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Hypericum Perforatum Extract CAS 84082-80-4

Molecular Formula: NULL

Formula Weight: 0

ZSpharmac: Hypericum Perforatum Extract Supplement

Product Name: Hypericum Perforatum Extract
CAS No: 84082-80-4
Purity: 99%

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Basic Info

Product Name:Hypericum Perforatum Extract
Other Names:St.-John’s-Wort, Hypericum Perforatum, Ext.
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:282-026-4
Provide:Hypericum Perforatum Extract MSDS;
Hypericum Perforatum Extract COA

What is Hypericum Perforatum Extract?

Hypericum perforatum remove is a product drawn out from the flowering suggestion or aerial part of Hypericum perforatum L., and the business essence is generally standard to have 0.3% of total hypericin.
[Unrefined medicine resources] Usual in hillside woodlands or grasslands at an elevation of 1000 to 2500 meters. Hypericum perforatum is commonly dispersed in my nation, consisting of Guizhou, Sichuan (such as Zhaojue, Yanyuan, Yanbian, etc in Liangshan Prefecture), Jiangsu, Hebei, Shandong, Shaanxi, Jiangxi and also various other districts, mainly generated in Jiangsu, Sichuan, Guizhou, etc land.
Plant form Seasonal herb, the entire plant is glabrous, the stem is erect, as well as the elevation is 10-100cm. The fallen leaves are oblong, 1.5-4cm long, sessile, contrary, glabrous, with transparent gland factors. The inflorescence is large and also round, cymes, each inflorescence has around 25 to 100 flowers, and also the blossoms are monoecious. Sepals 5, divided, 4.0-6.0 mm long, lanceolate, severe or acuminate, with black glandular factors. Petals 5, separated, 8.0-12.0 mm long, yellow, with black glands on the edge. Stamens 15-100, in 3-5 bundles, ovary exceptional, style 3-lobed. The fruit is a broken pill, 7.0-8.0 mm long, brown. Seeds round, pitted.

Hypericum Perforatum Extract Property

storage temp. -20°C
form neat
CAS DataBase Reference84082-80-4


Applications of Hypericum Perforatum Extract

Hypericum Perforatum Extract ingredients are made use of in cosmetics as skin conditioners, moisturizers; skin protectants; anti-oxidants, hair conditioners; as well as antibacterials. After safety evaluation, Hypericum perforatum extract is risk-free as a cosmetic active ingredient.

Hypericum Perforatum Essence has long been utilized as an antidepressant in Europe (specifically Germany), but research study on its mechanism and also energetic ingredients is still under investigation.
It is usually believed that Hypericum perforatum, like usual antidepressants, prevents the reuptake of norepinephrine and serotonin. It is theorized that Hypericum perforatum acts on numerous fronts at the same time: inhibiting the reuptake of norepinephrine, serotonin, and also dopamine; reduced degrees of MAOIs (monoamine oxidase preventions); and acting on the hypothalamus, hindering cortisol secretion. There are also theories that Hypericum Perforatum Remove has an excellent affinity for some substance receptors related to brain nerve mass transfer, such as GABA (gamma-aminobutyric acid). GABA is one of the major compounds that calm the central nerve system, as well as brand-new research reveals that GABA is likewise associated with antidepressants. GABA levels are low in individuals with clinical depression, and medicines that boost GABA task additionally have antidepressant results. It has also been suggested that Hypericum perforatum inhibits the activity of interleukin-6, an immune-boosting chemical that can cause anxiety. Hypericum perforatum can be utilized to deal with menopausal anxiety due to the activity of a moderate plant hormonal agent – beta-sitosterol.
The basic point of view is that the active ingredient of Hypericum perforatum antidepressant is hypericin, which overcomes the MAOI device. However, the researchers questioned that hypericin is the active component as well as the system of MAOI itself, and proposed new possible energetic components: flavonoids (similar chemical structure to MAOI), such as amantoflavin; Hinder MAO-A, MAO-B) and other unknown parts, as well as it is thought that several substances might act synergistically.
Many research studies can give evidence for the antidepressant effectiveness and safety and security of Hypericum perforatum, one of the most persuading is the record of Linde et al. The literary works shows that Hypericum perforatum is substantially far better than sugar pill in the therapy of light and also modest anxiety, with the exact same efficiency and also fewer negative effects than typical antidepressants (tricyclics).
However, Linde’s experiment has a brief training course of treatment and a small dosage. It just investigated people with light and also modest anxiety, and also did not compare it with other typical antidepressants (MAOIs, SSRIs, Effexnor, Paxil, etc), so it is thought that Hypericum perforatum can entirely change Conclusions about antidepressants are early. At the same time, Hypericum perforatum still has some adverse effects, consisting of interaction with MAOIs, serotonin disorder, photosensitivity, gastrointestinal inflammation, exhaustion, sleeplessness, and also allergic reactions.
The LD50 of Hypericum perforatum has not been reported, however the LD50 of some energetic components are known. Such as the LD50 of hyperin (hyperin)=(0.5 ± 0.014) g/kg. Volunteers were treated with 35 times the standard dosage of Hypericum perforatum remove with minimal adverse effects. It indicated that Hypericum perforatum had higher LD50 as well as lower poisoning.

Hypericum Perforatum Essence can be made use of as a secure neuronutrient to stop clinical depression, control mental illness and also mental illness, eliminate tension and depression, bring back confidence and enhance rest. Hypericum, an energetic component removed from Hypericum perforatum, has considerable anti-DNA, The role of RNA infection can straight act upon the DNA of bird flu, swine high temperature, foot-and-mouth condition as well as other viruses, disrupt the duplication as well as recreation of the infection and have a strong repressive result on the infection.

Analysis method of Hypericum Perforatum Extract

(1) USP method: Weigh 10g of medicinal powder or an equivalent amount of the extract, add 100ml of methanol, shake for 15 minutes, filter, and the filtrate is the test solution. Another reference substance of Hypericum Perforatum Extract was taken and dissolved in methanol to prepare a reference substance solution containing 0.5 mg per ml. Pipette 20 μl of each of the above two solutions, and spot them on the same 0.5mm silica gel G thin-layer plate respectively, with ethyl acetate-water-glacial acetic acid-methanol (10:2.6:1.1:1.1) as the developing agent, expand, and the front reaches the plate Take it out when it is 3/4 of the length, record the front of the solvent, and evaporate the solvent to dry in the air. It was sprayed with 1% methanol solution of 2-diphenylboronic acid-2-aminoethyl ethyl ester, and then immediately sprayed with 5% polyethylene glycol 400 ethanol solution, dried and inspected under a 365nm wavelength ultraviolet lamp. The test solution showed several light orange-yellow fluorescent spots, among which the spots with an Rf value of 0.5 were similar to the corresponding spots in the standard solution chromatogram; among the two red fluorescent spots in the test solution, the one with Rf0.85 was Hypericum Perforatum Extract, Rf0 .80 is pseudohypericin; the two bright blue fluorescent spots are chlorogenic acid and neochlorogenic acid, which are located below the orange spots of hypericin.

(2) AHP method: Weigh an appropriate amount of two reference substances, Hypericum Perforatum Extract and pseudohypericin, respectively, dissolve them in methanol, and dilute them to a solution of 0.1 mg/ml as the reference substance solution. Take 0.1g of the extract, add 10ml of methanol, shake for 5 minutes, transfer the supernatant to a 50ml volumetric flask, repeat the operation three times, adjust the volume to the mark, and filter it with a 0.45μm filter membrane as the test solution. Draw the above test solution and control solution, 5 μl each, and place them on the same silica gel G thin-layer plate, develop with toluene-n-butanol-glacial acetic acid (3:6:1) as the developing agent, dry in the air, and place the thin plate under a UV lamp (365nm), the same bright red fluorescent spots (Hypericum Perforatum ExtractRf0.71, pseudo-Hypericum Perforatum ExtractRf0.50) appear on the corresponding positions of the test substance and the reference substance in the chromatogram.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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