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Zhishang Chemical

Isoliquiritigenin Supplement CAS 961-29-5

Molecular Formula: C15H12O4

Formula Weight: 256.25

ZSpharmac: Isoliquiritigenin Supplement Supplement

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Product Name: Isoliquiritigenin Supplement
CAS No: 961-29-5
Purity: 99%

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Basic Info

Product Name:Isoliquiritigenin Supplement
Other Names:Isoliquiritigenin
CAS:961-29-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow to Orange Powder
EINECS No.:607-884-2
Storage:2-8°C
Provide:Isoliquiritigenin Supplement MSDS;
Isoliquiritigenin Supplement COA

What is Isoliquiritigenin Supplement ?

Isoliquiritigenin Supplement is a chalcone that has been shown to have interesting biological properties, including antioxidant, anti-inflammatory, antiviral, antidiabetic, antispasmodic and antitumor activity, due to its ability to affect Th2-mediated inflammation, chalcone Ketones exhibit anti-asthmatic properties in vitro by inhibiting the production of IL-4 and IL-5, by inhibiting memory Th2 responses and antigen-induced Th2 inflammation.

Isoliquiritigenin Supplement Properties:

Melting point 206-210°C
Boiling point 504.0±42.0 °C(Predicted)
density 1.384±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: <0.1 mg/mL
pka7.50±0.35(Predicted)
form powder
color yellow to orange

 

Isoliquiritigenin Supplement Uses

  1. Isoliquiritigenin Supplement is a soluble guanylate cyclase activator. Has antitumor activity.
  2. Isoliquiritigenin Supplement is used as cosmetic auxiliary, food additive, etc.
  3. Isoliquiritigenin Supplement, a flavonoid found in licorice and several other plants, has antioxidant, anti-inflammatory, and antitumor activity, as well as protecting the liver from steatosis and chemical oxidative stress. A phase II enzyme that inactivates free radicals and electrophiles at a concentration that requires a double activity (CD) value of 1.8 in mouse hepatomas.

Effects of Isoliquiritigenin Supplement on Ovarian Cancer Cells

Background: Ovarian cancer is just one of the most lethal gynecological hatreds, and also most clients are identified at an innovative stage because of dangerous beginning and lack of early-onset specific signs and symptoms. Previous researches have actually revealed that ILQ is an appealing dental cancer chemopreventive agent.

Products and Methods: Ovarian cancer cells cell lines SKOV3 and also OVCAR3 were treated with various concentrations of ILQ to detect the dose-dependent effect of Isoliquiritigenin Supplement as well as pick the appropriate focus. CCK8 assay and clone formation efficiency assay were used to detect stability and also expansion. Cell movement, intrusion and also apoptosis were examined by wound-healing assays, transwell as well as flow cytometry assays. Western blot also discovered the expression of apoptosis-related healthy proteins (Caspase-3, Caspase3-p17, Bcl-2, Bax and also Bim) as well as relevant signaling path healthy proteins.

Outcomes: Treatment with Isoliquiritigenin Supplement was observed to inhibit the survival and also expansion of SKOV3 and OVCAR3 cells. ILQ treatment prevents migration and intrusion, as well as induces apoptosis in SKOV3 as well as OVCAR3 cells. Furthermore, Isoliquiritigenin Supplement treatment raised the Bax/Bcl -2 proportion in SKOV3 and also OVCAR3 cells, suggesting that the mitochondrial apoptotic pathway is caused. It was additionally observed that the phosphorylated types of Akt and also mTOR were reduced, the expression of GSK3β was boosted, as well as P70/S6K was reduced after therapy with ILQ. Isoliquiritigenin Supplement therapy additionally reduced Wnt3a expression, therefore resulting in a reduction in phosphorylated ERK. Isoliquiritigenin Supplement likewise hinders the PI3K/Akt/mTOR pathway by lowering the expression degrees of p-Akt, p-mTOR, P70/S6K and Cyclin D1 in Ishikawa as well as ES-2 cells.

Verdict: The data suggest that ILQ inhibits the viability, spreading as well as invasion of SKOV3 as well as OVCAR3 cells and also generates apoptosis through the PI3K/Akt/mTOR path. Taken with each other, the data show that Isoliquiritigenin Supplement therapy can be used as a new strategy for ovarian cancer cells therapy.

Is Isoliquiritigenin Supplement a Potential Drug for Psoriasis?

Isoliquiritigenin has repressive activity on LPS-stimulated manufacturing of TNF-α, IL-6 and also IL-12 p40 (Li et al., 2014). Of certain interest in anti-inflammatory activity, Isoliquiritigenin Supplement prevents the expression as well as mRNA accumulation of E-selectin and also (vascular cell attachment particle) VCAM-1. In addition, chalcone undermined TNF-α-induced platelet endothelial cell adhesion particle 1 expression by blocking the deterioration of IkBα and also the nuclear translocation of NF-κB at the transcriptional degree, as well as down-regulated the expression of platelet endothelial cell attachment particle 1 in TNF-α-activated cells. cell adhesion molecule protein. Kwon et al., 2007). As reported by Hattori et al. (2007 ), Isoliquiritigenin Supplement additionally applies anti-inflammatory impacts with anti-nephritis effects.

Isoliquiritigenin Supplement reduces the inflammatory reaction of macrophages by hindering the activation of NF-κB p65 and also AP-1 (Feldman et al., 2011 ). In RAW264.7 macrophages, Isoliquiritigenin Supplement causes HO-1 expression by means of the ERK 1/2 path and also prevents LPS-induced NO, IL-1β as well as TNF-α production. Chen et al. (2012a, b) showed that Isoliquiritigenin Supplement had the ability to decrease the expression of the cytokine IL-6, recommending its prospective use in inflammatory conditions. Based on these results, Wu et al. (2016) examined the effect of chalcone in some psoriasis versions such as artificial insemination human keratinocyte HaCaT and also NHEK, keratin 14/vascular endothelial growth element (VEGF) transgenic mice and also IMQ-induced psoriasis-like cells computer mouse.

Isoliquiritigenin Supplement has been revealed to boost psoriatic lesions as well as sluggish psoriatic pathology in vivo by decreasing IL-6 and also IL-8 degrees as well as by reducing CD4, CD8, CD11b/c, F4/80 as well as VEGF expression in the ear Refine as well as back skin. Furthermore, Isoliquiritigenin Supplement hindered the expression of NF-κB as well as prevented its activation by downregulating the phosphorylation level of NF-κB, leading to the reduction of proinflammatory cytokines IL-6 and also IL-8. Comparable results were gotten in vitro. Isoliquiritigenin decreases NF-κB at both healthy protein and also mRNA levels. This result suggests Isoliquiritigenin Supplement as an encouraging NF-κB inhibitor and possible drug for the therapy of psoriasis.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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