Zhishang Chemical

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Zhishang Chemical

Isotretinoina Valeant CAS 4759-48-2

Molecular Formula: C20H28O2

Formula Weight: 300.44

ZSpharmac: Isotretinoina Valeant Supplement

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Product Name: Isotretinoina Valeant
CAS No: 4759-48-2
Purity: 99%

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Basic Info

Product Name:Isotretinoina Valeant
Other Names:Isotretinoin
CAS:4759-48-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow-Orange to Orange Fine Crystalline Powder
EINECS No.:225-296-0
Storage:-20°C
Provide:Isotretinoina Valeant MSDS;
Isotretinoina Valeant COA

Pharmacological Effects of Isotretinoina Valeant

Isotretinoina Valeant belongs to the very first generation of retinoic acid as well as is the stereoisomer of all-trans retinoic acid. It has anti-greasy result when taken by mouth and has a special effect on serious acne. The device of activity is as complies with:
① It has the functions of diminishing sweat glands, preventing sebaceous gland activity, as well as decreasing sebaceous gland secretion, thereby hindering the recreation of Propionibacterium acnes that grows depending on lipid atmosphere.
② It has anti-keratinization, hinders the extreme proliferation of skin cells as well as promotes their distinction, as well as can minimize the keratinization of the hair follicle orifice and also the sweat duct.
③ It can likewise affect the feature of monocytes as well as lymphocytes, hinder the chemotaxis of neutrophils and have anti-inflammatory task.
④ Selectively bind to retinoic acid nuclear receptors to play a restorative role. Hinders the expansion of Corynebacterium acnes, has immunostimulatory impacts at low dosages as well as immunosuppressive results at high doses.
⑤ Can hinder the formation of collagenase as well as gelatinase in the skin, and also can prevent the activity of ornithine decarboxylase. Because induction of ornithine decarboxylase may play a significant duty in skin mutations, Isotretinoina Valeant additionally hinders tumorigenesis.
⑥ When used locally, the mechanism of activity of this product resembles that of retinoic acid. It can cause the expansion of epidermal cells, advertise the differentiation of the granular layer of skin cells to the stratum corneum, and also manage the keratin plug in the uncommon process of keratinization of the hair roots sebum epithelium, thereby exerting a restorative impact.

Isotretinoina Valeant Properties

Melting point 172-175 °C (lit.)
Boiling point 381.66°C (rough estimate)
density 1.0597 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. -20°C
solubility Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
pka4.76±0.33(Predicted)
form Fine Crystalline Powder
color Yellow-orange to orange
Water Solubility insoluble

 

Isotretinoina Valeant Uses

  1. Isotretinoina Valeant is a vitamin A drug, which has the function of strongly as well as rapidly inhibiting the proliferation and also distinction of skin gland cells, as well as is highly efficient for severe nodular cystic acne. This item is well taken in from the stomach as well as intestines, but neighborhood management is inadequate. It is utilized for serious acne, cystic acne, and also congregational acne that are ineffective for various other medication treatments.
  2. Isotretinoina Valeant is utilized for severe acne as well as even more.
  3. Isotretinoina Valeant is made use of in anti-keratinization drugs.

Clinical Application of Isotretinoina Valeant

Isotretinoina Valeant is an efficient drug for the treatment of acne. It plays a role in the four phases of acne pathogenesis as well as prevents the formation of acne sores: ① hinders the secretion of sebaceous glands; ② inhibits the growth of acne bacillus; ③ hinders sweat gland hyperplasia; ④ anti-inflammatory result. Isotretinoina Valeant has no fondness with retinoic acid receptors, as well as the precise device of its action is not really clear. The anti-acne effect of isotretinoina Valeant might be related to its or its metabolites preventing the proliferation and also distinction of sweat glands. Decreased sebaceous gland volume, decreased skin DHT, and down-regulated skin androgen receptors. Other devices consist of the reduction of follicular keratinization, antibacterial results, and anti-inflammatory results. In the 1980s, Isotretinoina Valeant was only used in severe nodular cystic acne, as well as currently isotretinoin is likewise used in much less extreme acne that is often insensitive to standard treatments, especially those with lasting In clients with prescription antibiotics, Bacillus acnes has established resistance to a range of medicines (eg, erythromycin, tetracycline). It can also be utilized in the treatment of some acne susceptible individuals.

When beginning acne treatment with Isotretinoina Valeant, the dose made use of is too high, 1 mg/(kg · d), yet most clients have bad compliance because of damaging medicine responses. Later on, it was found that 0.5 mg/(kg · d) can additionally get comparable healing results. In order to achieve an appropriate cumulative amount, the drug use time can be prolonged. The cumulative dosage of Isotretinoina Valeant is determined by splitting the overall amount of the medicine taken by the patient’s body weight (mg/kg). Generally talking, when the cumulative dosage gets to 120 mg/kg, the illness is difficult to recur. The maximum cumulative dose taken normally does not exceed 150 mg/kg. Due to the fact that the medicine stays in the body for a time period, some clients continue to improve after stopping the medication, so upkeep therapy is not required till all skin lesions subside. Regarding one-third of clients require retreatment (as a result of relentless or persistent disease). 2 problems that are immune to isotretinoin are occlusive acne and microcystic acne. In the initial 1 to 2 weeks of therapy, the skin lesions in some patients will certainly intensify, as well as some cystic acnes will end up being pyogenic granulomatous lesions. This is due to the destruction of the typical obstacle function of the skin after taking isotretinoin, and the increase in the number of Staphylococcus aureus emigration. Females who are immune to treatment with Isotretinoina Valeant or have reoccurring episodes need to be observed for hirsutism, normal menstruations, and ovarian and also adrenal feature. Irregular adrenal function or high levels of 5α-reductase can create this to occur.

Twelve Side Effects of Isotretinoina Valeant

Dry lips are the most usual side effect. Practically every patient who takes Isotretinoina Valeant soft pills has this experience. It is typically really felt after 1-2 weeks of medicine. Naturally, this is also an indication of judging the efficiency of the medication. Normally, due focus is paid to strengthening. Moisturizing, such as using a lot more Vaseline moisturizing lip balm can essentially alleviate it. Since everybody’s tolerance to drugs is various, some clients can not alleviate even if they take little dosages and also strengthen moisturizing, as well as it is serious to chapped lips as well as blood loss, then the dosage of the medication requires to be minimized right now, and also it is required to stop if necessary. medicine.

Around 60% of people taking Isotretinoina Valeant will really feel the nasal mucosa dry, and also virtually 40% of people report that the dryness is severe sufficient to trigger nosebleeds. Right now, a cotton bud dipped in Vaseline or erythromycin lotion can be made use of to use the nasal dental caries, and also the motions need to be mild, To prevent annoying blood loss.

It is typically accompanied by some degree of itching or rash (retinoic dermatitis), such as an erythematous breakout on the arms, neck, or cheeks, which is the second most typical adverse effects of Isotretinoina Valeant, seen in almost half of the patients taking the drug, yet typically pay attention to hydrating can be soothed, do you really feel that hydrating is divine, rubbish, what is the skin doing! As well as individuals with a background of allergies, dermatitis, allergic asthma are more probable to have seriously dry and also itchy skin. Moreover, this negative effects is typically dose-dependent, especially in clients taking isotretinoin soft capsules at higher dosages, skin and mucous membranes are a lot more prone to dry skin.
According to a 2013 research in JAMA Dermatology, “retinoin dermatitis was extra usual in clients treated with high-dose Isotretinoina Valeant; Rash happened in 31.6% of clients in the group.

Concerning 40% of people that take isotretinoin experience dry eyes. For most individuals, this side effect is just temporary and also usually disappears within the initial 2 months of treatment. Nevertheless, around 25% of people experienced dry eyes throughout their therapy. On top of that, some individuals, especially those that use call lenses, likewise create conjunctivitis (red as well as red eyes). Usually, making use of man-made rips can help soothe symptoms of dry eyes.

Possibly some individuals do not recognize what this indicates, do you understand “standing out acne”? Hey, I get it, I get it (chicken-pecking nodding). Concerning 30% -35% of patients may experience short-term irritation of acne in the early stage of treatment, especially in the initial 1-2 months of treatment. The particular system is not very clear. The process of “popping acne” is recognized as drugs (retinoic acid medications) increase the aging as well as fatality of acne, particularly in individuals with dense acne and huge acne, and also when face swelling is reasonably severe, it is most likely to be intensified.

While the majority of common adverse effects of Isotretinoina Valeant entail the skin and also mucous membrane layers, some individuals might experience bone and joint side effects: 28% of clients experienced back pain; 29% knowledgeable joint discomfort regularly; 26% seasoned muscle mass pain. Usually, these signs disappear after the very first month of treatment. Nonetheless, some individuals continue to have pain throughout the treatment duration, 5% of low-dose individuals and also 8-9% of high-dose people, record consistent discomfort within one year of treatment, yet subsequent consistent discomfort likewise requires to be ruled out for various other causes of discomfort.

Persistent fatigue, also an usual side effect of Isotretinoina Valeant, can sometimes be serious sufficient to need discontinuation of therapy. One research study discovered that up to a quarter of clients experienced exhaustion within the very first month of therapy, as well as numerous remained to experience this negative effects as the training course of therapy continued. And like other side impacts, fatigue seemed dose-related. One research study found that only a minority of people taking isotretinoin at low doses experienced tiredness.

Throughout treatment with Isotretinoina Valeant, 10% -12% of individuals reported headaches. Frustrations did not appear to be dose-dependent, as individuals on reduced doses had the very same migraine threat as those on greater dosages. Most of the time, migraines triggered by Isotretinoina Valeant are moderate and not serious.

Hair loss, also a relatively common side effect of Isotretinoina Valeant, is not extremely usual, happening in 9% of clients. Hair loss does not appear to be dose-dependent, as taking lower doses of isotretinoin did not minimize the likelihood of this negative effects. As a matter of fact, this type of hair loss belongs to telogen effluvium, which is only short-lived as well as usually recuperates after the therapy mores than. According to one research study, individuals may discover loss of hair early after beginning isotretinoin therapy, but this adverse effects usually disappears swiftly. And one research study likewise reported an unusual side effect in which a patient’s hair texture transformed from straight to curly after taking isotretinoin.

Boosted level of sensitivity to sunlight, one more fairly usual side effect of taking Isotretinoina Valeant, was reported by 5% -12% of people, together with an enhanced risk of sunburn. Level of sensitivity to sunlight is dose-related; patients treated with high doses (over 0.5 mg/kg/day) were most likely to develop this adverse effects than those treated with reduced doses. However, both low and high doses can have adverse effects, so take precautions while taking Isotretinoina Valeant, such as frequent sun block, umbrellas, and also wide-brimmed hats.

Vision modifications might take place in 5% to 10% of people, the most typical being decreased night vision, according to a research released in the Journal of the American Medical Organization Dermatology in 1984./ d) or high dosages (up to 1 mg/kg/d) of Isotretinoina Valeant were most likely to have vision troubles than those on reduced doses.

2 researches reported upper body pain in a handful of individuals taking isotretinoin. While it’s vague just how Isotretinoina Valeant creates breast discomfort, it is a major side effect as well as anybody that experiences upper body discomfort while taking isotretinoin should look for instant medical focus and also quit taking the medicine.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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