Zhishang Chemical

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Zhishang Chemical

Itaconic Acid CAS 97-65-4

Molecular Formula: C5H6O4

Formula Weight: 130.1

ZSpharmac: Itaconic Acid Supplier

Product Name: Itaconic Acid
CAS No: 97-65-4
Purity: 99%

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Basic Info

Product Name:Itaconic Acid
Other Names:Itaconicaci
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to light beige Crystalline Powder
EINECS No.:202-599-6
Provide:Itaconic Acid MSDS;
Itaconic Acid COA

What is Itaconic Acid?

Itaconic acid is also known as methylene succinic acid, methylene succinic acid. It is an unsaturated acid containing conjugated double bonds and two carboxyl groups, and was rated as one of the top 12 value-added chemicals from biomass. It is white crystal or powder at room temperature, melting point is 165-168°C, specific gravity is 1.632, soluble in water, ethanol and other solvents. Itaconic acid has active chemical properties and can undergo various addition reactions, esterification reactions and polymerization reactions.

Itaconic acid contains an unsaturated double bond and two active carboxyl groups, which enable it to undergo many chemical reactions. At the same time, it is destined to be used in a wide range of fields. , surfactants, non-toxic food packaging materials, herbicides, scale removers, dental adhesives and other industrial raw materials.

Itaconic Acid Property

Melting point 165-168 °C (lit.)
Boiling point 268°C
density 1.573 g/mL at 25 °C (lit.)
vapor pressure 0.0000115 Pa (20 °C)
refractive index 1.4980 (estimate)
Fp 268°C
storage temp. Store below +30°C.
solubility 77.49g/l
form Crystalline Powder or Crystals
pka3.85(at 25℃)
Specific Gravity1.573
color White to light beige
PH3.5(1 mM solution);2.95(10 mM solution);2.43(100 mM solution);
Water Solubility Soluble in water, acetone, methanol, hexane and ethanol. Slightly soluble in benzene, chloroform, carbon disulfide and petroleum ether.


Itaconic Acid Uses

1. Itaconic acid and also its polymers can be made right into high-efficiency antiperspirants by including a percentage of natural compounds, which can react with acidic odorants such as ammonia, amine alkaline odorants as well as hydrogen sulfide, and can additionally be made right into paper with deodorization feature, plastic film and other items.
2. Itaconic acid can be made into S.B.R latex by copolymerization with styrene and also butadiene, which can be used for paper finishing to make the paper hard and the printing pattern intense; it can be used for steel and concrete finishings, easy to color as well as not influenced by all-natural conditions; Made use of in paint ingredients to improve paint high quality; made use of in carpet sizing to make artificial fiber carpets durable.
3. Itaconic acid is polymerized with acrylic acid or methacrylic acid or their esters to make a resin, which can be utilized for surface finish and emulsified paint. As a natural leather finish, it can enhance the plasticity of leather; as a covering for vehicles, electrical devices, as well as cold storage, it has the advantages of solid bond, stunning color, and also resistance to severe weather; as an electrophoretic covering, it has excellent adhesion; including multivalent metal oxides can be made Oral sticky with good extrusion efficiency, strong attachment and good physical flexibility; adding chloroalkyl dimethyl benzyl ammonium chloride can be made right into water-soluble paint, which can be made use of in food product packaging materials to minimize packaging Microbial contamination of surfaces.
4. Esters made from itaconic acid can be utilized in paints, weakly acidic ion exchange materials, lubing oil ingredients, binders as well as plasticizers, powder-pressed plastics as well as sealants.
5. Various other derivatives formed from itaconic acid can be utilized as medication, cosmetic representative, lubricating substance, thickener, herbicide and also enhance the efficiency of silk wool material.
6. Itaconic ester is the raw product for the production of citraconic acid, mesaconic acid as well as itaconic anhydride.

Production Method of Itaconic Acid

1. The fermentation approach is acquired by including ideal amount of nitrogen source as well as inorganic salt to carbs (glucose, starch, and so on), as well as with the biochemical activity of Aspergillus terreus.
2. Chemical synthesis methods can be split into the following 2 kinds according to various resources of basic materials: (1) Utilizing agricultural items as resources. Such resources consist of citric acid, isocitric acid, aconitic acid or its anhydrides, and so on. Making use of citric acid as raw material as well as crammed phosphate as catalyst, respond at 290-340 ° C to acquire citraconic acid, then warmth to 220 ° C for isomerization to get itaconic acid. (2) Making use of petrochemical products as raw materials, making use of succinic anhydride or succinic diester as basic materials, using thorium salts as drivers, reacting with formaldehyde to create citraconic acid, and afterwards heating and isomerizing to get itaconic acid.
3. A new chemical synthesis approach uses maleic anhydride as the main basic material to manufacture itaconic acid through 4 steps of esterification, addition, methylation and hydrolysis.

Anti-Inflammatory, Antibacterial and Antiviral Effects of Itaconic Acid

Itaconic acid mainly exerts anti-inflammatory function in macrophages. As a metabolite produced by the tricarboxylic acid cycle, itaconic acid can inhibit the activity of succinate dehydrogenase in the mitochondria, thereby reducing the generation of mitochondrial reactive oxygen species, and finally achieve the effect of weakening the inflammatory response. In addition, itaconic acid can also shuttle from the mitochondrial matrix into the cytoplasm. In the cytoplasm, the main mechanism for itaconate to exert its anti-inflammatory function is to modify the cysteine residues of related proteins through the alkylation of thia-Michael addition reaction. For example, modify KEAP1 (Kelch like ECH associated protein 1) protein by alkylation and activate Nrf2 signaling pathway to reduce the inflammatory response and oxidative stress of macrophages.

Itaconic acid also has antibacterial effects. Since 1977, scientists have discovered that itaconic acid inhibits the growth of Pseudomonas indigo under glucose-deprived conditions. Itaconic acid mainly inhibits the activity of isocitrate lyase in bacteria, thereby blocking the glyoxylate shunt pathway required for bacterial growth and pathogenicity, and then exerts its antibacterial effect. In addition, itaconyl-CoA, an intermediate metabolite of itaconic acid, can inhibit the activity of methylmalonyl-CoA mutase in bacteria, thereby blocking the growth of propionyl-CoA-dependent bacteria, such as Mycobacterium tuberculosis. The author’s postdoctoral research found that under the condition of macrophages infected by bacteria, itaconic acid-mediated TFEB alkylation induces the biosynthesis of lysosomes in macrophages, thereby enhancing the body’s antibacterial innate immunity. Our research expands other important biological functions of itaconic acid besides anti-inflammatory.

Itaconic acid enhances the body’s antibacterial ability by inducing lysosomal biosynthesis

Figure 2. Itaconic acid enhances the antibacterial ability of the body by inducing lysosomal biosynthesis

When macrophages find bacterial invasion, they will respond immediately to release itaconic acid from mitochondria. Itaconic acid modifies TFEB through alkylation to activate its nuclear entry and promote the biosynthesis of lysosomes, thereby destroying the invading bacteria.

Interestingly, itaconic acid also exhibited antiviral effects. For example, itaconic acid derivatives inhibit the replication of Zika virus, herpes simplex virus and vaccinia virus. This suggests that itaconic acid has the potential to treat viral infections.

About That Product:
If you need Itaconic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Itaconic Acid manufacturer and supplier, ZSpharmac will provide Itaconic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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