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Hydroxypropyl-BETA-Cyclodextrin CAS 128446-35-5

Molecular Formula: C63H112O42

Formula Weight: 1541.54

ZSpharmac: Hydroxypropyl-BETA-Cyclodextrin Supplier

Product Name: Hydroxypropyl-BETA-Cyclodextrin
CAS No: 128446-35-5
Purity: 99%

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Basic Info

Product Name:Hydroxypropyl-BETA-Cyclodextrin
Other Names:2-Hydroxypropyl-β-Cyclodextrin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White  Liquid
EINECS No.:420-920-1
Storage:Room Temp
Provide:Hydroxypropyl-BETA-Cyclodextrin MSDS;
Hydroxypropyl-BETA-Cyclodextrin COA

What is Hydroxypropyl-BETA-Cyclodextrin?

Hydroxypropyl-BETA-cyclodextrin, also known as Hydroxypropyl-beta-cyclodextrin or HPCD, is a white powder that can be either amorphous or crystalline at normal temperature and pressure. It is readily soluble in strong polar solvents like water, methanol, and ethanol, but does not dissolve in low polar organic solvents such as acetone. Its primary function as a carrier for intravenous injection is to enhance the solubility of poorly soluble drugs. When used as a carrier, hydroxypropyl-BETA-cyclodextrin can encapsulate all or part of the drug molecules in its cavities, potentially impacting the drug’s stability. However, if the unstable components of the drug are enclosed within the cavities, it can lead to an improvement in the drug’s stability

Hydroxypropyl-BETA-Cyclodextrin Property

Melting point 278 °C (dec.)
Boiling point 400℃
density 1.05 at 20.3℃
refractive index 125 ° (C=1, H2O)
storage temp. room temp
solubility H2O: 45 % (w/v)
form solution (clear, colorless)
color White to slightly yellow
optical activity[α]26/D +139°, c = 1 in H2O
Water Solubility Soluble in water.


Hydroxypropyl-BETA-Cyclodextrin Applications

Hydroxypropyl-BETA-cyclodextrin is a versatile solubilizer and pharmaceutical excipient used in various industries. In the pharmaceutical field, it can enhance the solubility of poorly soluble drugs, improve drug stability, and increase drug bioavailability. It can also adjust the release rate of the drug and reduce its toxic and side effects.

In the food and spice industry, it improves the stability and long-term effectiveness of nutritional molecules, as well as masks or corrects unpleasant smells and tastes. It is highly soluble in water and can be mixed with water in any proportion. It can also be dissolved in 50% ethanol and methanol.

In cosmetics, it is used as a stabilizer, emulsifier, and deodorant to reduce skin and mucous membrane irritation, enhance the stability of active ingredients, and prevent nutrient volatilization and oxidation. It also has relative hygroscopic properties.

In the pharmaceutical industry, it is an ideal solubilizer and excipient for injections due to its low surface activity, minimal hemolytic activity, and non-irritating properties.

Effects of Hydroxypropyl-BETA-Cyclodextrin on Drug Behavior in Vivo

The impact of inclusion compounds on the pharmacokinetics of drugs depends on the strength of the interaction between the drug and HPCD, as well as the plasma protein binding rate of the drug. A study on the inclusion complex of HPCD and all-trans retinoic acid found that when injected intravenously into rats, the pharmacokinetic properties of all-trans retinoic acid did not change significantly. The moderate molecular weight of HPCD allows it to pass through tight junctions between organs and enter tissues, but its polarity prevents it from crossing cell membranes, leading to distribution into certain tissues. HPCD’s ability to solubilize cholesterol and extract lipid components from cell membranes can disrupt membrane integrity, allowing carried drugs to cross barriers. The inclusion effect of hydroxypropyl-β-cyclodextrin on oral drugs can result in immediate release, delayed release, extended release, and controlled release. By selecting appropriate hydroxypropyl-β-cyclodextrin with different degrees of substitution and designing oral drug formulations, the release rate can be improved or regulated. For example, the hydroxypropyl-β-cyclodextrin inclusion complex of fentanyl dissociates at the injection site, releasing fentanyl and providing relief.

Contact Us

About Products:
If you need the cosmetic raw material Hydroxypropyl-BETA-Cyclodextrin, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Hydroxypropyl-BETA-Cyclodextrin manufacturer and supplier, ZSpharmac will provide Hydroxypropyl-BETA-Cyclodextrin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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