Zhishang Chemical

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Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: ISOEUGENOL Supplier

Product Name: ISOEUGENOL
CAS No: 97-54-1
Purity: 99%

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Basic Info

Other Names:Isoeugenol (cis- and Trans- Mixture)
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Yellow Viscous Liquid
EINECS No.:202-590-7


Isoeugenol (4-propenyl-2-methoxyphenol, molecular formula C10H12O2) is light yellow a little thick fluid, insoluble in water as well as glycerin, soluble in organic solvents such as ethanol;, clove-like floral fragrance; primarily utilized to prepare significance and also vanillin, can be made use of to prepare crucial oils such as ylang-ylang, nutmeg, and so on; can also be used to prepare food tastes with raspberry, peach, spicy, and clove flavors; it is likewise semi-synthetic Basic material of vanillin. The structure of isoeugenol exists in two types: cis and also mode, but due to the fact that cis isoeugenol has certain toxicity, when it is made use of as a product, it is usually called for that the percentage of cis in the cis-trans mixture must not go beyond 10%.
Isoeugenol is a phenylpropene, propene-substituted guaiacol. This is a phenylpropane found in the vital oils of plants such as ylang-ylang-ylang (Canangaodorata). Vanillin can be manufactured from eugenol and also made use of in the production of vanillin. It can be either the cis (Z) or trans (E) isomer. Trans (E) isoeugenol is crystalline, as well as cis (Z) isoeugenol is liquid.


Melting point 

-10 °C

Boiling point 

266 °C


1.082 g/mL at 25 °C

vapor density 

>1 (vs air)

vapor pressure 

<0.01 mm Hg ( 20 °C)

refractive index 

n20/D 1.575(lit.)


>230 °F

storage temp. 



Benzene (Slightly), Chloroform, Methanol (Sparingly)




Viscous Liquid


Clear yellow



  1. Isoeugenol is a flavoring that is briefly permitted in GB 2760-1996. It is generally utilized in the prep work of flavors such as pork, smoke as well as likewise flavors, in addition to is additionally generally made use of in numerous fruit tastes, such as banana, raspberry, strawberry, clove, nutmeg, cinnamon, peach, nuts, apricot in addition to numerous other flavors. It is likewise the raw product for the synthesis of vanillin.
  2. Isoeugenol is the significant raw material for carnation type, as well as additionally used in osmanthus as well as also oriental preference significances. It can be made use of in ylang-ylang, daffodil, brandy, climbed, and so on, as well as it operates well with musk in addition to civet in asian scents. It can be utilized in food flavors such as raspberry, peach, nutmeg, cinnamon, apricot, nut, flavor base or clove type.
  3. The isoeugenol scent is a lot a lot more elegant than eugenol. It is normally used as the major agent of carnation essence, along with various other flower relevances are furthermore extensively utilized. Made use of as value for cosmetics along with soap, and so on. This item can furthermore be used as a fragrance product for food such as apples, apricots, bananas, grapes, plums, raspberries (raspberries) or walnuts. In addition, it likewise has applications in dental medication.

ISOEUGENOL Application

CN201710412887.9 provides a method for preparing vanillin by extracting eugenol from cloves, comprising the following steps:

(1) Extraction and separation of eugenol: take the dried flower buds of lilac, carry out steam distillation, until the distillate is clear, no oil droplets drip out, then stop heating, collect the distillate, extract, and obtain eugenol;

(2) isomerization of eugenol: using rhodium trichloride as a catalyst, isoeugenol is prepared by the isomerization reaction of eugenol;

(3) Protection of phenolic hydroxyl group: reacting isoeugenol and acetic anhydride obtained in step (2) to generate isoeugenol acetate;

(4) Oxidation reaction of ethylenic bond: the carbon-carbon double bond of the isoeugenol acetate obtained in the step (3) is oxidized into an aldehyde group with potassium permanganate, and vanillin acetate is prepared;

(5) Preparation of vanillin. The method of the invention uses natural products as raw materials, which are easy to obtain, rich in resources, easy to control the production process, easy to separate the products, fast in the production cycle, and have broad market application prospects.

CN201110289720.0 provides a synthesis process of semi-synthetic perfume with high yield and good product quality. The present invention adopts the following technical scheme, extracts eugenol by a reflux method, and then uses carbonyl iron as a catalyst to perform isomerization to obtain isoeugenol, and reacts isoeugenol and benzyl chloride to synthesize the final product benzyl isoeugenol.

CN200610026926.3 discloses a strain of Bacillus pumilus and its application in biotransformation of isoeugenol to produce natural vanillin. The strain is named Bacillus pumilus S-1, and was deposited in China Center for Type Culture Collection on January 3, 2006, with the preservation number CCTCC M 205165. The process of using Bacillus pumilus S-1 CCTCC M 205165 to convert isoeugenol to produce natural vanillin includes: (1) slant culture, (2) preparation of seed culture solution, (3) transformation of cell culture, (4) transformation. The invention belongs to the field of biotechnology. The method can produce high-concentration vanillin with high conversion rate, solves the problems of low concentration and low yield of natural vanillin produced by biological methods, and has great application prospects.

Preparation of ISOEUGENOL

One, at present, the synthesis method of isoeugenol all exists the problem that production process is comparatively complicated, production cost is high, or reaction waste liquid pollutes environment, or cis-isoeugenol content is too high. CN201410100405.2 provides a synthetic method of isoeugenol, aiming to solve the complex production process and high production cost of the current synthetic method of isoeugenol, or the reaction waste liquid pollutes the environment, or the content of cis-isoeugenol is too high high question. Include the following steps:

(1) Add clove powder to 1mol/L potassium hydroxide solution and ethanol, place it at 100-130 °C for 1-2 hours under the condition of ultrasonic waves, and obtain a decomposition liquid; wherein, the clove powder, potassium hydroxide solution and ethanol The mass-to-volume ratio is (20-30) kg: (5-10) L: (5-10) L;

(2) Stir and mix the decomposed liquid with toluene, then heat and distill in a vacuum state, control the temperature of the distillation heating place to be 50-90°C, control the temperature of the volatilization outlet of the distillation gas to be 35-45°C, and condense the distillation gas with a condenser After collection, low-boiling impurities are obtained; wherein, the volume ratio of the decomposition liquid to toluene is (5-10): (3-4);

(3) Continue to distill the remaining filtrate after removing low-boiling impurities in the step (2), control the temperature of the distillation heating place to be 100°C-120°C, control the temperature of the distillation gas volatilization outlet to be 90-105°C, and use the distillation gas to The isoeugenol is obtained after condensation and collection in the condenser.

In the present invention, the amount of lye required is greatly reduced, and the liquid in the reaction process can be directly used for distillation without extraction and separation, and the operation is simpler; in addition, the reagents and test devices used in the present invention are all More commonly used, the production cost is very low; more importantly, the content of trans isoeugenol obtained in the present invention in isoeugenol can reach more than 95%.

2. CN201410811548.4 provides a method for preparing isoeugenol by catalytic pyrolysis of biomass using ruthenium or rhodium catalysts. According to the method provided by the invention, using biomass as raw material, the biomass and ruthenium or rhodium catalysts are mechanically mixed according to the mass ratio of (10:1) to (1:3), and then under anaerobic conditions at 250 Rapid pyrolysis at ~400°C, and the liquid product rich in isoeugenol can be obtained after the pyrolysis gas is condensed. The ruthenium-based or rhodium-based catalysts used in the present invention can greatly promote the formation of isoeugenol in the biomass pyrolysis process of Pinaceae, Sequoia, Cupressaceae or Araucariaceae, while inhibiting the pyrolysis of cellulose and hemicellulose Formation of volatile organic products and inhibition of lignin pyrolysis to form other phenolic products. Therefore the liquid product that obtains has relatively simple composition, and the purity of isoeugenol is higher, greatly simplifying its follow-up separation and purification process. Secondly, the performance of the catalyst is stable, and it can be separated from the pyrolysis residue by mechanical means to achieve recycling. In addition, the present invention controls the pyrolysis temperature at 250-400°C, and there are fewer pyrolysis products at a lower pyrolysis temperature, which is not only beneficial to control the product composition and further improve the selectivity to isoeugenol, but also has great impact on equipment and reaction conditions. The requirements are lower, which is conducive to reducing production costs.

About Products:
If you need ISOEUGENOL this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced ISOEUGENOL manufacturer and supplier, ZSpharmac will provide ISOEUGENOL raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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