( 1) Twenty-five grown-up subjects of unidentified age, sex, and also race participated in a photocontact allergy research of a bathroom oil having 45.6% isopropyl palmitate. Repeat application of 5 uL/sq centimeters of unmixed examination product two times a week for an overall of six applications. The examination website was hugged for 1 day after each application, and also the location was irradiated with a xenon solar simulator (25-30 mW/sq cm) after each patch was gotten rid of. Irradiation difficulty application was carried out 10 days after the last induction exposure. No examples of photocontact sensitization were reported, and also it was wrapped up that the formulation “is not likely to provide a danger of photocontact sensitization under normal conditions of use”
( 2) A phototoxicity research study of a bath oil formula having 45.6% isopropyl palmitate was carried out in 10 typical grown-up topics of unreported age, sex, and skin color. Apply 5 uL/sq cm of unmixed examination material under the occlusive spot and irradiate the application website with a xenon solar simulator (25-30 mW/sq cm) after 6 and also 24-hour of exposure. No phototoxic events were reported. It was ended that the solution “is not likely to offer a risk of phototoxicity under normal expected problems of use”.
( 3) Kligman’s customized maximization treatment was utilized on 25 based on evaluate unmixed examples of bath oil formulas having 45.6% isopropyl palmitate. All patch tests were negative, as well as it was concluded that “on the maximum range, the product would be taken into consideration a weak potential sensitizer at the lowest level and also is not likely to present a risk of contact sensitization under regular anticipated conditions of use. “.
( 4) 102 men and women of undefined race participated in a customized Draize-Shelanski duplicated disrespect patch test to figure out the inflammation and sensitization capacity of isopropyl palmitate. Spread approximately 0.1 mL of pure isopropyl palmitate on a 20 x 20 mm absorptive nonwoven cotton fabric as well as attach it to the upper back with an adhesive tape. The spot is utilized 3 times a week for 3 weeks and also is left on for 24-hour in between each application. Reactions were scored on a 0-4 irritation scale 24 hr after spot elimination. Test products underwent a 24-hour difficulty application 17 days after the last induction patch was eliminated; difficulty reactions were graded 24 and 48 hours after these applications were eliminated. After the second stimulated injury, the erythema was hardly noticeable in three topics. All other ratings for the induction and also difficulty stages were 0.0, wrapping up that isopropyl palmitate did not display the potential to cause sensitive sensitization.