Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Idebenone Tablet CAS 58186-27-9

Molecular Formula: C19H30O5

Formula Weight: 338.44

ZSpharmac: Idebenone Tablet Supplier

Product Name: Idebenone Tablet
CAS No: 58186-27-9
Purity: 99%

Navigation Bar

Basic Info

Product Name:Idebenone Tablet
Other Names:Idebenone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange Neat
EINECS No.:1308068-626-2
Storage:Room Temp
Provide:Idebenone Tablet MSDS;
Idebenone Tablet COA

What is Idebenone Tablet?

The chemical name of Idebenone Tablet is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylbenzoquinone, which is a type of intelligence-promoting medicine established as well as noted by Takeda Drug Co., Ltd. in Japan in 1986; The feature of thread pulling body can be triggered, which can enhance mind function metabolic process and also brain disorder, and can enhance the usage rate of glucose in the brain and promote the generation of ATP; enhance the metabolic process of natural chemical 5-hydroxytryptamine in the mind, which has a strong Antioxidant and also totally free radical scavenging impact. It is generally used scientifically to treat lots of degenerative diseases of the main nerve system related to oxidative anxiety, such as Parkinson’s condition, Alzheimer’s condition, multi-infarct dementia, analytical ischaemia as well as analytical failing, etc. Idebenone Tablet is likewise used free of cost The therapy of Dreich’s ataxia can additionally be used in cosmetic formulations, which have cosmetic features such as scavenging cost-free radicals, inhibiting lipid peroxidation, preventing inflammation, preventing DNA damages, photoprotection, and also minimizing coloring.

Idebenone Tablet Property

Melting point 52-550C
Boiling point 497.3±45.0 °C(Predicted)
density 1.08±0.1 g/cm3(Predicted)
storage temp. room temp
solubility Soluble in DMSO (up to 25 mg/ml).
form neat
color Orange


Pharmacodynamics of Idebenone Tablet

This product is a drug for improving brain metabolism and mental symptoms. It can activate brain mitochondrial respiratory activity, improve brain energy metabolism disorders, and relieve brain functions such as neurological symptoms, emotional disorders, and passive avoidance reaction disorders in stroke animals and experimental cerebral ischemia animals. obstacle.
1. The improvement effect of Idebenone Tablet on brain dysfunction during cerebral ischemia: ①This product is effective for post-stroke sequelae and emotional disorders (reduced spontaneous movement, easy to be stimulated) in spontaneously hypertensive rats (SHRSP) prone to stroke. Hyperactivity), quadriplegia, etc. can be improved. ②For rats with experimental cerebral infarction, experimental transient cerebral ischemia and damage to the base of the forebrain on both sides, it can improve the passive avoidance response disorder. ③This product can delay the onset time and death time of SHRSP spasm and death time of ligated common carotid arteries on both sides, and can also delay the lethal time of hypoxemia mice. ④ It can improve the low content of acetylcholine in the brain and the low metabolism of serotonin in rats with experimental transient cerebral ischemia, and can increase the monoamine metabolites in the cerebrospinal fluid of patients with cerebrovascular disorders.
2. The improvement effect of Idebenone Tablet on brain energy metabolism disorder during cerebral ischemia: ① It can inhibit the decrease of ATP and the increase of lactic acid in the brain of rats with bilateral common carotid artery ligation and experimental transient cerebral ischemia. ② This product can restore the low glucose utilization rate in the brain of rats with SHRSP stroke and damaged brain base.
3. The activation effect of Idebenone Tablet on the respiratory activity of brain mitochondria: ①In vitro, it can restore the activity of succinic acid and NADH oxidase (respiratory activity) in the mitochondrial samples of injured dog brain, and activate the electron transfer system function of rat brain mitochondria . ②In vivo, it can inhibit the generation of lipid peroxide in rat and dog brain mitochondria, prevent the mitochondrial membrane disorder (swelling) associated with the generation of lipid peroxide and maintain its function.

Preparation of Idebenone Tablet

(1), preparation of 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol

Install a mechanical stirrer and a thermometer in a dry and clean 5L reaction flask, and add 2000ml of 1,2-dichloroethane, 182g (about 1mol) of 3,4,5-trimethoxytoluene, and 10-acetoxydecanoyl chloride under stirring. 273g (about 1.5mol), then add 333g (about 2.5mol) of fresh anhydrous aluminum trichloride powder, start the reaction after cooling down to 5°C in an ice-water bath, control the temperature at 0-5°C, after 4 days of reaction, the reaction ends, pour Put into 5000ml of ice water, separate the organic layer, then add 2000ml of 1,2-dichloroethane to extract, combine the organic layers, wash with water three times, 1000ml each time; finally, dry with anhydrous sodium sulfate, decolorize with activated carbon, and evaporate the solvent , to obtain 310 g of a colorless oily substance, which is 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol, and the calculated molar yield is 81.5% , HPLC measured content 99.2%.

(2), preparation of 6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol

In a 5L hydrogenation kettle, add 380g of 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol (about 1.0 mol), DMF 3000ml, 19g of 5% Pd-C (mass is 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol 5% ). Catalytic hydrogenation under normal temperature and pressure and stirring reaction until no hydrogen absorption, then add 206g (about 1mol) of dehydrating agent DCC, continue stirring reaction at normal temperature and pressure for 7h, continue catalytic hydrogenation under normal temperature and pressure for more than 10h until no hydrogen absorption. After the reaction, the catalyst was filtered off, and the filtrate was concentrated to obtain 353 g of a light-colored oily substance, which was 6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol;

(3), hydrolysis

Add 40 g (1 mol) of sodium hydroxide and 1200 ml of methanol to the above oil, cool down to 5°C, stir for 24 hours, distill off the solvent under reduced pressure, add 1500 ml of dichloromethane to dissolve, wash with water for 3 times, dry over anhydrous sodium sulfate and reduce Concentrate to dryness under pressure to obtain 311.5 g of colorless oily matter which is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol, the calculated molar yield is 96.0%, and the HPLC content is 99.91 %, the maximum simple impurity is 0.06%).

(3) Preparation of Idebenone Tablet

Add 6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol 324.5g (about 1mol), DMF 3000ml, Cu(Salen) 10g (mass of 3% of the reaction substrate). Control the temperature at 35-40°C, pass pure oxygen to carry out the catalytic oxidation reaction, about 70 hours, TLC tracking until the raw material point disappears. After the reaction was completed, the catalyst was filtered off, concentrated to dryness under reduced pressure, then diluted with 2000ml of water, extracted 2 times with dichloromethane, 1000ml each time, the combined organic layers were washed 3 times with 1000ml each time, dried over anhydrous sodium sulfate, Distill to dryness under reduced pressure. Recrystallized with a mixed solvent of n-hexane-diethyl ether to obtain 254 g of orange needle-like product (0.75 mol, yield 75%, HPLC content 99.70%, maximum simplex 0.12%).

Production Method of Idebenone Tablet

Technique 1: 3,4,5-trimethoxytoluene, 10-acetoxydecanoyl chloride and light weight aluminum trichloride in dichloroethane, cooled as well as mixed in an ice bath for 2h, and then mixed at area temperature level for 70h. Pour into ice water, essence with dichloromethane, clean with water, as well as dry. The solvent was distilled off to get 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol as a light brown oil. Then methanol as well as sodium hydroxide were added as well as stirred at area temperature for 2h. The solvent was evaporated, water was included, as well as the pH value was adapted to 3 with hydrochloric acid. The precipitated crystals were filteringed system and also dried in vacuo. The crude product was liquified in chloroform and also divided by a silica gel column. Impurities were first eluted with chloroform-methanol (95:5) and after that with chloroform-methanol (90:10). The required parts were gathered, the solvent was vaporized, and also ether- Hexane (1:3) recrystallized to obtain white crystal 6-(10-hydroxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol, melting point 66.5 ~ 68 ℃, The yield is 63.1% (based upon 3,4,5-trimethoxytoluene). The above product, along with acetic acid, 5% Pd-C and 70% perchloric acid, was hydrogenated at room temperature level and also pressure for greater than 20 hours. After removing the stimulant by filtering, concentrate, include dichloromethane, wash twice with 5% sodium bicarbonate, and also dry. The solvent was distilled off to get 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol as a light oil with a return of 95%. The oil was mixed at 50 ° C. for 7 h with newly ready Frerny’s salt, dimethylformamide-water-methanol (1:1:1) and also a percentage of potassium dihydrogen phosphate. After the response was full, it was diluted with water, drawn out with dichloromethane, cleaned two times with water, and dried. Evaporate the solvent and recrystallize with n-hexane-ether (3:1) to get Idebenone Tablet computer in the form of orange-red needle crystals with a melting point of 54 ~ 55 ° C. Return 69.6%.
Technique 2: The acyl chloride of 3,4,5-trimethoxytoluene and also monoethyl sebacate is acylated under the catalysis of light weight aluminum trichloride, acylated at the 2-position, and afterwards hydrolyzed. It is after that lowered to create 10-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)decanoic acid, after that oxidized to quinone, ethylated and afterwards lowered to a hydroxyl team to obtain Idebenone Tablet computer. The difference from approach 1 is that it is first oxidized to quinone, and then the side chain is lowered. The procedure approach is similar to approach 1.

About Products:
If you need Idebenone Tablet, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Idebenone Tablet manufacturer and supplier, ZSpharmac will provide Idebenone Tablet raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Idebenone Tablet Quotation