Isotretinoina Valeant CAS 4759-48-2

Molecular Formula: C20H28O2

Formula Weight: 300.44

ZSpharmac: Isotretinoina Valeant Supplier

Product Name: Isotretinoina Valeant

CAS No: 4759-48-2

Purity: 99%

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Basic Info

Product Name:	Isotretinoina Valeant
Other Names:	Isotretinoin
CAS:	4759-48-2
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Yellow-Orange to Orange Fine Crystalline Powder
EINECS No.:	225-296-0
Storage:	-20°C
Provide:	Isotretinoina Valeant MSDS； Isotretinoina Valeant COA

Pharmacological Actions of Isotretinoina Valeant

Isotretinoina Valeant is the first generation of tretinoin, which is a stereoisomer of all-trans tretinoin. It has anti-greasy influence when taken by mouth, in addition to has unique alleviative result on severe acne. The system of task is as follow:
① It has the functions of minimizing gland, impeding the task of gland, and also minimizing the secretion of gland, for that reason preventing the leisure of Propionibacterium acnes that trusts the development of lipid environment.
② It has anti-keratosis, hinders method too much advancement of skin cells as well as advertises their difference, as well as can decrease keratinization of hair origins orifice as well as sebaceous air duct.
③ It can in addition affect the attribute of monocytes along with lymphocytes, avoid the chemotaxis of neutrophils and additionally have anti-inflammatory task.
④ Precisely bind to retinoic acid nuclear receptors to play a corrective duty. Quits the dispersing of Brevi Corynebacterium acnes, has immunostimulatory result at reduced does, as well as immunosuppressive result at high does.
⑤ It can impede the development of collagenase and also gelatinase in the skin, and can hinder the task of ornithine decarboxylase. Since the induction of ornithine decarboxylase can play a considerable function in skin anomalies, isotretinoin can also prevent tumorigenesis.
⑥ When used in your area, the system of activity of this product appears like that of tretinoin, which can trigger epidermal cell proliferation, advertise the differentiation of epidermal granule layer right into stratum corneum, as well as take care of the horny plug in the uncommon process of pilosebaceous epithelial keratinization, so regarding play a corrective function.

Isotretinoina Valeant Property

Melting point	172-175 °C (lit.)
Boiling point	381.66°C (rough estimate)
density	1.0597 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	-20°C
solubility	Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
pka	4.76±0.33(Predicted)
form	Fine Crystalline Powder
color	Yellow-orange to orange
Water Solubility	insoluble

Clinical Treatment of Isotretinoina Valeant Dermatology

Acne
Acne is a chronic inflammation of hair roots and sebaceous glands, which mainly takes place during puberty and also influences the appearance of the skin. The actual etiology is not very clear, and it may be related to raised secretion of secretory glands, hyperkeratosis of hair roots, uncommon plants as well as swelling. Isotretinoina Valeant can hinder the proliferation of keratinocytes, stop keratin blood clot, prevent sebaceous gland secretion and sebum manufacturing, and also make acne lesions decrease. It can inhibit the secretion of sebum, boost the conversion of thick epithelial cells, as well as turn around unusual keratinization., leading to a reduction in the cohesion of keratinocytes, loosening up and after that naturally eliminating acne, which has a substantial effect on the treatment of acne and has actually become the front runner for acne treatment. Isotretinoina Valeant can control cell spreading, distinction as well as apoptosis in the epidermis, has anti-proliferation, repair work as well as exfoliation results, and also has anti-inflammatory and also immune law results.

Palmoplantar keratosis
The most significant feature of palmoplantar keratoderma is the proportion, diffuse keratosis, and also hypertrophy in the hands as well as soles of the feet. Most of them start from babies, as well as the skin is pale yellow due to hyperkeratosis. General individuals are typically accompanied by hyperhidrosis. Because of keratinization and hypertrophy, chapping is prone to take place in winter season, and also one of the most severe type is mutilated palmoplantar keratoderma. Due to severe keratosis, hypertrophy as well as proliferation, the foot is deformed and also handicapped. Isotretinoina Valeant can bidirectionally regulate the development, differentiation and repair work of epithelial cells as well as other cells, and also normalize the process of keratinization and also distinction; it can normalize the circulation of Langerhans in the skin, and has a straight governing result on the body immune system; Can reduce the movement of neutrophils from the dermis to the skin and also change the attachment in between target cells.

Seborrheic dermatitis
The clinical manifestations of seborrheic dermatitis are scalp itching, oily scales and papules of numerous sizes, and the papules are covered with greasy ranges or scabs, consisting of greasy scalp on the top of the head, modern soft, sporadic hair, and raised shedding. The etiology of seborrheic dermatitis is not totally clear. A lot of research studies think that there is too much seborrhea, accompanied by inflammation second to irregular keratinization of the epithelium of the hair roots orifice. Isotretinoina Valeant prevents the activity of sebaceous glands, reduces sebum secretion, boosts unusual keratinization of epithelial cells, and also has anti-inflammatory effects.

Psoriasis vulgaris
It is normally believed that the mechanism of Isotretinoina Valeant in dealing with psoriasis is: 1. It can stabilize the hyperkeratotic epidermis of psoriasis as well as manage the expansion as well as distinction of the lesioned skin; 2. Trigger macrophages and epidermal Langerhans cells to adjust the sore 3. Decrease the task of polyamine synthetase, to make sure that the biochemical metabolic procedure in the body returns to normal; 4. Prevent keratinocytes, and prevent the DNA and also RNA of epidermal keratinocytes with overactive growth in patients with psoriasis Synthesis, inhibition of vascular endothelial development element, development of cell bond molecules in people.

Main cutaneous amyloidosis
Main cutaneous amyloidosis is an usual metabolic disorder skin disease. Its pathogenesis is not fully recognized, and also it is generally believed to be connected to genes, metabolic problems and also immune responses. Isotretinoina Valeant can manage the mitosis of epidermal cells, hinder the production of keratin, as well as restore the expansion and differentiation of lesioned skin to regular.

Adverse Reactions of Isotretinoina Valeant and How to Deal With Them

1. Acne exacerbation: Temporary exacerbation of acne may occur in the first month of treatment, especially in patients with severe disease, significant acne may require adjustment of treatment. For mild acne, no treatment adjustment is necessary.

2. Skin and mucous membranes: Dry skin and mucous membranes are common during treatment. Especially cheilitis. This can be done with a generous amount of topical emollient, such as petroleum jelly or another lip moisturizer.

Patients with crusted or dry nasal cavity or epistaxis may choose to use saline nasal spray and petroleum jelly to smear the nostrils to improve symptoms. Artificial tears may help relieve symptoms of dry eyes. Try not to wear contact lenses while taking this medicine.

Patients should take sun protection measures to reduce the effects of Isotretinoina Valeant-induced photosensitivity. Patients should use sunscreen with a sun protection factor (SPF) of at least 30 daily and wear protective clothing during sun exposure. Sunscreen should be applied to exposed skin areas before sun exposure and reapplied every two to three hours.

3. Myalgia: Although checking creatine kinase (CK) levels is not recommended in the absence of severe muscle pain, approximately 15% to 50% of patients with isotretinoin-induced myalgia have elevated CK levels. Mild to moderate pain can usually be controlled with anti-inflammatory drugs. Isotretinoin should be discontinued if pain becomes severe or does not improve with anti-inflammatory medications.

4. Laboratory abnormalities—Hypertriglyceridemia, elevated liver transaminases, and elevated CK are common laboratory abnormalities during isotretinoin treatment.

① Hypertriglyceridemia:

Mildly or moderately elevated triglyceride levels (300 to 500 mg/dL) do not require changes in isotretinoin dosage and can be managed with lifestyle changes.

Triglyceride levels between 500 and 800 mg/dL require additional intervention, such as reducing the dose of isotretinoin and/or adding lipid-lowering agents.

Severe hypertriglyceridemia (eg, above 800 mg/dL) may require discontinuation of isotretinoin treatment

② Elevated liver transaminases:

Mild, transient elevations in liver transaminases occur early in treatment in approximately 15% to 20% of patients; levels usually return to normal within a few weeks. If liver transaminase levels reach more than three times normal, it is recommended to discontinue Isotretinoina Valeant

③ Pregnancy:

Despite efforts to minimize the risk of pregnancy during treatment with Isotretinoina Valeant, isotretinoin should be discontinued immediately if pregnancy occurs during treatment. Pregnant patients should be referred for management and counseling to an obstetrician experienced in reproductive toxicity.

④Others:

Management of other extracutaneous adverse reactions of isotretinoin (eg, psychoactive effects, severe ocular symptoms) may require consultation with appropriate specialists to determine the best course of action for the individual patient.

Patients with signs and symptoms suggestive of pseudotumor cerebri (eg, headache with new-onset vision changes) require specialist evaluation and Isotretinoina Valeant should be discontinued.

Isotretinoina Valeant Preparation Method

1. Prepared by reacting C15-phosphonic acid alkyl ester with 5-hydroxy-4-methyl-2-furanone;
2. Preparation by reaction of C15 aldehyde with 3,3-dimethacrylate;
3. It is prepared by condensation reaction of Cl5 aldehyde and diethyl triethylenemalonate and then decarboxylation;
4. Preparation by reaction of C15-triphenyl phosphonium salt with 5-hydroxyl-4-methyl-2-furanone:

About Products:
If you need Isotretinoina Valeant this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Isotretinoina Valeant manufacturer and supplier, our company, ZSpharmac will provide Isotretinoina Valeant raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.