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Isovanillin CAS 621-59-0

Molecular Formula: C8H8O3

Formula Weight: 152.15 

ZSpharmac: Isovanillin Raw Material Supplier

Product Name: Isovanillin
CAS No: 621-59-0
Purity: 99%

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Basic Info

Product Name:Isovanillin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials

Light Brown Crystal

EINECS No.:210-694-9
Storage:Room Temperature
Provide:Isovanillin MSDS;
Isovanillin COA

What is Isovanillin?

Isovanillin is a significant fine chemical utilized in various industries such as spices, flavors, food and cosmetic additives, plant growth regulators, and pharmaceutical intermediates. It is distinct from vanillin in terms of its fragrance properties, as it can vary depending on ambient temperature. This characteristic makes it ideal for use in specialty cosmetics and specific fragrance industries.

Isovanillin Property

Melting point 113-116 °C
Boiling point 179 °C15 mm Hg(lit.)
density 1.20
vapor pressure 0Pa at 20℃
refractive index 1.4945 (estimate)
Fp 179°C/15mm
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in acetone and methanol.
pkapK1:8.889 (25°C)
form crystalline
color faintly brown
Water Solubility 2.27g/L at 20℃


Isovanillin Application

Isovanillin, also known as isovillyl aldehyde or 3-hydroxy-4-methoxybenzaldehyde, is a versatile chemical compound with a pleasant olive-like and milky aroma. It plays a crucial role in the food industry as a flavoring agent and sweetener, commonly found in sugar, popsicles, beverages, desserts, tobacco, and alcoholic beverages. Additionally, isovanillin is utilized in the fine chemical industry for plant growth regulation, cosmetics, and skincare products due to its unique fragrance properties that adjust with temperature changes.

Furthermore, isovanillin is a key ingredient in the production of various products such as deodorants, fragrances for soap, toothpaste, rubber, and plastic. Its active hydroxyl and aldehyde groups make it valuable in the synthesis of active pharmaceuticals, organic polymer acetal resins, and complex natural compounds like coumarin derivatives, alkaloids, and flavanones. This compound also serves as a spasm-relief medication, highlighting its diverse applications in the medical field.

Main Synthesis Methods of Isovanillin

Method 1: Catechol method
By using catechol and glyoxylic acid as starting materials, 3,4-dihydroxybenzaldehyde is first produced through condensation and oxidative decarboxylation. This compound is then used to synthesize isovanillin through a selective methylation reaction, achieving a yield of up to 70%. However, the reaction to convert 3,4-dihydroxybenzaldehyde into isovanillin is intricate, with challenges in selectivity and control over reaction conditions. Additionally, the reaction also generates vanillin and veratraldehyde, complicating the subsequent separation and purification processes.

Method 2: Alkyl vanillin method
In this method, ethyl vanillin is utilized as a raw material. The hydroxyl group is methylated with dimethyl sulfate to form 3-ethoxy-4-methoxybenzaldehyde. Due to the easier hydrolysis of the ethoxy group compared to the methoxy group, the reaction exhibits good selectivity. Isovanillin is then obtained through hydrolysis under concentrated sulfuric acid, with a reported yield of 96%. While this process is widely used in industrial production, it involves the utilization of ethyl vanillin, which is synthetically produced and may not be economically viable for direct conversion to isovanillin. Furthermore, the waste liquid produced contains high levels of acid, posing challenges for post-processing and environmental concerns.

Method 3: p-hydroxybenzaldehyde method
By using the by-product p-hydroxybenzaldehyde from the synthesis of neohesperidin dihydrochalcone as a starting material, a three-step synthesis process involving monobromination with bromine, methylation with dimethyl sulfate, and alkaline hydrolysis is conducted to produce isovanillin. This method offers a novel approach that addresses the limitations of previous processes. It is characterized by simplicity, high overall yield of 62%, and cost-effectiveness. Through pilot scale amplification, this method can be applicable for industrial-scale production.

Contact Us

As a company specializing in the production and supply of Isovanillin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Isovanillin raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Isovanillin Quotation