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Zhishang Chemical

Isopentanoic Acid CAS 503-74-2

Molecular Formula: C5H10O2

Formula Weight: 102.13

ZSpharmac: Isopentanoic Acid Supplement

Product Name: Isopentanoic Acid
CAS No: 503-74-2
Purity: 99%

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Basic Info

Product Name:Isopentanoic Acid
Other Names:Isovaleric Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Slightly Yellow Liquid
EINECS No.:207-975-3
Storage:Store Below +30°C.
Provide:Isopentanoic Acid MSDS;
Isopentanoic Acid COA

What is Isopentanoic Acid?

Isopentanoic Acid is also known as 3-methylbutyric acid. Natural products are found in essential oils such as valerian oil, vanilla oil, hop oil, bay leaf oil, and spearmint oil, as well as lemon leaf and tobacco. Has an unpleasant rancid odor and an irritating odor of sweat. Colorless viscous liquid. The relative molecular mass is 102.13. The relative density is 0.9286. Melting point -29.3 ℃. Boiling point 176.7 ℃. Refractive index 1.4033. Flash point 70 ℃. Soluble in water (1/24), ethanol, ether, chloroform. Mice were injected with LD501150mg/kg percutaneously.

Isopentanoic Acid is an important raw material for the production of spice isovalerate, which exists in valerian oil and hop oil. Traditional industrial production often adopts phase transfer catalysis method and stepwise oxidation method to prepare isovaleric acid, but these two methods both require the use of heavy metal salts, which will cause environmental pollution. Therefore, it is of great significance to select green alcohol oxidative synthesis pathways. Using O2 as oxidant to carry out alcohol oxidation under the action of catalyst has the advantages of high atomic utilization rate and no harm to the environment. Homogeneous catalysts such as Pd series and Ru series have been reported for the oxidation of alcohols, but this process needs to be carried out under organic solvents and high pressure conditions, which requires high production conditions, and at the same time, homogeneous catalysts have disadvantages such as difficulty in separation and recovery.

Isopentanoic Acid Property

Melting point 

-29 °C (lit.)

Boiling point 

175-177 °C (lit.)


0.925 g/mL at 20 °C (lit.)

vapor pressure 

0.38 mm Hg ( 20 °C)

refractive index 

n20/D 1.403(lit.)


159 °F

storage temp. 

Store below +30°C.




4.77(at 25℃)




Clear colorless to slightly yellow

Specific Gravity

0.928 (20/20℃)


3.92(1 mM solution);3.4(10 mM solution);2.89(100 mM solution);

explosive limit


Water Solubility 

25 g/L (20 ºC)


Isopentanoic Acid Uses

  1. Isopentanoic Acid is an allowed edible seasoning defined in GB 2760– 1996. Mostly utilized to prepare cheese as well as lotion tastes, and also used in a percentage for fruit flavors.
  2. Isopentanoic Acid is utilized in the manufacturing of the sedative-hypnotic drug bromoisovaleryl urea. Yet extra made use of in the manufacturing of flavors (80% of the overall usage in Japan). The reduced isovalerates are utilized as food flavorings, and the higher isovalerates are used in cosmetics. Mainly made use of to prepare cheese and also lotion tastes, and additionally made use of in a small amount for fruit tastes.
  3. Isopentanoic Acid is the raw product for the production of esters made use of in perfumes, fragrances, plasticizers and lubes.

Isopentanoic Acid Application

Isopentanoic Acid has a pungent rancidity taste, and when extremely weakened, it has a wonderful fruity aroma and also a lingonberry-like aroma. Isovaleric acid normally exists in valerian oil, vanilla oil, jump oil, bay fallen leave oil, spearmint oil, and so on, which are enabled to be utilized in edible flavors in my country’s nationwide requirement. In addition to being used to create cheese as well as cream tastes, isovaleric acid is utilized in trace amounts in the formula of fruit tastes. It can additionally be used in the manufacture of medication, seasonings, spices, and so on. It can likewise be used for baked goods as well as meat products.

Isopentanoic Acid is utilized in the manufacturing of sedative as well as hypnotic bromisovaleryl urea, however it is a lot more utilized in the manufacturing of fragrances. The isopentanoic acid esters used as fragrances are primarily hexyl isovalerate, propyl isovalerate, and also isopentyl isovalerate., geranyl isovalerate, benzyl isovalerate and also cinnamyl isovalerate. The lower isovalerates are made use of as food flavors, and also the higher isovalerates are used in cosmetics. Isovaleric acid is naturally present in valerian oil, vanilla oil, jump oil, bay fallen leave oil, spearmint oil, etc. The Chinese nationwide typical GB2760-86 states that it is an allowed edible seasoning. It is generally utilized to prepare cheese and lotion tastes, and likewise trace amounts. For fruit flavors.

On top of that, Isopentanoic Acid can also be used as an intermediate in pharmaceutical synthesis, such as for the synthesis of bromisoval. The initial step: Isopentanoic Acid reacts with bromine under the catalysis of phosphorus tribromide to create α-bromoisovaleric acid; Two actions: after the primary step is finished, the item is directly pushed right into the acyl bromide tank without splitting up, phosphorus tribromide and bromine are added, and the response is continued to produce α-bromoisovaleryl bromide. After the reaction is completed, The 85-95 ° C/20 -30 mmHg fraction is accumulated by purification under decreased pressure and also temperature to get α-bromoisovaleryl bromide; the 3rd step: α-bromoisovaleryl bromide is condensed with urea to acquire bromisoval.

It can additionally be used to prepare meso-2,3-diisopropyl succinic acid, the method is as adheres to: under cooling, the isovaleric acid is treated with lithium diisopropylamide, after that responded with titanium tetrachloride, acidified, drawn out, Concentrated and washed. The invention reduces the speculative steps, conserves the reaction time, and significantly enhances the synthesis performance.

On top of that, in order to examine the impact of Isopentanoic Acid on the development efficiency, growth axis hormone receptor mRNA and serum indexes of calves prior to discouraging, 39 15-day-old calf bones with regular development as well as similar body weight (45.09 ± 0.90 kg) were selected for the experiment. At the age of three animals, 3 pets were randomly chosen for slaughter tasting, and the remaining 36 pets were arbitrarily separated into 4 teams with 9 animals in each group. Valeric acid (ie, LIV group, MIV team and also HIV group) were slaughtered and also tasted at 30, 60, and 90 days old, specifically.

The test results showed that: at the age of 15 days as well as 60 days, there was no significant distinction in the body weight of the calf bones in the experimental group (P > 0.05); at the age of 30 days as well as 90 days, the body weight of the calf bones in the HIV team was substantially higher than that in the control group, LIV group and the control group. MIV team (P<0.05); 15-30 days old, the ordinary daily gain of calf bones in MIV group and also HIV group was substantially greater than that in control team and also LIV group (P<0.05); 30-60 days old, calf bones in experimental team The typical daily gain of calves in the LIV group, MIV group as well as HIV group was substantially greater than that of the control group (P<0.05), however the LIV group had substantially greater typical everyday weight gain (P<0.05)., MIV group and HIV were not significantly different (P>0.05); at the age of 60 and 90 days, the body elevation, body oblique size, upper body circumference, breast depth, upper body size as well as waist angle width of calves in the MIV team and HIV group were not substantial (P > 0.05). Substantially higher than the control group and LIV group (P<0.05).

There was no significant difference in the width of the ischial tip, the length of the rib and the circumference of the tube between the test groups (P><0.05). There was no substantial distinction in the size of the ischial tip, the length of the rib as well as the circumference of television in between the examination groups(P > 0.05 ); the changes in the digestibility of nutritional CP, EE, CF, ADF and also NDF coincided, and the MIV<0.05), and there was no significant difference between the two groups (P>team and also HIV group were substantially more than the control group( P > 0.05). P<0.05), and also there was no substantial distinction between both groups (P > 0.05 ), and there was no significant difference in between the LIV team and also the control team(P > 0.05); GH, INS, IGF-1 receptor mRNA in liver and also muscle cells The expression boosted considerably (P< 0.05), and there was no substantial difference in between MIV group and also HIV group (P > 0.05). Compared with the control group<0.05), but there was no significant difference between LIV group, MIV group and HIV group (P>, the expression of MSTN receptor mRNA in LIV team, MIV group and HIV team was substantially lowered(P<0.05), yet there was no considerable difference in between LIV group, MIV team and HIV group(P > 0.05 ); MIV group and HIV team serum indexes(Glu, Alb, BUN, LA, GOT, GPT, AKP, GH, INS, IGF-I )were dramatically greater than those in the control group (P < 0.05), but there was no significant difference in between the MIV group as well as HIV (P > 0.05); there was no considerable distinction in lotion TCH of calves in the examination group( P > 0.05 ); compared with the control team, there was no substantial difference in the changes of muscular tissue fat, healthy protein and eye muscular tissue area (P > 0.05). Based on the above analysis, the maximum dose of Isopentanoic Acid is 6g/d.

Preparation of Isopentanoic Acid

A synthetic method of pharmaceutical intermediate Isopentanoic Acid, comprising the steps:

i) 2mol of 1-chloro-3-isopropylacetone, 4-5mol of dimethyl carbonate solution were added in the reaction vessel, the stirring speed was controlled at 110-140rpm, the temperature of the solution was increased to 30-40°C, and then 3 -4mol of manganese chloride, react for 70-90min, add 900ml potassium chloride solution, reduce the solution temperature to 20-25 ° C, add potassium hydrogen sulfate solution to adjust pH to 4-5, leave standstill for 50-70min, the solution is layered, It is washed with methyl carbitol solution, washed with methyl hydrazine solution, recrystallized in 1-methyl oxazine solution, dehydrated with dehydrating agent, and the finished product isovaleric acid is obtained.

Wherein, the described dimethyl carbonate solution mass fraction of step (i) is 70-76%, the described potassium chloride solution mass fraction of step (i) is 10-16%, the described hydrogen sulfate of step (i) The mass fraction of potassium solution is 20-25%, the mass fraction of methyl carbitol solution described in step (i) is 60-68%, and the mass fraction of methyl hydrazine solution described in step (i) is 80-87%, The mass fraction of the 1-methyloxazine solution described in step (i) is 90-95%. The whole reaction process can be represented by the following reaction formula:

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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