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Icariin Solgar CAS 489-32-7

Molecular Formula: C33H40O15

Formula Weight: 676.66

ZSpharmac: Icariin Solgar Supplement

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Product Name: Icariin Solgar
CAS No: 489-32-7
Purity: 99%

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Basic Info

Product Name:Icariin Solgar
Other Names:Epimedium Extract Icariin
CAS:489-32-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:light Yellow to Yellow Powder
EINECS No.:610-440-0
Storage:2-8°C
Provide:Icariin Solgar MSDS;
Icariin Solgar COA

What is Icariin Solgar?

Icariin Solgar (icariin, ICA) is derived from the aerial parts of the Berberaceae plants, Epimedium koreanum and Epimdium berberidaceae maxim. Epimedium is a traditional Chinese herbal medicine in my country. It has the functions of tonifying kidney yang, strengthening muscles and bones, and dispelling rheumatism. . Icariin Solgar is the main component of Epimedium flavonoids extract and the main antioxidant active component in Epimedium. Its chemical structure is a flavonoid compound, which has a variety of biological activities in vivo and in vitro, and has the functions of enhancing human immunity, anti-tumor and anti-oxidation, promoting tissue protein synthesis, promoting osteoblast growth and inhibiting osteoclast activity. .

Icariin Solgar Properties:

Melting point 223-225 ºC
alpha D15 -87.09° (in pyridine)
Boiling point 948.5±65.0 °C(Predicted)
density 1.55
RTECS DJ2980500
storage temp. 2-8°C
solubility DMSO: soluble50mg/mL, clear, colorless to dark yellow
form Powder
pka5.90±0.40(Predicted)
color light yellow to yellow

 

Icariin Solgar Uses

  1. Icariin Solgar has the features of raising cardio as well as cerebrovascular blood flow, promoting hematopoietic feature, immune function and bone metabolism.
    ( 1 ) The result on endocrine: Icariin Solgar can promote sexual function as a result of hyperactive sperm secretion, after the seminal vesicle is complete, it boosts sensory nerves and also indirectly stimulates libido.
    ( 2 ) Influence on immune system feature: The variety of T cells, lymphatic turnover rate, antibody, antigen as well as phagocytic feature of reticuloendothelial system in people with kidney shortage are low, which can be enhanced after therapy with epimedium as well as various other kidney-tonifying drugs.
    ( 3 ) Anti-aging effect: Icariin Solgar can influence the aging system from various elements.
    ( 4 ) Effects on the cardiovascular system: Icariin Solgar on the posterior pituitary
  2. Icariin Solgar is used for assay/identification/pharmacological experiments, and so on.
    Medicinal impacts: Icariin can raise cardio and also cerebrovascular blood flow, promote hematopoietic feature, immune feature and bone metabolic rate.

Efficacy and Effects of Icariin Solgar

Icariin Solgar, as one of the active ingredients of Epimedium, a kidney-invigorating and yang-boosting herb, can promote the function of the reproductive system. Icariin can inhibit ferrous sulfate/hydrogen peroxide-induced oxidative stress injury of human sperm, activate ERK1/2 signaling pathway, promote the proliferation of testicular vegetative cells Sertoli, and enhance male reproductive function; The thalamus-pituitary-gonadal axis up-regulates the expression of dopamine and serotonin in the hypothalamus, activates the PI3K/AKT/eNOS/NO signaling pathway, increases the concentration of NO and serum testosterone, shortens the capture latency and ejaculation latency, and improves capture and ejaculation rates As well as testis and prostate index, it can improve the sexual function of male mice; it can activate the NO-cyclic guanosine monophosphate signaling pathway, inhibit the expression of phosphodiesterase type 5, and improve erectile dysfunction. Icariin Solgar can also up-regulate the levels of cytochrome P450 17 and 19, promote the expression of aromatase, induce the proliferation of ovarian granulosa cells, and increase the production of estrogen and progesterone; it can increase the weight of the ovary, uterus and pituitary gland, and promote the growth of female. Pubertal development in rats, prolonging the duration of estrus in pubertal rats. In addition, icariin can reduce the levels of follicle-stimulating hormone and luteinizing hormone, increase the level of estradiol, up-regulate the expression of ovarian anti-Mullerian hormone, increase the Bcl-2/Bax ratio in ovarian tissue, and improve the ovary of aging mice Follicular development, inhibits follicular atresia, and improves its fertility.

Icariin Solgar has a good effect on improving various neurological diseases such as cerebral ischemia, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and depression. Icariin Solgar can increase the level of superoxide dismutase (SOD), reduce the expression of amyloid precursor protein and β-secretase, reduce the production and accumulation of Aβ, and attenuate the Aβ-mediated axon and dendrites. Atrophy, and improve the spatial learning and memory ability of Alzheimer’s disease model rats. Icariin also inhibits Aβ-induced hyperphosphorylation of serine 396, 404 and threonine 205 of tau protein, thereby exerting a protective effect on nerve cells. Icariin Solgar can activate the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and MAPK/ERK signaling pathways, and reverse the B-lymphoma-2 gene in the striatum ( B-cell lymphoma-2, Bcl-2), Bcl-2 associated X protein (Bcl-2 associated X protein, Bax) and caspase-3 (cystein-asparate protease-3, Caspase- 3) Changes in expression that inhibit the sustained decrease in striatal dopamine content and the loss of tyrosine hydroxylase-immunoreactive neurons. Icariin also inhibited 6-hydroxydopamine/lipopolysaccharide-induced inflammatory damage and behavioral changes of brain dopamine neurons in rats. Icariin Solgar can inhibit NF-κB inhibitory protein α degradation and NF-κB activation, up-regulate peroxisome proliferators-activated receptors (PPARs) α and γ protein levels, and alleviate neuroinflammation. Icariin can also reduce the levels of lactate dehydrogenase and malondialdehyde, attenuate SOD activity, enhance antioxidant capacity, inhibit the increase of intracellular calcium concentration, and attenuate ischemia/reperfusion neuronal damage. In addition, icariin can inhibit the activation of myelin-associated growth inhibitory factor, myelin-associated glycoprotein and oligodendrocyte myelin glycoprotein in the ischemic area, promote axonal sprouting and regeneration, and improve neurological function.

Icariin Solgar can promote the formation and activation of osteoblasts, while inhibiting the formation and function of osteoclasts to relieve osteoporosis. Icariin can activate ERα-Wnt/β-catenin and Notch signaling pathways, up-regulate the expression of runt-related transcription factor 2, a key osteoblast gene, and play an osteogenic role; it can activate mitogen-activated protein kinase (mitogen-activated protein kinase) kinase, MAPK) signaling pathway, increase the gene expression of type I collagen, osteocalcin and osteotin, enhance the self-renewal ability of bone mesenchymal stem cells (BMSCs) in vitro and in vivo, induce BMSCs to osteoblasts differentiation, thereby enhancing osteogenic differentiation. In addition, icariin can promote the synthesis of estrogen and has estrogen-like effects, and can activate extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (c-jun n-terminal kinase) , JNK), promote the proliferation of osteoblasts, activate BMP-2/Smad4, and increase the viability of osteoblasts. Icariin Solgar can down-regulate hypoxia-inducible factor-1α, prostaglandin E2 and osteoclast differentiation factor-nuclear transcription factor receptor activator ligand by inhibiting the activity of MAPKs and nuclear factor kappa-B (NF-κB). The synthesis of receptor activator of NF-κB ligand (RANKL) inhibits the differentiation of hematopoietic cells into osteoclasts. Icariin and its derivatives can inhibit the expression of RANKL, which promotes osteoclastogenesis, promote the expression of alkaline phosphatase, osteocalcin, type I collagen, and osteoprotegerin, which have osteogenic effects, and inhibit osteoclast differentiation. In addition, icariin can reduce the generation of superoxide anion and the size and number of actin rings, reduce intracellular calcium concentration, inhibit osteoclast activity, thereby inhibiting bone resorption.

Cardiovascular disease is one of the main causes of human death in modern society. Icariin Solgar can protect cardiomyocytes, promote cardiomyocyte generation, improve endothelial dysfunction, and play a protective role in the cardiovascular system.

Icariin Solgar can block angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the activation of JNK and p38 pathways; activate ERK, scavenge reactive oxygen species, and inhibit oxidative stress in cardiomyocytes. Icariin can also activate the PI3K/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway, reduce the levels of creatine kinase, ischemia-modified albumin and lactate dehydrogenase, and reduce apoptotic cells , myocardial infarction area, improve myocardial ischemia-reperfusion injury in rats; down-regulate the activities of matrix metalloproteinase 2 and 9, improve myocardial cell apoptosis, reduce left ventricular dysfunction and cardiac remodeling.

Icariin Solgar can activate the p38MAPK pathway, increase the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, PPARα and nuclear respiratory factor 1, promote the differentiation of embryonic stem cells into cardiomyocytes, and upregulate the specificity of cardiomyocytes after differentiation. The expression of myosin light chain-1v, atrial natriuretic peptide, cardiac troponin I, troponin, and sodium-calcium exchanger maintains the normal functional structure of cardiomyocyte beating. In addition, icariin can also activate the ERK-dependent signaling pathway and stimulate the differentiation of mouse adipose-derived stem cells into cardiomyocytes.

Icariin Solgar can inhibit the activation of caspase-3, up-regulate the level of eNOS, promote the production of nitric oxide (NO), and reduce the oxidative stress damage of endothelial cells. Icariin can reduce reactive oxygen species levels, activate PI3K/Akt/eNOS signaling pathway, and delay homocysteine-induced endothelial cell senescence. Icariin can reduce the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin, inhibit the adhesion of monocytes and endothelial cells, and improve atherosclerotic lesions.

Icariin Solgar improves the condition of autoimmune diseases such as rheumatoid arthritis, bronchial asthma, multiple sclerosis and systemic lupus erythematosus, which is related to the regulation of lymphocyte function. Icariin can inhibit the differentiation of helper T cells (Th) 1, 17 and improve autoimmune encephalomyelitis in mice. Icariin can inhibit the activation of STAT3 in T cells, down-regulate the proportion of Th17 cells, inhibit the production of interleukin-17, and improve the symptoms of rheumatoid arthritis; it can regulate the ratio of Th1/Th2 cells in the lung tissue of asthmatic rats, the proportion of asthmatic The balance of Th17/regulatory T cells in mice improves asthma; it can increase the activity of lymphokine-activated killer cells and natural killer cells, and improve human immunity.

In addition, Icariin Solgar has anti-inflammatory, anti-cancer, anti-aging and other effects. The various pharmacological effects and low toxicity of icariin lay the foundation for its wide application. According to the relevant national website information, there are 183 formulas involving the raw material Epimedium in the formulas of health care products for relieving physical fatigue, indicating that Epimedium has great potential for development and utilization, so Epimedium as the main carrier of icariin is Epimedium Agaricus extract is bound to make a difference.

Icariin Solgar Analytical Methods

1. Thin-layer recognition approach
Take 0.5 g of Epimedium medicinal powder or a suitable quantity of essence, include 10ml of ethanol, warm saturate for thirty minutes, filter, evaporate the filtrate to dryness, add 1ml of ethanol to the residue to dissolve, and it is the test service. Weigh the Icariin Solgar reference material, liquify it with methanol and also weaken it to 0.1 mg/ml, which is the recommendation substance remedy. Attract 10 μl of the test option and the recommendation option, respectively, and position them on the very same silica gel H thin-layer plate with salt carboxymethyl cellulose as the binder. Ethyl acetate-butanone-formic acid-water (10:1: 1:1) is a developing agent, unravel, take out, dry, and consult an ultraviolet light (365nm). Light weight aluminum examination remedy, and afterwards put ultraviolet light (365nm) evaluation, showing the exact same orange-red fluorescent areas.

2. Spectrophotometry
Decision of the content of total flavonoids in Epimedium as well as its essences The referral substance Icariin Solgar was properly weighed and made into a 10ug/ml basic service with methanol. Accurately weigh an ideal quantity of this item powder (equivalent to concerning 1mg of icariin), ultrasonicate it with 25ml of methanol for thirty minutes, established the volume in a 50ml volumetric flask, and also filter it with a 0.45 μm microporous filter membrane layer. product option. Take the test service and the recommendation solution specifically, take the reagent as the empty, measure the absorbance at the wavelength of 270nm, as well as determine.

3. HPLC technique
Decision of Icariin Solgar in Epimedium and also its extracts Chromatographic conditions and also system viability examination: ODS25uC18 (4mm × 150mm) chromatographic column; mobile stage: acetonitrile-water (30:70); detection wavelength: 270nm; flow price: 0.8 ml/min. The academic plate number shall not be less than 1500 in regards to icariin. Preparation of referral substance service: Exactly evaluate referral substance Icariin Solgar as well as prepare a remedy of 0.1 mg/ml with methanol. Prep work of the examination service: Accurately consider an ideal amount of this product powder (matching to concerning 1mg of Icariin Solgar), ultrasonicate with 25ml of methanol for half an hour, set the volume in a 50ml volumetric flask, as well as filter with a 0.45 μm microporous membrane layer. is the test option. Decision technique: Inject 10 μl of the sample examination option and the reference service into the HPLC tool respectively, as well as calculate by the location outside criterion technique.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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