Zhishang Chemical

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Zhishang Chemical


Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: ISOEUGENOL Supplement

Product Name: ISOEUGENOL
CAS No: 97-54-1
Purity: 99%

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Basic Info

Other Names:Isoeugenol, Cis + Trans, 98+%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Yellow Viscous Liquid
EINECS No.:202-590-7


Isoeugenol (4-propenyl-2-methoxyphenol, molecular formula C10H12O2) is a light yellow and slightly thick liquid, insoluble in water and glycerol, but soluble in organic solvents such as ethanol; , clove flower-like fragrance; mainly used for preparing essence and vanillin, can be used to prepare ylang ylang, nutmeg and other essential oils; can also be used to prepare raspberry, peach, spice, clove flavor edible flavor; also semi-synthetic Raw materials of vanillin. The structure of isoeugenol has two types: cis and mode, but because cis-isoeugenol has certain toxicity, when it is used as a commodity, it is generally required that the proportion of cis in the cis-trans mixture should not be higher than 10%.

Isoeugenol is phenylpropene, a propene substituted guaiacol. This is a phenylpropane found in essential oils from plants such as ylang-ylang-ylang (Canangaodorata). Using eugenol as raw material, vanillin can be synthesized and used in the production of vanillin. It can be the cis (Z) or trans (E) isomer. Trans (E) isoeugenol is crystalline, and cis (Z) isoeugenol is liquid.


Melting point 

-10 °C

Boiling point 

266 °C


1.082 g/mL at 25 °C

vapor density 

>1 (vs air)

vapor pressure 

<0.01 mm Hg ( 20 °C)

refractive index 

n20/D 1.575(lit.)


>230 °F

storage temp. 



Benzene (Slightly), Chloroform, Methanol (Sparingly)




Viscous Liquid


Clear yellow



  1. Isoeugenol is an edible spice that is temporarily enabled to be utilized in GB 2760-1996. It is mainly utilized to prepare tastes such as pork, smoke and seasonings. It is likewise commonly made use of in different fruit tastes, such as banana, raspberry, strawberry, clove, nutmeg, cinnamon, peach, nuts, apricot and various other tastes. It is also the raw material for the synthesis of vanillin.
  2. Isoeugenol is the main raw material for carnation, and also is also used in woodsy as well as oriental flavors. It can be utilized in ylang-ylang, daffodils, white orchid, roses, etc. It is really effective in oriental fragrances along with musk as well as civet scent. It can be used in raspberry, peach, nutmeg, cinnamon, apricot, nut, spice or clove flavors.
  3. Isoeugenol notes are extra sophisticated than eugenol. It is typically used as the primary agent of carnation significance, and also various other numerous floral essences are also extensively made use of. Made use of in cosmetics and soap essences, etc. The item can also be made use of as a food scent item, used in tastes such as apples, apricots, bananas, grapes, plums, raspberries (raspberries) or walnuts. In addition, it also has applications in dental medicine.
  4. Alternatives to Eugenol. With the exception of medication. It can also be used as a basic material for synthesizing spices, and can also be made use of to prepare carnation-flavored daily flavors, as well as can additionally be made use of as edible flavors.

Isoeugenol Application

CN201710412887.9 provides a method for preparing vanillin by extracting eugenol from lilac flowers, comprising the following steps:

(1) extraction and separation of eugenol: take by weighing the dried flower buds of lilac, carry out steam distillation, until the distillate is clear, and no oil bead drips out, then stop heating, collect the distillate, and extract to obtain eugenol;

(2) isomerization of eugenol: take rhodium trichloride as a catalyst, prepare isoeugenol by the isomerization reaction of eugenol;

(3) protection of phenolic hydroxyl group: isoeugenol and acetic anhydride obtained in step (2) are reacted to generate isoeugenol acetate;

(4) Oxidation reaction of olefinic bond: the carbon-carbon double bond of isoeugenol acetate obtained in step (3) is oxidized into aldehyde group with potassium permanganate to prepare vanillin acetate;

(5) Preparation of vanillin. The method of the invention uses natural products as raw materials, is easy to obtain, has abundant resources, is easy to control the production process, easy to separate the products, has a fast production cycle, and has wide market application prospects.

CN201110289720.0 provides a process for synthesizing semi-synthetic fragrances with high yield and good product quality. The present invention adopts the following technical scheme, extracts eugenol through a reflux method, and then uses carbonyl iron as a catalyst for isomerization to obtain isoeugenol, and the isoeugenol reacts with benzyl chloride to synthesize the final product benzyl isoeugenol.

CN200610026926.3 discloses a strain of Bacillus pumilus and its application in biotransformation of isoeugenol to produce natural vanillin. The strain, named Bacillus pumilus S-1, was deposited in the China Center for Type Culture Collection on January 3, 2006, and the deposit number is CCTCC M 205165. The process of using Bacillus pumilus S-1 CCTCC M 205165 to transform isoeugenol to produce natural vanillin includes: (1) slant culture, (2) preparation of seed culture solution, (3) transformed cell culture, (4) transformation. The invention belongs to the field of biotechnology, and the method can produce high-concentration vanillin with high conversion rate, solve the problems of low concentration and low yield of natural vanillin produced by biological method, and has great application prospect.

Preparation of Isoeugenol

One, at present, the synthetic method of isoeugenol all has the relatively complicated production technique, and the production cost is high, or the reaction waste liquid pollutes the environment, or the problem that the cis-isoeugenol content is too high. CN201410100405.2 provides a method for synthesizing isoeugenol, aiming at solving the complicated production process and high production cost in the current synthesis method of isoeugenol, or the reaction waste liquid pollutes the environment, or the content of cis-isoeugenol is too high high problem. Include the following steps:

(1) Add clove powder to 1 mol/L potassium hydroxide solution and ethanol, and place at 100-130 °C under the action of ultrasonic waves for 1-2 hours to obtain a decomposition solution; wherein, the clove powder, potassium hydroxide solution and ethanol The mass-to-volume ratio is (20-30) kg: (5-10) L: (5-10) L;

(2) After stirring and mixing the decomposed liquid and toluene, heat and distill in a vacuum state, control the temperature of the distillation heating place to be 50-90°C, control the volatilization outlet temperature of the distillation gas to be 35-45°C, and condense the distilled gas with a condenser After collection, low-boiling impurities are obtained; wherein, the volume ratio of the decomposed liquid to toluene is (5-10): (3-4);

(3) Continue to distill the remaining filtrate after removing low-boiling impurities in the step (2), control the temperature of the distillation heating place to be 100°C to 120°C, and control the volatilization outlet temperature of the distillation gas to be 90 to 105°C. Isoeugenol is obtained after condenser condensation and collection.

In the present invention, the required amount of alkali liquor is greatly reduced, and the reaction process liquid can be directly used for distillation without extraction and separation, and the operation is simpler; It is more commonly used, and the production cost is very low; more importantly, the content of the trans-isoeugenol obtained by the present invention in the isoeugenol can reach more than 95%.

2. CN201410811548.4 provides a method for preparing isoeugenol by utilizing ruthenium-based or rhodium-based catalysts to catalyze pyrolysis of biomass. According to the method provided by the present invention, using biomass as raw material, biomass and ruthenium-based or rhodium-based catalysts are mechanically mixed in a mass ratio of (10:1) to (1:3), and then under anaerobic conditions at 250 Rapid pyrolysis is carried out at ~400°C, and a liquid product rich in isoeugenol can be obtained after the pyrolysis gas is condensed. The ruthenium-based or rhodium-based catalysts used in the present invention can greatly promote the formation of isoeugenol during the pyrolysis of Pinaceae, Cedaraceae, Cedaraceae or Araucaria biomass, and simultaneously inhibit the pyrolysis of cellulose and hemicellulose. Forms volatile organic products and inhibits the pyrolysis of lignin to form other phenolic products. Therefore, the composition of the liquid product obtained is relatively simple, and the purity of isoeugenol is higher, which greatly simplifies its subsequent separation and purification process. Secondly, the catalyst has stable performance and can be separated from the pyrolysis residue by a mechanical method to realize recycling. In addition, the present invention controls the pyrolysis temperature at 250-400°C, and the pyrolysis product is less at a lower pyrolysis temperature, which is not only beneficial to control the product composition and further improve the selectivity to isoeugenol, but also affects the equipment and reaction conditions. The requirements are lower, which is conducive to reducing production costs.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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