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Isopentanoic Acid CAS 503-74-2

Molecular Formula: C5H10O2

Formula Weight: 102.13

ZSpharmac: Isopentanoic Acid Supplier

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Product Name: Isopentanoic Acid
CAS No: 503-74-2
Purity: 99%

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Basic Info

Product Name:Isopentanoic Acid
Other Names:Isovaleric Acid
CAS:503-74-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Slightly Yellow Liquid
EINECS No.:207-975-3
Storage:Store Below +30°C.
Provide:Isopentanoic Acid MSDS;
Isopentanoic Acid COA

What is Isopentanoic Acid?

Isopentanoic Acid is additionally called 3-methylbutanoic acid. All-natural products are discovered in vital oils such as valerian oil, vanilla oil, hop oil, bay fallen leave oil in addition to spearmint oil, in addition to lemon leaf as well as also cigarette. There is an unfavorable rancid fragrance, as well as perspiring touching smell. Anemic thick fluid. Such one molecular mass is 102.13. The relative thickness is 0.9286. Melting point -29.3 ° C. The boiling point is 176.7 ° C. Refractive index 1.4033. The flash point is 70 ° C. Soluble in water (1/24), ethanol, ether, chloroform. Computer system computer mice were instilled with LD501150mg/kg percutaneously.
Isopentanoic Acid is an essential resources for the production of preference isovalerate, which exists in valerian oil and also moreover jump oil. Fundamental solution manufacturing generally manages phase transfer catalysis along with fractional oxidation to prepare isovaleric acid, nonetheless these 2 techniques require making use of heavy metal salts, which will absolutely pollute the setup. As a result of this, it is of remarkable relevance to choose the environmentally friendly alcohol oxidation synthesis program. Utilizing O2 as an oxidant to execute alcohol oxidation under the task of an energizer has the advantages of high atom use as well as no injury to the atmosphere. Pd-based, Ru-based in addition to numerous various other routine stimulants have actually truly been reported for the oxidation of alcohols.However, this treatment requests to be done under all-natural solvents in addition to furthermore high pressure problems, which calls for high manufacturing troubles. At the same time, uniform cars and truck motorists have drawbacks such as hard dividing along with furthermore healing.

Isopentanoic Acid Property

Melting point 

-29 °C (lit.)

Boiling point 

175-177 °C (lit.)

density 

0.925 g/mL at 20 °C (lit.)

vapor pressure 

0.38 mm Hg ( 20 °C)

refractive index 

n20/D 1.403(lit.)

Fp 

159 °F

storage temp. 

Store below +30°C.

solubility 

48g/l

pka

4.77(at 25℃)

form 

Liquid

Specific Gravity

0.928 (20/20℃)

color 

Clear colorless to slightly yellow

PH

3.92(1 mM solution);3.4(10 mM solution);2.89(100 mM solution);

Odor

at 1.00 % in propylene glycol. sour stinky feet sweaty cheese tropical

Odor Type

cheesy

explosive limit

1.5-6.8%(V)

Water Solubility 

25 g/L (20 ºC)

 

Isopentanoic Acid Uses

  1. Isopentanoic Acid is a food flavor that is enabled to be used according to GB 2760– 1996. It is primarily used in the preparation of cheese and also lotion tastes, and is additionally used in small amounts in fruit flavors.
  2. Isopentanoic Acid is a basic material for the production of esters used in fragrances, fragrances, plasticizers as well as lubricating substances.
  3. Isopentanoic Acid is utilized in the manufacture of the sedative-hypnotic medication bromisovaleride. However more for the manufacturing of seasonings (accountancy for 80% of the complete deboil in Japan). Isovaleric acid esters utilized as flavors mostly consist of hexyl isovalerate, propyl isovalerate, isopentyl isovalerate, geranyl isovalerate, benzyl isovalerate as well as cinnamyl isovalerate. Low-level isovaleric acid esters are utilized as food flavors, and top-level isovaleric acid esters are made use of in cosmetics.It is mainly utilized in the prep work of cheese and cream tastes, as well as is additionally utilized in small amounts in fruit tastes.

Isopentanoic Acid Application

Isopentanoic Acid has a pungent rancid preference, extremely weakened fruity, sweet as well as lingonberry-like scent. Isovaleric acid is naturally present in valerian oil, vanilla oil, hop oil, bay fallen leave oil, spearmint oil, etc, and also is allowed to be made use of in edible flavors in my nation’s national criterion. Isovaleric acid is not only utilized in the prep work of cheese as well as lotion flavors, but additionally in small amounts in the prep work of fruit flavors. It can likewise be utilized in the manufacture of medications, spices, spices, and so on. Can additionally be used in baked goods, meat products.

Isopentanoic Acid is made use of in the manufacturing of sedative and also hypnotic bromoisovaleryl urea, yet it is much more used in the manufacturing of scents. The isovaleric acid esters made use of in fragrances mainly consist of hexyl isovalerate, propyl isovalerate, and isopentyl isovalerate, geranyl isovalerate, benzyl isovalerate and also cinnamyl isovalerate. Low-level isovaleric acid esters are made use of as food flavors, and high-level isovaleric acid esters are used in cosmetics. Isovaleric acid is naturally existing in valerian oil, vanilla oil, hop oil, bay leaf oil, spearmint oil, and so on, and is stated in the Chinese nationwide basic GB2760-86 as an edible flavor that is allowed to be made use of. For fruit tastes.

In addition, Isopentanoic Acid can also be utilized as a pharmaceutical synthesis intermediate, such as for the synthesis of bromisoval, the very first step: isovaleric acid responds with bromine under the catalysis of phosphorus tribromide to generate α-bromoisovaleric acid; The 2nd step: after the very first step response, the item is directly pushed into the acid bromide container without separation, and phosphorus tribromide as well as bromine are included in continue the reaction to generate α-bromoisovaleryl bromide., Distilling under lowered stress and also elevating temperature to collect 85-95 ° C/20 -30 mmHg portions to obtain α-bromoisovaleryl bromide; the third step: condense α-bromoisovaleryl bromide with urea to obtain bromisoval.

It can additionally be utilized to prepare mesogenic 2,3-diisopropylsuccinic acid. The method is as follows: After treating isovaleric acid with lithium diisopropylamide under air conditioning, it is reacted with titanium tetrachloride, acidified, drawn out, Concentrated as well as washed. The invention shortens the speculative actions, saves the response time as well as substantially improves the synthesis effectiveness.

Additionally, in order to examine the results of Isopentanoic Acid on the development performance, growth axis hormone receptor mRNA and lotion indications of calf bones before discouraging, 39 15-day-old calves with normal advancement and also similar body weight (45.09 ± 0.90 kg) were chosen for the test. At the same age, 3 pigs were randomly chosen for slaughtering and tasting, and the staying 36 pigs were randomly split into 4 groups, 9 pigs in each group. Valeric acid (that is, LIV group, MIV group and also HIV team) was slaughtered and sampled at 30, 60 and also 90 days old, specifically.

The test results showed that: at 15 days of age as well as 60 days of age, there was no substantial difference in body weight of calves in the examination group (P > 0.05); at thirty day of age and also 90 days old, the body weight of calves in the HIV team was considerably greater than that of the control group, LIV group as well as MIV group (P<0.05); at 15-30 days old, the typical day-to-day gain of calf bones in MIV team as well as HIV team was dramatically greater than that of the control team and LIV team (P<0.05); There was no significant difference in average daily gain (P>0.05); at 60 to 90 days of age, the typical day-to-day gain of calf bones in LIV group, MIV group as well as HIV team was considerably higher than that in the control team (P<0.05), but the LIV group, MIV group and HIV were not significantly different (P><0.05), however the LIV team, MIV team and HIV were not significantly various (P > 0.05 ); at 60 days and also 90 days of age, MIV team and HIV team calf body height, body oblique size, upper body girth, breast deepness, chest width, midsection angle size Dramatically higher than the control group and also LIV group(P<0.05). There were no significant differences in ischial end width, rump size, as well as canal circumference between the examination teams (P > 0.05); the change guidelines of nutritional CP, EE, CF, ADF, and NDF digestibility coincided, and the MIV team as well as HIV group were significantly greater than the control team (P<0.05), and there was no significant difference between the two groups (P><0.05), and also there was no considerable difference between both teams (P > 0.05), and also there was no substantial difference in between the LIV team as well as the control team(P > 0.05); GH, INS, IGF-1 receptor mRNA in liver and muscle mass cells The expression was significantly boosted( P<0.05), as well as there was no considerable distinction between MIV
group as well as HIV group( P > 0.05). Compared to the control team, the expression of MSTN receptor mRNA in the LIV group, MIV group and HIV group was considerably lowered (P<0.05), but there was no significant difference between the LIV group, MIV group and HIV group (P><0.05), yet there was no significant distinction between the LIV group, MIV team as well as HIV team(P > 0.05); as well as HIV team serum signs(Glu, Alb, BUN, LA, GOT, GPT, AKP, GH, INS, IGF-I). Dramatically higher than the control team<0.05), but the difference between the MIV group and HIV was not significant (P>(P < 0.05 ), however the difference in between the MIV team as well as HIV was not substantial(P > 0.05); There was no substantial distinction in serum TCH of calf bones in the speculative team (P > 0.05); compared with the control group, the changes in muscle fat, healthy protein, and eye muscle mass location were not significantly various (P > 0.05). Based upon the above evaluation, the optimum dose of Isopentanoic Acid is 6g/d.

Preparation of Isopentanoic Acid

A kind of synthetic method of medicine intermediate Isopentanoic Acid, comprises the steps:

i) Add 2mol of 1-chloro-3-isopropylacetone and 4-5mol of dimethyl carbonate solution in the reaction vessel, control the stirring speed at 110-140rpm, increase the solution temperature to 30-40°C, and then add 3 -4mol of manganese chloride, react for 70-90min, add 900ml potassium chloride solution, lower the solution temperature to 20-25°C, add potassium bisulfate solution to adjust the pH to 4-5, let stand for 50-70min, the solution is layered, Wash with methyl carbitol solution, methylhydrazine solution, recrystallize in 1-methylpiperazine solution, and dehydrate with dehydrating agent to obtain finished isovaleric acid.

Wherein, the dimethyl carbonate solution mass fraction described in step (i) is 70-76%, the potassium chloride solution mass fraction described in step (i) is 10-16%, the hydrogen sulfate described in step (i) The potassium solution mass fraction is 20-25%, the methyl carbitol solution mass fraction described in step (i) is 60-68%, the methylhydrazine solution mass fraction described in step (i) is 80-87%, The mass fraction of the 1-methylpiperazine solution in the step (i) is 90-95%. The whole reaction process can be represented by the following reaction formula:

About Products:
If you need Isopentanoic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Isopentanoic Acid manufacturer and supplier, ZSpharmac will provide Isopentanoic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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