168 °C (lit.)
Boiling point 268°C
density 1.573 g/mL at 25 °C (lit.)
vapor pressure 0.0000115 Pa (20 °C)
refractive index 1.4980 (estimate)
Fp 268°C
storage temp. Store below +30°C.
solubility 77.49g/l
form Crystalline Powder or Crystals
pka3.85(at 25℃)
color White to light beige
Specific Gravity1.573
OdorCharacteristic Odor
PH3.5(1 mM solution);2.95(10 mM solution);2.43(100 mM solution);
Water Solubility Soluble in water, acetone, methanol, hexane and ethanol. Slightly soluble in benzene, chloroform, carbon disulfide and petroleum ether.


Ltaconic Acid Uses

  1. Polymer industry: Itaconic Acid can be used as a monomer for synthetic polymers, such as synthetic butyl acrylate (ABS) resin, butyl acrylate (BPA) resin, butyl methacrylate (BPI) resin, etc. These resins are widely used in plastic products, coatings, adhesives and other fields.
  2. Coatings and Inks: Itaconic Acid and its derivatives can be used as ingredients in coatings and inks to improve their viscosity, adhesion and gloss. In the coating and ink industry, Itaconic Acid is often used as a plasticizer and modifier.
  3. Medicine and medical treatment: Itaconic Acid also has certain applications in the pharmaceutical and medical fields. It can be used as one of the raw materials for drug synthesis and used to prepare various drugs. In addition, Itaconic Acid can also be used in the production of medical materials, such as medical glue, biodegradable materials, etc.
  4. Biotechnology: Itaconic Acid is a biologically based compound produced from biomass by microbial fermentation. Therefore, it has potential uses in the field of biotechnology, such as biodegradable plastics, biofuels, etc.
  5. Chemical synthesis: In addition to being used as a monomer in the polymer industry, Itaconic Acid can also be used in the synthesis of other chemicals. For example, it can react with other compounds to form various copolymers that serve as modifiers or plasticizers for polymers.

Application of Ltaconic Acid in Cosmetics

Conditioners and Stabilizers: Itaconic Acid is used as a conditioner and stabilizer in cosmetics. It can adjust the pH value of cosmetics to keep it within the ideal range, thereby ensuring the stability and safety of cosmetics.

Plasticizer: Itaconic Acid can be used as a plasticizer to improve the texture and taste of cosmetics. For example, in lotions, cream cosmetics, lipsticks and other products, Itaconic Acid can increase their softness and extensibility, making the products easier to apply and absorb.

Antibacterial agent: Because Itaconic Acid has certain antibacterial properties, it can also be used as an antibacterial agent in some cosmetics. It can effectively inhibit the growth of bacteria and fungi, extend the shelf life of cosmetics, and maintain the freshness and safety of products.

Conditioning agent: Itaconic Acid can also be used as a conditioning agent in cosmetics, which can help adjust the water and oil balance of the skin and improve the texture and gloss of the skin. In some skin care products, Itaconic Acid can moisturize, moisturize and balance skin pH.

Antioxidant:Some studies have shown that Itaconic Acid has certain antioxidant properties, which can fight against free radical damage and slow down the aging process of the skin. Therefore, in some anti-aging skin care products, Itaconic Acid may be added as an antioxidant.

Ltaconic Acid Features

  1. Bicarboxylic structure: Itaconic Acid molecule contains two carboxyl groups (-COOH), giving it a bicarboxylic structure. This structure gives Itaconic Acid acidity, allowing it to act as an acid catalyst in chemical reactions or participate in acid-base neutralization reactions.
  2. α,β-unsaturated acid: The carbon-carbon double bonds in the Itaconic Acid molecule are located at the α,β positions, forming an unsaturated structure. This unsaturation makes Itaconic Acid highly reactive and can undergo various chemical reactions such as addition reactions and oxidation reactions.
  3. Water solubility: Itaconic Acid is solid at room temperature, but easily soluble in water and many organic solvents. This water solubility enables Itaconic Acid to be evenly dispersed in aqueous systems and facilitates solution handling and application.
  4. Biodegradable: Itaconic Acid is a biologically based compound with certain biodegradability. Under appropriate environmental conditions, such as under the action of microorganisms, Itaconic Acid can gradually degrade into harmless substances without causing lasting pollution to the environment.
  5. Synthesis controllability: The synthesis method of Itaconic Acid is relatively simple and can be obtained through chemical synthesis or microbial fermentation. This makes the production of Itaconic Acid relatively easy to implement, and reaction conditions and raw material selection can be adjusted as needed to achieve precise control of product properties.
  6. Various functional group modifications: Since Itaconic Acid contains dicarboxylic and unsaturated structures, other functional groups can be introduced through functional group modification reactions to obtain a series of Itaconic Acid derivatives with different properties and uses.


Zhao, M., Lu, X., Zong, H. et al. Itaconic acid production in microorganisms. Biotechnol Lett 40, 455–464 (2018). https://doi.org/10.1007/s10529-017-2500-5

As a company specializing in the production and supply of Ltaconic Acid raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Ltaconic Acid raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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