Zhishang Chemical

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Zhishang Chemical


Molecular Formula: C8H14O4

Formula Weight: 174.2


CAS No: 5306-85-4
Purity: 99%

Basic Info

Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Daily Chemical Raw Materials
Appearance:Clear Colorless to Light Yellow Liquid
EINECS No.:226-159-8
Storage:Sealed in Dry,Room Temperature


ISOSORBIDE DIMETHYL ETHER, additionally referred to as dimethyl isosorbide (DMI), 1,4:3,6-dianhydro-2,5-di-O-methyl-D-glucitol. Isosorbide dimethyl ether is an anemic oily fluid in appearance, truly steady under neutral conditions, hygroscopic, and can be miscible with various all-natural solvents, along with is regularly made use of as a solvent.DMI can advertise the penetration of energetic components right into the skin layer of the skin and provide full play to the impact of energetic ingredients. It is generally used in medicines and also cosmetics.


Melting point -70°C
Boiling point 93-95 °C0.1 mm Hg(lit.)
density 1.15 g/mL at 25 °C(lit.)
refractive index n20/D 1.461(lit.)
Fp 227 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
color Clear colorless to light yellow
PH7.0-8.0 (100g/l, H2O, 20℃)
optical activity[α]21/D +96.1°, c = 2 in chloroform
Water Solubility Soluble in water.



  1. ISOSORBIDE DIMETHYL ETHER is a helpful research chemical.
  2. ① ISOSORBIDE DIMETHYL ETHER (DMI) made use of in cosmetics: it can certainly improve the effect of sunscreen, anti-wrinkle, blemish removal, acne elimination, skin care and hydrating, weight-loss, breast enhancement cream, hair growth agent, hair color and various other products. It is a suitable solvent as well as penetrant in the cosmetics market. and also carrier.
    ② Applied in the field of medicine: ointment as well as cast for outside usage. The efficacy of the item is dramatically enhanced.
    ③ Applied to chemicals: It can enhance the penetration of chemicals inside and also outside the pests, enhance the efficacy, and also decrease the resistance of insects; lower using chemicals, decrease the dose, minimize environmental pollution, and also specifically decrease the straight harm of pesticides to people.


ISOSORBIDE DIMETHYL ETHER is acquired by methylation of isosorbide. The utilized methylating reagents are dimethyl sulfate (United States License US4659846 as well as US4322359), dimethyl carbonate (United States Patent US4700871), methyl chloride (United States Patent US4435586 and World Patent WO2007096511).

When synthesizing ISOSORBIDE DIMETHYL ETHER with dimethyl sulfate, the yield can reach more than 70%, and also the highest possible reported in the literature is 83.5%. As we all know, dimethyl sulfate is an extremely harmful chemical, a health hazard, and damaging to the health of operators. When using dimethyl carbonate to manufacture dimethyl isosorbide, the highest possible conversion price of isosorbide is only 89%, and the weight proportion of isosorbide dimethyl ether to monomethyl ether in the product is 59:41. For that reason, dimethyl carbonate is not a suitable beginning product for the synthesis of dimethyl isosorbide.

When manufacturing ISOSORBIDE DIMETHYL ETHER, the solvents used are tert-butanol, acetone, dimethyl sulfoxide, and so on. These solvents have the drawbacks of low boiling point, very easy volatility, problem in solvent healing, environmental pollution and high price of use. Fuertes, Patrick enhanced the solvent in TO2007096511, utilizing the methylated item isosorbide dimethyl ether as the solvent, as well as the return was raised to 95%. However, with ISOSORBIDE DIMETHYL ETHER as solvent, the manufacturing price is reasonably high.

A maximized and also enhanced process for manufacturing ISOSORBIDE DIMETHYL ETHER can not only decrease production expenses, yet also reduce environmental pollution. It is identified because,

Proceed as follows:
( 1) in response vessel, add solvent, isosorbide, alkali as well as phase transfer stimulant;
( 2) mixing, warming up, unwinding and also dehydrating;
( 3) feed right into methyl chloride, total etherification response under particular pressure and also temperature level;
( 4) Add acid to reduce the effects of;
( 5) filtering desalination;

( 6) underpressure purification, acquire item ISOSORBIDE DIMETHYL ETHER as well as recover solvent; The antacids used in reaction is selected from sodium hydroxide, potassium hydroxide or salt methylate; Explained stage transfer stimulant is the stage transfer driver of quaternary ammonium salts, or It is a quaternary phosphonium salt type phase transfer driver; The solvent adopts an alkyl-terminated low-molecular-weight polyether, as well as the architectural formula of the alkyl-terminated low-molecular-weight polyether is:

In the formula R1, R2 are to select the same or various straight-chain or branched alkyl teams; The alkyl group utilized includes 1 ~ 15 carbon atoms; R3, R4 are hydrogen atoms or methyl teams; m+n is an integer of 4 ~ 15.

ISOSORBIDE DIMETHYL ETHER As a Sustainable Green Solvent

ISOSORBIDE DIMETHYL ETHER (DMI) – a well-known bio-based high-boiling eco-friendly solvent – was utilized for the first time to prepare poly(vinylidene fluoride) and also poly(ethersulfone)-based membranes. Preliminary thermodynamic (Hansen and Hildebrand solubility parameters, loved one power difference) and kinetic (viscosity) researches of DMI confirmed that this solvent has the needed physical/chemical properties for casting films. Membranes were prepared by a combination of non-solvent-induced stage separation (NIPS) as well as vapor-phase generated phase separation (VIPS)-NIPS strategies with differing exposure times to humidity. The last approach results in the formation of membranes with a permeable framework, preventing using any kind of pore-forming additives. The membranes thus prepared were after that fully identified in regards to morphology, polymorphism (in the case of PVDF), wettability, density, porosity, pore size and water leaks in the structure. These membranes show various structures and also tunable pore dimensions in the ultrafiltration (UF) and microfiltration (MF) varies, making them perfect for water treatment process applications.

Co-Diffusion of Propylene Glycol And ISOSORBIDE DIMETHYL ETHER in Mouse Skin

The in vitro transdermal changes of propylene glycol (PG), cis-oleic acid (OA), as well as ISOSORBIDE DIMETHYL ETHER (DI) were determined and their results on nifedipine (N) flux as well as lag time were examined. PG, OA, and DI changes via hairless computer mouse (HM) skin were determined artificial insemination by beta scintigraphy, and N permeation was measured by HPLC under finite and limitless dosage problems.Individual evaluation of each solvent showed that pure DI has an inherent ability to penetrate the skin (12% over 24 hours). For the test formulation after 24 hours, 57% PG and 40% DI penetrated into the skin with an almost linear penetration between 4 and 18 hours, in a relative order of PG > DI > N. DI penetration was further aided by the presence of PG and OA. The N flux depends on the accompanying solvent permeation.

DMI As a Bio-Derived Solvent For Pd-Catalyzed Cross-Coupling Reactions

Palladium-catalyzed bonding responses, such as the Suzuki-Miyaura and also Mizoroki-Heck reactions, are some of the most utilized responses in the chemical sector. These responses commonly utilize hazardous solvents; nonetheless, in order to abide by boosting sustainability pressures and restrictions on making use of such solvents, there is a strong demand for choices. Right here, we demonstrate the utility of dimethylisosorbide (DMI) as a bio-derived solvent in numerous benchmark Pd-catalyzed reactions: Suzuki-Miyaura (13 examples, 62-100% yield), Mizoroki-Heck (13 instances, 47-91% yield) as well as Sonogashira (12 instances, 65-98% return).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.