Zhishang Chemical

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Zhishang Chemical

Icariin Powder CAS 489-32-7

Molecular Formula: C33H40O15

Formula Weight: 676.66

ZSpharmac: Icariin Powder Cosmetic Raw Material Suppliers

Product Name: Icariin Powder
CAS No: 489-32-7
Purity: 99%

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Basic Info

Product Name:Icariin Powder
Other Names:Icariin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
EINECS No.:610-440-0
Provide:Icariin Powder MSDS;
Icariin Powder COA

What is Icariin Powder?

Epimedium is a typical Chinese medicine that nurtures yang. It is warm, pleasant and comfortable in nature. It has the features of tonifying the kidneys and enhancing yang, getting rid of wind and dehumidification. It is usually used in traditional Chinese medication to handle erectile dysfunction and spermatorrhea, stranguria, weak muscle mass and bones, rheumatic arthralgia, pins and needles and convulsion, and so on. The significant chemical aspects of Epimedium include flavonoids, lignans, polysaccharides, etc. Modern medicinal research study shows that Epimedium has a regulative impact on bone metabolic process, the immune system, and the neuro-endocrine system, and has anti-inflammatory, antioxidant, anti-tumor and various other medicinal tasks. Icariin is the energised ingredient removed from it.

Icariin Powder Property

Melting point 223-225 ºC
alpha D15 -87.09° (in pyridine)
Boiling point 948.5±65.0 °C(Predicted)
density 1.55
RTECS DJ2980500
storage temp. 2-8°C
solubility DMSO: soluble50mg/mL, clear, colorless to dark yellow
form Powder
color light yellow to yellow


Icariin Powder Uses

Icariin Powder can enhance cardio and cerebrovascular blood flow, market hematopoietic function, immune attribute and bone metabolic rate. It has kidney-tonifying, anti-aging, anti-tumor and numerous other end results.
1. Influence on endocrine: Icariin Powder can market sex-related attribute as a result of hypersecretion of seminal fluid. After the influential vesicles are complete, it promotes sensory nerves and indirectly enhances sex drive.
2. Influence on body immune system function: The variety of T cells, lymphatic price, antibodies, antigens and reticuloendothelial system phagocytosis in clients with kidney absence are lowered, yet these can be boosted after therapy with epimedium and various other kidney-tonifying medications.
3. Anti-aging impact: Icariin Powder can influence the aging device in various elements. As an example, it affects cell flow, extends the development period, regulates the immune and secretory systems, and improves body metabolic treatment and many body organ functions.
4. Result on the cardiovascular system: Icariin on the posterior pituitary gland

Icariin Powder Analysis Method

1. Thin layer identification method
Take 0.5 g of epimedium medicinal powder or an ideal amount of extract, include 10ml of ethanol, take in warm temperature for half an hour, filter, vaporize the filtrate to dryness, include 1ml of ethanol to the residue to dissolve, which is the examination remedy. Weigh the icariin referral substance, dissolve it in methanol and dilute it to 0.1 mg/ml, which is the recommendation material remedy. Take 10 μl each of the test remedy and the recommendation solution, and put them on the very same silica gel H thin-layer plate with salt carboxymethylcellulose as the adhesive, and utilize ethyl acetate-butanone-formic acid-water (10:1: 1:1) is the creating agent, unravel it, take it out, completely dry it, and examine it under a UV lamp (365nm). In the chromatogram of the examination item, the same dark red places show up at the settings corresponding to the chromatogram of the recommendation material; spray with trichloride Aluminum examination option, and then placed under UV light (365nm) for inspection, the exact same orange-red fluorescent areas were disclosed.
2. Decision of complete flavonoid material in Epimedium and its extracts by spectrophotometry
Precisely evaluate the reference substance icariin and prepare a typical service of 10ug/ml with methanol. Precisely weigh a suitable amount of the powder of this item (equivalent to around 1 mg of icariin), ultrasonicate with 25 ml of methanol for thirty minutes, weaken to volume in a 50 ml gauging bottle, and filter with a 0.45 μm microporous membrane layer to prepare for screening. product solution. Take the examination option and the recommendation solution respectively, make use of the reagent as the blank, gauge the absorbance at a wavelength of 270nm, and determine it.
3. HPLC approach to identify the content of icariin in Epimedium and its essences
Chromatographic conditions and system suitability examination: ODS25uC18 (4mm × 150mm) chromatographic column; mobile stage: acetonitrile-water (30:70); discovery wavelength: 270nm; flow price: 0.8 ml/min. The variety of academic plates based upon icariin is not less than 1500.
Preparation of the reference substance solution: Exactly consider the recommendation material icariin and prepare a 0.1 mg/ml remedy with methanol.
Preparation of the examination option: Precisely evaluate an ideal quantity of this item powder (comparable to around 1 mg of icariin), sonicate with 25 ml of methanol for half an hour, water down to quantity in a 50 ml determining container, filter with a 0.45 μm micropore Membrane layer filtering is the test service.
Decision method: Inject 10 μl of each example examination remedy and recommendation service right into the HPLC instrument, and compute the location utilizing the external criterion approach.

Icariin Powder Preparation Method

Although Icariin Powder has really wide leads for use in the field of medication and healthcare, most of the icariin removed and separated in the industry presently has a reduced web content, which can not meet the requirements of high-purity basic materials such as injections; some refining methods make use of Organic solvents such as ethyl acetate, chloroform, and methanol are gotten rid of, resulting in too much solvent deposits in the product. At the same time, there are significant safety and security threats in production, which is not for industrial production.

A preparation technique of high-content icariin, including the following steps:
( 1) Stir and extract the Epimedium extract with an Icariin Powder content of 15% to 40% with 2 to 10 times its mass of ethanol at space temperature and then filter to obtain a filtrate and filter cake; at the same time, recoup the ethanol in the filtrate; (2) Include 5 to 15 times the mass of ethanol to the filter cake, and add triggered carbon at 2 to 10% of the ethanol quantity. After refluxing and decolorizing, filter out the triggered carbon, and the resulting filtrate is entrusted to stand at 0 to 30 ° C., precipitate crystals; (3) Strain the crystals acquired in step (2 ), add 5 to 15 times the quantity of ethanol of the crystal high quality to it, warmth and dissolve it at 50 to 70 ° C, and dissolve it according to the quantity of ethanol. 2 to 10% of triggered carbon is included, and the activated carbon is removed after refluxing and decolorizing. The resulting filtrate is delegated stand at a temperature of 0 to 30 ° C to speed up secondary crystals; (4) filter the additional crystals gotten in step (3 ). After drying out, icariin with a material of more than 98% is gotten.

About Products:
If you need the cosmetic raw material Icariin Powder, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Icariin Powder manufacturer and supplier, ZSpharmac will provide Icariin Powder raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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