Isoliquiritigenin CAS 961-29-5

Molecular Formula: C15H12O4

Formula Weight: 256.25

ZSpharmac: Isoliquiritigenin Raw Material Supplier

Product Name: Isoliquiritigenin

CAS No: 961-29-5

Purity: 99%

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Basic Info

Product Name:	Isoliquiritigenin
Other Names:	4μ-Trihydroxychalcone
CAS:	961-29-5
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Yellow to Orange Powder
EINECS No.:	607-884-2
Storage:	2-8°C
Provide:	Isoliquiritigenin MSDS； Isoliquiritigenin COA

What is Isoliquiritigenin?

Isoliquiritigenin, also referred to as (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 4,2′,4′-tri Hydroxychalcone, English name isoliquiritigenin, acronym ISL. Molecular formula C15H12O4, molecular weight 256.25, chemically identified as Flavonoids, naturally found in Caryophyllaceae plants, the detoxified substance is a yellow powder, virtually insoluble in water.

Isoliquiritigenin Property

Melting point	206-210°C
Boiling point	504.0±42.0 °C(Predicted)
density	1.384±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: <0.1 mg/mL
pka	7.50±0.35(Predicted)
form	powder
color	yellow to orange

Isoliquiritigenin Uses

1) Enhance brain energy metabolism. The computer mouse learning and memory disorder model was triggered by duplicated clamping and reperfusion of reciprocal typical carotid arteries. The understanding and memory ability of computer mice was tested by platform jumping examination and Y-shaped maze examination. The ATF content and adenylate content of mind cells were detected by reversed-phase high-performance fluid chromatography. Swimming Pool (TAN) level and energy lots value (EC). The outcomes show that isoliquiritigenin can enhance cognitive disorder in mice with duplicated cerebral ischemia-reperfusion, and its mechanism of action might be connected to improving brain basal metabolism.

2) Isoliquiritigenin hinders the spreading of cervical cancer cells, and its mechanism is connected to obstructing the cell cycle in the S and G2/M phases and affecting the expression of the cell cycle element cyclinB1.

3) Inhibit the expansion of prostate cancer cells artificial insemination. The growth contour was identified by feasible cell checking method, and cell spreading was figured out by MTT method. The outcomes show that isoliquiritigenin can successfully inhibit the proliferation of prostate cancer cells, and isoliquiritigenin might end up being a brand-new medicine for the therapy of prostate cancer.

4) Avoid and treat pathological alveolar bone traction. Isoliquiritigenin may act as a possible restorative approach to target bone loss related to periapical condition.

5) The combined use isoliquiritigenin and cefoxitin or gentamicin can substantially decrease the hazardous negative effects and dosage of antibiotics, has strong anti-MRSA task, and can even reverse drug resistance, showing a good collaborating anti-bacterial impact. Isoliquiritigenin can additionally boost the antibacterial impact of β-lactam anti-biotics and aminoglycoside anti-biotics, which can offer a referral for finding antibacterial animating compounds and be made use of to prepare medicines versus methicillin-resistant Staphylococcus aureus.

6) Isoliquiritigenin has anti-arrhythmic effects.

7) Anti-asthma activity of isoliquiritigenin. The leisure result of isoliquiritigenin on test subject tracheal smooth muscle mass was observed using the guinea pig isolated tracheal spiral strip method, spray asthma approach and customized lung overflow technique. Isoliquiritigenin has a substantial relaxing impact on the tracheal tightening generated by acetylcholine, potassium chloride, and histamine. Its system is probably associated with turning on guanylyl cyclase, boosting cGMP degrees in cells, and opening up Ca+-triggered potassium channels.

8) Utilized as aesthetic accessories, food additives, and so on.

Isoliquiritigenin Assay Method

HPLC method
A Cromasil C18 column was used, with methanol-0.5% glacial acetic acid as the mobile phase, slope elution, and dual-wavelength discovery. The determined wavelengths were λ1= 276nm and λ2= 372nm. Isoliquiritigenin has a good linear partnership in the series of 3.0-6.0 ng, r= 0.999, the ordinary sample recuperation rate is 98.73%, and the RSD is 0.89% (n= 6). This approach is simple to run, has reliable outcomes and good reproducibility, and can be utilized as a technique for quality assurance of this item.

High performance capillary electrophoresis
In 50 mmol/L borax barrier solution (pH=9.0), isoliquiritigenin has a good linear relationship with the electrophoresis optimal elevation in the range of 5.0 × 10-4 ~ 1.0 × 10-6g/ mL, and the detection restriction is 2.0 × 10-g/mL, which has actually been efficiently put on the resolution of real samples.

Isoliquiritigenin in Vitro Studies

Isoliquiritigenin could have the ability to effectively protect against diabetic person troubles by avoiding rat lens aldose reductase, with an IC50 of 320nM, and can avoid the buildup of sorbitol in human red blood cells, with an IC50 of 2.0 μM. Isoliquiritigenin can be used as a whitening representative by avoiding the task of monophenol tyrosinase and diphenol tyrosinase, with an IC50 of 8.1 μM. Isoliquiritigenin generates cell cycle concern and hinders cell development in DU145 and LNCaP cell lines. In human stomach cancer MGC-803 cells, isoliquiritigenin generates apoptosis by increasing intracellular completely complimentary calcium ion focus and decreasing mitochondrial membrane layer possibility (Deltapsi(m)).

About Products:
If you need the cosmetic raw material Isoliquiritigenin, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Isoliquiritigenin manufacturer and supplier, ZSpharmac will provide Isoliquiritigenin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.