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Isobutylparaben CAS 4247-02-3

Molecular Formula: C11H14O3

Formula Weight: 194.23

ZSpharmac: Isobutylparaben Supplier

Product Name: Isobutylparaben
CAS No: 4247-02-3
Purity: 99%

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Basic Info

Product Name:Isobutylparaben
Other Names:Isobutyl 4-Hydroxybenzoate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Neat
EINECS No.:224-208-8
Provide:Isobutylparaben MSDS;
Isobutylparaben COA

What is Isobutylparaben?

The preservative isobutylparaben, likewise called paraben, has the advantages of high performance, low toxicity, broad range, and also easy compatibility, so it is not only the mainstream food preservative in lots of industrialized countries, yet likewise widely utilized in Anticorrosion in everyday chemical, pharmaceutical and also feed industries. Industrially, isobutylparaben can be obtained from the catalytic esterification of p-hydroxybenzoic acid and isobutanol in the presence of concentrated sulfuric acid, which has the disadvantages of severe equipment corrosion, many side reactions, and a large amount of waste liquid. Using sodium bisulfate, solid super acid, sulfamic acid and vitamin C as catalysts can overcome some disadvantages of concentrated sulfuric acid catalysis to varying degrees.

Isobutylparaben Property

Melting point 76°C
Boiling point 302.3±15.0 °C(Predicted)
density 1.105±0.06 g/cm3(Predicted)
vapor pressure 0.001Pa at 20℃
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form neat
color White
Water Solubility Insoluble in water.


Isobutylparaben Uses

  1. Isobutylparaben is utilized as an oil-in-water emulsifier. Compared with the solubility of pure butyl ester, the solubility is enhanced by 2 to 3 times. Easy to use in soy sauce.
  2. Isobutylparaben, like butyl p-hydroxybenzoate, can be used as a food preservative and likewise antifungal agent. Presently, there are 6 type of parabens allowed to be used in Japan, including ethyl ester, propyl ester, isopropyl ester, butyl ester, isobutyl ester as well as other butyl ester, among which butyl ester has the best antibacterial result. Normally talking, the bigger the number of carbon atoms of the alcohol constituting the ester, the more powerful the antibacterial result, while the poisoning is contrary, the smaller sized the variety of carbon atoms, the greater the toxicity. This product has repressive or murder impacts on various mold and molds as well as yeasts, as well as likewise is not influenced by pH. It is restricted to soy sauce, vinegar, sodas, sherbet, fruit sauce, fruit and additionally veggies and fruits (limited to the skin component). The dose is 1.4 times that of p-hydroxybenzoic acid.

Isobutylparaben Application

Isobutylparaben, additionally called paraben, has a great antibacterial effect on grain mold and mildew, yeast and microorganisms, ruins the cell membrane of microbes, denatures the protein in the cell, and also hinders the respiratory enzyme system as well as The task of the electron transfer enzyme system, and the anti-bacterial effect have great impacts in a broad pH array. Consequently, it is extensively made use of in food, feed, cosmetics, daily chemicals and also medication sectors. It is a secure and also effective chemical used worldwide as well as among the crucial food chemicals established in my country. Its application examples are as follows:

1) Prepare an insulating and durable coating, the insulating and durable coating is made of shellac resin, antistatic agent, dispersant, conductivity control agent, pigments and fillers, preservatives and antioxidants, and the antistatic agent is glycerin hard Fatty acid ester, the dispersant is fatty acid polyethylene glycol ester, the conductive control agent is hydroxyl silicone oil, the pigment and filler is calcium metasilicate, the preservative is isobutylparaben, and the anti-corrosion agent The oxygen agent is p-phenylenediamine. The invention is prepared from shellac resin, antistatic agent, dispersant, conductive control agent, pigment and filler, preservative and antioxidant, and the prepared product has good insulation effect, high safety, good corrosion resistance, aging resistance, Low cost, stable quality and long service life.

2) Prepare a high-temperature-resistant patch red glue, which is prepared from the following components: o-cresol novolac epoxy resin, polyketone resin, 12-aminododecanoic acid, rhodium picolinate, methyl Nadic anhydride, isobutylparaben, bisphenol A phenolic resin, diaminodiphenyl sulfone, 1-methyl-3-alkylimidazole chloride, gelatin, white carbon black, lithium magnesium silicate, pine oil Alcohol, Vanillyl Butyl Ether, Cardanol Glycidyl Ether, 2-Carboxyethylphenylphosphinate, Glycine, Tannin, Isopropylbiphenylphosphine, Polyethylene Oxide, Samarium Sulfate, Bismuth Octanoate, Diisostearyl Alcohol Malic acid ester, red lead, scarlet material. The patch red glue provided by the invention has high temperature resistance, good bonding performance and stability, can improve the stability of the red glue, prevent the phenomenon of falling off during processing, and can meet the application of high-end electronics industry need.

Preparation of Isobutylparaben

Method 1: Add 0.05mol p-hydroxybenzoic acid, 10mL toluene and a certain amount of isobutanol and catalyst into a three-necked flask equipped with a thermometer, a water separator, and a reflux condenser. The water separator is pre-filled with isobutanol, and heated Reflux the reaction and start timing when condensate appears. After reacting for a certain period of time, let stand and cool, the reaction liquid is transferred to a distillation bottle by decantation, and the unreacted isobutanol is separated by distillation under reduced pressure. Pour the distilled residue into distilled water, adjust the pH value to 7-8 with 10% sodium carbonate solution, stir first and then let stand until all solid products are precipitated, filter with suction, wash, and dry at 40°C to constant weight to obtain White powdery product, weigh and calculate the yield. The yield of isobutylparaben is 88.7%.

Method 2: Nano-solid superacid TiO2/SO42-catalyzed synthesis of isobutylparaben

1) Preparation of catalyst

Place the Erlenmeyer flask equipped with magnets on a constant temperature magnetic stirrer, add a certain amount of titanium tetrachloride and a small amount of ethylene glycol as a dispersant in the Erlenmeyer flask, start the magnetic stirrer, and add water to the Erlenmeyer flask until When titanium tetrachloride meets water, the titanium hydroxide produced is completely dissolved. Under the condition of stirring at low temperature, slowly add 12% ammonia water into the titanium tetrachloride solution, adjust the pH value to 9, and continue stirring for 3 hours to obtain Ti(OH)·4nH2O precipitate, age at room temperature for 24 hours, and filter with suction , washed with distilled water until no Cl- is detected, then dried at 110°C, ground, and sieved (100 mesh) to obtain the former yield of amorphous TiO2. A certain concentration of H2SO4 aqueous solution is impregnated, soaked for 1 hour, suction filtered, dried and ground, and roasted in a muffle furnace at 450-500 °C for 2-3 hours to obtain nano-solid superacid catalyst TiO2/SO42 under different conditions. -, put in a desiccator for later use.

2) Synthesis of isobutylparaben In a 100mL three-neck flask equipped with a stirrer, water separator and thermometer, add a certain amount of p-hydroxybenzoic acid, isobutanol, catalyst and water-carrying agent benzene, and heat slowly , timing at the beginning of reflux, stop heating after a certain period of reaction, remove the catalyst by suction filtration, steam distillation to remove excess isobutanol and water-carrying agent benzene (recovery treatment), filter the remaining reaction liquid while it is hot, and pour the filtrate into a container Cool in a beaker with a certain amount of distilled water to obtain light yellow crystals, filter and dry with suction to obtain crude ester. Recrystallize with a certain proportion of ethanol solution to obtain a white solid product. Dry in vacuum, weigh the mass, determine the melting point and calculate the yield.

About Products:
If you need Isobutylparaben, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Isobutylparaben manufacturer and supplier, ZSpharmac will provide Isobutylparaben raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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