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Zhishang Chemical

Isopropylparaben CAS 4191-73-5

Molecular Formula: C10H12O3

Formula Weight: 180.2

ZSpharmac: Isopropylparaben Supplier

Product Name: Isopropylparaben
CAS No: 4191-73-5
Purity: 99%

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Basic Info

Product Name:Isopropylparaben
Other Names:Isopropyl Paraben
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder to Lump
EINECS No.:224-069-3
Storage:Sealed in Dry,2-8°C
Provide:Isopropylparaben MSDS;
Isopropylparaben COA

What is Isopropylparaben?

Isopropylparaben is a carboxylic acid ester derivative, which can be used in soy sauce, vinegar, soft drinks (except soda), fruit flavoring, fruits and vegetables, pickled products, etc., and is also widely used in food, cosmetics, and medicine for antiseptic and anti-mold Agents and fungicides and other fields.

Isopropylparaben Property

Melting point 84-86°C
Boiling point 160 °C / 5mmHg
density 1.132±0.06 g/cm3(Predicted)
vapor pressure 0.155Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility Soluble in Chloroform, Ethyl Acetate.
form powder to lump
color White
Water Solubility 1.204g/L


Isopropylparaben Uses

Seldom used alone, commonly combined with isopropyl ester, butyl ester, etc, as an oil-in-water emulsifier. Contrasted to the solubility of pure butyl ester, the solubility is enhanced by 2 to 3 times. Easy to use in soy sauce.

Like Isopropylparaben, it can be capitalized on as a food chemical along with additionally antifungal representative. Presently, there are 6 type of Isopropylparaben permitted to be used in Japan, including ethyl ester, propyl ester, isopropyl ester, butyl ester, isobutyl ester along with an extra butyl ester, among which butyl ester has the most effective anti-bacterial result. Generally speaking, the larger the selection of carbon atoms of the alcohol making up the ester, the more powerful the anti-bacterial outcome, while the poisoning is in comparison, the smaller sized the variety of carbon atoms, the much better the poisoning. This item has repressive or getting rid of outcomes on various mold as well as mildew and mold and mildews along with yeasts, in addition to is not influenced by pH. It is limited to soy sauce, vinegar, sodas, sherbet, fruit sauce, fruit as well as also veggies and additionally fruits (restricted to the skin part). The dose is 1.4 times that of p-hydroxybenzoic acid.

Preparation Method of Isopropylparaben

There are many kinds of Isopropylparaben that have been reported in China, most of which use p-hydroxybenzoic acid and isopropanol to react under the action of sulfuric acid. The content of the product made by such synthetic route product is very low, and the yield is also very low, because the steric hindrance of isopropanol is very large, it is difficult to dehydrate and form ester with common catalyst and p-hydroxybenzoic acid. At the same time, this type of reaction is a reversible reaction, with low synthesis efficiency, low yield and high production cost.

A kind of preparation method of Isopropylparaben is characterized in that: the preparation method of described isopropyl p-hydroxybenzoate comprises the steps:

A, drop into isopropanol in the reactor that is provided with stirring device, condensing device and freezing device, stirs and freezes;

B, in the isopropanol after freezing, add thionyl chloride dropwise, keep stirring and control the reaction temperature to be in a low temperature state all the time, the total amount of thionyl chloride added dropwise is: n isopropanol: n thionyl chloride= 1:0.2-1:0.3, after the dropwise addition, remove the freezing, and keep stirring for 2-3 hours, the chemical equation of isopropanol and thionyl chloride reacting at low temperature is as shown in formula (I);


C, add p-hydroxybenzoic acid in the reactor, n isopropanol:n p-hydroxybenzoic acid=1:0.18-1:0.20, stir at room temperature for 3-5 hours, slowly warming up to reflux, And keep stirring under the reflux state for 5-6 hours, and the sampling HPLC detects that when the conversion rate reaches more than 85%, the reaction is terminated, and the reaction equation of this step is as shown in formula (II);


D. Add pure water to the reaction kettle, heat up to 80°C, separate the oil while it is hot, separate the lower layer of oil, keep warm and add toluene to the oil to completely dissolve the oil. The amount of toluene added is η isopropanol: n Toluene=1:0.1-1:0.12;

E, carry out crystallization and recrystallization operation to the solution that step D obtains, until the crystallization product purity of isopropyl p-hydroxybenzoate is qualified, qualified product is blast-dried below 65 ℃; The stirring temperature of step A is freezing to not Higher than 0°C; The low-temperature state described in step B is to keep the reaction temperature no higher than 5°C; Slowly warming up to reflux in step C is 1°C/min.

About Products:
If you need Isopropylparaben, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Isopropylparaben manufacturer and supplier, ZSpharmac will provide Isopropylparaben raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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