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Isopropylparaben CAS 4191-73-5

Molecular Formula: C10H12O3

Formula Weight: 180.2

ZSpharmac: Isopropylparaben Raw Material Supplier

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Product Name: Isopropylparaben
CAS No: 4191-73-5
Purity: 99%

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Basic Info

Product Name:Isopropylparaben
Other Names:Isopropyl Paraben
CAS:4191-73-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:224-069-3
Storage:Sealed in Dry,2-8°C
Provide:Isopropylparaben MSDS;
Isopropylparaben COA

What is Isopropylparaben?

Isopropyl 4-hydroxybenzoate is a carboxylic acid ester derivative that has a wide range of applications. It can be used in soy sauce, vinegar, soft drinks (except soda), fruit flavorings, fruits and vegetables, pickled products, and more. Additionally, it is commonly used in the food and cosmetics industries, as well as in pharmaceuticals as an antiseptic, antifungal agent, and fungicide.

Isopropylparaben Property

Melting point 84-86°C
Boiling point 160 °C / 5mmHg
density 1.132±0.06 g/cm3(Predicted)
vapor pressure 0.155Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility Soluble in Chloroform, Ethyl Acetate.
form powder to lump
pka8.40±0.15(Predicted)
color White
Water Solubility 1.204g/L

 

Isopropylparaben Uses

  1. Isopropyl 4-hydroxybenzoate, also known as isopropyl paraben, is commonly used in combination with isopropyl ester, butyl ester, and other compounds as an oil-in-water emulsifier. It has a higher solubility compared to pure butyl ester, making it easy to use in soy sauce.
  2. Isopropyl paraben, similar to butyl paraben, can function as a food preservative and antifungal agent. In Japan, six types of parabens are permitted for use, including ethyl, propyl, isopropyl, butyl, isobutyl, and other butyl. Among these, butyl paraben has the strongest antibacterial effect. Generally, parabens with a higher number of carbon atoms in the alcohol component of the ester exhibit stronger antibacterial properties. However, they also tend to have higher toxicity. Isopropyl paraben demonstrates inhibitory or killing effects on various molds and yeasts, and is relatively unaffected by pH. Its use is restricted to soy sauce, vinegar, soft drinks, sherbet, fruit sauce, and fruits and vegetables (limited to the skin part). The recommended dosage is 1.4 times that of parahydroxybenzoic acid.

Isopropylparaben Preparation Method

There are numerous domestic reports detailing the preparation of Isopropylparaben, most of which involve the use of p-hydroxybenzoic acid and isopropyl alcohol in the presence of sulfuric acid. However, the product content and yield of such a synthetic route are very low. This is due to the large steric hindrance of isopropyl alcohol, making it difficult to dehydrate into ester using ordinary catalysts and p-hydroxybenzoic acid. Additionally, this type of reaction is reversible, leading to low synthesis efficiency, low yield, and high production cost.

A new method for the preparation of Isopropylparaben is characterized by the following steps:

A. Isopropyl alcohol is placed into a reaction kettle equipped with a stirring device, a condensing device, and a freezing device, and stirred and frozen.

B. Thionyl chloride is added dropwise to the frozen isopropyl alcohol while stirring continuously and controlling the reaction temperature to remain low. The total amount of thionyl chloride added is: eta isopropyl alcohol: n thionyl chloride = 1:0.2-1:0.3. After the dropwise addition is completed, the freeze is removed, and stirring is continued for 2-3 hours. The chemical equation of the reaction between isopropyl alcohol and thionyl chloride at low temperature is as shown in formula (I).

1.jpg

C. P-hydroxybenzoic acid is added to the reaction kettle, with n isopropyl alcohol: n p-hydroxybenzoic acid = 1:0.18-1:0.20. The mixture is stirred at room temperature for 3-5 hours, slowly heated to reflux, and stirred in the reflux state for 5-6 hours. The reaction is stopped when the sampling HPLC detects that the conversion rate reaches more than 85%. The reaction equation for this step is as shown in formula (II).

2.jpg

D. Pure water is added to the reaction kettle, and the temperature is raised to 80°C. The liquids are separated while hot, and the lower oil is separated. The oil is kept warm and toluene is added to completely dissolve it. The amount of toluene added is eta isopropyl alcohol: n Toluene=1:0. 1-1:0. 12.

E. The solution obtained in step D undergoes crystallization and recrystallization operations until the purity of the crystallized product of isopropyl parahydroxybenzoate is qualified. The qualified product is air-dried below 65°C. The stirring temperature in step A ranges from freezing to no higher than 0°C. The low temperature state described in step B is to keep the reaction temperature no higher than 5°C. The temperature rise rate from slowly heating to reflux in step C is 1°C/min.

Contact Us

About Products:
If you need the cosmetic raw material Isopropylparaben, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Isopropylparaben manufacturer and supplier, ZSpharmac will provide Isopropylparaben raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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