Zhishang Chemical

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Zhishang Chemical

Ionone CAS 8013-90-9

Molecular Formula: C13H20O

Formula Weight: 192.3

ZSpharmac: Ionone Supplement

Product Name: Ionone
CAS No: 8013-90-9
Purity: 99%

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Basic Info

Product Name:Ionone
Other Names:Ionon
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Viscous liquid
EINECS No.:232-396-8
Storage:Store Below +30°C.
Provide:Ionone MSDS;
Ionone COA

What is Ionone?

Ionone is a terpenoid with 3 isomers depending upon the position of the double bond. Chinese commonly mistranslate Viola as Violet, the two are in fact different varieties, and ionone is commonly equated as ionone.

Ionone belongs to the climbed ketones, which are found in a range of blossom crucial oils, including rose crucial oil. Beta-ionone is a major factor to climb aroma, although it exists in relatively reduced quantities in essential oils. Ionone is an essential fragrance chemical made use of in fragrances, fragrances as well as flavorings.

Ionone Properties

Boiling point 

288.3°C (rough estimate)


0.9275 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Store below +30°C.


Ionone Uses

  1. Ionone is made use of in various fragrance types, and also can play the duty of alteration, consistency, sweetening, flower scent, and ripening. It is a commonly used spice with violet blossom, sweet-scented osmanthus, tree orchid, climbed, acacia, mimosa, tuberose, lily of the valley, turf orchid, Suxin orchid, as well as woody scent. Additionally appropriate for ambergris as well as lotion tastes. It is likewise available in herbal, want or orange flavors. It is additionally suitable for raspberry, strawberry, cherry, grape, pear and also various other berry fragrance or fruity and also nutty, floral and also other edible flavors. It can be utilized in a small amount in white wine scent and also tobacco flavor. Reduced pureness can be used in soap essence.
  2. Ionone is the major scent of violet, acacia, sweet-scented osmanthus, orchid and other flower scents. It is extensively made use of in cosmetics and soaps. It can likewise be used as fruit food tastes such as bayberry. Beta-ionone is likewise made use of as an intermediate for vitamin A. Presently, it is just one of the pharmaceutical intermediates that my country mostly relies on imported.

Ionone Ecological Information

The manufacturing and also use ionones as intermediates in the synthesis of vitamins A, E as well as K and as flavoring substances in food products might cause their launch right into the environment via various waste streams. Its usage as a fragrance component in fragrances, cosmetic and individual care products, household cleansers as well as cleaning agents will result in its direct launch right into the environment. Beta-ionone has been determined as a component of cigarette smoke. Beta-ionones are extremely typical in nature and also are located in many plants, including roses, osmanthus, raspberries, cherries, tobacco, carrots, and also peppers. If launched into air, the estimated vapor stress at 25 ° C is 0.054 mm Hg, which indicates that β-ionone will exist in the atmosphere just as a vapor. Gas-phase β-ionone is weakened in the ambience by response with photochemically created hydroxyl radicals; the half-life of this reaction in air is estimated to be 3.3 hrs. Beta-ionone additionally travels through with ozone and nitrate radicals in the atmosphere. The half-lives for reactions with ozone and nitrate are approximated to be 14 as well as 0.8 hrs, specifically. Nitrate_Free radicals are the leading atmospheric oxidants during the night in many climatic environments, consequently, nocturnal degradation appears to be the leading destiny process for β-ionones. Beta-ionone absorbs at wavelengths > 290 nm and also for that reason might be susceptible to guide photolysis by sunshine. If released right into dirt, β-ionone is expected to have actually low flexibility based upon an approximated Koc of 670. Based upon the approximated Henry’s Regulation constant of 8.1X10-5 atm-cu, volatilization from moist soil surface areas is expected to be an important destiny procedure m/mol. Also at typical temperatures and pressures, the ambient vapor stress is low, yet the odor can still be scented; as a result, beta-ionones might evaporate from completely dry dirts. Utilizing the OECD 301F test, 79% of the academic body was accomplished within 4 weeks, suggesting that biodegradation is an essential environmental fate procedure. Beta-ionone was additionally categorized as easily naturally degradable based on the results of the carbon dioxide release test, where beta-ionone accomplished 46% and also 73% carbon dioxide launch after 7 and also 28 days, respectively. If launched to the estimated Koc, β-ionone is anticipated to adsorb into suspended solids as well as sediments. In the spiked river demise assay, beta-ionone was about 95% deteriorated after 20 hours of incubation. Volatilization from water is anticipated to be an essential destiny process from the surface based upon the estimated Henry’s Law constant for this substance. The estimated volatilization half-lives for the design river and design lake are 19 hrs and also 10 days, respectively. The approximated BCF is 202, indicating a high potential for bioconcentration in aquatic organisms. Hydrolysis is not anticipated to be a vital environmental destiny process since this substance does not have practical groups to hydrolyze under ambient conditions. Photooxidation might occur in surface area water subjected to sunshine. Job-related exposure to ionones might happen through inhalation and also dermal direct exposure to this substance in work environments where beta-ionones are created or made use of. Monitoring and also make use of data suggest that the basic populace may be subjected to ionones with breathing of ambient air, water as well as skin contact with this beta-ionone-containing customer product.

Interaction Experiment of Ionone

The possible responsibility of cytochrome P450 (P450) metabolic activation in thioacetamide-induced hepatotoxicity was explored in male BALB/c computer system mice. Computer mice were pre-treated with the P450 inducer beta-ionone at 600 mg/kg subcutaneously 72 in addition to 2 days before intraperitoneal administration of 100 or 200 mg/kg of thioacetamide. Pretreatment with β-ionone significantly enhanced the thioacetamide-induced altitude of cream alanine aminotransferase and also product aspartate aminotransferase activities. In addition, improved thioacetamide-induced hepatotoxicity was also observed in histopathological examination of the liver. Liver necrosis was improved by thioacetamide when computer system mice were pretreated with ionone. In liver microsomes, β-ionone therapy considerably generated the task of P450 2B-specific pentoxyresorufin O-depentylase as well as also benzyloxyresorufin O-debenzylase. β-ionone in addition triggers numerous other P450-related monooxygenases. Because pretreatment with β-ionone had no hepatotoxicity at doses that caused P450s. Our existing results suggest that β-ionone might be a valuable style inducer of P450 enzymes to look into the gadgets of toxicity of certain chemicals that call for P450 metabolic activation in computer mice.

Women ICR computer mice were treated with drug alone or in mix with amongst a number of cytochrome P450 (CYP) inducers, particularly phenobarbital, ionone, dexamethasone, as well as beta-naphthoflavone. Cocaine-induced hepatotoxicity was first observed by pretreatment with phenobarbital, β-ionone, or dexamethasone with a significant increase in medicine N-demethylation, the really initial step in medication bioactivation. Phenobarbital as well as beta-ionone occurred in the periportal area (location 1) and dexamethasone in the perivenous location (area 3). The tasks of enzymes specific for CYP isozymes were identified to light up the induction of CYP with CYP outcome of pretreatment. Beta-naphthoflavone causes CYP1A and also 2B nonetheless has no impact on drug hepatotoxicity. On the other hand, ionone improved hepatotoxicity without creating CYP3A. Medicine N-demethylase job was extremely carefully related to CYP2A (r=0.83) as well as CYP2B (r=0.81). Drug N-demethylation was hindered, specifically by the enhancement of the CYP2A-specific prevention 8-methoxypsoralen. On top of that, pretreatment with 8-methoxypsoralen substantially protected against cocaine-induced hepatotoxicity in phenobarbital. cured computer mice. These results recommend that cocaine-induced hepatotoxicity in women computer system mice is moderated in part by CYP2A associated with cocaine N-demethylation.

Production Method of Ionone

Ionone was first synthesized by Thieman in 1893 with citral and acetone to form pseudo-ionone, and then obtained by cyclization. The condensation reaction of lemon and acetone is usually carried out in the presence of an aqueous or hydroalcoholic solution of caustic soda, and solid caustic soda, benzene solution of sodium phenate and other alkaline reagents can also be used. The cyclization of the pseudoionone is carried out in the presence of sulfuric, phosphoric and formic acids, aluminum chloride, ferric chloride, zinc chloride, boron fluoride, and the like. Chemicalbook’s use of 60-65% sulfuric or concentrated phosphoric acid results in pseudo-ionone cyclization and is producing alpha-ionone-based substances that are valuable for perfumery. Large amounts of dilute sulfuric acid will slow down the cyclization process and will leave many unreacted pseudoionones, resulting in less alpha-ionone and more beta-ionone. The type and concentration of acid used in the cyclization reaction are different, and the ratio of the generated α- and β-ionone also changes accordingly.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Ionone Quotation